{"bundle_type":"pith_open_graph_bundle","bundle_version":"1.0","pith_number":"pith:2017:7TOVHEGCTQP7U2S3EE42RUNWLY","short_pith_number":"pith:7TOVHEGC","canonical_record":{"source":{"id":"1705.07990","kind":"arxiv","version":1},"metadata":{"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.BM","submitted_at":"2017-05-22T20:44:46Z","cross_cats_sorted":[],"title_canon_sha256":"c90aff9309963cffb3b80b8f667fda983c113260525af151f52bab448a9ac62b","abstract_canon_sha256":"82b6e5f3d02994a5c9c59ea79ecccf496d529ff671110ef58924b6d5a57f3540"},"schema_version":"1.0"},"canonical_sha256":"fcdd5390c29c1ffa6a5b2139a8d1b65e036617a73c2e75d3f8ccbea5cd45eaa6","source":{"kind":"arxiv","id":"1705.07990","version":1},"source_aliases":[{"alias_kind":"arxiv","alias_value":"1705.07990","created_at":"2026-05-18T00:44:03Z"},{"alias_kind":"arxiv_version","alias_value":"1705.07990v1","created_at":"2026-05-18T00:44:03Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.1705.07990","created_at":"2026-05-18T00:44:03Z"},{"alias_kind":"pith_short_12","alias_value":"7TOVHEGCTQP7","created_at":"2026-05-18T12:31:05Z"},{"alias_kind":"pith_short_16","alias_value":"7TOVHEGCTQP7U2S3","created_at":"2026-05-18T12:31:05Z"},{"alias_kind":"pith_short_8","alias_value":"7TOVHEGC","created_at":"2026-05-18T12:31:05Z"}],"events":[{"event_type":"record_created","subject_pith_number":"pith:2017:7TOVHEGCTQP7U2S3EE42RUNWLY","target":"record","payload":{"canonical_record":{"source":{"id":"1705.07990","kind":"arxiv","version":1},"metadata":{"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.BM","submitted_at":"2017-05-22T20:44:46Z","cross_cats_sorted":[],"title_canon_sha256":"c90aff9309963cffb3b80b8f667fda983c113260525af151f52bab448a9ac62b","abstract_canon_sha256":"82b6e5f3d02994a5c9c59ea79ecccf496d529ff671110ef58924b6d5a57f3540"},"schema_version":"1.0"},"canonical_sha256":"fcdd5390c29c1ffa6a5b2139a8d1b65e036617a73c2e75d3f8ccbea5cd45eaa6","receipt":{"kind":"pith_receipt","key_id":"pith-v1-2026-05","algorithm":"ed25519","signed_at":"2026-05-18T00:44:03.924860Z","signature_b64":"xqORnqrLJaaQ6Iw3NSTVxHWFs/F9pvByFcfMSPQkP1RyfUcZH8sEUfnV/A8Rd4PqBi24JUnbxarQVLJ4vb/SCw==","signed_message":"canonical_sha256_bytes","builder_version":"pith-number-builder-2026-05-17-v1","receipt_version":"0.3","canonical_sha256":"fcdd5390c29c1ffa6a5b2139a8d1b65e036617a73c2e75d3f8ccbea5cd45eaa6","last_reissued_at":"2026-05-18T00:44:03.924112Z","signature_status":"signed_v1","first_computed_at":"2026-05-18T00:44:03.924112Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"source_kind":"arxiv","source_id":"1705.07990","source_version":1,"attestation_state":"computed"},"signer":{"signer_id":"pith.science","signer_type":"pith_registry","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"created_at":"2026-05-18T00:44:03Z","supersedes":[],"prev_event":null,"signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"/xbYR23euKvpce/F9AORjzjKVFsydDGdbTQKyjzCYRhNPK5E7Rf3lRsXFnn0GCDASCmM6f5ek7Qd8N11yGr+BA==","signed_message":"open_graph_event_sha256_bytes","signed_at":"2026-06-06T10:07:40.338677Z"},"content_sha256":"45a01c395674e7cb903cf312e98e6e1443766d9415b813526d0ccf99d2cc2646","schema_version":"1.0","event_id":"sha256:45a01c395674e7cb903cf312e98e6e1443766d9415b813526d0ccf99d2cc2646"},{"event_type":"graph_snapshot","subject_pith_number":"pith:2017:7TOVHEGCTQP7U2S3EE42RUNWLY","target":"graph","payload":{"graph_snapshot":{"paper":{"title":"Aqueous solution interactions with sex hormone-binding globulin and estradiol: A theoretical investigation","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","headline":"","cross_cats":[],"primary_cat":"q-bio.BM","authors_text":"A. J. da Silva, E. S. Santos","submitted_at":"2017-05-22T20:44:46Z","abstract_excerpt":"Sex hormone-binding globulin (SHBG) is a binding protein that regulates availability of steroids hormones in the plasma. Although best known as steroid carrier, studies have associated SHBG in modulating behavioral aspects related to sexual receptivity. Among steroids, estradiol (17\\b{eta}-estradiol, oestradiol or E2) is well recognized as the most active endogenous female hormone, exerting important roles in reproductive and nonreproductive functions. Thus, in this study we aimed to employ molecular dynamics (MD) and docking techniques for quantifying the interaction energy between a complex "},"claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"1705.07990","kind":"arxiv","version":1},"verdict":{"id":null,"model_set":{},"created_at":null,"strongest_claim":"","one_line_summary":"","pipeline_version":null,"weakest_assumption":"","pith_extraction_headline":""},"references":{"count":0,"sample":[],"resolved_work":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","internal_anchors":0},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"author_claims":{"count":0,"strong_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"builder_version":"pith-number-builder-2026-05-17-v1"},"verdict_id":null},"signer":{"signer_id":"pith.science","signer_type":"pith_registry","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"created_at":"2026-05-18T00:44:03Z","supersedes":[],"prev_event":null,"signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"ylsNdUw7QClA590hko9nQYBlcsho4PlMJYEd1i7clLjMDODbimBbr96OxHIA1NVKPw9M2ZkDKB2zj042wsHZBA==","signed_message":"open_graph_event_sha256_bytes","signed_at":"2026-06-06T10:07:40.339346Z"},"content_sha256":"1dde0a77005901be55320cc9113c07ac4ddae4fef52891cd120bf307c3a1a839","schema_version":"1.0","event_id":"sha256:1dde0a77005901be55320cc9113c07ac4ddae4fef52891cd120bf307c3a1a839"}],"timestamp_proofs":[],"mirror_hints":[{"mirror_type":"https","name":"Pith Resolver","base_url":"https://pith.science","bundle_url":"https://pith.science/pith/7TOVHEGCTQP7U2S3EE42RUNWLY/bundle.json","state_url":"https://pith.science/pith/7TOVHEGCTQP7U2S3EE42RUNWLY/state.json","well_known_bundle_url":"https://pith.science/.well-known/pith/7TOVHEGCTQP7U2S3EE42RUNWLY/bundle.json","status":"primary"}],"public_keys":[{"key_id":"pith-v1-2026-05","algorithm":"ed25519","format":"raw","public_key_b64":"stVStoiQhXFxp4s2pdzPNoqVNBMojDU/fJ2db5S3CbM=","public_key_hex":"b2d552b68890857171a78b36a5dccf368a953413288c353f7c9d9d6f94b709b3","fingerprint_sha256_b32_first128bits":"RVFV5Z2OI2J3ZUO7ERDEBCYNKS","fingerprint_sha256_hex":"8d4b5ee74e4693bcd1df2446408b0d54","rotates_at":null,"url":"https://pith.science/pith-signing-key.json","notes":"Pith uses this Ed25519 key to sign canonical record SHA-256 digests. Verify with: ed25519_verify(public_key, message=canonical_sha256_bytes, signature=base64decode(signature_b64))."}],"merge_version":"pith-open-graph-merge-v1","built_at":"2026-06-06T10:07:40Z","links":{"resolver":"https://pith.science/pith/7TOVHEGCTQP7U2S3EE42RUNWLY","bundle":"https://pith.science/pith/7TOVHEGCTQP7U2S3EE42RUNWLY/bundle.json","state":"https://pith.science/pith/7TOVHEGCTQP7U2S3EE42RUNWLY/state.json","well_known_bundle":"https://pith.science/.well-known/pith/7TOVHEGCTQP7U2S3EE42RUNWLY/bundle.json"},"state":{"state_type":"pith_open_graph_state","state_version":"1.0","pith_number":"pith:2017:7TOVHEGCTQP7U2S3EE42RUNWLY","merge_version":"pith-open-graph-merge-v1","event_count":2,"valid_event_count":2,"invalid_event_count":0,"equivocation_count":0,"current":{"canonical_record":{"metadata":{"abstract_canon_sha256":"82b6e5f3d02994a5c9c59ea79ecccf496d529ff671110ef58924b6d5a57f3540","cross_cats_sorted":[],"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.BM","submitted_at":"2017-05-22T20:44:46Z","title_canon_sha256":"c90aff9309963cffb3b80b8f667fda983c113260525af151f52bab448a9ac62b"},"schema_version":"1.0","source":{"id":"1705.07990","kind":"arxiv","version":1}},"source_aliases":[{"alias_kind":"arxiv","alias_value":"1705.07990","created_at":"2026-05-18T00:44:03Z"},{"alias_kind":"arxiv_version","alias_value":"1705.07990v1","created_at":"2026-05-18T00:44:03Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.1705.07990","created_at":"2026-05-18T00:44:03Z"},{"alias_kind":"pith_short_12","alias_value":"7TOVHEGCTQP7","created_at":"2026-05-18T12:31:05Z"},{"alias_kind":"pith_short_16","alias_value":"7TOVHEGCTQP7U2S3","created_at":"2026-05-18T12:31:05Z"},{"alias_kind":"pith_short_8","alias_value":"7TOVHEGC","created_at":"2026-05-18T12:31:05Z"}],"graph_snapshots":[{"event_id":"sha256:1dde0a77005901be55320cc9113c07ac4ddae4fef52891cd120bf307c3a1a839","target":"graph","created_at":"2026-05-18T00:44:03Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"graph_snapshot":{"author_claims":{"count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","strong_count":0},"builder_version":"pith-number-builder-2026-05-17-v1","claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"paper":{"abstract_excerpt":"Sex hormone-binding globulin (SHBG) is a binding protein that regulates availability of steroids hormones in the plasma. Although best known as steroid carrier, studies have associated SHBG in modulating behavioral aspects related to sexual receptivity. Among steroids, estradiol (17\\b{eta}-estradiol, oestradiol or E2) is well recognized as the most active endogenous female hormone, exerting important roles in reproductive and nonreproductive functions. Thus, in this study we aimed to employ molecular dynamics (MD) and docking techniques for quantifying the interaction energy between a complex ","authors_text":"A. J. da Silva, E. S. Santos","cross_cats":[],"headline":"","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.BM","submitted_at":"2017-05-22T20:44:46Z","title":"Aqueous solution interactions with sex hormone-binding globulin and estradiol: A theoretical investigation"},"references":{"count":0,"internal_anchors":0,"resolved_work":0,"sample":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"1705.07990","kind":"arxiv","version":1},"verdict":{"created_at":null,"id":null,"model_set":{},"one_line_summary":"","pipeline_version":null,"pith_extraction_headline":"","strongest_claim":"","weakest_assumption":""}},"verdict_id":null}}],"author_attestations":[],"timestamp_anchors":[],"storage_attestations":[],"citation_signatures":[],"replication_records":[],"corrections":[],"mirror_hints":[],"record_created":{"event_id":"sha256:45a01c395674e7cb903cf312e98e6e1443766d9415b813526d0ccf99d2cc2646","target":"record","created_at":"2026-05-18T00:44:03Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"attestation_state":"computed","canonical_record":{"metadata":{"abstract_canon_sha256":"82b6e5f3d02994a5c9c59ea79ecccf496d529ff671110ef58924b6d5a57f3540","cross_cats_sorted":[],"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.BM","submitted_at":"2017-05-22T20:44:46Z","title_canon_sha256":"c90aff9309963cffb3b80b8f667fda983c113260525af151f52bab448a9ac62b"},"schema_version":"1.0","source":{"id":"1705.07990","kind":"arxiv","version":1}},"canonical_sha256":"fcdd5390c29c1ffa6a5b2139a8d1b65e036617a73c2e75d3f8ccbea5cd45eaa6","receipt":{"algorithm":"ed25519","builder_version":"pith-number-builder-2026-05-17-v1","canonical_sha256":"fcdd5390c29c1ffa6a5b2139a8d1b65e036617a73c2e75d3f8ccbea5cd45eaa6","first_computed_at":"2026-05-18T00:44:03.924112Z","key_id":"pith-v1-2026-05","kind":"pith_receipt","last_reissued_at":"2026-05-18T00:44:03.924112Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","receipt_version":"0.3","signature_b64":"xqORnqrLJaaQ6Iw3NSTVxHWFs/F9pvByFcfMSPQkP1RyfUcZH8sEUfnV/A8Rd4PqBi24JUnbxarQVLJ4vb/SCw==","signature_status":"signed_v1","signed_at":"2026-05-18T00:44:03.924860Z","signed_message":"canonical_sha256_bytes"},"source_id":"1705.07990","source_kind":"arxiv","source_version":1}}},"equivocations":[],"invalid_events":[],"applied_event_ids":["sha256:45a01c395674e7cb903cf312e98e6e1443766d9415b813526d0ccf99d2cc2646","sha256:1dde0a77005901be55320cc9113c07ac4ddae4fef52891cd120bf307c3a1a839"],"state_sha256":"ccb2cddd62fcc501ee817e42e7a8472648b3f1df0687166aab635d2834501cab"},"bundle_signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"74uoG9Ffd35d+vq/p0Bfs9OxPok1LzwszDJhJGOvSismi3XDbGrzGeOHezvIMMOlpkqH0MouqxexsT16UqpZCw==","signed_message":"bundle_sha256_bytes","signed_at":"2026-06-06T10:07:40.343587Z","bundle_sha256":"95206b6b2f237f40ef76e3696cfc093609f1778f93ec4c3fd6240ede4c1dfbe6"}}