{"record_type":"pith_number_record","schema_url":"https://pith.science/schemas/pith-number/v1.json","pith_number":"pith:2018:7FOJFAWQPMYP7XSNA4YSR4YJZG","short_pith_number":"pith:7FOJFAWQ","schema_version":"1.0","canonical_sha256":"f95c9282d07b30ffde4d073128f309c99d6a509bff2ca59f68c072765567b209","source":{"kind":"arxiv","id":"1810.01019","version":1},"attestation_state":"computed","paper":{"title":"Synchrotron radiation microtomography of brain hemisphere and spinal cord of a mouse model of multiple sclerosis revealed a correlation between capillary dilation and clinical score","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","headline":"","cross_cats":["physics.med-ph"],"primary_cat":"physics.bio-ph","authors_text":"Akemi Kamijo, Akihisa Takeuchi, Katsuko Naitou, Kentaro Uesugi, Masato Hoshino, Masato Ohtsuka, Noboru Kawabe, Rino Saiga, Ryuta Mizutani, Shunya Takizawa","submitted_at":"2018-10-02T00:08:52Z","abstract_excerpt":"Multiple sclerosis is a neurological disorder in which the myelin sheaths of axons are damaged by the immune response. We report here a three-dimensional structural analysis of brain and spinal cord tissues of a mouse model of multiple sclerosis, known as experimental autoimmune encephalomyelitis (EAE). EAE-induced mice were raised with or without administration of fingolimod, which is used in the treatment of multiple sclerosis. Brains and spinal cords dissected from the EAE mice were lyophilized so as to reconstitute the intrinsic contrast of tissue elements, such as axons, in X-ray images. "},"verification_status":{"content_addressed":true,"pith_receipt":true,"author_attested":false,"weak_author_claims":0,"strong_author_claims":0,"externally_anchored":false,"storage_verified":false,"citation_signatures":0,"replication_records":0,"graph_snapshot":true,"references_resolved":false,"formal_links_present":false},"canonical_record":{"source":{"id":"1810.01019","kind":"arxiv","version":1},"metadata":{"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"physics.bio-ph","submitted_at":"2018-10-02T00:08:52Z","cross_cats_sorted":["physics.med-ph"],"title_canon_sha256":"990d254506c9855dc3e2f0727885b6496cb209c38a6ea681396807c2efad91c0","abstract_canon_sha256":"1ab03126beae881d4597051318d90c80a36df3e568377b54882a99bb2648903d"},"schema_version":"1.0"},"receipt":{"kind":"pith_receipt","key_id":"pith-v1-2026-05","algorithm":"ed25519","signed_at":"2026-05-17T23:53:50.634374Z","signature_b64":"L79IbYhi79IMHuX4Ljx8X45DdAVgtZf3TOvIAfSXlWbebmTL6s8PxXTK7Vu4SacB6Umn/H+Iy8LdL2ifjdjIDw==","signed_message":"canonical_sha256_bytes","builder_version":"pith-number-builder-2026-05-17-v1","receipt_version":"0.3","canonical_sha256":"f95c9282d07b30ffde4d073128f309c99d6a509bff2ca59f68c072765567b209","last_reissued_at":"2026-05-17T23:53:50.634019Z","signature_status":"signed_v1","first_computed_at":"2026-05-17T23:53:50.634019Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"graph_snapshot":{"paper":{"title":"Synchrotron radiation microtomography of brain hemisphere and spinal cord of a mouse model of multiple sclerosis revealed a correlation between capillary dilation and clinical score","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","headline":"","cross_cats":["physics.med-ph"],"primary_cat":"physics.bio-ph","authors_text":"Akemi Kamijo, Akihisa Takeuchi, Katsuko Naitou, Kentaro Uesugi, Masato Hoshino, Masato Ohtsuka, Noboru Kawabe, Rino Saiga, Ryuta Mizutani, Shunya Takizawa","submitted_at":"2018-10-02T00:08:52Z","abstract_excerpt":"Multiple sclerosis is a neurological disorder in which the myelin sheaths of axons are damaged by the immune response. We report here a three-dimensional structural analysis of brain and spinal cord tissues of a mouse model of multiple sclerosis, known as experimental autoimmune encephalomyelitis (EAE). EAE-induced mice were raised with or without administration of fingolimod, which is used in the treatment of multiple sclerosis. Brains and spinal cords dissected from the EAE mice were lyophilized so as to reconstitute the intrinsic contrast of tissue elements, such as axons, in X-ray images. "},"claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"1810.01019","kind":"arxiv","version":1},"verdict":{"id":null,"model_set":{},"created_at":null,"strongest_claim":"","one_line_summary":"","pipeline_version":null,"weakest_assumption":"","pith_extraction_headline":""},"references":{"count":0,"sample":[],"resolved_work":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","internal_anchors":0},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"author_claims":{"count":0,"strong_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"builder_version":"pith-number-builder-2026-05-17-v1"},"aliases":[{"alias_kind":"arxiv","alias_value":"1810.01019","created_at":"2026-05-17T23:53:50.634073+00:00"},{"alias_kind":"arxiv_version","alias_value":"1810.01019v1","created_at":"2026-05-17T23:53:50.634073+00:00"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.1810.01019","created_at":"2026-05-17T23:53:50.634073+00:00"},{"alias_kind":"pith_short_12","alias_value":"7FOJFAWQPMYP","created_at":"2026-05-18T12:32:11.075285+00:00"},{"alias_kind":"pith_short_16","alias_value":"7FOJFAWQPMYP7XSN","created_at":"2026-05-18T12:32:11.075285+00:00"},{"alias_kind":"pith_short_8","alias_value":"7FOJFAWQ","created_at":"2026-05-18T12:32:11.075285+00:00"}],"events":[],"event_summary":{},"paper_claims":[],"inbound_citations":{"count":0,"internal_anchor_count":0,"sample":[]},"formal_canon":{"evidence_count":0,"sample":[],"anchors":[]},"links":{"html":"https://pith.science/pith/7FOJFAWQPMYP7XSNA4YSR4YJZG","json":"https://pith.science/pith/7FOJFAWQPMYP7XSNA4YSR4YJZG.json","graph_json":"https://pith.science/api/pith-number/7FOJFAWQPMYP7XSNA4YSR4YJZG/graph.json","events_json":"https://pith.science/api/pith-number/7FOJFAWQPMYP7XSNA4YSR4YJZG/events.json","paper":"https://pith.science/paper/7FOJFAWQ"},"agent_actions":{"view_html":"https://pith.science/pith/7FOJFAWQPMYP7XSNA4YSR4YJZG","download_json":"https://pith.science/pith/7FOJFAWQPMYP7XSNA4YSR4YJZG.json","view_paper":"https://pith.science/paper/7FOJFAWQ","resolve_alias":"https://pith.science/api/pith-number/resolve?arxiv=1810.01019&json=true","fetch_graph":"https://pith.science/api/pith-number/7FOJFAWQPMYP7XSNA4YSR4YJZG/graph.json","fetch_events":"https://pith.science/api/pith-number/7FOJFAWQPMYP7XSNA4YSR4YJZG/events.json","actions":{"anchor_timestamp":"https://pith.science/pith/7FOJFAWQPMYP7XSNA4YSR4YJZG/action/timestamp_anchor","attest_storage":"https://pith.science/pith/7FOJFAWQPMYP7XSNA4YSR4YJZG/action/storage_attestation","attest_author":"https://pith.science/pith/7FOJFAWQPMYP7XSNA4YSR4YJZG/action/author_attestation","sign_citation":"https://pith.science/pith/7FOJFAWQPMYP7XSNA4YSR4YJZG/action/citation_signature","submit_replication":"https://pith.science/pith/7FOJFAWQPMYP7XSNA4YSR4YJZG/action/replication_record"}},"created_at":"2026-05-17T23:53:50.634073+00:00","updated_at":"2026-05-17T23:53:50.634073+00:00"}