{"state_type":"pith_open_graph_state","state_version":"1.0","pith_number":"pith:2017:AEQHWHRNZ7IQ7SLHHJ6SQ3MJTK","merge_version":"pith-open-graph-merge-v1","event_count":2,"valid_event_count":2,"invalid_event_count":0,"equivocation_count":0,"current":{"canonical_record":{"metadata":{"abstract_canon_sha256":"670845f08e4cd329731544d6b1d113e0f5802533c4cb47e7050e3149652f3aa9","cross_cats_sorted":["cond-mat.soft"],"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"physics.bio-ph","submitted_at":"2017-04-14T17:51:36Z","title_canon_sha256":"d3d4e4b83f681a48d3361df8dc76c43faeff4189c8ac1cf9e16456e1e07be639"},"schema_version":"1.0","source":{"id":"1704.04496","kind":"arxiv","version":1}},"source_aliases":[{"alias_kind":"arxiv","alias_value":"1704.04496","created_at":"2026-05-18T00:38:55Z"},{"alias_kind":"arxiv_version","alias_value":"1704.04496v1","created_at":"2026-05-18T00:38:55Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.1704.04496","created_at":"2026-05-18T00:38:55Z"},{"alias_kind":"pith_short_12","alias_value":"AEQHWHRNZ7IQ","created_at":"2026-05-18T12:31:05Z"},{"alias_kind":"pith_short_16","alias_value":"AEQHWHRNZ7IQ7SLH","created_at":"2026-05-18T12:31:05Z"},{"alias_kind":"pith_short_8","alias_value":"AEQHWHRN","created_at":"2026-05-18T12:31:05Z"}],"graph_snapshots":[{"event_id":"sha256:934715f96b0730f44d4efcf7a91dc9bf08e19995a84f3746a99a18b5f72cb1b7","target":"graph","created_at":"2026-05-18T00:38:55Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"graph_snapshot":{"author_claims":{"count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","strong_count":0},"builder_version":"pith-number-builder-2026-05-17-v1","claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"paper":{"abstract_excerpt":"Recent experiments have revealed that the diffusivity of exothermic and fast enzymes is enhanced when they are catalytically active, and different physical mechanisms have been explored and quantified to account for this observation. We perform measurements on the endothermic and relatively slow enzyme aldolase, which also shows substrate-induced enhanced diffusion. We propose a new physical paradigm, which reveals that the diffusion coefficient of a model enzyme hydrodynamically coupled to its environment increases significantly when undergoing changes in conformational fluctuations in a subs","authors_text":"Ayusman Sen, Krishna K. Dey, Peter J. Butler, Pierre Illien, Ramin Golestanian, Xi Zhao","cross_cats":["cond-mat.soft"],"headline":"","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"physics.bio-ph","submitted_at":"2017-04-14T17:51:36Z","title":"Exothermicity is not a necessary condition for enhanced diffusion of enzymes"},"references":{"count":0,"internal_anchors":0,"resolved_work":0,"sample":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"1704.04496","kind":"arxiv","version":1},"verdict":{"created_at":null,"id":null,"model_set":{},"one_line_summary":"","pipeline_version":null,"pith_extraction_headline":"","strongest_claim":"","weakest_assumption":""}},"verdict_id":null}}],"author_attestations":[],"timestamp_anchors":[],"storage_attestations":[],"citation_signatures":[],"replication_records":[],"corrections":[],"mirror_hints":[],"record_created":{"event_id":"sha256:0f25c2c9abd836696731308c663ea8f250793d05f7262a9c2ff00866c41e8aa0","target":"record","created_at":"2026-05-18T00:38:55Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"attestation_state":"computed","canonical_record":{"metadata":{"abstract_canon_sha256":"670845f08e4cd329731544d6b1d113e0f5802533c4cb47e7050e3149652f3aa9","cross_cats_sorted":["cond-mat.soft"],"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"physics.bio-ph","submitted_at":"2017-04-14T17:51:36Z","title_canon_sha256":"d3d4e4b83f681a48d3361df8dc76c43faeff4189c8ac1cf9e16456e1e07be639"},"schema_version":"1.0","source":{"id":"1704.04496","kind":"arxiv","version":1}},"canonical_sha256":"01207b1e2dcfd10fc9673a7d286d899abf80302649c4f16450c358e94ba08345","receipt":{"algorithm":"ed25519","builder_version":"pith-number-builder-2026-05-17-v1","canonical_sha256":"01207b1e2dcfd10fc9673a7d286d899abf80302649c4f16450c358e94ba08345","first_computed_at":"2026-05-18T00:38:55.482436Z","key_id":"pith-v1-2026-05","kind":"pith_receipt","last_reissued_at":"2026-05-18T00:38:55.482436Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","receipt_version":"0.3","signature_b64":"brb/QqttIGYktqCHNiKgplgotdMT3FbbbWz8o6A2ReU1I2R1+rU4KT56665q0jXjd3WrvfQRo6T6P05sCB1hCw==","signature_status":"signed_v1","signed_at":"2026-05-18T00:38:55.482941Z","signed_message":"canonical_sha256_bytes"},"source_id":"1704.04496","source_kind":"arxiv","source_version":1}}},"equivocations":[],"invalid_events":[],"applied_event_ids":["sha256:0f25c2c9abd836696731308c663ea8f250793d05f7262a9c2ff00866c41e8aa0","sha256:934715f96b0730f44d4efcf7a91dc9bf08e19995a84f3746a99a18b5f72cb1b7"],"state_sha256":"927bcb4f0bf8fa29ff7639234f7f1e8e125a46aae77bf79bd363ab1ca7b68319"}