{"bundle_type":"pith_open_graph_bundle","bundle_version":"1.0","pith_number":"pith:2018:A6KPYIU2SNNX6EJEGFT457YROW","short_pith_number":"pith:A6KPYIU2","canonical_record":{"source":{"id":"1806.05753","kind":"arxiv","version":2},"metadata":{"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.PE","submitted_at":"2018-06-14T22:03:55Z","cross_cats_sorted":[],"title_canon_sha256":"a2e3a43e8e9aedff93e72279b0210ecde61db563fcd048011236968a530f3bf8","abstract_canon_sha256":"a12db98be07024f07eff85a671c51f64b1d88a7dc9302adf84f068bfe110a412"},"schema_version":"1.0"},"canonical_sha256":"0794fc229a935b7f11243167ceff1175bc4bb314cbefbb5d82e58ff2485521fa","source":{"kind":"arxiv","id":"1806.05753","version":2},"source_aliases":[{"alias_kind":"arxiv","alias_value":"1806.05753","created_at":"2026-05-17T23:46:30Z"},{"alias_kind":"arxiv_version","alias_value":"1806.05753v2","created_at":"2026-05-17T23:46:30Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.1806.05753","created_at":"2026-05-17T23:46:30Z"},{"alias_kind":"pith_short_12","alias_value":"A6KPYIU2SNNX","created_at":"2026-05-18T12:32:13Z"},{"alias_kind":"pith_short_16","alias_value":"A6KPYIU2SNNX6EJE","created_at":"2026-05-18T12:32:13Z"},{"alias_kind":"pith_short_8","alias_value":"A6KPYIU2","created_at":"2026-05-18T12:32:13Z"}],"events":[{"event_type":"record_created","subject_pith_number":"pith:2018:A6KPYIU2SNNX6EJEGFT457YROW","target":"record","payload":{"canonical_record":{"source":{"id":"1806.05753","kind":"arxiv","version":2},"metadata":{"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.PE","submitted_at":"2018-06-14T22:03:55Z","cross_cats_sorted":[],"title_canon_sha256":"a2e3a43e8e9aedff93e72279b0210ecde61db563fcd048011236968a530f3bf8","abstract_canon_sha256":"a12db98be07024f07eff85a671c51f64b1d88a7dc9302adf84f068bfe110a412"},"schema_version":"1.0"},"canonical_sha256":"0794fc229a935b7f11243167ceff1175bc4bb314cbefbb5d82e58ff2485521fa","receipt":{"kind":"pith_receipt","key_id":"pith-v1-2026-05","algorithm":"ed25519","signed_at":"2026-05-17T23:46:30.366564Z","signature_b64":"YE+GT6aB9sCyMI1T+blruD5qHCYh/A5rL23FTA0TxK93XO+xc0b6mSOaodtxA2ePHh7MP2/QrWW14HgChx7GCw==","signed_message":"canonical_sha256_bytes","builder_version":"pith-number-builder-2026-05-17-v1","receipt_version":"0.3","canonical_sha256":"0794fc229a935b7f11243167ceff1175bc4bb314cbefbb5d82e58ff2485521fa","last_reissued_at":"2026-05-17T23:46:30.366006Z","signature_status":"signed_v1","first_computed_at":"2026-05-17T23:46:30.366006Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"source_kind":"arxiv","source_id":"1806.05753","source_version":2,"attestation_state":"computed"},"signer":{"signer_id":"pith.science","signer_type":"pith_registry","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"created_at":"2026-05-17T23:46:30Z","supersedes":[],"prev_event":null,"signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"iJEzn5xtDWYEhWADtiGC/xNIKWIPT3R1hb0CF4EO82RuYJnmmXp8pYYGtc4B7f7Xrgg40vgFn8BW40s7sIKxDw==","signed_message":"open_graph_event_sha256_bytes","signed_at":"2026-05-27T20:22:42.736459Z"},"content_sha256":"eda9cd86068cfc9c45a406273a94afd6a3a71e22684e7542cc5e02dd96e46cd1","schema_version":"1.0","event_id":"sha256:eda9cd86068cfc9c45a406273a94afd6a3a71e22684e7542cc5e02dd96e46cd1"},{"event_type":"graph_snapshot","subject_pith_number":"pith:2018:A6KPYIU2SNNX6EJEGFT457YROW","target":"graph","payload":{"graph_snapshot":{"paper":{"title":"How a well-adapting immune system remembers","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","headline":"","cross_cats":[],"primary_cat":"q-bio.PE","authors_text":"Aleksandra M. Walczak, Andreas Mayer, Thierry Mora, Vijay Balasubramanian","submitted_at":"2018-06-14T22:03:55Z","abstract_excerpt":"An adaptive agent predicting the future state of an environment must weigh trust in new observations against prior experiences. In this light, we propose a view of the adaptive immune system as a dynamic Bayesian machinery that updates its memory repertoire by balancing evidence from new pathogen encounters against past experience of infection to predict and prepare for future threats. This framework links the observed initial rapid increase of the memory pool early in life followed by a mid-life plateau to the ease of learning salient features of sparse environments. We also derive a modulate"},"claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"1806.05753","kind":"arxiv","version":2},"verdict":{"id":null,"model_set":{},"created_at":null,"strongest_claim":"","one_line_summary":"","pipeline_version":null,"weakest_assumption":"","pith_extraction_headline":""},"references":{"count":0,"sample":[],"resolved_work":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","internal_anchors":0},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"author_claims":{"count":0,"strong_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"builder_version":"pith-number-builder-2026-05-17-v1"},"verdict_id":null},"signer":{"signer_id":"pith.science","signer_type":"pith_registry","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"created_at":"2026-05-17T23:46:30Z","supersedes":[],"prev_event":null,"signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"4Xp5ttdHigkYIDFDDGahIzZoEqcqU4M2hNE9CquJk7b+a23VRbkxB4B+bgctyGjD9ZelIoNb76Oc3GAb62v7DQ==","signed_message":"open_graph_event_sha256_bytes","signed_at":"2026-05-27T20:22:42.737031Z"},"content_sha256":"fe60abc71a5be18874c156d9a56dbe23fa12710965c39181564936279d4b0dc7","schema_version":"1.0","event_id":"sha256:fe60abc71a5be18874c156d9a56dbe23fa12710965c39181564936279d4b0dc7"}],"timestamp_proofs":[],"mirror_hints":[{"mirror_type":"https","name":"Pith Resolver","base_url":"https://pith.science","bundle_url":"https://pith.science/pith/A6KPYIU2SNNX6EJEGFT457YROW/bundle.json","state_url":"https://pith.science/pith/A6KPYIU2SNNX6EJEGFT457YROW/state.json","well_known_bundle_url":"https://pith.science/.well-known/pith/A6KPYIU2SNNX6EJEGFT457YROW/bundle.json","status":"primary"}],"public_keys":[{"key_id":"pith-v1-2026-05","algorithm":"ed25519","format":"raw","public_key_b64":"stVStoiQhXFxp4s2pdzPNoqVNBMojDU/fJ2db5S3CbM=","public_key_hex":"b2d552b68890857171a78b36a5dccf368a953413288c353f7c9d9d6f94b709b3","fingerprint_sha256_b32_first128bits":"RVFV5Z2OI2J3ZUO7ERDEBCYNKS","fingerprint_sha256_hex":"8d4b5ee74e4693bcd1df2446408b0d54","rotates_at":null,"url":"https://pith.science/pith-signing-key.json","notes":"Pith uses this Ed25519 key to sign canonical record SHA-256 digests. Verify with: ed25519_verify(public_key, message=canonical_sha256_bytes, signature=base64decode(signature_b64))."}],"merge_version":"pith-open-graph-merge-v1","built_at":"2026-05-27T20:22:42Z","links":{"resolver":"https://pith.science/pith/A6KPYIU2SNNX6EJEGFT457YROW","bundle":"https://pith.science/pith/A6KPYIU2SNNX6EJEGFT457YROW/bundle.json","state":"https://pith.science/pith/A6KPYIU2SNNX6EJEGFT457YROW/state.json","well_known_bundle":"https://pith.science/.well-known/pith/A6KPYIU2SNNX6EJEGFT457YROW/bundle.json"},"state":{"state_type":"pith_open_graph_state","state_version":"1.0","pith_number":"pith:2018:A6KPYIU2SNNX6EJEGFT457YROW","merge_version":"pith-open-graph-merge-v1","event_count":2,"valid_event_count":2,"invalid_event_count":0,"equivocation_count":0,"current":{"canonical_record":{"metadata":{"abstract_canon_sha256":"a12db98be07024f07eff85a671c51f64b1d88a7dc9302adf84f068bfe110a412","cross_cats_sorted":[],"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.PE","submitted_at":"2018-06-14T22:03:55Z","title_canon_sha256":"a2e3a43e8e9aedff93e72279b0210ecde61db563fcd048011236968a530f3bf8"},"schema_version":"1.0","source":{"id":"1806.05753","kind":"arxiv","version":2}},"source_aliases":[{"alias_kind":"arxiv","alias_value":"1806.05753","created_at":"2026-05-17T23:46:30Z"},{"alias_kind":"arxiv_version","alias_value":"1806.05753v2","created_at":"2026-05-17T23:46:30Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.1806.05753","created_at":"2026-05-17T23:46:30Z"},{"alias_kind":"pith_short_12","alias_value":"A6KPYIU2SNNX","created_at":"2026-05-18T12:32:13Z"},{"alias_kind":"pith_short_16","alias_value":"A6KPYIU2SNNX6EJE","created_at":"2026-05-18T12:32:13Z"},{"alias_kind":"pith_short_8","alias_value":"A6KPYIU2","created_at":"2026-05-18T12:32:13Z"}],"graph_snapshots":[{"event_id":"sha256:fe60abc71a5be18874c156d9a56dbe23fa12710965c39181564936279d4b0dc7","target":"graph","created_at":"2026-05-17T23:46:30Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"graph_snapshot":{"author_claims":{"count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","strong_count":0},"builder_version":"pith-number-builder-2026-05-17-v1","claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"paper":{"abstract_excerpt":"An adaptive agent predicting the future state of an environment must weigh trust in new observations against prior experiences. In this light, we propose a view of the adaptive immune system as a dynamic Bayesian machinery that updates its memory repertoire by balancing evidence from new pathogen encounters against past experience of infection to predict and prepare for future threats. This framework links the observed initial rapid increase of the memory pool early in life followed by a mid-life plateau to the ease of learning salient features of sparse environments. We also derive a modulate","authors_text":"Aleksandra M. Walczak, Andreas Mayer, Thierry Mora, Vijay Balasubramanian","cross_cats":[],"headline":"","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.PE","submitted_at":"2018-06-14T22:03:55Z","title":"How a well-adapting immune system remembers"},"references":{"count":0,"internal_anchors":0,"resolved_work":0,"sample":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"1806.05753","kind":"arxiv","version":2},"verdict":{"created_at":null,"id":null,"model_set":{},"one_line_summary":"","pipeline_version":null,"pith_extraction_headline":"","strongest_claim":"","weakest_assumption":""}},"verdict_id":null}}],"author_attestations":[],"timestamp_anchors":[],"storage_attestations":[],"citation_signatures":[],"replication_records":[],"corrections":[],"mirror_hints":[],"record_created":{"event_id":"sha256:eda9cd86068cfc9c45a406273a94afd6a3a71e22684e7542cc5e02dd96e46cd1","target":"record","created_at":"2026-05-17T23:46:30Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"attestation_state":"computed","canonical_record":{"metadata":{"abstract_canon_sha256":"a12db98be07024f07eff85a671c51f64b1d88a7dc9302adf84f068bfe110a412","cross_cats_sorted":[],"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.PE","submitted_at":"2018-06-14T22:03:55Z","title_canon_sha256":"a2e3a43e8e9aedff93e72279b0210ecde61db563fcd048011236968a530f3bf8"},"schema_version":"1.0","source":{"id":"1806.05753","kind":"arxiv","version":2}},"canonical_sha256":"0794fc229a935b7f11243167ceff1175bc4bb314cbefbb5d82e58ff2485521fa","receipt":{"algorithm":"ed25519","builder_version":"pith-number-builder-2026-05-17-v1","canonical_sha256":"0794fc229a935b7f11243167ceff1175bc4bb314cbefbb5d82e58ff2485521fa","first_computed_at":"2026-05-17T23:46:30.366006Z","key_id":"pith-v1-2026-05","kind":"pith_receipt","last_reissued_at":"2026-05-17T23:46:30.366006Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","receipt_version":"0.3","signature_b64":"YE+GT6aB9sCyMI1T+blruD5qHCYh/A5rL23FTA0TxK93XO+xc0b6mSOaodtxA2ePHh7MP2/QrWW14HgChx7GCw==","signature_status":"signed_v1","signed_at":"2026-05-17T23:46:30.366564Z","signed_message":"canonical_sha256_bytes"},"source_id":"1806.05753","source_kind":"arxiv","source_version":2}}},"equivocations":[],"invalid_events":[],"applied_event_ids":["sha256:eda9cd86068cfc9c45a406273a94afd6a3a71e22684e7542cc5e02dd96e46cd1","sha256:fe60abc71a5be18874c156d9a56dbe23fa12710965c39181564936279d4b0dc7"],"state_sha256":"b426f8d994d06d5d2657ea6542ce8ef1e7f2a277eae63f449bea60442e78c743"},"bundle_signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"pUyfR2KT2N1j0ChxXIG0+8l/oXn22Uw0xNZMIUZGVjDOCIzmxWvpiGIozEvgJOGS/rFszo+iNfm9LdG08scnCg==","signed_message":"bundle_sha256_bytes","signed_at":"2026-05-27T20:22:42.740418Z","bundle_sha256":"6b5bd0d89bcf7fba4497b644ab8b972a1f849dd2072354e15441f31e557450f7"}}