{"bundle_type":"pith_open_graph_bundle","bundle_version":"1.0","pith_number":"pith:2025:ADRNIHXY5RYCU24RIGVSRTLQQS","short_pith_number":"pith:ADRNIHXY","canonical_record":{"source":{"id":"2506.03279","kind":"arxiv","version":1},"metadata":{"license":"http://creativecommons.org/licenses/by/4.0/","primary_cat":"q-bio.PE","submitted_at":"2025-06-03T18:12:09Z","cross_cats_sorted":["physics.soc-ph"],"title_canon_sha256":"b49f36a570ed2ac9eacca40999107e3865469ac1e9a28c39bcf28c94756e8063","abstract_canon_sha256":"46bc3c589e95fd3f982ce0799feb6ab5412b0bbefa6a591061962d35a2af8c40"},"schema_version":"1.0"},"canonical_sha256":"00e2d41ef8ec702a6b9141ab28cd7084a1ad289ae8006df32a1f8ab77e25ce22","source":{"kind":"arxiv","id":"2506.03279","version":1},"source_aliases":[{"alias_kind":"arxiv","alias_value":"2506.03279","created_at":"2026-07-05T11:15:24Z"},{"alias_kind":"arxiv_version","alias_value":"2506.03279v1","created_at":"2026-07-05T11:15:24Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.2506.03279","created_at":"2026-07-05T11:15:24Z"},{"alias_kind":"pith_short_12","alias_value":"ADRNIHXY5RYC","created_at":"2026-07-05T11:15:24Z"},{"alias_kind":"pith_short_16","alias_value":"ADRNIHXY5RYCU24R","created_at":"2026-07-05T11:15:24Z"},{"alias_kind":"pith_short_8","alias_value":"ADRNIHXY","created_at":"2026-07-05T11:15:24Z"}],"events":[{"event_type":"record_created","subject_pith_number":"pith:2025:ADRNIHXY5RYCU24RIGVSRTLQQS","target":"record","payload":{"canonical_record":{"source":{"id":"2506.03279","kind":"arxiv","version":1},"metadata":{"license":"http://creativecommons.org/licenses/by/4.0/","primary_cat":"q-bio.PE","submitted_at":"2025-06-03T18:12:09Z","cross_cats_sorted":["physics.soc-ph"],"title_canon_sha256":"b49f36a570ed2ac9eacca40999107e3865469ac1e9a28c39bcf28c94756e8063","abstract_canon_sha256":"46bc3c589e95fd3f982ce0799feb6ab5412b0bbefa6a591061962d35a2af8c40"},"schema_version":"1.0"},"canonical_sha256":"00e2d41ef8ec702a6b9141ab28cd7084a1ad289ae8006df32a1f8ab77e25ce22","receipt":{"kind":"pith_receipt","key_id":"pith-v1-2026-05","algorithm":"ed25519","signed_at":"2026-07-05T11:15:24.018827Z","signature_b64":"4/BCkSpjU7B/R2RAgfgrp1t1V2hbGfLkASdsZApVjAvlEZKUgY89YMWZp0SkfV8hcHYNLxLAtlxJvcqJYeH8BA==","signed_message":"canonical_sha256_bytes","builder_version":"pith-number-builder-2026-05-17-v1","receipt_version":"0.3","canonical_sha256":"00e2d41ef8ec702a6b9141ab28cd7084a1ad289ae8006df32a1f8ab77e25ce22","last_reissued_at":"2026-07-05T11:15:24.018312Z","signature_status":"signed_v1","first_computed_at":"2026-07-05T11:15:24.018312Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"source_kind":"arxiv","source_id":"2506.03279","source_version":1,"attestation_state":"computed"},"signer":{"signer_id":"pith.science","signer_type":"pith_registry","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"created_at":"2026-07-05T11:15:24Z","supersedes":[],"prev_event":null,"signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"Fm+GUAU89AGiRhfxLf7NpRfObSNxpFLl3xmwq6iS7b360oLeGqQrq8t3cN82+YHG7hJXNda+MTVT2FC1YYTVDg==","signed_message":"open_graph_event_sha256_bytes","signed_at":"2026-08-08T11:44:18.776815Z"},"content_sha256":"4145101b7d4358a5d3ca047e977a8228c5ca2d6926ee4009ba874611d9c7dab6","schema_version":"1.0","event_id":"sha256:4145101b7d4358a5d3ca047e977a8228c5ca2d6926ee4009ba874611d9c7dab6"},{"event_type":"graph_snapshot","subject_pith_number":"pith:2025:ADRNIHXY5RYCU24RIGVSRTLQQS","target":"graph","payload":{"graph_snapshot":{"paper":{"title":"Genotype networks drive oscillating endemicity and epidemic trajectories in viral evolution","license":"http://creativecommons.org/licenses/by/4.0/","headline":"","cross_cats":["physics.soc-ph"],"primary_cat":"q-bio.PE","authors_text":"Alex Arenas, David Soriano-Pa\\~nos, Jes\\'us G\\'omez-Garde\\~nes, Octavian C. Rotita-Ion, Santiago Lamata-Ot\\'in","submitted_at":"2025-06-03T18:12:09Z","abstract_excerpt":"Rapidly evolving viruses use antigenic drift as a key mechanism to evade host immunity and persist in real populations. While traditional models of antigenic drift and epidemic spread rely on low-dimensional antigenic spaces, genomic surveillance data reveal that viral evolution produces complex antigenic genotype networks with hierarchical modular structures. In this study, we present an eco-evolutionary framework in which viral evolution and population immunity dynamics are shaped by the structure of antigenic genotype networks. Using synthetic networks, we demonstrate that network topology "},"claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"2506.03279","kind":"arxiv","version":1},"verdict":{"id":null,"model_set":{},"created_at":null,"strongest_claim":"","one_line_summary":"","pipeline_version":null,"weakest_assumption":"","pith_extraction_headline":""},"integrity":{"clean":true,"summary":{"advisory":0,"critical":0,"by_detector":{},"informational":0},"endpoint":"/pith/2506.03279/integrity.json","findings":[],"available":true,"detectors_run":[],"snapshot_sha256":"c28c3603d3b5d939e8dc4c7e95fa8dfce3d595e45f758748cecf8e644a296938"},"references":{"count":0,"sample":[],"resolved_work":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","internal_anchors":0},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"author_claims":{"count":0,"strong_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"builder_version":"pith-number-builder-2026-05-17-v1"},"verdict_id":null},"signer":{"signer_id":"pith.science","signer_type":"pith_registry","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"created_at":"2026-07-05T11:15:24Z","supersedes":[],"prev_event":null,"signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"cWhVvq3nAUqHCpOed/KQww6LswEJDhVQtnAxJHNJJ/i0NIDVVjTrBZgGYNBf1kGU/hp+XOULbZkWT8NqI0GyBg==","signed_message":"open_graph_event_sha256_bytes","signed_at":"2026-08-08T11:44:18.777881Z"},"content_sha256":"3a9913c03846b2d69d4573e32d5fb1c5652db9a23207edc077573618edd529ee","schema_version":"1.0","event_id":"sha256:3a9913c03846b2d69d4573e32d5fb1c5652db9a23207edc077573618edd529ee"}],"timestamp_proofs":[],"mirror_hints":[{"mirror_type":"https","name":"Pith Resolver","base_url":"https://pith.science","bundle_url":"https://pith.science/pith/ADRNIHXY5RYCU24RIGVSRTLQQS/bundle.json","state_url":"https://pith.science/pith/ADRNIHXY5RYCU24RIGVSRTLQQS/state.json","well_known_bundle_url":"https://pith.science/.well-known/pith/ADRNIHXY5RYCU24RIGVSRTLQQS/bundle.json","status":"primary"}],"public_keys":[{"key_id":"pith-v1-2026-05","algorithm":"ed25519","format":"raw","public_key_b64":"stVStoiQhXFxp4s2pdzPNoqVNBMojDU/fJ2db5S3CbM=","public_key_hex":"b2d552b68890857171a78b36a5dccf368a953413288c353f7c9d9d6f94b709b3","fingerprint_sha256_b32_first128bits":"RVFV5Z2OI2J3ZUO7ERDEBCYNKS","fingerprint_sha256_hex":"8d4b5ee74e4693bcd1df2446408b0d54","rotates_at":null,"url":"https://pith.science/pith-signing-key.json","notes":"Pith uses this Ed25519 key to sign canonical record SHA-256 digests. Verify with: ed25519_verify(public_key, message=canonical_sha256_bytes, signature=base64decode(signature_b64))."}],"merge_version":"pith-open-graph-merge-v1","built_at":"2026-08-08T11:44:18Z","links":{"resolver":"https://pith.science/pith/ADRNIHXY5RYCU24RIGVSRTLQQS","bundle":"https://pith.science/pith/ADRNIHXY5RYCU24RIGVSRTLQQS/bundle.json","state":"https://pith.science/pith/ADRNIHXY5RYCU24RIGVSRTLQQS/state.json","well_known_bundle":"https://pith.science/.well-known/pith/ADRNIHXY5RYCU24RIGVSRTLQQS/bundle.json"},"state":{"state_type":"pith_open_graph_state","state_version":"1.0","pith_number":"pith:2025:ADRNIHXY5RYCU24RIGVSRTLQQS","merge_version":"pith-open-graph-merge-v1","event_count":2,"valid_event_count":2,"invalid_event_count":0,"equivocation_count":0,"current":{"canonical_record":{"metadata":{"abstract_canon_sha256":"46bc3c589e95fd3f982ce0799feb6ab5412b0bbefa6a591061962d35a2af8c40","cross_cats_sorted":["physics.soc-ph"],"license":"http://creativecommons.org/licenses/by/4.0/","primary_cat":"q-bio.PE","submitted_at":"2025-06-03T18:12:09Z","title_canon_sha256":"b49f36a570ed2ac9eacca40999107e3865469ac1e9a28c39bcf28c94756e8063"},"schema_version":"1.0","source":{"id":"2506.03279","kind":"arxiv","version":1}},"source_aliases":[{"alias_kind":"arxiv","alias_value":"2506.03279","created_at":"2026-07-05T11:15:24Z"},{"alias_kind":"arxiv_version","alias_value":"2506.03279v1","created_at":"2026-07-05T11:15:24Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.2506.03279","created_at":"2026-07-05T11:15:24Z"},{"alias_kind":"pith_short_12","alias_value":"ADRNIHXY5RYC","created_at":"2026-07-05T11:15:24Z"},{"alias_kind":"pith_short_16","alias_value":"ADRNIHXY5RYCU24R","created_at":"2026-07-05T11:15:24Z"},{"alias_kind":"pith_short_8","alias_value":"ADRNIHXY","created_at":"2026-07-05T11:15:24Z"}],"graph_snapshots":[{"event_id":"sha256:3a9913c03846b2d69d4573e32d5fb1c5652db9a23207edc077573618edd529ee","target":"graph","created_at":"2026-07-05T11:15:24Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"graph_snapshot":{"author_claims":{"count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","strong_count":0},"builder_version":"pith-number-builder-2026-05-17-v1","claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"integrity":{"available":true,"clean":true,"detectors_run":[],"endpoint":"/pith/2506.03279/integrity.json","findings":[],"snapshot_sha256":"c28c3603d3b5d939e8dc4c7e95fa8dfce3d595e45f758748cecf8e644a296938","summary":{"advisory":0,"by_detector":{},"critical":0,"informational":0}},"paper":{"abstract_excerpt":"Rapidly evolving viruses use antigenic drift as a key mechanism to evade host immunity and persist in real populations. While traditional models of antigenic drift and epidemic spread rely on low-dimensional antigenic spaces, genomic surveillance data reveal that viral evolution produces complex antigenic genotype networks with hierarchical modular structures. In this study, we present an eco-evolutionary framework in which viral evolution and population immunity dynamics are shaped by the structure of antigenic genotype networks. Using synthetic networks, we demonstrate that network topology ","authors_text":"Alex Arenas, David Soriano-Pa\\~nos, Jes\\'us G\\'omez-Garde\\~nes, Octavian C. Rotita-Ion, Santiago Lamata-Ot\\'in","cross_cats":["physics.soc-ph"],"headline":"","license":"http://creativecommons.org/licenses/by/4.0/","primary_cat":"q-bio.PE","submitted_at":"2025-06-03T18:12:09Z","title":"Genotype networks drive oscillating endemicity and epidemic trajectories in viral evolution"},"references":{"count":0,"internal_anchors":0,"resolved_work":0,"sample":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"2506.03279","kind":"arxiv","version":1},"verdict":{"created_at":null,"id":null,"model_set":{},"one_line_summary":"","pipeline_version":null,"pith_extraction_headline":"","strongest_claim":"","weakest_assumption":""}},"verdict_id":null}}],"author_attestations":[],"timestamp_anchors":[],"storage_attestations":[],"citation_signatures":[],"replication_records":[],"corrections":[],"mirror_hints":[],"record_created":{"event_id":"sha256:4145101b7d4358a5d3ca047e977a8228c5ca2d6926ee4009ba874611d9c7dab6","target":"record","created_at":"2026-07-05T11:15:24Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"attestation_state":"computed","canonical_record":{"metadata":{"abstract_canon_sha256":"46bc3c589e95fd3f982ce0799feb6ab5412b0bbefa6a591061962d35a2af8c40","cross_cats_sorted":["physics.soc-ph"],"license":"http://creativecommons.org/licenses/by/4.0/","primary_cat":"q-bio.PE","submitted_at":"2025-06-03T18:12:09Z","title_canon_sha256":"b49f36a570ed2ac9eacca40999107e3865469ac1e9a28c39bcf28c94756e8063"},"schema_version":"1.0","source":{"id":"2506.03279","kind":"arxiv","version":1}},"canonical_sha256":"00e2d41ef8ec702a6b9141ab28cd7084a1ad289ae8006df32a1f8ab77e25ce22","receipt":{"algorithm":"ed25519","builder_version":"pith-number-builder-2026-05-17-v1","canonical_sha256":"00e2d41ef8ec702a6b9141ab28cd7084a1ad289ae8006df32a1f8ab77e25ce22","first_computed_at":"2026-07-05T11:15:24.018312Z","key_id":"pith-v1-2026-05","kind":"pith_receipt","last_reissued_at":"2026-07-05T11:15:24.018312Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","receipt_version":"0.3","signature_b64":"4/BCkSpjU7B/R2RAgfgrp1t1V2hbGfLkASdsZApVjAvlEZKUgY89YMWZp0SkfV8hcHYNLxLAtlxJvcqJYeH8BA==","signature_status":"signed_v1","signed_at":"2026-07-05T11:15:24.018827Z","signed_message":"canonical_sha256_bytes"},"source_id":"2506.03279","source_kind":"arxiv","source_version":1}}},"equivocations":[],"invalid_events":[],"applied_event_ids":["sha256:4145101b7d4358a5d3ca047e977a8228c5ca2d6926ee4009ba874611d9c7dab6","sha256:3a9913c03846b2d69d4573e32d5fb1c5652db9a23207edc077573618edd529ee"],"state_sha256":"08de975474e4e55d73d648d21226fc24d01f798340f2ec20124f6e4e6d4a6cde"},"bundle_signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"Bz7gAe/XaL0L7QY3NNo2r5Wo3C2FRDvw300rZaSI4CGMQRmZkQS1kTQBrolaselRm/eB4GqOtit8FSqqySTZAg==","signed_message":"bundle_sha256_bytes","signed_at":"2026-08-08T11:44:18.783712Z","bundle_sha256":"a04f69c4957e004e33daf5998a5dcc3f0ff34f5de56cf0d6e75c8a28234c7ff6"}}