{"bundle_type":"pith_open_graph_bundle","bundle_version":"1.0","pith_number":"pith:2021:73BB4NRZQYTZZTP2256JI57LCV","short_pith_number":"pith:73BB4NRZ","canonical_record":{"source":{"id":"2107.09442","kind":"arxiv","version":1},"metadata":{"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"eess.IV","submitted_at":"2021-07-20T12:21:45Z","cross_cats_sorted":["cs.CV"],"title_canon_sha256":"c08dbfa46d2a998f5ba8b57cc9b6d5a31b2ea64ba3a340fb407a3d7139c5a663","abstract_canon_sha256":"cc6732c65e437101f9ddc78f5e343cda673c5a916a0b734406b8a0befaf1e694"},"schema_version":"1.0"},"canonical_sha256":"fec21e363986279ccdfad77c9477eb157085e825220f15dd41fcf38af8a085c2","source":{"kind":"arxiv","id":"2107.09442","version":1},"source_aliases":[{"alias_kind":"arxiv","alias_value":"2107.09442","created_at":"2026-07-05T02:59:30Z"},{"alias_kind":"arxiv_version","alias_value":"2107.09442v1","created_at":"2026-07-05T02:59:30Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.2107.09442","created_at":"2026-07-05T02:59:30Z"},{"alias_kind":"pith_short_12","alias_value":"73BB4NRZQYTZ","created_at":"2026-07-05T02:59:30Z"},{"alias_kind":"pith_short_16","alias_value":"73BB4NRZQYTZZTP2","created_at":"2026-07-05T02:59:30Z"},{"alias_kind":"pith_short_8","alias_value":"73BB4NRZ","created_at":"2026-07-05T02:59:30Z"}],"events":[{"event_type":"record_created","subject_pith_number":"pith:2021:73BB4NRZQYTZZTP2256JI57LCV","target":"record","payload":{"canonical_record":{"source":{"id":"2107.09442","kind":"arxiv","version":1},"metadata":{"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"eess.IV","submitted_at":"2021-07-20T12:21:45Z","cross_cats_sorted":["cs.CV"],"title_canon_sha256":"c08dbfa46d2a998f5ba8b57cc9b6d5a31b2ea64ba3a340fb407a3d7139c5a663","abstract_canon_sha256":"cc6732c65e437101f9ddc78f5e343cda673c5a916a0b734406b8a0befaf1e694"},"schema_version":"1.0"},"canonical_sha256":"fec21e363986279ccdfad77c9477eb157085e825220f15dd41fcf38af8a085c2","receipt":{"kind":"pith_receipt","key_id":"pith-v1-2026-05","algorithm":"ed25519","signed_at":"2026-07-05T02:59:30.862302Z","signature_b64":"cn5lTOQttrHHhZ48SIUDpSm8ishRdbN7rHQThpmzWWgdQAOA6u4eJJgMgmJnQQUmA+z5F/7cbXmAiMWgugVvDQ==","signed_message":"canonical_sha256_bytes","builder_version":"pith-number-builder-2026-05-17-v1","receipt_version":"0.3","canonical_sha256":"fec21e363986279ccdfad77c9477eb157085e825220f15dd41fcf38af8a085c2","last_reissued_at":"2026-07-05T02:59:30.861766Z","signature_status":"signed_v1","first_computed_at":"2026-07-05T02:59:30.861766Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"source_kind":"arxiv","source_id":"2107.09442","source_version":1,"attestation_state":"computed"},"signer":{"signer_id":"pith.science","signer_type":"pith_registry","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"created_at":"2026-07-05T02:59:30Z","supersedes":[],"prev_event":null,"signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"aglwHC1+qgkkuYC14o9fvOhsWuN/6LpRXEViyosW8F6o0VrlbjHnGDpuHyVBa9gLmwJwHav/pXBLSA1gOG4eAg==","signed_message":"open_graph_event_sha256_bytes","signed_at":"2026-08-13T16:31:18.280100Z"},"content_sha256":"3370fdcdb5019f6ebd63850a54fd8124635a3d60fcbf6a818a9e7ca2e5712947","schema_version":"1.0","event_id":"sha256:3370fdcdb5019f6ebd63850a54fd8124635a3d60fcbf6a818a9e7ca2e5712947"},{"event_type":"graph_snapshot","subject_pith_number":"pith:2021:73BB4NRZQYTZZTP2256JI57LCV","target":"graph","payload":{"graph_snapshot":{"paper":{"title":"Automated Segmentation and Volume Measurement of Intracranial Carotid Artery Calcification on Non-Contrast CT","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","headline":"","cross_cats":["cs.CV"],"primary_cat":"eess.IV","authors_text":"Daniel Bos, Florian Dubost, Gerda Bortsova, Gijs van Tulder, Marleen de Bruijne, Meike W. Vernooij, M. Kamran Ikram","submitted_at":"2021-07-20T12:21:45Z","abstract_excerpt":"Purpose: To evaluate a fully-automated deep-learning-based method for assessment of intracranial carotid artery calcification (ICAC). Methods: Two observers manually delineated ICAC in non-contrast CT scans of 2,319 participants (mean age 69 (SD 7) years; 1154 women) of the Rotterdam Study, prospectively collected between 2003 and 2006. These data were used to retrospectively develop and validate a deep-learning-based method for automated ICAC delineation and volume measurement. To evaluate the method, we compared manual and automatic assessment (computed using ten-fold cross-validation) with "},"claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"2107.09442","kind":"arxiv","version":1},"verdict":{"id":null,"model_set":{},"created_at":null,"strongest_claim":"","one_line_summary":"","pipeline_version":null,"weakest_assumption":"","pith_extraction_headline":""},"integrity":{"clean":true,"summary":{"advisory":0,"critical":0,"by_detector":{},"informational":0},"endpoint":"/pith/2107.09442/integrity.json","findings":[],"available":true,"detectors_run":[],"snapshot_sha256":"c28c3603d3b5d939e8dc4c7e95fa8dfce3d595e45f758748cecf8e644a296938"},"references":{"count":0,"sample":[],"resolved_work":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","internal_anchors":0},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"author_claims":{"count":0,"strong_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"builder_version":"pith-number-builder-2026-05-17-v1"},"verdict_id":null},"signer":{"signer_id":"pith.science","signer_type":"pith_registry","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"created_at":"2026-07-05T02:59:30Z","supersedes":[],"prev_event":null,"signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"7nX72aM4otB6PJpU3NFmyuPQekHQlbBc1bX45twjOb0P3QqUmKNiYgVl/ZH5HlcZXFj90nS/OBgSzDq4PzTRCQ==","signed_message":"open_graph_event_sha256_bytes","signed_at":"2026-08-13T16:31:18.280642Z"},"content_sha256":"f55a3a93197a63493a92295aa90ad6c6de3d5880b2f5b8ae200b84d40ef18c52","schema_version":"1.0","event_id":"sha256:f55a3a93197a63493a92295aa90ad6c6de3d5880b2f5b8ae200b84d40ef18c52"}],"timestamp_proofs":[],"mirror_hints":[{"mirror_type":"https","name":"Pith Resolver","base_url":"https://pith.science","bundle_url":"https://pith.science/pith/73BB4NRZQYTZZTP2256JI57LCV/bundle.json","state_url":"https://pith.science/pith/73BB4NRZQYTZZTP2256JI57LCV/state.json","well_known_bundle_url":"https://pith.science/.well-known/pith/73BB4NRZQYTZZTP2256JI57LCV/bundle.json","status":"primary"}],"public_keys":[{"key_id":"pith-v1-2026-05","algorithm":"ed25519","format":"raw","public_key_b64":"stVStoiQhXFxp4s2pdzPNoqVNBMojDU/fJ2db5S3CbM=","public_key_hex":"b2d552b68890857171a78b36a5dccf368a953413288c353f7c9d9d6f94b709b3","fingerprint_sha256_b32_first128bits":"RVFV5Z2OI2J3ZUO7ERDEBCYNKS","fingerprint_sha256_hex":"8d4b5ee74e4693bcd1df2446408b0d54","rotates_at":null,"url":"https://pith.science/pith-signing-key.json","notes":"Pith uses this Ed25519 key to sign canonical record SHA-256 digests. Verify with: ed25519_verify(public_key, message=canonical_sha256_bytes, signature=base64decode(signature_b64))."}],"merge_version":"pith-open-graph-merge-v1","built_at":"2026-08-13T16:31:18Z","links":{"resolver":"https://pith.science/pith/73BB4NRZQYTZZTP2256JI57LCV","bundle":"https://pith.science/pith/73BB4NRZQYTZZTP2256JI57LCV/bundle.json","state":"https://pith.science/pith/73BB4NRZQYTZZTP2256JI57LCV/state.json","well_known_bundle":"https://pith.science/.well-known/pith/73BB4NRZQYTZZTP2256JI57LCV/bundle.json"},"state":{"state_type":"pith_open_graph_state","state_version":"1.0","pith_number":"pith:2021:73BB4NRZQYTZZTP2256JI57LCV","merge_version":"pith-open-graph-merge-v1","event_count":2,"valid_event_count":2,"invalid_event_count":0,"equivocation_count":0,"current":{"canonical_record":{"metadata":{"abstract_canon_sha256":"cc6732c65e437101f9ddc78f5e343cda673c5a916a0b734406b8a0befaf1e694","cross_cats_sorted":["cs.CV"],"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"eess.IV","submitted_at":"2021-07-20T12:21:45Z","title_canon_sha256":"c08dbfa46d2a998f5ba8b57cc9b6d5a31b2ea64ba3a340fb407a3d7139c5a663"},"schema_version":"1.0","source":{"id":"2107.09442","kind":"arxiv","version":1}},"source_aliases":[{"alias_kind":"arxiv","alias_value":"2107.09442","created_at":"2026-07-05T02:59:30Z"},{"alias_kind":"arxiv_version","alias_value":"2107.09442v1","created_at":"2026-07-05T02:59:30Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.2107.09442","created_at":"2026-07-05T02:59:30Z"},{"alias_kind":"pith_short_12","alias_value":"73BB4NRZQYTZ","created_at":"2026-07-05T02:59:30Z"},{"alias_kind":"pith_short_16","alias_value":"73BB4NRZQYTZZTP2","created_at":"2026-07-05T02:59:30Z"},{"alias_kind":"pith_short_8","alias_value":"73BB4NRZ","created_at":"2026-07-05T02:59:30Z"}],"graph_snapshots":[{"event_id":"sha256:f55a3a93197a63493a92295aa90ad6c6de3d5880b2f5b8ae200b84d40ef18c52","target":"graph","created_at":"2026-07-05T02:59:30Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"graph_snapshot":{"author_claims":{"count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","strong_count":0},"builder_version":"pith-number-builder-2026-05-17-v1","claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"integrity":{"available":true,"clean":true,"detectors_run":[],"endpoint":"/pith/2107.09442/integrity.json","findings":[],"snapshot_sha256":"c28c3603d3b5d939e8dc4c7e95fa8dfce3d595e45f758748cecf8e644a296938","summary":{"advisory":0,"by_detector":{},"critical":0,"informational":0}},"paper":{"abstract_excerpt":"Purpose: To evaluate a fully-automated deep-learning-based method for assessment of intracranial carotid artery calcification (ICAC). Methods: Two observers manually delineated ICAC in non-contrast CT scans of 2,319 participants (mean age 69 (SD 7) years; 1154 women) of the Rotterdam Study, prospectively collected between 2003 and 2006. These data were used to retrospectively develop and validate a deep-learning-based method for automated ICAC delineation and volume measurement. To evaluate the method, we compared manual and automatic assessment (computed using ten-fold cross-validation) with ","authors_text":"Daniel Bos, Florian Dubost, Gerda Bortsova, Gijs van Tulder, Marleen de Bruijne, Meike W. Vernooij, M. Kamran Ikram","cross_cats":["cs.CV"],"headline":"","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"eess.IV","submitted_at":"2021-07-20T12:21:45Z","title":"Automated Segmentation and Volume Measurement of Intracranial Carotid Artery Calcification on Non-Contrast CT"},"references":{"count":0,"internal_anchors":0,"resolved_work":0,"sample":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"2107.09442","kind":"arxiv","version":1},"verdict":{"created_at":null,"id":null,"model_set":{},"one_line_summary":"","pipeline_version":null,"pith_extraction_headline":"","strongest_claim":"","weakest_assumption":""}},"verdict_id":null}}],"author_attestations":[],"timestamp_anchors":[],"storage_attestations":[],"citation_signatures":[],"replication_records":[],"corrections":[],"mirror_hints":[],"record_created":{"event_id":"sha256:3370fdcdb5019f6ebd63850a54fd8124635a3d60fcbf6a818a9e7ca2e5712947","target":"record","created_at":"2026-07-05T02:59:30Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"attestation_state":"computed","canonical_record":{"metadata":{"abstract_canon_sha256":"cc6732c65e437101f9ddc78f5e343cda673c5a916a0b734406b8a0befaf1e694","cross_cats_sorted":["cs.CV"],"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"eess.IV","submitted_at":"2021-07-20T12:21:45Z","title_canon_sha256":"c08dbfa46d2a998f5ba8b57cc9b6d5a31b2ea64ba3a340fb407a3d7139c5a663"},"schema_version":"1.0","source":{"id":"2107.09442","kind":"arxiv","version":1}},"canonical_sha256":"fec21e363986279ccdfad77c9477eb157085e825220f15dd41fcf38af8a085c2","receipt":{"algorithm":"ed25519","builder_version":"pith-number-builder-2026-05-17-v1","canonical_sha256":"fec21e363986279ccdfad77c9477eb157085e825220f15dd41fcf38af8a085c2","first_computed_at":"2026-07-05T02:59:30.861766Z","key_id":"pith-v1-2026-05","kind":"pith_receipt","last_reissued_at":"2026-07-05T02:59:30.861766Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","receipt_version":"0.3","signature_b64":"cn5lTOQttrHHhZ48SIUDpSm8ishRdbN7rHQThpmzWWgdQAOA6u4eJJgMgmJnQQUmA+z5F/7cbXmAiMWgugVvDQ==","signature_status":"signed_v1","signed_at":"2026-07-05T02:59:30.862302Z","signed_message":"canonical_sha256_bytes"},"source_id":"2107.09442","source_kind":"arxiv","source_version":1}}},"equivocations":[],"invalid_events":[],"applied_event_ids":["sha256:3370fdcdb5019f6ebd63850a54fd8124635a3d60fcbf6a818a9e7ca2e5712947","sha256:f55a3a93197a63493a92295aa90ad6c6de3d5880b2f5b8ae200b84d40ef18c52"],"state_sha256":"174814c914525b00fa2fa31a624a85655f31a920a423edf28df98eb24e4fae5b"},"bundle_signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"JJ/pTb9XqMfLNBcSN1BSgZR68667NrAFFHoFHmtemOBzNhOm3U4E0PvDSjnDPmQ+b4FZtlkPbHYVhQL9JLN6CQ==","signed_message":"bundle_sha256_bytes","signed_at":"2026-08-13T16:31:18.285263Z","bundle_sha256":"5378b684e2ec2e7fed0e1694fd653b0a00d554eca525dcb993dad5ed41d2d774"}}