{"bundle_type":"pith_open_graph_bundle","bundle_version":"1.0","pith_number":"pith:2020:A5JAW22IJJQ5OQKD2YBTKU2M5Z","short_pith_number":"pith:A5JAW22I","canonical_record":{"source":{"id":"2007.14391","kind":"arxiv","version":1},"metadata":{"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.QM","submitted_at":"2020-07-27T22:37:56Z","cross_cats_sorted":["stat.ME"],"title_canon_sha256":"d9faabadee5e93e92bc060311d65cd99f5bc1a624fd849a7b23e832a840ab772","abstract_canon_sha256":"a87d2a67aa4370de9a9498455d51a222f3cd4a3215e76f7cce65fe0d17cbc1fa"},"schema_version":"1.0"},"canonical_sha256":"07520b6b484a61d74143d60335534cee657ca9b0e6018d93e1eca4f33f3418b6","source":{"kind":"arxiv","id":"2007.14391","version":1},"source_aliases":[{"alias_kind":"arxiv","alias_value":"2007.14391","created_at":"2026-07-05T02:40:27Z"},{"alias_kind":"arxiv_version","alias_value":"2007.14391v1","created_at":"2026-07-05T02:40:27Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.2007.14391","created_at":"2026-07-05T02:40:27Z"},{"alias_kind":"pith_short_12","alias_value":"A5JAW22IJJQ5","created_at":"2026-07-05T02:40:27Z"},{"alias_kind":"pith_short_16","alias_value":"A5JAW22IJJQ5OQKD","created_at":"2026-07-05T02:40:27Z"},{"alias_kind":"pith_short_8","alias_value":"A5JAW22I","created_at":"2026-07-05T02:40:27Z"}],"events":[{"event_type":"record_created","subject_pith_number":"pith:2020:A5JAW22IJJQ5OQKD2YBTKU2M5Z","target":"record","payload":{"canonical_record":{"source":{"id":"2007.14391","kind":"arxiv","version":1},"metadata":{"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.QM","submitted_at":"2020-07-27T22:37:56Z","cross_cats_sorted":["stat.ME"],"title_canon_sha256":"d9faabadee5e93e92bc060311d65cd99f5bc1a624fd849a7b23e832a840ab772","abstract_canon_sha256":"a87d2a67aa4370de9a9498455d51a222f3cd4a3215e76f7cce65fe0d17cbc1fa"},"schema_version":"1.0"},"canonical_sha256":"07520b6b484a61d74143d60335534cee657ca9b0e6018d93e1eca4f33f3418b6","receipt":{"kind":"pith_receipt","key_id":"pith-v1-2026-05","algorithm":"ed25519","signed_at":"2026-07-05T02:40:27.863127Z","signature_b64":"FF/I9SFEU9K6rN2Zyv24JqT0ii+pQ5+HohE/sX0k0lPAFAmSeeRC6cku8YpGmuebDEtOhHsAz6VTRwcu3o7yAA==","signed_message":"canonical_sha256_bytes","builder_version":"pith-number-builder-2026-05-17-v1","receipt_version":"0.3","canonical_sha256":"07520b6b484a61d74143d60335534cee657ca9b0e6018d93e1eca4f33f3418b6","last_reissued_at":"2026-07-05T02:40:27.862595Z","signature_status":"signed_v1","first_computed_at":"2026-07-05T02:40:27.862595Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"source_kind":"arxiv","source_id":"2007.14391","source_version":1,"attestation_state":"computed"},"signer":{"signer_id":"pith.science","signer_type":"pith_registry","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"created_at":"2026-07-05T02:40:27Z","supersedes":[],"prev_event":null,"signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"h8Ccd0JL6rq3Oq85TPvo/FJHYDCRTfa9IXQWqXVQJBc0JnncB2iZwsFqhaP+yVDRVM3YgSUHI4R5fq1y6TWZBQ==","signed_message":"open_graph_event_sha256_bytes","signed_at":"2026-08-07T04:06:17.909587Z"},"content_sha256":"e0444272bcc055e5dd1c80ddd9947bac2e396aed7df2ecb2d6eb354b64a2b8b9","schema_version":"1.0","event_id":"sha256:e0444272bcc055e5dd1c80ddd9947bac2e396aed7df2ecb2d6eb354b64a2b8b9"},{"event_type":"graph_snapshot","subject_pith_number":"pith:2020:A5JAW22IJJQ5OQKD2YBTKU2M5Z","target":"graph","payload":{"graph_snapshot":{"paper":{"title":"A calibration-free method for biosensing in cell manufacturing","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","headline":"","cross_cats":["stat.ME"],"primary_cat":"q-bio.QM","authors_text":"Ben Wang, Chen Jiang, Chuck Zhang, Jialei Chen, Kan Wang, Zhaonan Liu","submitted_at":"2020-07-27T22:37:56Z","abstract_excerpt":"Chimeric antigen receptor T cell therapy has demonstrated innovative therapeutic effectiveness in fighting cancers; however, it is extremely expensive due to the intrinsic patient-to-patient variability in cell manufacturing. We propose in this work a novel calibration-free statistical framework to effectively recover critical quality attributes under the patient-to-patient variability. Specifically, we model this variability via a patient-specific calibration parameter, and use readings from multiple biosensors to construct a patient-invariance statistic, thereby alleviating the effect of the"},"claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"2007.14391","kind":"arxiv","version":1},"verdict":{"id":null,"model_set":{},"created_at":null,"strongest_claim":"","one_line_summary":"","pipeline_version":null,"weakest_assumption":"","pith_extraction_headline":""},"integrity":{"clean":true,"summary":{"advisory":0,"critical":0,"by_detector":{},"informational":0},"endpoint":"/pith/2007.14391/integrity.json","findings":[],"available":true,"detectors_run":[],"snapshot_sha256":"c28c3603d3b5d939e8dc4c7e95fa8dfce3d595e45f758748cecf8e644a296938"},"references":{"count":0,"sample":[],"resolved_work":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","internal_anchors":0},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"author_claims":{"count":0,"strong_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"builder_version":"pith-number-builder-2026-05-17-v1"},"verdict_id":null},"signer":{"signer_id":"pith.science","signer_type":"pith_registry","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"created_at":"2026-07-05T02:40:27Z","supersedes":[],"prev_event":null,"signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"e0Gv1EhXLz49773Y+Tl9ZL8aiQT5KHTtxGJKSLsjYz7VqKFdokuJ3Rtb2xsmItkyPm8CEjDw6RpdFNdxlx4tAw==","signed_message":"open_graph_event_sha256_bytes","signed_at":"2026-08-07T04:06:17.910232Z"},"content_sha256":"72d0b8c75da74b47e1e7dd3102a2661f41fdc31dcfded226f2d4d61d2ff62e81","schema_version":"1.0","event_id":"sha256:72d0b8c75da74b47e1e7dd3102a2661f41fdc31dcfded226f2d4d61d2ff62e81"}],"timestamp_proofs":[],"mirror_hints":[{"mirror_type":"https","name":"Pith Resolver","base_url":"https://pith.science","bundle_url":"https://pith.science/pith/A5JAW22IJJQ5OQKD2YBTKU2M5Z/bundle.json","state_url":"https://pith.science/pith/A5JAW22IJJQ5OQKD2YBTKU2M5Z/state.json","well_known_bundle_url":"https://pith.science/.well-known/pith/A5JAW22IJJQ5OQKD2YBTKU2M5Z/bundle.json","status":"primary"}],"public_keys":[{"key_id":"pith-v1-2026-05","algorithm":"ed25519","format":"raw","public_key_b64":"stVStoiQhXFxp4s2pdzPNoqVNBMojDU/fJ2db5S3CbM=","public_key_hex":"b2d552b68890857171a78b36a5dccf368a953413288c353f7c9d9d6f94b709b3","fingerprint_sha256_b32_first128bits":"RVFV5Z2OI2J3ZUO7ERDEBCYNKS","fingerprint_sha256_hex":"8d4b5ee74e4693bcd1df2446408b0d54","rotates_at":null,"url":"https://pith.science/pith-signing-key.json","notes":"Pith uses this Ed25519 key to sign canonical record SHA-256 digests. Verify with: ed25519_verify(public_key, message=canonical_sha256_bytes, signature=base64decode(signature_b64))."}],"merge_version":"pith-open-graph-merge-v1","built_at":"2026-08-07T04:06:17Z","links":{"resolver":"https://pith.science/pith/A5JAW22IJJQ5OQKD2YBTKU2M5Z","bundle":"https://pith.science/pith/A5JAW22IJJQ5OQKD2YBTKU2M5Z/bundle.json","state":"https://pith.science/pith/A5JAW22IJJQ5OQKD2YBTKU2M5Z/state.json","well_known_bundle":"https://pith.science/.well-known/pith/A5JAW22IJJQ5OQKD2YBTKU2M5Z/bundle.json"},"state":{"state_type":"pith_open_graph_state","state_version":"1.0","pith_number":"pith:2020:A5JAW22IJJQ5OQKD2YBTKU2M5Z","merge_version":"pith-open-graph-merge-v1","event_count":2,"valid_event_count":2,"invalid_event_count":0,"equivocation_count":0,"current":{"canonical_record":{"metadata":{"abstract_canon_sha256":"a87d2a67aa4370de9a9498455d51a222f3cd4a3215e76f7cce65fe0d17cbc1fa","cross_cats_sorted":["stat.ME"],"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.QM","submitted_at":"2020-07-27T22:37:56Z","title_canon_sha256":"d9faabadee5e93e92bc060311d65cd99f5bc1a624fd849a7b23e832a840ab772"},"schema_version":"1.0","source":{"id":"2007.14391","kind":"arxiv","version":1}},"source_aliases":[{"alias_kind":"arxiv","alias_value":"2007.14391","created_at":"2026-07-05T02:40:27Z"},{"alias_kind":"arxiv_version","alias_value":"2007.14391v1","created_at":"2026-07-05T02:40:27Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.2007.14391","created_at":"2026-07-05T02:40:27Z"},{"alias_kind":"pith_short_12","alias_value":"A5JAW22IJJQ5","created_at":"2026-07-05T02:40:27Z"},{"alias_kind":"pith_short_16","alias_value":"A5JAW22IJJQ5OQKD","created_at":"2026-07-05T02:40:27Z"},{"alias_kind":"pith_short_8","alias_value":"A5JAW22I","created_at":"2026-07-05T02:40:27Z"}],"graph_snapshots":[{"event_id":"sha256:72d0b8c75da74b47e1e7dd3102a2661f41fdc31dcfded226f2d4d61d2ff62e81","target":"graph","created_at":"2026-07-05T02:40:27Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"graph_snapshot":{"author_claims":{"count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","strong_count":0},"builder_version":"pith-number-builder-2026-05-17-v1","claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"integrity":{"available":true,"clean":true,"detectors_run":[],"endpoint":"/pith/2007.14391/integrity.json","findings":[],"snapshot_sha256":"c28c3603d3b5d939e8dc4c7e95fa8dfce3d595e45f758748cecf8e644a296938","summary":{"advisory":0,"by_detector":{},"critical":0,"informational":0}},"paper":{"abstract_excerpt":"Chimeric antigen receptor T cell therapy has demonstrated innovative therapeutic effectiveness in fighting cancers; however, it is extremely expensive due to the intrinsic patient-to-patient variability in cell manufacturing. We propose in this work a novel calibration-free statistical framework to effectively recover critical quality attributes under the patient-to-patient variability. Specifically, we model this variability via a patient-specific calibration parameter, and use readings from multiple biosensors to construct a patient-invariance statistic, thereby alleviating the effect of the","authors_text":"Ben Wang, Chen Jiang, Chuck Zhang, Jialei Chen, Kan Wang, Zhaonan Liu","cross_cats":["stat.ME"],"headline":"","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.QM","submitted_at":"2020-07-27T22:37:56Z","title":"A calibration-free method for biosensing in cell manufacturing"},"references":{"count":0,"internal_anchors":0,"resolved_work":0,"sample":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"2007.14391","kind":"arxiv","version":1},"verdict":{"created_at":null,"id":null,"model_set":{},"one_line_summary":"","pipeline_version":null,"pith_extraction_headline":"","strongest_claim":"","weakest_assumption":""}},"verdict_id":null}}],"author_attestations":[],"timestamp_anchors":[],"storage_attestations":[],"citation_signatures":[],"replication_records":[],"corrections":[],"mirror_hints":[],"record_created":{"event_id":"sha256:e0444272bcc055e5dd1c80ddd9947bac2e396aed7df2ecb2d6eb354b64a2b8b9","target":"record","created_at":"2026-07-05T02:40:27Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"attestation_state":"computed","canonical_record":{"metadata":{"abstract_canon_sha256":"a87d2a67aa4370de9a9498455d51a222f3cd4a3215e76f7cce65fe0d17cbc1fa","cross_cats_sorted":["stat.ME"],"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.QM","submitted_at":"2020-07-27T22:37:56Z","title_canon_sha256":"d9faabadee5e93e92bc060311d65cd99f5bc1a624fd849a7b23e832a840ab772"},"schema_version":"1.0","source":{"id":"2007.14391","kind":"arxiv","version":1}},"canonical_sha256":"07520b6b484a61d74143d60335534cee657ca9b0e6018d93e1eca4f33f3418b6","receipt":{"algorithm":"ed25519","builder_version":"pith-number-builder-2026-05-17-v1","canonical_sha256":"07520b6b484a61d74143d60335534cee657ca9b0e6018d93e1eca4f33f3418b6","first_computed_at":"2026-07-05T02:40:27.862595Z","key_id":"pith-v1-2026-05","kind":"pith_receipt","last_reissued_at":"2026-07-05T02:40:27.862595Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","receipt_version":"0.3","signature_b64":"FF/I9SFEU9K6rN2Zyv24JqT0ii+pQ5+HohE/sX0k0lPAFAmSeeRC6cku8YpGmuebDEtOhHsAz6VTRwcu3o7yAA==","signature_status":"signed_v1","signed_at":"2026-07-05T02:40:27.863127Z","signed_message":"canonical_sha256_bytes"},"source_id":"2007.14391","source_kind":"arxiv","source_version":1}}},"equivocations":[],"invalid_events":[],"applied_event_ids":["sha256:e0444272bcc055e5dd1c80ddd9947bac2e396aed7df2ecb2d6eb354b64a2b8b9","sha256:72d0b8c75da74b47e1e7dd3102a2661f41fdc31dcfded226f2d4d61d2ff62e81"],"state_sha256":"44bb12e96a958b31899e09759fded0a1ce62c5c2561282a64bbcea6a346f636a"},"bundle_signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"Bift6IaMQUB94+XXUh6hBfRECBT9roly/c/0iUIlaVClo/o6oeNHwodVcvm78n13bziIceLEWsFHZDTkHD7kDA==","signed_message":"bundle_sha256_bytes","signed_at":"2026-08-07T04:06:17.914159Z","bundle_sha256":"e9b1bed16289ba468d7eb7a7ece4adc0f78c44d46df11de8715d3dd2b51ae2c1"}}