{"bundle_type":"pith_open_graph_bundle","bundle_version":"1.0","pith_number":"pith:2017:7TKSWTGJXM7S65NVM3CQ6XVXGS","short_pith_number":"pith:7TKSWTGJ","canonical_record":{"source":{"id":"1701.05503","kind":"arxiv","version":1},"metadata":{"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.MN","submitted_at":"2017-01-19T16:31:34Z","cross_cats_sorted":[],"title_canon_sha256":"705467d5825dd84cd90915a48176b6a0741f3f70ab0f3fabc202baf586e22ee6","abstract_canon_sha256":"b323e317774a0df22b0a5b0c9a989bdd7ea92cd710e932e6c58bacfa53991524"},"schema_version":"1.0"},"canonical_sha256":"fcd52b4cc9bb3f2f75b566c50f5eb734906db10d19cd150a923689b41504eb05","source":{"kind":"arxiv","id":"1701.05503","version":1},"source_aliases":[{"alias_kind":"arxiv","alias_value":"1701.05503","created_at":"2026-05-18T00:52:29Z"},{"alias_kind":"arxiv_version","alias_value":"1701.05503v1","created_at":"2026-05-18T00:52:29Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.1701.05503","created_at":"2026-05-18T00:52:29Z"},{"alias_kind":"pith_short_12","alias_value":"7TKSWTGJXM7S","created_at":"2026-05-18T12:31:05Z"},{"alias_kind":"pith_short_16","alias_value":"7TKSWTGJXM7S65NV","created_at":"2026-05-18T12:31:05Z"},{"alias_kind":"pith_short_8","alias_value":"7TKSWTGJ","created_at":"2026-05-18T12:31:05Z"}],"events":[{"event_type":"record_created","subject_pith_number":"pith:2017:7TKSWTGJXM7S65NVM3CQ6XVXGS","target":"record","payload":{"canonical_record":{"source":{"id":"1701.05503","kind":"arxiv","version":1},"metadata":{"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.MN","submitted_at":"2017-01-19T16:31:34Z","cross_cats_sorted":[],"title_canon_sha256":"705467d5825dd84cd90915a48176b6a0741f3f70ab0f3fabc202baf586e22ee6","abstract_canon_sha256":"b323e317774a0df22b0a5b0c9a989bdd7ea92cd710e932e6c58bacfa53991524"},"schema_version":"1.0"},"canonical_sha256":"fcd52b4cc9bb3f2f75b566c50f5eb734906db10d19cd150a923689b41504eb05","receipt":{"kind":"pith_receipt","key_id":"pith-v1-2026-05","algorithm":"ed25519","signed_at":"2026-05-18T00:52:29.677491Z","signature_b64":"A3IUPa+7XGbUDXvHCzvnGQ1TGIsWrfqVHJM4TD36xW3H05i5vaY71PlXH3juwkt1zaRQw2QBn/FNrKZb64nAAQ==","signed_message":"canonical_sha256_bytes","builder_version":"pith-number-builder-2026-05-17-v1","receipt_version":"0.3","canonical_sha256":"fcd52b4cc9bb3f2f75b566c50f5eb734906db10d19cd150a923689b41504eb05","last_reissued_at":"2026-05-18T00:52:29.676893Z","signature_status":"signed_v1","first_computed_at":"2026-05-18T00:52:29.676893Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"source_kind":"arxiv","source_id":"1701.05503","source_version":1,"attestation_state":"computed"},"signer":{"signer_id":"pith.science","signer_type":"pith_registry","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"created_at":"2026-05-18T00:52:29Z","supersedes":[],"prev_event":null,"signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"UP9XQbjCX0XWKPKr96OL7ZD8weQb8krHgbqaW33u9Sr4RQhy8FMTQgRXbknJyMO/IWhiqngz+QYVByIds3mGDA==","signed_message":"open_graph_event_sha256_bytes","signed_at":"2026-06-12T09:33:08.384990Z"},"content_sha256":"8c7abf1d1224d89b974ae5ddfd25633a17d567cf3acd355db29c398889812d49","schema_version":"1.0","event_id":"sha256:8c7abf1d1224d89b974ae5ddfd25633a17d567cf3acd355db29c398889812d49"},{"event_type":"graph_snapshot","subject_pith_number":"pith:2017:7TKSWTGJXM7S65NVM3CQ6XVXGS","target":"graph","payload":{"graph_snapshot":{"paper":{"title":"The competitive nature of STAT complex formation drives phenotype switching of T cells","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","headline":"","cross_cats":[],"primary_cat":"q-bio.MN","authors_text":"Claudia Kemper, Diana V Salakhieva, Gavin I Welsh, Ildar I Sadreev, Michael Z Q Chen, Nikolay V Kotov, Vadim N Biktashev, Yoshinori Umezawa","submitted_at":"2017-01-19T16:31:34Z","abstract_excerpt":"Signal transducers and activators of transcription (STATs) are key molecular determinants of T cell fate and effector function. A number of inflammatory diseases are characterized by an altered balance of T cell phenotypes and cytokine secretion. STATs, therefore, represent viable therapeutic targets in numerous pathologies. However, the underlying mechanisms of how the same STAT proteins regulate both the development of different T cell phenotypes and their plasticity during changes in extracellular conditions remain unclear. In this study, we investigated the STAT mediated regulation of T ce"},"claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"1701.05503","kind":"arxiv","version":1},"verdict":{"id":null,"model_set":{},"created_at":null,"strongest_claim":"","one_line_summary":"","pipeline_version":null,"weakest_assumption":"","pith_extraction_headline":""},"references":{"count":0,"sample":[],"resolved_work":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","internal_anchors":0},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"author_claims":{"count":0,"strong_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"builder_version":"pith-number-builder-2026-05-17-v1"},"verdict_id":null},"signer":{"signer_id":"pith.science","signer_type":"pith_registry","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"created_at":"2026-05-18T00:52:29Z","supersedes":[],"prev_event":null,"signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"2I3rKSmyAbVE3UmQUAgdVp7CnWl4yPls/K9Nde/Y4go8ZCsa74iMbxpbiNwS4jHZGBhCYDrJEYv8DvP9a4vQAw==","signed_message":"open_graph_event_sha256_bytes","signed_at":"2026-06-12T09:33:08.385394Z"},"content_sha256":"94f51abe3f606697ca4fcf9077bd3ee744cb2324a7d7d8c856f52a865f850a61","schema_version":"1.0","event_id":"sha256:94f51abe3f606697ca4fcf9077bd3ee744cb2324a7d7d8c856f52a865f850a61"}],"timestamp_proofs":[],"mirror_hints":[{"mirror_type":"https","name":"Pith Resolver","base_url":"https://pith.science","bundle_url":"https://pith.science/pith/7TKSWTGJXM7S65NVM3CQ6XVXGS/bundle.json","state_url":"https://pith.science/pith/7TKSWTGJXM7S65NVM3CQ6XVXGS/state.json","well_known_bundle_url":"https://pith.science/.well-known/pith/7TKSWTGJXM7S65NVM3CQ6XVXGS/bundle.json","status":"primary"}],"public_keys":[{"key_id":"pith-v1-2026-05","algorithm":"ed25519","format":"raw","public_key_b64":"stVStoiQhXFxp4s2pdzPNoqVNBMojDU/fJ2db5S3CbM=","public_key_hex":"b2d552b68890857171a78b36a5dccf368a953413288c353f7c9d9d6f94b709b3","fingerprint_sha256_b32_first128bits":"RVFV5Z2OI2J3ZUO7ERDEBCYNKS","fingerprint_sha256_hex":"8d4b5ee74e4693bcd1df2446408b0d54","rotates_at":null,"url":"https://pith.science/pith-signing-key.json","notes":"Pith uses this Ed25519 key to sign canonical record SHA-256 digests. Verify with: ed25519_verify(public_key, message=canonical_sha256_bytes, signature=base64decode(signature_b64))."}],"merge_version":"pith-open-graph-merge-v1","built_at":"2026-06-12T09:33:08Z","links":{"resolver":"https://pith.science/pith/7TKSWTGJXM7S65NVM3CQ6XVXGS","bundle":"https://pith.science/pith/7TKSWTGJXM7S65NVM3CQ6XVXGS/bundle.json","state":"https://pith.science/pith/7TKSWTGJXM7S65NVM3CQ6XVXGS/state.json","well_known_bundle":"https://pith.science/.well-known/pith/7TKSWTGJXM7S65NVM3CQ6XVXGS/bundle.json"},"state":{"state_type":"pith_open_graph_state","state_version":"1.0","pith_number":"pith:2017:7TKSWTGJXM7S65NVM3CQ6XVXGS","merge_version":"pith-open-graph-merge-v1","event_count":2,"valid_event_count":2,"invalid_event_count":0,"equivocation_count":0,"current":{"canonical_record":{"metadata":{"abstract_canon_sha256":"b323e317774a0df22b0a5b0c9a989bdd7ea92cd710e932e6c58bacfa53991524","cross_cats_sorted":[],"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.MN","submitted_at":"2017-01-19T16:31:34Z","title_canon_sha256":"705467d5825dd84cd90915a48176b6a0741f3f70ab0f3fabc202baf586e22ee6"},"schema_version":"1.0","source":{"id":"1701.05503","kind":"arxiv","version":1}},"source_aliases":[{"alias_kind":"arxiv","alias_value":"1701.05503","created_at":"2026-05-18T00:52:29Z"},{"alias_kind":"arxiv_version","alias_value":"1701.05503v1","created_at":"2026-05-18T00:52:29Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.1701.05503","created_at":"2026-05-18T00:52:29Z"},{"alias_kind":"pith_short_12","alias_value":"7TKSWTGJXM7S","created_at":"2026-05-18T12:31:05Z"},{"alias_kind":"pith_short_16","alias_value":"7TKSWTGJXM7S65NV","created_at":"2026-05-18T12:31:05Z"},{"alias_kind":"pith_short_8","alias_value":"7TKSWTGJ","created_at":"2026-05-18T12:31:05Z"}],"graph_snapshots":[{"event_id":"sha256:94f51abe3f606697ca4fcf9077bd3ee744cb2324a7d7d8c856f52a865f850a61","target":"graph","created_at":"2026-05-18T00:52:29Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"graph_snapshot":{"author_claims":{"count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","strong_count":0},"builder_version":"pith-number-builder-2026-05-17-v1","claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"paper":{"abstract_excerpt":"Signal transducers and activators of transcription (STATs) are key molecular determinants of T cell fate and effector function. A number of inflammatory diseases are characterized by an altered balance of T cell phenotypes and cytokine secretion. STATs, therefore, represent viable therapeutic targets in numerous pathologies. However, the underlying mechanisms of how the same STAT proteins regulate both the development of different T cell phenotypes and their plasticity during changes in extracellular conditions remain unclear. In this study, we investigated the STAT mediated regulation of T ce","authors_text":"Claudia Kemper, Diana V Salakhieva, Gavin I Welsh, Ildar I Sadreev, Michael Z Q Chen, Nikolay V Kotov, Vadim N Biktashev, Yoshinori Umezawa","cross_cats":[],"headline":"","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.MN","submitted_at":"2017-01-19T16:31:34Z","title":"The competitive nature of STAT complex formation drives phenotype switching of T cells"},"references":{"count":0,"internal_anchors":0,"resolved_work":0,"sample":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"1701.05503","kind":"arxiv","version":1},"verdict":{"created_at":null,"id":null,"model_set":{},"one_line_summary":"","pipeline_version":null,"pith_extraction_headline":"","strongest_claim":"","weakest_assumption":""}},"verdict_id":null}}],"author_attestations":[],"timestamp_anchors":[],"storage_attestations":[],"citation_signatures":[],"replication_records":[],"corrections":[],"mirror_hints":[],"record_created":{"event_id":"sha256:8c7abf1d1224d89b974ae5ddfd25633a17d567cf3acd355db29c398889812d49","target":"record","created_at":"2026-05-18T00:52:29Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"attestation_state":"computed","canonical_record":{"metadata":{"abstract_canon_sha256":"b323e317774a0df22b0a5b0c9a989bdd7ea92cd710e932e6c58bacfa53991524","cross_cats_sorted":[],"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.MN","submitted_at":"2017-01-19T16:31:34Z","title_canon_sha256":"705467d5825dd84cd90915a48176b6a0741f3f70ab0f3fabc202baf586e22ee6"},"schema_version":"1.0","source":{"id":"1701.05503","kind":"arxiv","version":1}},"canonical_sha256":"fcd52b4cc9bb3f2f75b566c50f5eb734906db10d19cd150a923689b41504eb05","receipt":{"algorithm":"ed25519","builder_version":"pith-number-builder-2026-05-17-v1","canonical_sha256":"fcd52b4cc9bb3f2f75b566c50f5eb734906db10d19cd150a923689b41504eb05","first_computed_at":"2026-05-18T00:52:29.676893Z","key_id":"pith-v1-2026-05","kind":"pith_receipt","last_reissued_at":"2026-05-18T00:52:29.676893Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","receipt_version":"0.3","signature_b64":"A3IUPa+7XGbUDXvHCzvnGQ1TGIsWrfqVHJM4TD36xW3H05i5vaY71PlXH3juwkt1zaRQw2QBn/FNrKZb64nAAQ==","signature_status":"signed_v1","signed_at":"2026-05-18T00:52:29.677491Z","signed_message":"canonical_sha256_bytes"},"source_id":"1701.05503","source_kind":"arxiv","source_version":1}}},"equivocations":[],"invalid_events":[],"applied_event_ids":["sha256:8c7abf1d1224d89b974ae5ddfd25633a17d567cf3acd355db29c398889812d49","sha256:94f51abe3f606697ca4fcf9077bd3ee744cb2324a7d7d8c856f52a865f850a61"],"state_sha256":"1bd6bf4b3e959c1da3d3809db9a0f1d7c9ad7c186a4bc10cc35d8fe38e68871d"},"bundle_signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"1fAISU3BzMtSuc55591PQnmkgpHtTtpinjcVF4xjrwB7BSGNB3X8ZdeZ3Kks83IcD5huCrfopKBL8svax0zBDw==","signed_message":"bundle_sha256_bytes","signed_at":"2026-06-12T09:33:08.387404Z","bundle_sha256":"31d6a5b16571e26d22e48c4488765cf122d09a5dbefc4cd9ae0b7265b97e98d8"}}