{"bundle_type":"pith_open_graph_bundle","bundle_version":"1.0","pith_number":"pith:2016:772RYP57PICEL7OVDGP44RKDGA","short_pith_number":"pith:772RYP57","canonical_record":{"source":{"id":"1604.05565","kind":"arxiv","version":1},"metadata":{"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"physics.bio-ph","submitted_at":"2016-04-19T13:40:37Z","cross_cats_sorted":[],"title_canon_sha256":"00a55b77a0960746c8e4cf694e3d707bc5817c02073b3e64836be494b1a921e0","abstract_canon_sha256":"1189cb3ef61c0b9a00b8d067261e2b4fa1e18fc6573c2fd05f53b92126426de3"},"schema_version":"1.0"},"canonical_sha256":"fff51c3fbf7a0445fdd5199fce4543302b809336fbd75a655e27f911050675a6","source":{"kind":"arxiv","id":"1604.05565","version":1},"source_aliases":[{"alias_kind":"arxiv","alias_value":"1604.05565","created_at":"2026-05-18T00:53:26Z"},{"alias_kind":"arxiv_version","alias_value":"1604.05565v1","created_at":"2026-05-18T00:53:26Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.1604.05565","created_at":"2026-05-18T00:53:26Z"},{"alias_kind":"pith_short_12","alias_value":"772RYP57PICE","created_at":"2026-05-18T12:30:04Z"},{"alias_kind":"pith_short_16","alias_value":"772RYP57PICEL7OV","created_at":"2026-05-18T12:30:04Z"},{"alias_kind":"pith_short_8","alias_value":"772RYP57","created_at":"2026-05-18T12:30:04Z"}],"events":[{"event_type":"record_created","subject_pith_number":"pith:2016:772RYP57PICEL7OVDGP44RKDGA","target":"record","payload":{"canonical_record":{"source":{"id":"1604.05565","kind":"arxiv","version":1},"metadata":{"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"physics.bio-ph","submitted_at":"2016-04-19T13:40:37Z","cross_cats_sorted":[],"title_canon_sha256":"00a55b77a0960746c8e4cf694e3d707bc5817c02073b3e64836be494b1a921e0","abstract_canon_sha256":"1189cb3ef61c0b9a00b8d067261e2b4fa1e18fc6573c2fd05f53b92126426de3"},"schema_version":"1.0"},"canonical_sha256":"fff51c3fbf7a0445fdd5199fce4543302b809336fbd75a655e27f911050675a6","receipt":{"kind":"pith_receipt","key_id":"pith-v1-2026-05","algorithm":"ed25519","signed_at":"2026-05-18T00:53:26.128160Z","signature_b64":"1kn37DsgdCj5oPj6/VA97OAhQzGgdAc7dGhyFrLuo65tEGkpBha2eY0Tg1CRR5Vai40chVshtyUwEPUM/QfGAw==","signed_message":"canonical_sha256_bytes","builder_version":"pith-number-builder-2026-05-17-v1","receipt_version":"0.3","canonical_sha256":"fff51c3fbf7a0445fdd5199fce4543302b809336fbd75a655e27f911050675a6","last_reissued_at":"2026-05-18T00:53:26.127794Z","signature_status":"signed_v1","first_computed_at":"2026-05-18T00:53:26.127794Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"source_kind":"arxiv","source_id":"1604.05565","source_version":1,"attestation_state":"computed"},"signer":{"signer_id":"pith.science","signer_type":"pith_registry","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"created_at":"2026-05-18T00:53:26Z","supersedes":[],"prev_event":null,"signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"GzGWFp96XSZkJthYaF4lSi/kMLWKoqZlnaSTag6c+2W7CQNj9EeeXHRKSTiB2yphvV2pBeCDohFje6QwapVmAA==","signed_message":"open_graph_event_sha256_bytes","signed_at":"2026-05-29T21:04:31.976997Z"},"content_sha256":"c9019f2302a53cbabdc8ca27b29e3bb79e2925d2fef4c28cca32e251e2ec7dac","schema_version":"1.0","event_id":"sha256:c9019f2302a53cbabdc8ca27b29e3bb79e2925d2fef4c28cca32e251e2ec7dac"},{"event_type":"graph_snapshot","subject_pith_number":"pith:2016:772RYP57PICEL7OVDGP44RKDGA","target":"graph","payload":{"graph_snapshot":{"paper":{"title":"Complementarity of PALM and SOFI for super-resolution live cell imaging of focal adhesions","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","headline":"","cross_cats":[],"primary_cat":"physics.bio-ph","authors_text":"Aleksandra Radenovic, Azat Sharipov, Daniel Szlag, Hendrik Deschout, Johan Hofkens, Lely Feletti, Marcel Leutenegger, Peter Dedecker, Theo Lasser, Tomas Lukes, Wim Vandenberg","submitted_at":"2016-04-19T13:40:37Z","abstract_excerpt":"Live cell imaging of focal adhesions requires a sufficiently high temporal resolution, which remains a challenging task for super-resolution microscopy. We have addressed this important issue by combining photo-activated localization microscopy (PALM) with super-resolution optical fluctuation imaging (SOFI). Using simulations and fixed cell focal adhesion images, we investigated the complementarity between PALM and SOFI in terms of spatial and temporal resolution. This PALM-SOFI framework was used to image focal adhesions in living cells, while obtaining a temporal resolution below 10 s. We vi"},"claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"1604.05565","kind":"arxiv","version":1},"verdict":{"id":null,"model_set":{},"created_at":null,"strongest_claim":"","one_line_summary":"","pipeline_version":null,"weakest_assumption":"","pith_extraction_headline":""},"references":{"count":0,"sample":[],"resolved_work":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","internal_anchors":0},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"author_claims":{"count":0,"strong_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"builder_version":"pith-number-builder-2026-05-17-v1"},"verdict_id":null},"signer":{"signer_id":"pith.science","signer_type":"pith_registry","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"created_at":"2026-05-18T00:53:26Z","supersedes":[],"prev_event":null,"signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"utIYn2q3Z4r+gJBbM93amq02m103i25KI4zz5+cjIQX2omnw5/TONGjc14TCogdCDGKhFxHkVJfmMjbovMkFCg==","signed_message":"open_graph_event_sha256_bytes","signed_at":"2026-05-29T21:04:31.977360Z"},"content_sha256":"9539cf83437da96306a3834c98c3499eccd34bbc61224c7a5b6ade46a47bfb35","schema_version":"1.0","event_id":"sha256:9539cf83437da96306a3834c98c3499eccd34bbc61224c7a5b6ade46a47bfb35"}],"timestamp_proofs":[],"mirror_hints":[{"mirror_type":"https","name":"Pith Resolver","base_url":"https://pith.science","bundle_url":"https://pith.science/pith/772RYP57PICEL7OVDGP44RKDGA/bundle.json","state_url":"https://pith.science/pith/772RYP57PICEL7OVDGP44RKDGA/state.json","well_known_bundle_url":"https://pith.science/.well-known/pith/772RYP57PICEL7OVDGP44RKDGA/bundle.json","status":"primary"}],"public_keys":[{"key_id":"pith-v1-2026-05","algorithm":"ed25519","format":"raw","public_key_b64":"stVStoiQhXFxp4s2pdzPNoqVNBMojDU/fJ2db5S3CbM=","public_key_hex":"b2d552b68890857171a78b36a5dccf368a953413288c353f7c9d9d6f94b709b3","fingerprint_sha256_b32_first128bits":"RVFV5Z2OI2J3ZUO7ERDEBCYNKS","fingerprint_sha256_hex":"8d4b5ee74e4693bcd1df2446408b0d54","rotates_at":null,"url":"https://pith.science/pith-signing-key.json","notes":"Pith uses this Ed25519 key to sign canonical record SHA-256 digests. Verify with: ed25519_verify(public_key, message=canonical_sha256_bytes, signature=base64decode(signature_b64))."}],"merge_version":"pith-open-graph-merge-v1","built_at":"2026-05-29T21:04:31Z","links":{"resolver":"https://pith.science/pith/772RYP57PICEL7OVDGP44RKDGA","bundle":"https://pith.science/pith/772RYP57PICEL7OVDGP44RKDGA/bundle.json","state":"https://pith.science/pith/772RYP57PICEL7OVDGP44RKDGA/state.json","well_known_bundle":"https://pith.science/.well-known/pith/772RYP57PICEL7OVDGP44RKDGA/bundle.json"},"state":{"state_type":"pith_open_graph_state","state_version":"1.0","pith_number":"pith:2016:772RYP57PICEL7OVDGP44RKDGA","merge_version":"pith-open-graph-merge-v1","event_count":2,"valid_event_count":2,"invalid_event_count":0,"equivocation_count":0,"current":{"canonical_record":{"metadata":{"abstract_canon_sha256":"1189cb3ef61c0b9a00b8d067261e2b4fa1e18fc6573c2fd05f53b92126426de3","cross_cats_sorted":[],"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"physics.bio-ph","submitted_at":"2016-04-19T13:40:37Z","title_canon_sha256":"00a55b77a0960746c8e4cf694e3d707bc5817c02073b3e64836be494b1a921e0"},"schema_version":"1.0","source":{"id":"1604.05565","kind":"arxiv","version":1}},"source_aliases":[{"alias_kind":"arxiv","alias_value":"1604.05565","created_at":"2026-05-18T00:53:26Z"},{"alias_kind":"arxiv_version","alias_value":"1604.05565v1","created_at":"2026-05-18T00:53:26Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.1604.05565","created_at":"2026-05-18T00:53:26Z"},{"alias_kind":"pith_short_12","alias_value":"772RYP57PICE","created_at":"2026-05-18T12:30:04Z"},{"alias_kind":"pith_short_16","alias_value":"772RYP57PICEL7OV","created_at":"2026-05-18T12:30:04Z"},{"alias_kind":"pith_short_8","alias_value":"772RYP57","created_at":"2026-05-18T12:30:04Z"}],"graph_snapshots":[{"event_id":"sha256:9539cf83437da96306a3834c98c3499eccd34bbc61224c7a5b6ade46a47bfb35","target":"graph","created_at":"2026-05-18T00:53:26Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"graph_snapshot":{"author_claims":{"count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","strong_count":0},"builder_version":"pith-number-builder-2026-05-17-v1","claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"paper":{"abstract_excerpt":"Live cell imaging of focal adhesions requires a sufficiently high temporal resolution, which remains a challenging task for super-resolution microscopy. We have addressed this important issue by combining photo-activated localization microscopy (PALM) with super-resolution optical fluctuation imaging (SOFI). Using simulations and fixed cell focal adhesion images, we investigated the complementarity between PALM and SOFI in terms of spatial and temporal resolution. This PALM-SOFI framework was used to image focal adhesions in living cells, while obtaining a temporal resolution below 10 s. We vi","authors_text":"Aleksandra Radenovic, Azat Sharipov, Daniel Szlag, Hendrik Deschout, Johan Hofkens, Lely Feletti, Marcel Leutenegger, Peter Dedecker, Theo Lasser, Tomas Lukes, Wim Vandenberg","cross_cats":[],"headline":"","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"physics.bio-ph","submitted_at":"2016-04-19T13:40:37Z","title":"Complementarity of PALM and SOFI for super-resolution live cell imaging of focal adhesions"},"references":{"count":0,"internal_anchors":0,"resolved_work":0,"sample":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"1604.05565","kind":"arxiv","version":1},"verdict":{"created_at":null,"id":null,"model_set":{},"one_line_summary":"","pipeline_version":null,"pith_extraction_headline":"","strongest_claim":"","weakest_assumption":""}},"verdict_id":null}}],"author_attestations":[],"timestamp_anchors":[],"storage_attestations":[],"citation_signatures":[],"replication_records":[],"corrections":[],"mirror_hints":[],"record_created":{"event_id":"sha256:c9019f2302a53cbabdc8ca27b29e3bb79e2925d2fef4c28cca32e251e2ec7dac","target":"record","created_at":"2026-05-18T00:53:26Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"attestation_state":"computed","canonical_record":{"metadata":{"abstract_canon_sha256":"1189cb3ef61c0b9a00b8d067261e2b4fa1e18fc6573c2fd05f53b92126426de3","cross_cats_sorted":[],"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"physics.bio-ph","submitted_at":"2016-04-19T13:40:37Z","title_canon_sha256":"00a55b77a0960746c8e4cf694e3d707bc5817c02073b3e64836be494b1a921e0"},"schema_version":"1.0","source":{"id":"1604.05565","kind":"arxiv","version":1}},"canonical_sha256":"fff51c3fbf7a0445fdd5199fce4543302b809336fbd75a655e27f911050675a6","receipt":{"algorithm":"ed25519","builder_version":"pith-number-builder-2026-05-17-v1","canonical_sha256":"fff51c3fbf7a0445fdd5199fce4543302b809336fbd75a655e27f911050675a6","first_computed_at":"2026-05-18T00:53:26.127794Z","key_id":"pith-v1-2026-05","kind":"pith_receipt","last_reissued_at":"2026-05-18T00:53:26.127794Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","receipt_version":"0.3","signature_b64":"1kn37DsgdCj5oPj6/VA97OAhQzGgdAc7dGhyFrLuo65tEGkpBha2eY0Tg1CRR5Vai40chVshtyUwEPUM/QfGAw==","signature_status":"signed_v1","signed_at":"2026-05-18T00:53:26.128160Z","signed_message":"canonical_sha256_bytes"},"source_id":"1604.05565","source_kind":"arxiv","source_version":1}}},"equivocations":[],"invalid_events":[],"applied_event_ids":["sha256:c9019f2302a53cbabdc8ca27b29e3bb79e2925d2fef4c28cca32e251e2ec7dac","sha256:9539cf83437da96306a3834c98c3499eccd34bbc61224c7a5b6ade46a47bfb35"],"state_sha256":"7c44bd4e9792470bee15dc471c6a535b6688b23b18a54c83595d31ae8a80b55c"},"bundle_signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"nsTma+anBzO4ZomhwmC7HJS+WsfNaU9YtNgeRiXB2SIJz1+9pAripR0m/PsaV/KaXKJMQKQdJvR8JkKjtASVDg==","signed_message":"bundle_sha256_bytes","signed_at":"2026-05-29T21:04:31.979514Z","bundle_sha256":"aff517b8742bb79df720e7b1b03a269911600860c7f9458fd96074d4da6d0d2c"}}