{"bundle_type":"pith_open_graph_bundle","bundle_version":"1.0","pith_number":"pith:2018:7PG3HVYCRCOCRM3K7PC3BOUAFW","short_pith_number":"pith:7PG3HVYC","canonical_record":{"source":{"id":"1809.08534","kind":"arxiv","version":1},"metadata":{"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"physics.med-ph","submitted_at":"2018-09-23T04:39:20Z","cross_cats_sorted":["physics.bio-ph"],"title_canon_sha256":"0b423d8ec9e33b969bafa1d9c8b5506049616109b581ce26f85c2812f488e90b","abstract_canon_sha256":"29e0b8d91c9345df66932deb7e2f77aaa239cf52c19c98987e493ff3b4dbcccf"},"schema_version":"1.0"},"canonical_sha256":"fbcdb3d702889c28b36afbc5b0ba802d80290455ea381d73679e8353d68b66f8","source":{"kind":"arxiv","id":"1809.08534","version":1},"source_aliases":[{"alias_kind":"arxiv","alias_value":"1809.08534","created_at":"2026-05-18T00:05:04Z"},{"alias_kind":"arxiv_version","alias_value":"1809.08534v1","created_at":"2026-05-18T00:05:04Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.1809.08534","created_at":"2026-05-18T00:05:04Z"},{"alias_kind":"pith_short_12","alias_value":"7PG3HVYCRCOC","created_at":"2026-05-18T12:32:11Z"},{"alias_kind":"pith_short_16","alias_value":"7PG3HVYCRCOCRM3K","created_at":"2026-05-18T12:32:11Z"},{"alias_kind":"pith_short_8","alias_value":"7PG3HVYC","created_at":"2026-05-18T12:32:11Z"}],"events":[{"event_type":"record_created","subject_pith_number":"pith:2018:7PG3HVYCRCOCRM3K7PC3BOUAFW","target":"record","payload":{"canonical_record":{"source":{"id":"1809.08534","kind":"arxiv","version":1},"metadata":{"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"physics.med-ph","submitted_at":"2018-09-23T04:39:20Z","cross_cats_sorted":["physics.bio-ph"],"title_canon_sha256":"0b423d8ec9e33b969bafa1d9c8b5506049616109b581ce26f85c2812f488e90b","abstract_canon_sha256":"29e0b8d91c9345df66932deb7e2f77aaa239cf52c19c98987e493ff3b4dbcccf"},"schema_version":"1.0"},"canonical_sha256":"fbcdb3d702889c28b36afbc5b0ba802d80290455ea381d73679e8353d68b66f8","receipt":{"kind":"pith_receipt","key_id":"pith-v1-2026-05","algorithm":"ed25519","signed_at":"2026-05-18T00:05:04.155930Z","signature_b64":"uNnc3KZ4u87IV7HMPezr+SWM1Noe03ESFtqrdfXPTxh0N5jCHoy9rYadccDw1hpsOwKGqOHLz8RGnN1ot94+AQ==","signed_message":"canonical_sha256_bytes","builder_version":"pith-number-builder-2026-05-17-v1","receipt_version":"0.3","canonical_sha256":"fbcdb3d702889c28b36afbc5b0ba802d80290455ea381d73679e8353d68b66f8","last_reissued_at":"2026-05-18T00:05:04.155430Z","signature_status":"signed_v1","first_computed_at":"2026-05-18T00:05:04.155430Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"source_kind":"arxiv","source_id":"1809.08534","source_version":1,"attestation_state":"computed"},"signer":{"signer_id":"pith.science","signer_type":"pith_registry","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"created_at":"2026-05-18T00:05:04Z","supersedes":[],"prev_event":null,"signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"MyLCYjKftqcvboNXmxNDe0WlvQIJ5hf1zYkxY724Wc/VvMEb5V44buse9Yju+XuLd3mwi54+/hGuqiGMOb0qDQ==","signed_message":"open_graph_event_sha256_bytes","signed_at":"2026-05-22T12:40:41.715540Z"},"content_sha256":"48f909e74feb54fd2e542c5c403aa667116b32d959cc64e82e93cc9473939033","schema_version":"1.0","event_id":"sha256:48f909e74feb54fd2e542c5c403aa667116b32d959cc64e82e93cc9473939033"},{"event_type":"graph_snapshot","subject_pith_number":"pith:2018:7PG3HVYCRCOCRM3K7PC3BOUAFW","target":"graph","payload":{"graph_snapshot":{"paper":{"title":"Predicting patient outcomes (TNBC) based on positions of cancer islands and CD8+ T cells using machine learning approach","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","headline":"","cross_cats":["physics.bio-ph"],"primary_cat":"physics.med-ph","authors_text":"Guangyuan Yu, Herbert Levine, Xuefei Li","submitted_at":"2018-09-23T04:39:20Z","abstract_excerpt":"Machine learning method is being applied in cancer research. In this work, we propose a method to classify the small patch of triple-negative breast cancer (TNBC) tumor and use the overall percentage of \"good\" patches as a marker to predict the prognosis, which is an automatic method of prognosis and could also be used for other cancers."},"claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"1809.08534","kind":"arxiv","version":1},"verdict":{"id":null,"model_set":{},"created_at":null,"strongest_claim":"","one_line_summary":"","pipeline_version":null,"weakest_assumption":"","pith_extraction_headline":""},"references":{"count":0,"sample":[],"resolved_work":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","internal_anchors":0},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"author_claims":{"count":0,"strong_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"builder_version":"pith-number-builder-2026-05-17-v1"},"verdict_id":null},"signer":{"signer_id":"pith.science","signer_type":"pith_registry","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"created_at":"2026-05-18T00:05:04Z","supersedes":[],"prev_event":null,"signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"NPZ7sZpIXLPDSOXtIxD2YwIql3BOh6FMQRqU6FNU56hoKImlR5X9aPHN4JHkxbCKGmn4R9To50FP9howRHnBCg==","signed_message":"open_graph_event_sha256_bytes","signed_at":"2026-05-22T12:40:41.715994Z"},"content_sha256":"740a4ffeefb86fda19995b1cbf7ab034f5038815dd452a7176541d8601cc31db","schema_version":"1.0","event_id":"sha256:740a4ffeefb86fda19995b1cbf7ab034f5038815dd452a7176541d8601cc31db"}],"timestamp_proofs":[],"mirror_hints":[{"mirror_type":"https","name":"Pith Resolver","base_url":"https://pith.science","bundle_url":"https://pith.science/pith/7PG3HVYCRCOCRM3K7PC3BOUAFW/bundle.json","state_url":"https://pith.science/pith/7PG3HVYCRCOCRM3K7PC3BOUAFW/state.json","well_known_bundle_url":"https://pith.science/.well-known/pith/7PG3HVYCRCOCRM3K7PC3BOUAFW/bundle.json","status":"primary"}],"public_keys":[{"key_id":"pith-v1-2026-05","algorithm":"ed25519","format":"raw","public_key_b64":"stVStoiQhXFxp4s2pdzPNoqVNBMojDU/fJ2db5S3CbM=","public_key_hex":"b2d552b68890857171a78b36a5dccf368a953413288c353f7c9d9d6f94b709b3","fingerprint_sha256_b32_first128bits":"RVFV5Z2OI2J3ZUO7ERDEBCYNKS","fingerprint_sha256_hex":"8d4b5ee74e4693bcd1df2446408b0d54","rotates_at":null,"url":"https://pith.science/pith-signing-key.json","notes":"Pith uses this Ed25519 key to sign canonical record SHA-256 digests. Verify with: ed25519_verify(public_key, message=canonical_sha256_bytes, signature=base64decode(signature_b64))."}],"merge_version":"pith-open-graph-merge-v1","built_at":"2026-05-22T12:40:41Z","links":{"resolver":"https://pith.science/pith/7PG3HVYCRCOCRM3K7PC3BOUAFW","bundle":"https://pith.science/pith/7PG3HVYCRCOCRM3K7PC3BOUAFW/bundle.json","state":"https://pith.science/pith/7PG3HVYCRCOCRM3K7PC3BOUAFW/state.json","well_known_bundle":"https://pith.science/.well-known/pith/7PG3HVYCRCOCRM3K7PC3BOUAFW/bundle.json"},"state":{"state_type":"pith_open_graph_state","state_version":"1.0","pith_number":"pith:2018:7PG3HVYCRCOCRM3K7PC3BOUAFW","merge_version":"pith-open-graph-merge-v1","event_count":2,"valid_event_count":2,"invalid_event_count":0,"equivocation_count":0,"current":{"canonical_record":{"metadata":{"abstract_canon_sha256":"29e0b8d91c9345df66932deb7e2f77aaa239cf52c19c98987e493ff3b4dbcccf","cross_cats_sorted":["physics.bio-ph"],"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"physics.med-ph","submitted_at":"2018-09-23T04:39:20Z","title_canon_sha256":"0b423d8ec9e33b969bafa1d9c8b5506049616109b581ce26f85c2812f488e90b"},"schema_version":"1.0","source":{"id":"1809.08534","kind":"arxiv","version":1}},"source_aliases":[{"alias_kind":"arxiv","alias_value":"1809.08534","created_at":"2026-05-18T00:05:04Z"},{"alias_kind":"arxiv_version","alias_value":"1809.08534v1","created_at":"2026-05-18T00:05:04Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.1809.08534","created_at":"2026-05-18T00:05:04Z"},{"alias_kind":"pith_short_12","alias_value":"7PG3HVYCRCOC","created_at":"2026-05-18T12:32:11Z"},{"alias_kind":"pith_short_16","alias_value":"7PG3HVYCRCOCRM3K","created_at":"2026-05-18T12:32:11Z"},{"alias_kind":"pith_short_8","alias_value":"7PG3HVYC","created_at":"2026-05-18T12:32:11Z"}],"graph_snapshots":[{"event_id":"sha256:740a4ffeefb86fda19995b1cbf7ab034f5038815dd452a7176541d8601cc31db","target":"graph","created_at":"2026-05-18T00:05:04Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"graph_snapshot":{"author_claims":{"count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","strong_count":0},"builder_version":"pith-number-builder-2026-05-17-v1","claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"paper":{"abstract_excerpt":"Machine learning method is being applied in cancer research. In this work, we propose a method to classify the small patch of triple-negative breast cancer (TNBC) tumor and use the overall percentage of \"good\" patches as a marker to predict the prognosis, which is an automatic method of prognosis and could also be used for other cancers.","authors_text":"Guangyuan Yu, Herbert Levine, Xuefei Li","cross_cats":["physics.bio-ph"],"headline":"","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"physics.med-ph","submitted_at":"2018-09-23T04:39:20Z","title":"Predicting patient outcomes (TNBC) based on positions of cancer islands and CD8+ T cells using machine learning approach"},"references":{"count":0,"internal_anchors":0,"resolved_work":0,"sample":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"1809.08534","kind":"arxiv","version":1},"verdict":{"created_at":null,"id":null,"model_set":{},"one_line_summary":"","pipeline_version":null,"pith_extraction_headline":"","strongest_claim":"","weakest_assumption":""}},"verdict_id":null}}],"author_attestations":[],"timestamp_anchors":[],"storage_attestations":[],"citation_signatures":[],"replication_records":[],"corrections":[],"mirror_hints":[],"record_created":{"event_id":"sha256:48f909e74feb54fd2e542c5c403aa667116b32d959cc64e82e93cc9473939033","target":"record","created_at":"2026-05-18T00:05:04Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"attestation_state":"computed","canonical_record":{"metadata":{"abstract_canon_sha256":"29e0b8d91c9345df66932deb7e2f77aaa239cf52c19c98987e493ff3b4dbcccf","cross_cats_sorted":["physics.bio-ph"],"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"physics.med-ph","submitted_at":"2018-09-23T04:39:20Z","title_canon_sha256":"0b423d8ec9e33b969bafa1d9c8b5506049616109b581ce26f85c2812f488e90b"},"schema_version":"1.0","source":{"id":"1809.08534","kind":"arxiv","version":1}},"canonical_sha256":"fbcdb3d702889c28b36afbc5b0ba802d80290455ea381d73679e8353d68b66f8","receipt":{"algorithm":"ed25519","builder_version":"pith-number-builder-2026-05-17-v1","canonical_sha256":"fbcdb3d702889c28b36afbc5b0ba802d80290455ea381d73679e8353d68b66f8","first_computed_at":"2026-05-18T00:05:04.155430Z","key_id":"pith-v1-2026-05","kind":"pith_receipt","last_reissued_at":"2026-05-18T00:05:04.155430Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","receipt_version":"0.3","signature_b64":"uNnc3KZ4u87IV7HMPezr+SWM1Noe03ESFtqrdfXPTxh0N5jCHoy9rYadccDw1hpsOwKGqOHLz8RGnN1ot94+AQ==","signature_status":"signed_v1","signed_at":"2026-05-18T00:05:04.155930Z","signed_message":"canonical_sha256_bytes"},"source_id":"1809.08534","source_kind":"arxiv","source_version":1}}},"equivocations":[],"invalid_events":[],"applied_event_ids":["sha256:48f909e74feb54fd2e542c5c403aa667116b32d959cc64e82e93cc9473939033","sha256:740a4ffeefb86fda19995b1cbf7ab034f5038815dd452a7176541d8601cc31db"],"state_sha256":"2ca493b7cf30820687d3f667fa4573886ac14ce6f718f3e87fac33e6f58fe97c"},"bundle_signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"VbIg9jYZ7Usfz/tBtrD998yhb79COUJCN/OFMQ8ZoML7pMaiaRmLSWGVT1/s7lIpNJGw1KSUcvDvkkie8OUtDg==","signed_message":"bundle_sha256_bytes","signed_at":"2026-05-22T12:40:41.718835Z","bundle_sha256":"ddf6e72352f10ac4b690e3f07a4a7fe1281f760a2528fa997f97bc04ef78ad01"}}