{"bundle_type":"pith_open_graph_bundle","bundle_version":"1.0","pith_number":"pith:2024:AI2ZLPWUHBITHP42ZYWOVJKUGJ","short_pith_number":"pith:AI2ZLPWU","canonical_record":{"source":{"id":"2404.04086","kind":"arxiv","version":1},"metadata":{"license":"http://creativecommons.org/licenses/by/4.0/","primary_cat":"q-bio.QM","submitted_at":"2024-04-05T13:21:48Z","cross_cats_sorted":["math.AP"],"title_canon_sha256":"7476a46ca9ba0be5ed63d90ef8fa3b109b48f5f5ea67899308fd84a4cfdcec4a","abstract_canon_sha256":"b7d18b55e76a8e13780ca6b96cbf3ab0ea095baf9337eeefd136f3fc2df68217"},"schema_version":"1.0"},"canonical_sha256":"023595bed4385133bf9ace2ceaa554325edd8fdb47514e8b06f3a3f224dba25a","source":{"kind":"arxiv","id":"2404.04086","version":1},"source_aliases":[{"alias_kind":"arxiv","alias_value":"2404.04086","created_at":"2026-07-05T09:21:42Z"},{"alias_kind":"arxiv_version","alias_value":"2404.04086v1","created_at":"2026-07-05T09:21:42Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.2404.04086","created_at":"2026-07-05T09:21:42Z"},{"alias_kind":"pith_short_12","alias_value":"AI2ZLPWUHBIT","created_at":"2026-07-05T09:21:42Z"},{"alias_kind":"pith_short_16","alias_value":"AI2ZLPWUHBITHP42","created_at":"2026-07-05T09:21:42Z"},{"alias_kind":"pith_short_8","alias_value":"AI2ZLPWU","created_at":"2026-07-05T09:21:42Z"}],"events":[{"event_type":"record_created","subject_pith_number":"pith:2024:AI2ZLPWUHBITHP42ZYWOVJKUGJ","target":"record","payload":{"canonical_record":{"source":{"id":"2404.04086","kind":"arxiv","version":1},"metadata":{"license":"http://creativecommons.org/licenses/by/4.0/","primary_cat":"q-bio.QM","submitted_at":"2024-04-05T13:21:48Z","cross_cats_sorted":["math.AP"],"title_canon_sha256":"7476a46ca9ba0be5ed63d90ef8fa3b109b48f5f5ea67899308fd84a4cfdcec4a","abstract_canon_sha256":"b7d18b55e76a8e13780ca6b96cbf3ab0ea095baf9337eeefd136f3fc2df68217"},"schema_version":"1.0"},"canonical_sha256":"023595bed4385133bf9ace2ceaa554325edd8fdb47514e8b06f3a3f224dba25a","receipt":{"kind":"pith_receipt","key_id":"pith-v1-2026-05","algorithm":"ed25519","signed_at":"2026-07-05T09:21:42.622537Z","signature_b64":"l/y+UuJzGpKQFdyQ+wU6LDKzSMaANs8WwdJePJrKoLCSnji2E6kKj7qYpDgJS3Gqg8VJB798TbbZhS1zIQC4Cg==","signed_message":"canonical_sha256_bytes","builder_version":"pith-number-builder-2026-05-17-v1","receipt_version":"0.3","canonical_sha256":"023595bed4385133bf9ace2ceaa554325edd8fdb47514e8b06f3a3f224dba25a","last_reissued_at":"2026-07-05T09:21:42.622027Z","signature_status":"signed_v1","first_computed_at":"2026-07-05T09:21:42.622027Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"source_kind":"arxiv","source_id":"2404.04086","source_version":1,"attestation_state":"computed"},"signer":{"signer_id":"pith.science","signer_type":"pith_registry","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"created_at":"2026-07-05T09:21:42Z","supersedes":[],"prev_event":null,"signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"0Unk7uPb9d7CPIaI5sYixW5SEuALZZiqwXZLtyd/2Acgm2ZUI3UpgdaHnM9yBd957GnsLqgK7L3B+muMjgGjBA==","signed_message":"open_graph_event_sha256_bytes","signed_at":"2026-07-12T14:31:44.521613Z"},"content_sha256":"c7f2f48d030f9c9e82d17e41187cbd9a34ed05ffc3373cba43092237dcbf6aae","schema_version":"1.0","event_id":"sha256:c7f2f48d030f9c9e82d17e41187cbd9a34ed05ffc3373cba43092237dcbf6aae"},{"event_type":"graph_snapshot","subject_pith_number":"pith:2024:AI2ZLPWUHBITHP42ZYWOVJKUGJ","target":"graph","payload":{"graph_snapshot":{"paper":{"title":"A first passage model of intravitreal drug delivery and residence time, in relation to ocular geometry, individual variability, and injection location","license":"http://creativecommons.org/licenses/by/4.0/","headline":"","cross_cats":["math.AP"],"primary_cat":"q-bio.QM","authors_text":"Antonello Caruso, Eamonn A. Gaffney, Jessica R. Crawshaw, Michael Gertz, Patricia Lamirande, Philip K. Maini","submitted_at":"2024-04-05T13:21:48Z","abstract_excerpt":"Purpose: Standard of care for various retinal diseases involves recurrent intravitreal injections. This motivates mathematical modelling efforts to identify influential factors for drug residence time, aiming to minimise administration frequency. We sought to describe the vitreal diffusion of therapeutics in nonclinical species used during drug development assessments. In human eyes, we investigated the impact of variability in vitreous cavity size and eccentricity, and in injection location, on drug elimination.\n  Methods: Using a first passage time approach, we modelled the transport-control"},"claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"2404.04086","kind":"arxiv","version":1},"verdict":{"id":null,"model_set":{},"created_at":null,"strongest_claim":"","one_line_summary":"","pipeline_version":null,"weakest_assumption":"","pith_extraction_headline":""},"integrity":{"clean":true,"summary":{"advisory":0,"critical":0,"by_detector":{},"informational":0},"endpoint":"/pith/2404.04086/integrity.json","findings":[],"available":true,"detectors_run":[],"snapshot_sha256":"c28c3603d3b5d939e8dc4c7e95fa8dfce3d595e45f758748cecf8e644a296938"},"references":{"count":0,"sample":[],"resolved_work":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","internal_anchors":0},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"author_claims":{"count":0,"strong_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"builder_version":"pith-number-builder-2026-05-17-v1"},"verdict_id":null},"signer":{"signer_id":"pith.science","signer_type":"pith_registry","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"created_at":"2026-07-05T09:21:42Z","supersedes":[],"prev_event":null,"signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"/jjx7BSmNGU89rpOe7z5fCdv6MxIGbuikTVBXcwFumGGoNqg7kQHJrOKBrEdQUQdJoP880Fq0G0t0JNYkF5cAw==","signed_message":"open_graph_event_sha256_bytes","signed_at":"2026-07-12T14:31:44.522000Z"},"content_sha256":"29ad108370aff4cf34ce33af60eed2eb6f94698af2db4f28421fdddbc3b0f421","schema_version":"1.0","event_id":"sha256:29ad108370aff4cf34ce33af60eed2eb6f94698af2db4f28421fdddbc3b0f421"}],"timestamp_proofs":[],"mirror_hints":[{"mirror_type":"https","name":"Pith Resolver","base_url":"https://pith.science","bundle_url":"https://pith.science/pith/AI2ZLPWUHBITHP42ZYWOVJKUGJ/bundle.json","state_url":"https://pith.science/pith/AI2ZLPWUHBITHP42ZYWOVJKUGJ/state.json","well_known_bundle_url":"https://pith.science/.well-known/pith/AI2ZLPWUHBITHP42ZYWOVJKUGJ/bundle.json","status":"primary"}],"public_keys":[{"key_id":"pith-v1-2026-05","algorithm":"ed25519","format":"raw","public_key_b64":"stVStoiQhXFxp4s2pdzPNoqVNBMojDU/fJ2db5S3CbM=","public_key_hex":"b2d552b68890857171a78b36a5dccf368a953413288c353f7c9d9d6f94b709b3","fingerprint_sha256_b32_first128bits":"RVFV5Z2OI2J3ZUO7ERDEBCYNKS","fingerprint_sha256_hex":"8d4b5ee74e4693bcd1df2446408b0d54","rotates_at":null,"url":"https://pith.science/pith-signing-key.json","notes":"Pith uses this Ed25519 key to sign canonical record SHA-256 digests. Verify with: ed25519_verify(public_key, message=canonical_sha256_bytes, signature=base64decode(signature_b64))."}],"merge_version":"pith-open-graph-merge-v1","built_at":"2026-07-12T14:31:44Z","links":{"resolver":"https://pith.science/pith/AI2ZLPWUHBITHP42ZYWOVJKUGJ","bundle":"https://pith.science/pith/AI2ZLPWUHBITHP42ZYWOVJKUGJ/bundle.json","state":"https://pith.science/pith/AI2ZLPWUHBITHP42ZYWOVJKUGJ/state.json","well_known_bundle":"https://pith.science/.well-known/pith/AI2ZLPWUHBITHP42ZYWOVJKUGJ/bundle.json"},"state":{"state_type":"pith_open_graph_state","state_version":"1.0","pith_number":"pith:2024:AI2ZLPWUHBITHP42ZYWOVJKUGJ","merge_version":"pith-open-graph-merge-v1","event_count":2,"valid_event_count":2,"invalid_event_count":0,"equivocation_count":0,"current":{"canonical_record":{"metadata":{"abstract_canon_sha256":"b7d18b55e76a8e13780ca6b96cbf3ab0ea095baf9337eeefd136f3fc2df68217","cross_cats_sorted":["math.AP"],"license":"http://creativecommons.org/licenses/by/4.0/","primary_cat":"q-bio.QM","submitted_at":"2024-04-05T13:21:48Z","title_canon_sha256":"7476a46ca9ba0be5ed63d90ef8fa3b109b48f5f5ea67899308fd84a4cfdcec4a"},"schema_version":"1.0","source":{"id":"2404.04086","kind":"arxiv","version":1}},"source_aliases":[{"alias_kind":"arxiv","alias_value":"2404.04086","created_at":"2026-07-05T09:21:42Z"},{"alias_kind":"arxiv_version","alias_value":"2404.04086v1","created_at":"2026-07-05T09:21:42Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.2404.04086","created_at":"2026-07-05T09:21:42Z"},{"alias_kind":"pith_short_12","alias_value":"AI2ZLPWUHBIT","created_at":"2026-07-05T09:21:42Z"},{"alias_kind":"pith_short_16","alias_value":"AI2ZLPWUHBITHP42","created_at":"2026-07-05T09:21:42Z"},{"alias_kind":"pith_short_8","alias_value":"AI2ZLPWU","created_at":"2026-07-05T09:21:42Z"}],"graph_snapshots":[{"event_id":"sha256:29ad108370aff4cf34ce33af60eed2eb6f94698af2db4f28421fdddbc3b0f421","target":"graph","created_at":"2026-07-05T09:21:42Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"graph_snapshot":{"author_claims":{"count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","strong_count":0},"builder_version":"pith-number-builder-2026-05-17-v1","claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"integrity":{"available":true,"clean":true,"detectors_run":[],"endpoint":"/pith/2404.04086/integrity.json","findings":[],"snapshot_sha256":"c28c3603d3b5d939e8dc4c7e95fa8dfce3d595e45f758748cecf8e644a296938","summary":{"advisory":0,"by_detector":{},"critical":0,"informational":0}},"paper":{"abstract_excerpt":"Purpose: Standard of care for various retinal diseases involves recurrent intravitreal injections. This motivates mathematical modelling efforts to identify influential factors for drug residence time, aiming to minimise administration frequency. We sought to describe the vitreal diffusion of therapeutics in nonclinical species used during drug development assessments. In human eyes, we investigated the impact of variability in vitreous cavity size and eccentricity, and in injection location, on drug elimination.\n  Methods: Using a first passage time approach, we modelled the transport-control","authors_text":"Antonello Caruso, Eamonn A. Gaffney, Jessica R. Crawshaw, Michael Gertz, Patricia Lamirande, Philip K. Maini","cross_cats":["math.AP"],"headline":"","license":"http://creativecommons.org/licenses/by/4.0/","primary_cat":"q-bio.QM","submitted_at":"2024-04-05T13:21:48Z","title":"A first passage model of intravitreal drug delivery and residence time, in relation to ocular geometry, individual variability, and injection location"},"references":{"count":0,"internal_anchors":0,"resolved_work":0,"sample":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"2404.04086","kind":"arxiv","version":1},"verdict":{"created_at":null,"id":null,"model_set":{},"one_line_summary":"","pipeline_version":null,"pith_extraction_headline":"","strongest_claim":"","weakest_assumption":""}},"verdict_id":null}}],"author_attestations":[],"timestamp_anchors":[],"storage_attestations":[],"citation_signatures":[],"replication_records":[],"corrections":[],"mirror_hints":[],"record_created":{"event_id":"sha256:c7f2f48d030f9c9e82d17e41187cbd9a34ed05ffc3373cba43092237dcbf6aae","target":"record","created_at":"2026-07-05T09:21:42Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"attestation_state":"computed","canonical_record":{"metadata":{"abstract_canon_sha256":"b7d18b55e76a8e13780ca6b96cbf3ab0ea095baf9337eeefd136f3fc2df68217","cross_cats_sorted":["math.AP"],"license":"http://creativecommons.org/licenses/by/4.0/","primary_cat":"q-bio.QM","submitted_at":"2024-04-05T13:21:48Z","title_canon_sha256":"7476a46ca9ba0be5ed63d90ef8fa3b109b48f5f5ea67899308fd84a4cfdcec4a"},"schema_version":"1.0","source":{"id":"2404.04086","kind":"arxiv","version":1}},"canonical_sha256":"023595bed4385133bf9ace2ceaa554325edd8fdb47514e8b06f3a3f224dba25a","receipt":{"algorithm":"ed25519","builder_version":"pith-number-builder-2026-05-17-v1","canonical_sha256":"023595bed4385133bf9ace2ceaa554325edd8fdb47514e8b06f3a3f224dba25a","first_computed_at":"2026-07-05T09:21:42.622027Z","key_id":"pith-v1-2026-05","kind":"pith_receipt","last_reissued_at":"2026-07-05T09:21:42.622027Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","receipt_version":"0.3","signature_b64":"l/y+UuJzGpKQFdyQ+wU6LDKzSMaANs8WwdJePJrKoLCSnji2E6kKj7qYpDgJS3Gqg8VJB798TbbZhS1zIQC4Cg==","signature_status":"signed_v1","signed_at":"2026-07-05T09:21:42.622537Z","signed_message":"canonical_sha256_bytes"},"source_id":"2404.04086","source_kind":"arxiv","source_version":1}}},"equivocations":[],"invalid_events":[],"applied_event_ids":["sha256:c7f2f48d030f9c9e82d17e41187cbd9a34ed05ffc3373cba43092237dcbf6aae","sha256:29ad108370aff4cf34ce33af60eed2eb6f94698af2db4f28421fdddbc3b0f421"],"state_sha256":"e77fe9b3b7dee4b3156aafd8b3ce8d1b85c609a4570edc369e54cb7397bfa7ed"},"bundle_signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"g/cVi/XY2c9R1M0LPNbo8jJlRWpm6BSEwbx1k9O8cB/TOxEAl38eqPN7fPLHe5/huCg8b1hIZbOjUL9JwzUPDA==","signed_message":"bundle_sha256_bytes","signed_at":"2026-07-12T14:31:44.525397Z","bundle_sha256":"a52f7699fded4ce8c11a51673b7d766c03ae8a6873a07b7c74eb79d83fde48f0"}}