{"bundle_type":"pith_open_graph_bundle","bundle_version":"1.0","pith_number":"pith:2016:AJWS7WCFP7CGSNPD6JNGOHK4FX","short_pith_number":"pith:AJWS7WCF","canonical_record":{"source":{"id":"1612.01104","kind":"arxiv","version":2},"metadata":{"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.MN","submitted_at":"2016-12-04T11:42:44Z","cross_cats_sorted":["nlin.AO","q-bio.SC"],"title_canon_sha256":"810e2dde03b3063732043b401b48df0a6ab0a7314c5485d38d70753518cde04a","abstract_canon_sha256":"325ba52eb41bb9a400e98b033bc9af9b1073b00e0e1d45aefeee2b5ebf3609ce"},"schema_version":"1.0"},"canonical_sha256":"026d2fd8457fc46935e3f25a671d5c2dcc054755eeb9585c4ad013ed23ac45c5","source":{"kind":"arxiv","id":"1612.01104","version":2},"source_aliases":[{"alias_kind":"arxiv","alias_value":"1612.01104","created_at":"2026-05-18T00:37:36Z"},{"alias_kind":"arxiv_version","alias_value":"1612.01104v2","created_at":"2026-05-18T00:37:36Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.1612.01104","created_at":"2026-05-18T00:37:36Z"},{"alias_kind":"pith_short_12","alias_value":"AJWS7WCFP7CG","created_at":"2026-05-18T12:30:07Z"},{"alias_kind":"pith_short_16","alias_value":"AJWS7WCFP7CGSNPD","created_at":"2026-05-18T12:30:07Z"},{"alias_kind":"pith_short_8","alias_value":"AJWS7WCF","created_at":"2026-05-18T12:30:07Z"}],"events":[{"event_type":"record_created","subject_pith_number":"pith:2016:AJWS7WCFP7CGSNPD6JNGOHK4FX","target":"record","payload":{"canonical_record":{"source":{"id":"1612.01104","kind":"arxiv","version":2},"metadata":{"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.MN","submitted_at":"2016-12-04T11:42:44Z","cross_cats_sorted":["nlin.AO","q-bio.SC"],"title_canon_sha256":"810e2dde03b3063732043b401b48df0a6ab0a7314c5485d38d70753518cde04a","abstract_canon_sha256":"325ba52eb41bb9a400e98b033bc9af9b1073b00e0e1d45aefeee2b5ebf3609ce"},"schema_version":"1.0"},"canonical_sha256":"026d2fd8457fc46935e3f25a671d5c2dcc054755eeb9585c4ad013ed23ac45c5","receipt":{"kind":"pith_receipt","key_id":"pith-v1-2026-05","algorithm":"ed25519","signed_at":"2026-05-18T00:37:36.385994Z","signature_b64":"3EeeF+PkM++FipS1o1Fc5mSFekqObvcmlV6VaxH2bhQ8lhyh4fL8jefyIakrNmXVxoZFehsyyyy2CC7YCwonAQ==","signed_message":"canonical_sha256_bytes","builder_version":"pith-number-builder-2026-05-17-v1","receipt_version":"0.3","canonical_sha256":"026d2fd8457fc46935e3f25a671d5c2dcc054755eeb9585c4ad013ed23ac45c5","last_reissued_at":"2026-05-18T00:37:36.385267Z","signature_status":"signed_v1","first_computed_at":"2026-05-18T00:37:36.385267Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"source_kind":"arxiv","source_id":"1612.01104","source_version":2,"attestation_state":"computed"},"signer":{"signer_id":"pith.science","signer_type":"pith_registry","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"created_at":"2026-05-18T00:37:36Z","supersedes":[],"prev_event":null,"signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"bHfAM88Hyyeo5Vk64garm2o9wln47Z/EKlSU7NamhMOG7oZnWcZh5R+kznOt7nT8UfuFkQW39GmcozD6QPPOCA==","signed_message":"open_graph_event_sha256_bytes","signed_at":"2026-06-06T08:07:20.273800Z"},"content_sha256":"bcbcae1c996dc4298fdcb709c2128a6f87aba7d8c78549f8d9a09de24975e7ec","schema_version":"1.0","event_id":"sha256:bcbcae1c996dc4298fdcb709c2128a6f87aba7d8c78549f8d9a09de24975e7ec"},{"event_type":"graph_snapshot","subject_pith_number":"pith:2016:AJWS7WCFP7CGSNPD6JNGOHK4FX","target":"graph","payload":{"graph_snapshot":{"paper":{"title":"Regime shifts driven by dynamic correlations in gene expression noise","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","headline":"","cross_cats":["nlin.AO","q-bio.SC"],"primary_cat":"q-bio.MN","authors_text":"Partha Sharathi Dutta, Yogita Sharma","submitted_at":"2016-12-04T11:42:44Z","abstract_excerpt":"Gene expression is a noisy process that leads to regime shift between alternative steady states among individual living cells, inducing phenotypic variability. The effects of white noise on the regime shift in bistable systems have been well characterized, however little is known about such effects of colored noise (noise with non-zero correlation time). Here, we show that noise correlation time, by considering a genetic circuit of autoactivation, can have significant effect on the regime shift in gene expression. We demonstrate this theoretically, using stochastic potential, stationary probab"},"claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"1612.01104","kind":"arxiv","version":2},"verdict":{"id":null,"model_set":{},"created_at":null,"strongest_claim":"","one_line_summary":"","pipeline_version":null,"weakest_assumption":"","pith_extraction_headline":""},"references":{"count":0,"sample":[],"resolved_work":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","internal_anchors":0},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"author_claims":{"count":0,"strong_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"builder_version":"pith-number-builder-2026-05-17-v1"},"verdict_id":null},"signer":{"signer_id":"pith.science","signer_type":"pith_registry","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"created_at":"2026-05-18T00:37:36Z","supersedes":[],"prev_event":null,"signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"rpz4Lb5EKSB2k/uF0j7VSsbXQBeRcVt81IYHh8+Jad+VV0M6qVZ5Vz0aPeq8XsHyMVtazfEg7UaxrukHv4lgBA==","signed_message":"open_graph_event_sha256_bytes","signed_at":"2026-06-06T08:07:20.274854Z"},"content_sha256":"ea8e63e899125fbe5dc717c594ca0c04f2e22036b1414120d8a2d258c109e4b5","schema_version":"1.0","event_id":"sha256:ea8e63e899125fbe5dc717c594ca0c04f2e22036b1414120d8a2d258c109e4b5"}],"timestamp_proofs":[],"mirror_hints":[{"mirror_type":"https","name":"Pith Resolver","base_url":"https://pith.science","bundle_url":"https://pith.science/pith/AJWS7WCFP7CGSNPD6JNGOHK4FX/bundle.json","state_url":"https://pith.science/pith/AJWS7WCFP7CGSNPD6JNGOHK4FX/state.json","well_known_bundle_url":"https://pith.science/.well-known/pith/AJWS7WCFP7CGSNPD6JNGOHK4FX/bundle.json","status":"primary"}],"public_keys":[{"key_id":"pith-v1-2026-05","algorithm":"ed25519","format":"raw","public_key_b64":"stVStoiQhXFxp4s2pdzPNoqVNBMojDU/fJ2db5S3CbM=","public_key_hex":"b2d552b68890857171a78b36a5dccf368a953413288c353f7c9d9d6f94b709b3","fingerprint_sha256_b32_first128bits":"RVFV5Z2OI2J3ZUO7ERDEBCYNKS","fingerprint_sha256_hex":"8d4b5ee74e4693bcd1df2446408b0d54","rotates_at":null,"url":"https://pith.science/pith-signing-key.json","notes":"Pith uses this Ed25519 key to sign canonical record SHA-256 digests. Verify with: ed25519_verify(public_key, message=canonical_sha256_bytes, signature=base64decode(signature_b64))."}],"merge_version":"pith-open-graph-merge-v1","built_at":"2026-06-06T08:07:20Z","links":{"resolver":"https://pith.science/pith/AJWS7WCFP7CGSNPD6JNGOHK4FX","bundle":"https://pith.science/pith/AJWS7WCFP7CGSNPD6JNGOHK4FX/bundle.json","state":"https://pith.science/pith/AJWS7WCFP7CGSNPD6JNGOHK4FX/state.json","well_known_bundle":"https://pith.science/.well-known/pith/AJWS7WCFP7CGSNPD6JNGOHK4FX/bundle.json"},"state":{"state_type":"pith_open_graph_state","state_version":"1.0","pith_number":"pith:2016:AJWS7WCFP7CGSNPD6JNGOHK4FX","merge_version":"pith-open-graph-merge-v1","event_count":2,"valid_event_count":2,"invalid_event_count":0,"equivocation_count":0,"current":{"canonical_record":{"metadata":{"abstract_canon_sha256":"325ba52eb41bb9a400e98b033bc9af9b1073b00e0e1d45aefeee2b5ebf3609ce","cross_cats_sorted":["nlin.AO","q-bio.SC"],"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.MN","submitted_at":"2016-12-04T11:42:44Z","title_canon_sha256":"810e2dde03b3063732043b401b48df0a6ab0a7314c5485d38d70753518cde04a"},"schema_version":"1.0","source":{"id":"1612.01104","kind":"arxiv","version":2}},"source_aliases":[{"alias_kind":"arxiv","alias_value":"1612.01104","created_at":"2026-05-18T00:37:36Z"},{"alias_kind":"arxiv_version","alias_value":"1612.01104v2","created_at":"2026-05-18T00:37:36Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.1612.01104","created_at":"2026-05-18T00:37:36Z"},{"alias_kind":"pith_short_12","alias_value":"AJWS7WCFP7CG","created_at":"2026-05-18T12:30:07Z"},{"alias_kind":"pith_short_16","alias_value":"AJWS7WCFP7CGSNPD","created_at":"2026-05-18T12:30:07Z"},{"alias_kind":"pith_short_8","alias_value":"AJWS7WCF","created_at":"2026-05-18T12:30:07Z"}],"graph_snapshots":[{"event_id":"sha256:ea8e63e899125fbe5dc717c594ca0c04f2e22036b1414120d8a2d258c109e4b5","target":"graph","created_at":"2026-05-18T00:37:36Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"graph_snapshot":{"author_claims":{"count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","strong_count":0},"builder_version":"pith-number-builder-2026-05-17-v1","claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"paper":{"abstract_excerpt":"Gene expression is a noisy process that leads to regime shift between alternative steady states among individual living cells, inducing phenotypic variability. The effects of white noise on the regime shift in bistable systems have been well characterized, however little is known about such effects of colored noise (noise with non-zero correlation time). Here, we show that noise correlation time, by considering a genetic circuit of autoactivation, can have significant effect on the regime shift in gene expression. We demonstrate this theoretically, using stochastic potential, stationary probab","authors_text":"Partha Sharathi Dutta, Yogita Sharma","cross_cats":["nlin.AO","q-bio.SC"],"headline":"","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.MN","submitted_at":"2016-12-04T11:42:44Z","title":"Regime shifts driven by dynamic correlations in gene expression noise"},"references":{"count":0,"internal_anchors":0,"resolved_work":0,"sample":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"1612.01104","kind":"arxiv","version":2},"verdict":{"created_at":null,"id":null,"model_set":{},"one_line_summary":"","pipeline_version":null,"pith_extraction_headline":"","strongest_claim":"","weakest_assumption":""}},"verdict_id":null}}],"author_attestations":[],"timestamp_anchors":[],"storage_attestations":[],"citation_signatures":[],"replication_records":[],"corrections":[],"mirror_hints":[],"record_created":{"event_id":"sha256:bcbcae1c996dc4298fdcb709c2128a6f87aba7d8c78549f8d9a09de24975e7ec","target":"record","created_at":"2026-05-18T00:37:36Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"attestation_state":"computed","canonical_record":{"metadata":{"abstract_canon_sha256":"325ba52eb41bb9a400e98b033bc9af9b1073b00e0e1d45aefeee2b5ebf3609ce","cross_cats_sorted":["nlin.AO","q-bio.SC"],"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.MN","submitted_at":"2016-12-04T11:42:44Z","title_canon_sha256":"810e2dde03b3063732043b401b48df0a6ab0a7314c5485d38d70753518cde04a"},"schema_version":"1.0","source":{"id":"1612.01104","kind":"arxiv","version":2}},"canonical_sha256":"026d2fd8457fc46935e3f25a671d5c2dcc054755eeb9585c4ad013ed23ac45c5","receipt":{"algorithm":"ed25519","builder_version":"pith-number-builder-2026-05-17-v1","canonical_sha256":"026d2fd8457fc46935e3f25a671d5c2dcc054755eeb9585c4ad013ed23ac45c5","first_computed_at":"2026-05-18T00:37:36.385267Z","key_id":"pith-v1-2026-05","kind":"pith_receipt","last_reissued_at":"2026-05-18T00:37:36.385267Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","receipt_version":"0.3","signature_b64":"3EeeF+PkM++FipS1o1Fc5mSFekqObvcmlV6VaxH2bhQ8lhyh4fL8jefyIakrNmXVxoZFehsyyyy2CC7YCwonAQ==","signature_status":"signed_v1","signed_at":"2026-05-18T00:37:36.385994Z","signed_message":"canonical_sha256_bytes"},"source_id":"1612.01104","source_kind":"arxiv","source_version":2}}},"equivocations":[],"invalid_events":[],"applied_event_ids":["sha256:bcbcae1c996dc4298fdcb709c2128a6f87aba7d8c78549f8d9a09de24975e7ec","sha256:ea8e63e899125fbe5dc717c594ca0c04f2e22036b1414120d8a2d258c109e4b5"],"state_sha256":"c921922292da0d8629a2da05f4d6baab849f1a6fc3a3accdeddba6d35eb6b446"},"bundle_signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"cqPa1Rsnoyt6JkaIqKVocIzCv/mgCCSVBeMDz4F0GzUrq9nmLTrm+iDrGmtVnrtTlAXU8zohsQx/fIXrs+AsCw==","signed_message":"bundle_sha256_bytes","signed_at":"2026-06-06T08:07:20.278786Z","bundle_sha256":"fe05a9c675e1756504593dce65c3bdccb8a8396f6b56a039ac2d212f6cbe7d10"}}