{"bundle_type":"pith_open_graph_bundle","bundle_version":"1.0","pith_number":"pith:2025:7HHPTZY52QP4FABCT5WOKZLLCO","short_pith_number":"pith:7HHPTZY5","canonical_record":{"source":{"id":"2510.12577","kind":"arxiv","version":2},"metadata":{"license":"http://creativecommons.org/licenses/by/4.0/","primary_cat":"q-bio.MN","submitted_at":"2025-10-14T14:37:06Z","cross_cats_sorted":["cs.ET","physics.bio-ph","q-bio.QM"],"title_canon_sha256":"8cc4c15459874da3cc566e87dc2ec4c7f482613e69ed05b36ff3244379ba1324","abstract_canon_sha256":"10fb8ea0dc90a38c1bc66f5af78d718938609acb1dd995abc84dbdcd8ca1a650"},"schema_version":"1.0"},"canonical_sha256":"f9cef9e71dd41fc280229f6ce5656b139e8beedd964ab961691f5c067168f6b4","source":{"kind":"arxiv","id":"2510.12577","version":2},"source_aliases":[{"alias_kind":"arxiv","alias_value":"2510.12577","created_at":"2026-05-26T01:02:28Z"},{"alias_kind":"arxiv_version","alias_value":"2510.12577v2","created_at":"2026-05-26T01:02:28Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.2510.12577","created_at":"2026-05-26T01:02:28Z"},{"alias_kind":"pith_short_12","alias_value":"7HHPTZY52QP4","created_at":"2026-05-26T01:02:28Z"},{"alias_kind":"pith_short_16","alias_value":"7HHPTZY52QP4FABC","created_at":"2026-05-26T01:02:28Z"},{"alias_kind":"pith_short_8","alias_value":"7HHPTZY5","created_at":"2026-05-26T01:02:28Z"}],"events":[{"event_type":"record_created","subject_pith_number":"pith:2025:7HHPTZY52QP4FABCT5WOKZLLCO","target":"record","payload":{"canonical_record":{"source":{"id":"2510.12577","kind":"arxiv","version":2},"metadata":{"license":"http://creativecommons.org/licenses/by/4.0/","primary_cat":"q-bio.MN","submitted_at":"2025-10-14T14:37:06Z","cross_cats_sorted":["cs.ET","physics.bio-ph","q-bio.QM"],"title_canon_sha256":"8cc4c15459874da3cc566e87dc2ec4c7f482613e69ed05b36ff3244379ba1324","abstract_canon_sha256":"10fb8ea0dc90a38c1bc66f5af78d718938609acb1dd995abc84dbdcd8ca1a650"},"schema_version":"1.0"},"canonical_sha256":"f9cef9e71dd41fc280229f6ce5656b139e8beedd964ab961691f5c067168f6b4","receipt":{"kind":"pith_receipt","key_id":"pith-v1-2026-05","algorithm":"ed25519","signed_at":"2026-05-26T01:02:28.444672Z","signature_b64":"QfDc9FYG/f3gRcZywVx4RDhQ0d90+oCivAi6OdemUgZkyWNxjyMl62dYdB0PgHKNJ1Glm+czyiP5u/B6BGCfAw==","signed_message":"canonical_sha256_bytes","builder_version":"pith-number-builder-2026-05-17-v1","receipt_version":"0.3","canonical_sha256":"f9cef9e71dd41fc280229f6ce5656b139e8beedd964ab961691f5c067168f6b4","last_reissued_at":"2026-05-26T01:02:28.443561Z","signature_status":"signed_v1","first_computed_at":"2026-05-26T01:02:28.443561Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"source_kind":"arxiv","source_id":"2510.12577","source_version":2,"attestation_state":"computed"},"signer":{"signer_id":"pith.science","signer_type":"pith_registry","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"created_at":"2026-05-26T01:02:28Z","supersedes":[],"prev_event":null,"signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"O1jFIEof5u1CQZxL4kjstpC1Bkr+hO0gvJkocHbHoK7Ulvgt+S9QVVSyQgc/cYcj21ebBdCaHgycrufw9W37AQ==","signed_message":"open_graph_event_sha256_bytes","signed_at":"2026-06-03T19:05:44.784938Z"},"content_sha256":"81f2f2b8ad33206b008b8fde892cb8efc2f8b9d29070aeac8fc2af6565e31830","schema_version":"1.0","event_id":"sha256:81f2f2b8ad33206b008b8fde892cb8efc2f8b9d29070aeac8fc2af6565e31830"},{"event_type":"graph_snapshot","subject_pith_number":"pith:2025:7HHPTZY52QP4FABCT5WOKZLLCO","target":"graph","payload":{"graph_snapshot":{"paper":{"title":"ECMSim: A high-performance interactive web application for real-time spatiotemporal simulation of cardiac ECM signaling and diffusion","license":"http://creativecommons.org/licenses/by/4.0/","headline":"","cross_cats":["cs.ET","physics.bio-ph","q-bio.QM"],"primary_cat":"q-bio.MN","authors_text":"Hasi Hays, William J. Richardson","submitted_at":"2025-10-14T14:37:06Z","abstract_excerpt":"Extracellular matrix (ECM) remodeling is central to a wide variety of healthy and diseased tissue processes. Unfortunately, predicting ECM remodeling under various chemical and mechanical conditions has proven to be excessively challenging, due in part to its complex regulation by intracellular and extracellular molecular reaction networks that are spatially and temporally dynamic. We introduce ECMSim, which is a highly interactive, real-time, and web application designed to simulate heterogeneous matrix remodeling. The current model simulates cardiac scar tissue with configurable input condit"},"claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"2510.12577","kind":"arxiv","version":2},"verdict":{"id":null,"model_set":{},"created_at":null,"strongest_claim":"","one_line_summary":"","pipeline_version":null,"weakest_assumption":"","pith_extraction_headline":""},"integrity":{"clean":true,"summary":{"advisory":0,"critical":0,"by_detector":{},"informational":0},"endpoint":"/pith/2510.12577/integrity.json","findings":[],"available":true,"detectors_run":[],"snapshot_sha256":"c28c3603d3b5d939e8dc4c7e95fa8dfce3d595e45f758748cecf8e644a296938"},"references":{"count":0,"sample":[],"resolved_work":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","internal_anchors":0},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"author_claims":{"count":0,"strong_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"builder_version":"pith-number-builder-2026-05-17-v1"},"verdict_id":null},"signer":{"signer_id":"pith.science","signer_type":"pith_registry","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"created_at":"2026-05-26T01:02:28Z","supersedes":[],"prev_event":null,"signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"H2M61muUjYhv+CTwz/S8yPCUTxL2AUOKJuQhR9FytQhF6+xLJ3rDp1cU3SUA59c3wwK0t4S4doZRz58acAjsBQ==","signed_message":"open_graph_event_sha256_bytes","signed_at":"2026-06-03T19:05:44.785365Z"},"content_sha256":"cf590a507be8618177be399a888bce8fb4749b2d8293e816adbb2a36bd0bf08b","schema_version":"1.0","event_id":"sha256:cf590a507be8618177be399a888bce8fb4749b2d8293e816adbb2a36bd0bf08b"}],"timestamp_proofs":[],"mirror_hints":[{"mirror_type":"https","name":"Pith Resolver","base_url":"https://pith.science","bundle_url":"https://pith.science/pith/7HHPTZY52QP4FABCT5WOKZLLCO/bundle.json","state_url":"https://pith.science/pith/7HHPTZY52QP4FABCT5WOKZLLCO/state.json","well_known_bundle_url":"https://pith.science/.well-known/pith/7HHPTZY52QP4FABCT5WOKZLLCO/bundle.json","status":"primary"}],"public_keys":[{"key_id":"pith-v1-2026-05","algorithm":"ed25519","format":"raw","public_key_b64":"stVStoiQhXFxp4s2pdzPNoqVNBMojDU/fJ2db5S3CbM=","public_key_hex":"b2d552b68890857171a78b36a5dccf368a953413288c353f7c9d9d6f94b709b3","fingerprint_sha256_b32_first128bits":"RVFV5Z2OI2J3ZUO7ERDEBCYNKS","fingerprint_sha256_hex":"8d4b5ee74e4693bcd1df2446408b0d54","rotates_at":null,"url":"https://pith.science/pith-signing-key.json","notes":"Pith uses this Ed25519 key to sign canonical record SHA-256 digests. Verify with: ed25519_verify(public_key, message=canonical_sha256_bytes, signature=base64decode(signature_b64))."}],"merge_version":"pith-open-graph-merge-v1","built_at":"2026-06-03T19:05:44Z","links":{"resolver":"https://pith.science/pith/7HHPTZY52QP4FABCT5WOKZLLCO","bundle":"https://pith.science/pith/7HHPTZY52QP4FABCT5WOKZLLCO/bundle.json","state":"https://pith.science/pith/7HHPTZY52QP4FABCT5WOKZLLCO/state.json","well_known_bundle":"https://pith.science/.well-known/pith/7HHPTZY52QP4FABCT5WOKZLLCO/bundle.json"},"state":{"state_type":"pith_open_graph_state","state_version":"1.0","pith_number":"pith:2025:7HHPTZY52QP4FABCT5WOKZLLCO","merge_version":"pith-open-graph-merge-v1","event_count":2,"valid_event_count":2,"invalid_event_count":0,"equivocation_count":0,"current":{"canonical_record":{"metadata":{"abstract_canon_sha256":"10fb8ea0dc90a38c1bc66f5af78d718938609acb1dd995abc84dbdcd8ca1a650","cross_cats_sorted":["cs.ET","physics.bio-ph","q-bio.QM"],"license":"http://creativecommons.org/licenses/by/4.0/","primary_cat":"q-bio.MN","submitted_at":"2025-10-14T14:37:06Z","title_canon_sha256":"8cc4c15459874da3cc566e87dc2ec4c7f482613e69ed05b36ff3244379ba1324"},"schema_version":"1.0","source":{"id":"2510.12577","kind":"arxiv","version":2}},"source_aliases":[{"alias_kind":"arxiv","alias_value":"2510.12577","created_at":"2026-05-26T01:02:28Z"},{"alias_kind":"arxiv_version","alias_value":"2510.12577v2","created_at":"2026-05-26T01:02:28Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.2510.12577","created_at":"2026-05-26T01:02:28Z"},{"alias_kind":"pith_short_12","alias_value":"7HHPTZY52QP4","created_at":"2026-05-26T01:02:28Z"},{"alias_kind":"pith_short_16","alias_value":"7HHPTZY52QP4FABC","created_at":"2026-05-26T01:02:28Z"},{"alias_kind":"pith_short_8","alias_value":"7HHPTZY5","created_at":"2026-05-26T01:02:28Z"}],"graph_snapshots":[{"event_id":"sha256:cf590a507be8618177be399a888bce8fb4749b2d8293e816adbb2a36bd0bf08b","target":"graph","created_at":"2026-05-26T01:02:28Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"graph_snapshot":{"author_claims":{"count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","strong_count":0},"builder_version":"pith-number-builder-2026-05-17-v1","claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"integrity":{"available":true,"clean":true,"detectors_run":[],"endpoint":"/pith/2510.12577/integrity.json","findings":[],"snapshot_sha256":"c28c3603d3b5d939e8dc4c7e95fa8dfce3d595e45f758748cecf8e644a296938","summary":{"advisory":0,"by_detector":{},"critical":0,"informational":0}},"paper":{"abstract_excerpt":"Extracellular matrix (ECM) remodeling is central to a wide variety of healthy and diseased tissue processes. Unfortunately, predicting ECM remodeling under various chemical and mechanical conditions has proven to be excessively challenging, due in part to its complex regulation by intracellular and extracellular molecular reaction networks that are spatially and temporally dynamic. We introduce ECMSim, which is a highly interactive, real-time, and web application designed to simulate heterogeneous matrix remodeling. The current model simulates cardiac scar tissue with configurable input condit","authors_text":"Hasi Hays, William J. Richardson","cross_cats":["cs.ET","physics.bio-ph","q-bio.QM"],"headline":"","license":"http://creativecommons.org/licenses/by/4.0/","primary_cat":"q-bio.MN","submitted_at":"2025-10-14T14:37:06Z","title":"ECMSim: A high-performance interactive web application for real-time spatiotemporal simulation of cardiac ECM signaling and diffusion"},"references":{"count":0,"internal_anchors":0,"resolved_work":0,"sample":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"2510.12577","kind":"arxiv","version":2},"verdict":{"created_at":null,"id":null,"model_set":{},"one_line_summary":"","pipeline_version":null,"pith_extraction_headline":"","strongest_claim":"","weakest_assumption":""}},"verdict_id":null}}],"author_attestations":[],"timestamp_anchors":[],"storage_attestations":[],"citation_signatures":[],"replication_records":[],"corrections":[],"mirror_hints":[],"record_created":{"event_id":"sha256:81f2f2b8ad33206b008b8fde892cb8efc2f8b9d29070aeac8fc2af6565e31830","target":"record","created_at":"2026-05-26T01:02:28Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"attestation_state":"computed","canonical_record":{"metadata":{"abstract_canon_sha256":"10fb8ea0dc90a38c1bc66f5af78d718938609acb1dd995abc84dbdcd8ca1a650","cross_cats_sorted":["cs.ET","physics.bio-ph","q-bio.QM"],"license":"http://creativecommons.org/licenses/by/4.0/","primary_cat":"q-bio.MN","submitted_at":"2025-10-14T14:37:06Z","title_canon_sha256":"8cc4c15459874da3cc566e87dc2ec4c7f482613e69ed05b36ff3244379ba1324"},"schema_version":"1.0","source":{"id":"2510.12577","kind":"arxiv","version":2}},"canonical_sha256":"f9cef9e71dd41fc280229f6ce5656b139e8beedd964ab961691f5c067168f6b4","receipt":{"algorithm":"ed25519","builder_version":"pith-number-builder-2026-05-17-v1","canonical_sha256":"f9cef9e71dd41fc280229f6ce5656b139e8beedd964ab961691f5c067168f6b4","first_computed_at":"2026-05-26T01:02:28.443561Z","key_id":"pith-v1-2026-05","kind":"pith_receipt","last_reissued_at":"2026-05-26T01:02:28.443561Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","receipt_version":"0.3","signature_b64":"QfDc9FYG/f3gRcZywVx4RDhQ0d90+oCivAi6OdemUgZkyWNxjyMl62dYdB0PgHKNJ1Glm+czyiP5u/B6BGCfAw==","signature_status":"signed_v1","signed_at":"2026-05-26T01:02:28.444672Z","signed_message":"canonical_sha256_bytes"},"source_id":"2510.12577","source_kind":"arxiv","source_version":2}}},"equivocations":[],"invalid_events":[],"applied_event_ids":["sha256:81f2f2b8ad33206b008b8fde892cb8efc2f8b9d29070aeac8fc2af6565e31830","sha256:cf590a507be8618177be399a888bce8fb4749b2d8293e816adbb2a36bd0bf08b"],"state_sha256":"0626d84725b9431ff737bd961086c9774ed6be565acef8f17e5a78f4a96fd218"},"bundle_signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"Tr0tghEbFrz+6/bvdM4iM/hExygT557IP/18Be2OiLxyByWfwGuvsVIGAn9mOYaLNe5khfMqeujM7LrPZ3D0Dg==","signed_message":"bundle_sha256_bytes","signed_at":"2026-06-03T19:05:44.787392Z","bundle_sha256":"3c5a1277ad52efbaabb294a09dc7b111ada963e8016d2ff6aad06858844f5978"}}