{"bundle_type":"pith_open_graph_bundle","bundle_version":"1.0","pith_number":"pith:2013:7L7ZTADLONHHYF7MGL6TGJQUQF","short_pith_number":"pith:7L7ZTADL","canonical_record":{"source":{"id":"1306.1215","kind":"arxiv","version":1},"metadata":{"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.PE","submitted_at":"2013-06-05T19:38:32Z","cross_cats_sorted":[],"title_canon_sha256":"3587aca8e21771673f9762eda4663d262e46c7756aac5778a9be2e819bebc226","abstract_canon_sha256":"38ec991c80e8695db8b4a3c2acb611f719b989f1199ef3d26f9fd38a1aef4165"},"schema_version":"1.0"},"canonical_sha256":"faff99806b734e7c17ec32fd3326148144b38f8f27217cb5efbdf3e23bdeba5e","source":{"kind":"arxiv","id":"1306.1215","version":1},"source_aliases":[{"alias_kind":"arxiv","alias_value":"1306.1215","created_at":"2026-05-18T03:21:43Z"},{"alias_kind":"arxiv_version","alias_value":"1306.1215v1","created_at":"2026-05-18T03:21:43Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.1306.1215","created_at":"2026-05-18T03:21:43Z"},{"alias_kind":"pith_short_12","alias_value":"7L7ZTADLONHH","created_at":"2026-05-18T12:27:36Z"},{"alias_kind":"pith_short_16","alias_value":"7L7ZTADLONHHYF7M","created_at":"2026-05-18T12:27:36Z"},{"alias_kind":"pith_short_8","alias_value":"7L7ZTADL","created_at":"2026-05-18T12:27:36Z"}],"events":[{"event_type":"record_created","subject_pith_number":"pith:2013:7L7ZTADLONHHYF7MGL6TGJQUQF","target":"record","payload":{"canonical_record":{"source":{"id":"1306.1215","kind":"arxiv","version":1},"metadata":{"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.PE","submitted_at":"2013-06-05T19:38:32Z","cross_cats_sorted":[],"title_canon_sha256":"3587aca8e21771673f9762eda4663d262e46c7756aac5778a9be2e819bebc226","abstract_canon_sha256":"38ec991c80e8695db8b4a3c2acb611f719b989f1199ef3d26f9fd38a1aef4165"},"schema_version":"1.0"},"canonical_sha256":"faff99806b734e7c17ec32fd3326148144b38f8f27217cb5efbdf3e23bdeba5e","receipt":{"kind":"pith_receipt","key_id":"pith-v1-2026-05","algorithm":"ed25519","signed_at":"2026-05-18T03:21:43.924573Z","signature_b64":"tzCAXiyBR14FctYMMegd+xhzzrrgudgJ+ii2bopg+crPnNTbtMrGPP95v6ZUwocKAlQ+pu83WRpiZZ4ttJ07Dw==","signed_message":"canonical_sha256_bytes","builder_version":"pith-number-builder-2026-05-17-v1","receipt_version":"0.3","canonical_sha256":"faff99806b734e7c17ec32fd3326148144b38f8f27217cb5efbdf3e23bdeba5e","last_reissued_at":"2026-05-18T03:21:43.923503Z","signature_status":"signed_v1","first_computed_at":"2026-05-18T03:21:43.923503Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"source_kind":"arxiv","source_id":"1306.1215","source_version":1,"attestation_state":"computed"},"signer":{"signer_id":"pith.science","signer_type":"pith_registry","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"created_at":"2026-05-18T03:21:43Z","supersedes":[],"prev_event":null,"signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"/sv0fQdQThBJ4iy4FqH3/wH/ZIkf2v6VEpCt4CxAQzEFg/ACj8I6DgszUz2b/Z0pE8F5d088o4nm5my9iD+kDg==","signed_message":"open_graph_event_sha256_bytes","signed_at":"2026-05-26T21:23:26.989483Z"},"content_sha256":"2f531f67a246c038065e168ffa442101319177939f8f3c2aef39334844acece1","schema_version":"1.0","event_id":"sha256:2f531f67a246c038065e168ffa442101319177939f8f3c2aef39334844acece1"},{"event_type":"graph_snapshot","subject_pith_number":"pith:2013:7L7ZTADLONHHYF7MGL6TGJQUQF","target":"graph","payload":{"graph_snapshot":{"paper":{"title":"Interference limits resolution of selection pressures from linked neutral diversity","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","headline":"","cross_cats":[],"primary_cat":"q-bio.PE","authors_text":"Aleksandra M. Walczak, Benjamin H. Good, Michael M. Desai, Richard A. Neher","submitted_at":"2013-06-05T19:38:32Z","abstract_excerpt":"Pervasive natural selection can strongly influence observed patterns of genetic variation, but these effects remain poorly understood when multiple selected variants segregate in nearby regions of the genome. Classical population genetics fails to account for interference between linked mutations, which grows increasingly severe as the density of selected polymorphisms increases. Here, we describe a simple limit that emerges when interference is common, in which the fitness effects of individual mutations play a relatively minor role. Instead, molecular evolution is determined by the variance "},"claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"1306.1215","kind":"arxiv","version":1},"verdict":{"id":null,"model_set":{},"created_at":null,"strongest_claim":"","one_line_summary":"","pipeline_version":null,"weakest_assumption":"","pith_extraction_headline":""},"references":{"count":0,"sample":[],"resolved_work":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","internal_anchors":0},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"author_claims":{"count":0,"strong_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"builder_version":"pith-number-builder-2026-05-17-v1"},"verdict_id":null},"signer":{"signer_id":"pith.science","signer_type":"pith_registry","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"created_at":"2026-05-18T03:21:43Z","supersedes":[],"prev_event":null,"signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"NbwAoopBFlbgoz3R3qh697roTJinf+gX4nU8SWIbDA3Q+RSzY0I5+qTb/0pB0F8CQCsU3ccxpRBLQqO6V0sZCw==","signed_message":"open_graph_event_sha256_bytes","signed_at":"2026-05-26T21:23:26.989855Z"},"content_sha256":"4c5d5d5200e69ae68a5b7c93a1f825decd5dce3df4a15b05a679f2a487c9deb9","schema_version":"1.0","event_id":"sha256:4c5d5d5200e69ae68a5b7c93a1f825decd5dce3df4a15b05a679f2a487c9deb9"}],"timestamp_proofs":[],"mirror_hints":[{"mirror_type":"https","name":"Pith Resolver","base_url":"https://pith.science","bundle_url":"https://pith.science/pith/7L7ZTADLONHHYF7MGL6TGJQUQF/bundle.json","state_url":"https://pith.science/pith/7L7ZTADLONHHYF7MGL6TGJQUQF/state.json","well_known_bundle_url":"https://pith.science/.well-known/pith/7L7ZTADLONHHYF7MGL6TGJQUQF/bundle.json","status":"primary"}],"public_keys":[{"key_id":"pith-v1-2026-05","algorithm":"ed25519","format":"raw","public_key_b64":"stVStoiQhXFxp4s2pdzPNoqVNBMojDU/fJ2db5S3CbM=","public_key_hex":"b2d552b68890857171a78b36a5dccf368a953413288c353f7c9d9d6f94b709b3","fingerprint_sha256_b32_first128bits":"RVFV5Z2OI2J3ZUO7ERDEBCYNKS","fingerprint_sha256_hex":"8d4b5ee74e4693bcd1df2446408b0d54","rotates_at":null,"url":"https://pith.science/pith-signing-key.json","notes":"Pith uses this Ed25519 key to sign canonical record SHA-256 digests. Verify with: ed25519_verify(public_key, message=canonical_sha256_bytes, signature=base64decode(signature_b64))."}],"merge_version":"pith-open-graph-merge-v1","built_at":"2026-05-26T21:23:26Z","links":{"resolver":"https://pith.science/pith/7L7ZTADLONHHYF7MGL6TGJQUQF","bundle":"https://pith.science/pith/7L7ZTADLONHHYF7MGL6TGJQUQF/bundle.json","state":"https://pith.science/pith/7L7ZTADLONHHYF7MGL6TGJQUQF/state.json","well_known_bundle":"https://pith.science/.well-known/pith/7L7ZTADLONHHYF7MGL6TGJQUQF/bundle.json"},"state":{"state_type":"pith_open_graph_state","state_version":"1.0","pith_number":"pith:2013:7L7ZTADLONHHYF7MGL6TGJQUQF","merge_version":"pith-open-graph-merge-v1","event_count":2,"valid_event_count":2,"invalid_event_count":0,"equivocation_count":0,"current":{"canonical_record":{"metadata":{"abstract_canon_sha256":"38ec991c80e8695db8b4a3c2acb611f719b989f1199ef3d26f9fd38a1aef4165","cross_cats_sorted":[],"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.PE","submitted_at":"2013-06-05T19:38:32Z","title_canon_sha256":"3587aca8e21771673f9762eda4663d262e46c7756aac5778a9be2e819bebc226"},"schema_version":"1.0","source":{"id":"1306.1215","kind":"arxiv","version":1}},"source_aliases":[{"alias_kind":"arxiv","alias_value":"1306.1215","created_at":"2026-05-18T03:21:43Z"},{"alias_kind":"arxiv_version","alias_value":"1306.1215v1","created_at":"2026-05-18T03:21:43Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.1306.1215","created_at":"2026-05-18T03:21:43Z"},{"alias_kind":"pith_short_12","alias_value":"7L7ZTADLONHH","created_at":"2026-05-18T12:27:36Z"},{"alias_kind":"pith_short_16","alias_value":"7L7ZTADLONHHYF7M","created_at":"2026-05-18T12:27:36Z"},{"alias_kind":"pith_short_8","alias_value":"7L7ZTADL","created_at":"2026-05-18T12:27:36Z"}],"graph_snapshots":[{"event_id":"sha256:4c5d5d5200e69ae68a5b7c93a1f825decd5dce3df4a15b05a679f2a487c9deb9","target":"graph","created_at":"2026-05-18T03:21:43Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"graph_snapshot":{"author_claims":{"count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","strong_count":0},"builder_version":"pith-number-builder-2026-05-17-v1","claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"paper":{"abstract_excerpt":"Pervasive natural selection can strongly influence observed patterns of genetic variation, but these effects remain poorly understood when multiple selected variants segregate in nearby regions of the genome. Classical population genetics fails to account for interference between linked mutations, which grows increasingly severe as the density of selected polymorphisms increases. Here, we describe a simple limit that emerges when interference is common, in which the fitness effects of individual mutations play a relatively minor role. Instead, molecular evolution is determined by the variance ","authors_text":"Aleksandra M. Walczak, Benjamin H. Good, Michael M. Desai, Richard A. Neher","cross_cats":[],"headline":"","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.PE","submitted_at":"2013-06-05T19:38:32Z","title":"Interference limits resolution of selection pressures from linked neutral diversity"},"references":{"count":0,"internal_anchors":0,"resolved_work":0,"sample":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"1306.1215","kind":"arxiv","version":1},"verdict":{"created_at":null,"id":null,"model_set":{},"one_line_summary":"","pipeline_version":null,"pith_extraction_headline":"","strongest_claim":"","weakest_assumption":""}},"verdict_id":null}}],"author_attestations":[],"timestamp_anchors":[],"storage_attestations":[],"citation_signatures":[],"replication_records":[],"corrections":[],"mirror_hints":[],"record_created":{"event_id":"sha256:2f531f67a246c038065e168ffa442101319177939f8f3c2aef39334844acece1","target":"record","created_at":"2026-05-18T03:21:43Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"attestation_state":"computed","canonical_record":{"metadata":{"abstract_canon_sha256":"38ec991c80e8695db8b4a3c2acb611f719b989f1199ef3d26f9fd38a1aef4165","cross_cats_sorted":[],"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.PE","submitted_at":"2013-06-05T19:38:32Z","title_canon_sha256":"3587aca8e21771673f9762eda4663d262e46c7756aac5778a9be2e819bebc226"},"schema_version":"1.0","source":{"id":"1306.1215","kind":"arxiv","version":1}},"canonical_sha256":"faff99806b734e7c17ec32fd3326148144b38f8f27217cb5efbdf3e23bdeba5e","receipt":{"algorithm":"ed25519","builder_version":"pith-number-builder-2026-05-17-v1","canonical_sha256":"faff99806b734e7c17ec32fd3326148144b38f8f27217cb5efbdf3e23bdeba5e","first_computed_at":"2026-05-18T03:21:43.923503Z","key_id":"pith-v1-2026-05","kind":"pith_receipt","last_reissued_at":"2026-05-18T03:21:43.923503Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","receipt_version":"0.3","signature_b64":"tzCAXiyBR14FctYMMegd+xhzzrrgudgJ+ii2bopg+crPnNTbtMrGPP95v6ZUwocKAlQ+pu83WRpiZZ4ttJ07Dw==","signature_status":"signed_v1","signed_at":"2026-05-18T03:21:43.924573Z","signed_message":"canonical_sha256_bytes"},"source_id":"1306.1215","source_kind":"arxiv","source_version":1}}},"equivocations":[],"invalid_events":[],"applied_event_ids":["sha256:2f531f67a246c038065e168ffa442101319177939f8f3c2aef39334844acece1","sha256:4c5d5d5200e69ae68a5b7c93a1f825decd5dce3df4a15b05a679f2a487c9deb9"],"state_sha256":"b3ffff65657ffe16fabc59c8bd321def33c19411e8ef68cb0929e6e9c058ac0f"},"bundle_signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"vBhpqaG4nODBVNWO93TVJur8hX8IxFF1Rqz0tD4S0HvYBlBpJTp1MaHLhP7AWGipL/c+XnATVCwU3zHsMiNDCQ==","signed_message":"bundle_sha256_bytes","signed_at":"2026-05-26T21:23:26.992435Z","bundle_sha256":"183937fe5e6a7be9abbeae4d525631cb28ccf0e771078a0f013345dcb2244058"}}