{"bundle_type":"pith_open_graph_bundle","bundle_version":"1.0","pith_number":"pith:2025:74SGOWUGZWCPDKJ4VIL7AI4UHV","short_pith_number":"pith:74SGOWUG","canonical_record":{"source":{"id":"2505.17130","kind":"arxiv","version":1},"metadata":{"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"physics.bio-ph","submitted_at":"2025-05-22T01:00:46Z","cross_cats_sorted":["cond-mat.stat-mech"],"title_canon_sha256":"6dd0a14b14a2f19871ac218d287650911ad68b7801fb89bc40092539747cf898","abstract_canon_sha256":"0e1f9047ef8c37931bce9e1983ed17ce2d4a00495d2594949c88d7500f62f915"},"schema_version":"1.0"},"canonical_sha256":"ff24675a86cd84f1a93caa17f023943d411e3e2e6d6567395ab6bfe1506788c3","source":{"kind":"arxiv","id":"2505.17130","version":1},"source_aliases":[{"alias_kind":"arxiv","alias_value":"2505.17130","created_at":"2026-07-05T11:07:47Z"},{"alias_kind":"arxiv_version","alias_value":"2505.17130v1","created_at":"2026-07-05T11:07:47Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.2505.17130","created_at":"2026-07-05T11:07:47Z"},{"alias_kind":"pith_short_12","alias_value":"74SGOWUGZWCP","created_at":"2026-07-05T11:07:47Z"},{"alias_kind":"pith_short_16","alias_value":"74SGOWUGZWCPDKJ4","created_at":"2026-07-05T11:07:47Z"},{"alias_kind":"pith_short_8","alias_value":"74SGOWUG","created_at":"2026-07-05T11:07:47Z"}],"events":[{"event_type":"record_created","subject_pith_number":"pith:2025:74SGOWUGZWCPDKJ4VIL7AI4UHV","target":"record","payload":{"canonical_record":{"source":{"id":"2505.17130","kind":"arxiv","version":1},"metadata":{"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"physics.bio-ph","submitted_at":"2025-05-22T01:00:46Z","cross_cats_sorted":["cond-mat.stat-mech"],"title_canon_sha256":"6dd0a14b14a2f19871ac218d287650911ad68b7801fb89bc40092539747cf898","abstract_canon_sha256":"0e1f9047ef8c37931bce9e1983ed17ce2d4a00495d2594949c88d7500f62f915"},"schema_version":"1.0"},"canonical_sha256":"ff24675a86cd84f1a93caa17f023943d411e3e2e6d6567395ab6bfe1506788c3","receipt":{"kind":"pith_receipt","key_id":"pith-v1-2026-05","algorithm":"ed25519","signed_at":"2026-07-05T11:07:47.573736Z","signature_b64":"CohBFHdws5URqC/TQQu7Zsra7vpzrTO3hsMxVUUQ/EgMIaof2dMgHT3UJkjeu6aDHo2x3B1KUGO4E9btDuFxCg==","signed_message":"canonical_sha256_bytes","builder_version":"pith-number-builder-2026-05-17-v1","receipt_version":"0.3","canonical_sha256":"ff24675a86cd84f1a93caa17f023943d411e3e2e6d6567395ab6bfe1506788c3","last_reissued_at":"2026-07-05T11:07:47.573225Z","signature_status":"signed_v1","first_computed_at":"2026-07-05T11:07:47.573225Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"source_kind":"arxiv","source_id":"2505.17130","source_version":1,"attestation_state":"computed"},"signer":{"signer_id":"pith.science","signer_type":"pith_registry","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"created_at":"2026-07-05T11:07:47Z","supersedes":[],"prev_event":null,"signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"cnhMqDemq7T6GMXFGMDHbw851Utwkb/2a/4xVs4jj54cb9zT+LTPIgseXiPp3xgRkX58rS7c6PE7LIE53f+WDw==","signed_message":"open_graph_event_sha256_bytes","signed_at":"2026-08-23T00:55:33.348193Z"},"content_sha256":"454bacec287623234479d2dae2d180c37653df2ee4fc985efd3a8b75f538f950","schema_version":"1.0","event_id":"sha256:454bacec287623234479d2dae2d180c37653df2ee4fc985efd3a8b75f538f950"},{"event_type":"graph_snapshot","subject_pith_number":"pith:2025:74SGOWUGZWCPDKJ4VIL7AI4UHV","target":"graph","payload":{"graph_snapshot":{"paper":{"title":"Acceleration of enzymatic reaction-diffusion kinetics by intermediate state","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","headline":"","cross_cats":["cond-mat.stat-mech"],"primary_cat":"physics.bio-ph","authors_text":"Akihiro Fukuda, Shoichi Toyabe, Yohei Nakayama","submitted_at":"2025-05-22T01:00:46Z","abstract_excerpt":"Biological molecular motors are high-performance nanomachines that convert chemical energy into mechanical motion via chemomechanical coupling. Their reaction cycles typically comprise a series of intermediate chemical states between the initial and final primary states. However, the influence of these intermediate states on motor performance has not yet been fully explored. In this study, we investigate the impact of intermediate states on the motor kinetics using a reaction-diffusion model. In most cases, the intermediate states accelerate the motor by lowering the effective barrier height. "},"claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"2505.17130","kind":"arxiv","version":1},"verdict":{"id":null,"model_set":{},"created_at":null,"strongest_claim":"","one_line_summary":"","pipeline_version":null,"weakest_assumption":"","pith_extraction_headline":""},"integrity":{"clean":true,"summary":{"advisory":0,"critical":0,"by_detector":{},"informational":0},"endpoint":"/pith/2505.17130/integrity.json","findings":[],"available":true,"detectors_run":[],"snapshot_sha256":"c28c3603d3b5d939e8dc4c7e95fa8dfce3d595e45f758748cecf8e644a296938"},"references":{"count":0,"sample":[],"resolved_work":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","internal_anchors":0},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"author_claims":{"count":0,"strong_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"builder_version":"pith-number-builder-2026-05-17-v1"},"verdict_id":null},"signer":{"signer_id":"pith.science","signer_type":"pith_registry","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"created_at":"2026-07-05T11:07:47Z","supersedes":[],"prev_event":null,"signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"ZLizIkKMxJ49bfzOUozPiiaCMhNH+NqRqSvWkuvLQfjZPI5nqfWdDKWd3ymm+Rwv5BoISZc6YJ4pXi0VTOAEAw==","signed_message":"open_graph_event_sha256_bytes","signed_at":"2026-08-23T00:55:33.348738Z"},"content_sha256":"7a36b9a36fa0377d1340faec710940c7e8351f908a9c30fd633d04a12ba89a55","schema_version":"1.0","event_id":"sha256:7a36b9a36fa0377d1340faec710940c7e8351f908a9c30fd633d04a12ba89a55"}],"timestamp_proofs":[],"mirror_hints":[{"mirror_type":"https","name":"Pith Resolver","base_url":"https://pith.science","bundle_url":"https://pith.science/pith/74SGOWUGZWCPDKJ4VIL7AI4UHV/bundle.json","state_url":"https://pith.science/pith/74SGOWUGZWCPDKJ4VIL7AI4UHV/state.json","well_known_bundle_url":"https://pith.science/.well-known/pith/74SGOWUGZWCPDKJ4VIL7AI4UHV/bundle.json","status":"primary"}],"public_keys":[{"key_id":"pith-v1-2026-05","algorithm":"ed25519","format":"raw","public_key_b64":"stVStoiQhXFxp4s2pdzPNoqVNBMojDU/fJ2db5S3CbM=","public_key_hex":"b2d552b68890857171a78b36a5dccf368a953413288c353f7c9d9d6f94b709b3","fingerprint_sha256_b32_first128bits":"RVFV5Z2OI2J3ZUO7ERDEBCYNKS","fingerprint_sha256_hex":"8d4b5ee74e4693bcd1df2446408b0d54","rotates_at":null,"url":"https://pith.science/pith-signing-key.json","notes":"Pith uses this Ed25519 key to sign canonical record SHA-256 digests. Verify with: ed25519_verify(public_key, message=canonical_sha256_bytes, signature=base64decode(signature_b64))."}],"merge_version":"pith-open-graph-merge-v1","built_at":"2026-08-23T00:55:33Z","links":{"resolver":"https://pith.science/pith/74SGOWUGZWCPDKJ4VIL7AI4UHV","bundle":"https://pith.science/pith/74SGOWUGZWCPDKJ4VIL7AI4UHV/bundle.json","state":"https://pith.science/pith/74SGOWUGZWCPDKJ4VIL7AI4UHV/state.json","well_known_bundle":"https://pith.science/.well-known/pith/74SGOWUGZWCPDKJ4VIL7AI4UHV/bundle.json"},"state":{"state_type":"pith_open_graph_state","state_version":"1.0","pith_number":"pith:2025:74SGOWUGZWCPDKJ4VIL7AI4UHV","merge_version":"pith-open-graph-merge-v1","event_count":2,"valid_event_count":2,"invalid_event_count":0,"equivocation_count":0,"current":{"canonical_record":{"metadata":{"abstract_canon_sha256":"0e1f9047ef8c37931bce9e1983ed17ce2d4a00495d2594949c88d7500f62f915","cross_cats_sorted":["cond-mat.stat-mech"],"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"physics.bio-ph","submitted_at":"2025-05-22T01:00:46Z","title_canon_sha256":"6dd0a14b14a2f19871ac218d287650911ad68b7801fb89bc40092539747cf898"},"schema_version":"1.0","source":{"id":"2505.17130","kind":"arxiv","version":1}},"source_aliases":[{"alias_kind":"arxiv","alias_value":"2505.17130","created_at":"2026-07-05T11:07:47Z"},{"alias_kind":"arxiv_version","alias_value":"2505.17130v1","created_at":"2026-07-05T11:07:47Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.2505.17130","created_at":"2026-07-05T11:07:47Z"},{"alias_kind":"pith_short_12","alias_value":"74SGOWUGZWCP","created_at":"2026-07-05T11:07:47Z"},{"alias_kind":"pith_short_16","alias_value":"74SGOWUGZWCPDKJ4","created_at":"2026-07-05T11:07:47Z"},{"alias_kind":"pith_short_8","alias_value":"74SGOWUG","created_at":"2026-07-05T11:07:47Z"}],"graph_snapshots":[{"event_id":"sha256:7a36b9a36fa0377d1340faec710940c7e8351f908a9c30fd633d04a12ba89a55","target":"graph","created_at":"2026-07-05T11:07:47Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"graph_snapshot":{"author_claims":{"count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","strong_count":0},"builder_version":"pith-number-builder-2026-05-17-v1","claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"integrity":{"available":true,"clean":true,"detectors_run":[],"endpoint":"/pith/2505.17130/integrity.json","findings":[],"snapshot_sha256":"c28c3603d3b5d939e8dc4c7e95fa8dfce3d595e45f758748cecf8e644a296938","summary":{"advisory":0,"by_detector":{},"critical":0,"informational":0}},"paper":{"abstract_excerpt":"Biological molecular motors are high-performance nanomachines that convert chemical energy into mechanical motion via chemomechanical coupling. Their reaction cycles typically comprise a series of intermediate chemical states between the initial and final primary states. However, the influence of these intermediate states on motor performance has not yet been fully explored. In this study, we investigate the impact of intermediate states on the motor kinetics using a reaction-diffusion model. In most cases, the intermediate states accelerate the motor by lowering the effective barrier height. ","authors_text":"Akihiro Fukuda, Shoichi Toyabe, Yohei Nakayama","cross_cats":["cond-mat.stat-mech"],"headline":"","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"physics.bio-ph","submitted_at":"2025-05-22T01:00:46Z","title":"Acceleration of enzymatic reaction-diffusion kinetics by intermediate state"},"references":{"count":0,"internal_anchors":0,"resolved_work":0,"sample":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"2505.17130","kind":"arxiv","version":1},"verdict":{"created_at":null,"id":null,"model_set":{},"one_line_summary":"","pipeline_version":null,"pith_extraction_headline":"","strongest_claim":"","weakest_assumption":""}},"verdict_id":null}}],"author_attestations":[],"timestamp_anchors":[],"storage_attestations":[],"citation_signatures":[],"replication_records":[],"corrections":[],"mirror_hints":[],"record_created":{"event_id":"sha256:454bacec287623234479d2dae2d180c37653df2ee4fc985efd3a8b75f538f950","target":"record","created_at":"2026-07-05T11:07:47Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"attestation_state":"computed","canonical_record":{"metadata":{"abstract_canon_sha256":"0e1f9047ef8c37931bce9e1983ed17ce2d4a00495d2594949c88d7500f62f915","cross_cats_sorted":["cond-mat.stat-mech"],"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"physics.bio-ph","submitted_at":"2025-05-22T01:00:46Z","title_canon_sha256":"6dd0a14b14a2f19871ac218d287650911ad68b7801fb89bc40092539747cf898"},"schema_version":"1.0","source":{"id":"2505.17130","kind":"arxiv","version":1}},"canonical_sha256":"ff24675a86cd84f1a93caa17f023943d411e3e2e6d6567395ab6bfe1506788c3","receipt":{"algorithm":"ed25519","builder_version":"pith-number-builder-2026-05-17-v1","canonical_sha256":"ff24675a86cd84f1a93caa17f023943d411e3e2e6d6567395ab6bfe1506788c3","first_computed_at":"2026-07-05T11:07:47.573225Z","key_id":"pith-v1-2026-05","kind":"pith_receipt","last_reissued_at":"2026-07-05T11:07:47.573225Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","receipt_version":"0.3","signature_b64":"CohBFHdws5URqC/TQQu7Zsra7vpzrTO3hsMxVUUQ/EgMIaof2dMgHT3UJkjeu6aDHo2x3B1KUGO4E9btDuFxCg==","signature_status":"signed_v1","signed_at":"2026-07-05T11:07:47.573736Z","signed_message":"canonical_sha256_bytes"},"source_id":"2505.17130","source_kind":"arxiv","source_version":1}}},"equivocations":[],"invalid_events":[],"applied_event_ids":["sha256:454bacec287623234479d2dae2d180c37653df2ee4fc985efd3a8b75f538f950","sha256:7a36b9a36fa0377d1340faec710940c7e8351f908a9c30fd633d04a12ba89a55"],"state_sha256":"30c4250f2670cdfde18ad9aca1fbbb8593b2ca1ff0f961c46d7c0fa96f9c76d0"},"bundle_signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"krQt3+2l0pCVPx9ptqgN+AUA4PuUoRitYmsk6WvkvZlSfOezL/Xy7kWrXa7Oc0G9pUy4UxOa9yMQb0qNvC7aDQ==","signed_message":"bundle_sha256_bytes","signed_at":"2026-08-23T00:55:33.352627Z","bundle_sha256":"31a580d330438ca7dd11da15ff3bf49491000a4e0fb29165f7da0a203d20426a"}}