{"bundle_type":"pith_open_graph_bundle","bundle_version":"1.0","pith_number":"pith:2011:AS65XHVQNGSNI5FI6TB7KVIOK2","short_pith_number":"pith:AS65XHVQ","canonical_record":{"source":{"id":"1103.4425","kind":"arxiv","version":1},"metadata":{"license":"http://creativecommons.org/licenses/by-nc-sa/3.0/","primary_cat":"physics.bio-ph","submitted_at":"2011-03-23T00:24:02Z","cross_cats_sorted":["physics.comp-ph"],"title_canon_sha256":"0e136ec1c2568400b2d18e8dfc0f41c2b6efa2a09164ac4fba85569e294f1207","abstract_canon_sha256":"d7559591011c71a7eae3e4ab24e9a88579f5d6335fb7b41b0116879a742dea23"},"schema_version":"1.0"},"canonical_sha256":"04bddb9eb069a4d474a8f4c3f5550e56b4958e4aebce16b937e98bcb09220707","source":{"kind":"arxiv","id":"1103.4425","version":1},"source_aliases":[{"alias_kind":"arxiv","alias_value":"1103.4425","created_at":"2026-05-18T03:20:33Z"},{"alias_kind":"arxiv_version","alias_value":"1103.4425v1","created_at":"2026-05-18T03:20:33Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.1103.4425","created_at":"2026-05-18T03:20:33Z"},{"alias_kind":"pith_short_12","alias_value":"AS65XHVQNGSN","created_at":"2026-05-18T12:26:24Z"},{"alias_kind":"pith_short_16","alias_value":"AS65XHVQNGSNI5FI","created_at":"2026-05-18T12:26:24Z"},{"alias_kind":"pith_short_8","alias_value":"AS65XHVQ","created_at":"2026-05-18T12:26:24Z"}],"events":[{"event_type":"record_created","subject_pith_number":"pith:2011:AS65XHVQNGSNI5FI6TB7KVIOK2","target":"record","payload":{"canonical_record":{"source":{"id":"1103.4425","kind":"arxiv","version":1},"metadata":{"license":"http://creativecommons.org/licenses/by-nc-sa/3.0/","primary_cat":"physics.bio-ph","submitted_at":"2011-03-23T00:24:02Z","cross_cats_sorted":["physics.comp-ph"],"title_canon_sha256":"0e136ec1c2568400b2d18e8dfc0f41c2b6efa2a09164ac4fba85569e294f1207","abstract_canon_sha256":"d7559591011c71a7eae3e4ab24e9a88579f5d6335fb7b41b0116879a742dea23"},"schema_version":"1.0"},"canonical_sha256":"04bddb9eb069a4d474a8f4c3f5550e56b4958e4aebce16b937e98bcb09220707","receipt":{"kind":"pith_receipt","key_id":"pith-v1-2026-05","algorithm":"ed25519","signed_at":"2026-05-18T03:20:33.161529Z","signature_b64":"enad3wejLB9QDu+5o368Pp9QQxcenTukWj39+XjMRt33803ybv4msJ1rg38UuYKRjsMCp0m89FyUKyfJFxwqDw==","signed_message":"canonical_sha256_bytes","builder_version":"pith-number-builder-2026-05-17-v1","receipt_version":"0.3","canonical_sha256":"04bddb9eb069a4d474a8f4c3f5550e56b4958e4aebce16b937e98bcb09220707","last_reissued_at":"2026-05-18T03:20:33.160607Z","signature_status":"signed_v1","first_computed_at":"2026-05-18T03:20:33.160607Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"source_kind":"arxiv","source_id":"1103.4425","source_version":1,"attestation_state":"computed"},"signer":{"signer_id":"pith.science","signer_type":"pith_registry","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"created_at":"2026-05-18T03:20:33Z","supersedes":[],"prev_event":null,"signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"Vp3sJmQhnBmyhdUdAu5l47FZWPZY8UR/IIQt+701JzxT2R3PZEZcswWLxfVr9zm4YPXpvgv72fb05gL5nkR+BA==","signed_message":"open_graph_event_sha256_bytes","signed_at":"2026-05-31T21:26:47.319457Z"},"content_sha256":"5de85a0c369b0bbb5f159760ee28edb82f1249e2378d83cdda2e0b4bef2099fd","schema_version":"1.0","event_id":"sha256:5de85a0c369b0bbb5f159760ee28edb82f1249e2378d83cdda2e0b4bef2099fd"},{"event_type":"graph_snapshot","subject_pith_number":"pith:2011:AS65XHVQNGSNI5FI6TB7KVIOK2","target":"graph","payload":{"graph_snapshot":{"paper":{"title":"Exact and efficient calculation of Lagrange multipliers in constrained biological polymers: Proteins and nucleic acids as example cases","license":"http://creativecommons.org/licenses/by-nc-sa/3.0/","headline":"","cross_cats":["physics.comp-ph"],"primary_cat":"physics.bio-ph","authors_text":"Jos\\'e Luis Alonso, Pablo Echenique, Pablo Garc\\'ia-Risue\\~no","submitted_at":"2011-03-23T00:24:02Z","abstract_excerpt":"In order to accelerate molecular dynamics simulations, it is very common to impose holonomic constraints on their hardest degrees of freedom. In this way, the time step used to integrate the equations of motion can be increased, thus allowing, in principle, to reach longer total simulation times. The imposition of such constraints results in an aditional set of Nc equations (the equations of constraint) and unknowns (their associated Lagrange multipliers), that must be solved in one way or another at each time step of the dynamics. In this work it is shown that, due to the essentially linear s"},"claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"1103.4425","kind":"arxiv","version":1},"verdict":{"id":null,"model_set":{},"created_at":null,"strongest_claim":"","one_line_summary":"","pipeline_version":null,"weakest_assumption":"","pith_extraction_headline":""},"references":{"count":0,"sample":[],"resolved_work":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","internal_anchors":0},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"author_claims":{"count":0,"strong_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"builder_version":"pith-number-builder-2026-05-17-v1"},"verdict_id":null},"signer":{"signer_id":"pith.science","signer_type":"pith_registry","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"created_at":"2026-05-18T03:20:33Z","supersedes":[],"prev_event":null,"signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"9Zta6KuNODkK1LK9iQQiYdvrIKDFohchLLSeuo63HNMUrdfd5xbUdpwWjXOsh4YaxdvgvfCOp959+XgPY+J6BA==","signed_message":"open_graph_event_sha256_bytes","signed_at":"2026-05-31T21:26:47.319813Z"},"content_sha256":"f0d93e4ca6a473e188db248e7c1abf1dd76fede992299059329d7d719bdd41ff","schema_version":"1.0","event_id":"sha256:f0d93e4ca6a473e188db248e7c1abf1dd76fede992299059329d7d719bdd41ff"}],"timestamp_proofs":[],"mirror_hints":[{"mirror_type":"https","name":"Pith Resolver","base_url":"https://pith.science","bundle_url":"https://pith.science/pith/AS65XHVQNGSNI5FI6TB7KVIOK2/bundle.json","state_url":"https://pith.science/pith/AS65XHVQNGSNI5FI6TB7KVIOK2/state.json","well_known_bundle_url":"https://pith.science/.well-known/pith/AS65XHVQNGSNI5FI6TB7KVIOK2/bundle.json","status":"primary"}],"public_keys":[{"key_id":"pith-v1-2026-05","algorithm":"ed25519","format":"raw","public_key_b64":"stVStoiQhXFxp4s2pdzPNoqVNBMojDU/fJ2db5S3CbM=","public_key_hex":"b2d552b68890857171a78b36a5dccf368a953413288c353f7c9d9d6f94b709b3","fingerprint_sha256_b32_first128bits":"RVFV5Z2OI2J3ZUO7ERDEBCYNKS","fingerprint_sha256_hex":"8d4b5ee74e4693bcd1df2446408b0d54","rotates_at":null,"url":"https://pith.science/pith-signing-key.json","notes":"Pith uses this Ed25519 key to sign canonical record SHA-256 digests. Verify with: ed25519_verify(public_key, message=canonical_sha256_bytes, signature=base64decode(signature_b64))."}],"merge_version":"pith-open-graph-merge-v1","built_at":"2026-05-31T21:26:47Z","links":{"resolver":"https://pith.science/pith/AS65XHVQNGSNI5FI6TB7KVIOK2","bundle":"https://pith.science/pith/AS65XHVQNGSNI5FI6TB7KVIOK2/bundle.json","state":"https://pith.science/pith/AS65XHVQNGSNI5FI6TB7KVIOK2/state.json","well_known_bundle":"https://pith.science/.well-known/pith/AS65XHVQNGSNI5FI6TB7KVIOK2/bundle.json"},"state":{"state_type":"pith_open_graph_state","state_version":"1.0","pith_number":"pith:2011:AS65XHVQNGSNI5FI6TB7KVIOK2","merge_version":"pith-open-graph-merge-v1","event_count":2,"valid_event_count":2,"invalid_event_count":0,"equivocation_count":0,"current":{"canonical_record":{"metadata":{"abstract_canon_sha256":"d7559591011c71a7eae3e4ab24e9a88579f5d6335fb7b41b0116879a742dea23","cross_cats_sorted":["physics.comp-ph"],"license":"http://creativecommons.org/licenses/by-nc-sa/3.0/","primary_cat":"physics.bio-ph","submitted_at":"2011-03-23T00:24:02Z","title_canon_sha256":"0e136ec1c2568400b2d18e8dfc0f41c2b6efa2a09164ac4fba85569e294f1207"},"schema_version":"1.0","source":{"id":"1103.4425","kind":"arxiv","version":1}},"source_aliases":[{"alias_kind":"arxiv","alias_value":"1103.4425","created_at":"2026-05-18T03:20:33Z"},{"alias_kind":"arxiv_version","alias_value":"1103.4425v1","created_at":"2026-05-18T03:20:33Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.1103.4425","created_at":"2026-05-18T03:20:33Z"},{"alias_kind":"pith_short_12","alias_value":"AS65XHVQNGSN","created_at":"2026-05-18T12:26:24Z"},{"alias_kind":"pith_short_16","alias_value":"AS65XHVQNGSNI5FI","created_at":"2026-05-18T12:26:24Z"},{"alias_kind":"pith_short_8","alias_value":"AS65XHVQ","created_at":"2026-05-18T12:26:24Z"}],"graph_snapshots":[{"event_id":"sha256:f0d93e4ca6a473e188db248e7c1abf1dd76fede992299059329d7d719bdd41ff","target":"graph","created_at":"2026-05-18T03:20:33Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"graph_snapshot":{"author_claims":{"count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","strong_count":0},"builder_version":"pith-number-builder-2026-05-17-v1","claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"paper":{"abstract_excerpt":"In order to accelerate molecular dynamics simulations, it is very common to impose holonomic constraints on their hardest degrees of freedom. In this way, the time step used to integrate the equations of motion can be increased, thus allowing, in principle, to reach longer total simulation times. The imposition of such constraints results in an aditional set of Nc equations (the equations of constraint) and unknowns (their associated Lagrange multipliers), that must be solved in one way or another at each time step of the dynamics. In this work it is shown that, due to the essentially linear s","authors_text":"Jos\\'e Luis Alonso, Pablo Echenique, Pablo Garc\\'ia-Risue\\~no","cross_cats":["physics.comp-ph"],"headline":"","license":"http://creativecommons.org/licenses/by-nc-sa/3.0/","primary_cat":"physics.bio-ph","submitted_at":"2011-03-23T00:24:02Z","title":"Exact and efficient calculation of Lagrange multipliers in constrained biological polymers: Proteins and nucleic acids as example cases"},"references":{"count":0,"internal_anchors":0,"resolved_work":0,"sample":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"1103.4425","kind":"arxiv","version":1},"verdict":{"created_at":null,"id":null,"model_set":{},"one_line_summary":"","pipeline_version":null,"pith_extraction_headline":"","strongest_claim":"","weakest_assumption":""}},"verdict_id":null}}],"author_attestations":[],"timestamp_anchors":[],"storage_attestations":[],"citation_signatures":[],"replication_records":[],"corrections":[],"mirror_hints":[],"record_created":{"event_id":"sha256:5de85a0c369b0bbb5f159760ee28edb82f1249e2378d83cdda2e0b4bef2099fd","target":"record","created_at":"2026-05-18T03:20:33Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"attestation_state":"computed","canonical_record":{"metadata":{"abstract_canon_sha256":"d7559591011c71a7eae3e4ab24e9a88579f5d6335fb7b41b0116879a742dea23","cross_cats_sorted":["physics.comp-ph"],"license":"http://creativecommons.org/licenses/by-nc-sa/3.0/","primary_cat":"physics.bio-ph","submitted_at":"2011-03-23T00:24:02Z","title_canon_sha256":"0e136ec1c2568400b2d18e8dfc0f41c2b6efa2a09164ac4fba85569e294f1207"},"schema_version":"1.0","source":{"id":"1103.4425","kind":"arxiv","version":1}},"canonical_sha256":"04bddb9eb069a4d474a8f4c3f5550e56b4958e4aebce16b937e98bcb09220707","receipt":{"algorithm":"ed25519","builder_version":"pith-number-builder-2026-05-17-v1","canonical_sha256":"04bddb9eb069a4d474a8f4c3f5550e56b4958e4aebce16b937e98bcb09220707","first_computed_at":"2026-05-18T03:20:33.160607Z","key_id":"pith-v1-2026-05","kind":"pith_receipt","last_reissued_at":"2026-05-18T03:20:33.160607Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","receipt_version":"0.3","signature_b64":"enad3wejLB9QDu+5o368Pp9QQxcenTukWj39+XjMRt33803ybv4msJ1rg38UuYKRjsMCp0m89FyUKyfJFxwqDw==","signature_status":"signed_v1","signed_at":"2026-05-18T03:20:33.161529Z","signed_message":"canonical_sha256_bytes"},"source_id":"1103.4425","source_kind":"arxiv","source_version":1}}},"equivocations":[],"invalid_events":[],"applied_event_ids":["sha256:5de85a0c369b0bbb5f159760ee28edb82f1249e2378d83cdda2e0b4bef2099fd","sha256:f0d93e4ca6a473e188db248e7c1abf1dd76fede992299059329d7d719bdd41ff"],"state_sha256":"9dd8620cd14164f48f00e9263744ff03b1659a088cce7ff1292fa997507ea726"},"bundle_signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"d9qmT8X0QFr4U3Rk3wCIjkDt0NfREhmnv6bZ1/bWb/rJZXmoJirUVuPSWahQqUHa8Y5+5ciF6W5v/HXDmziEDw==","signed_message":"bundle_sha256_bytes","signed_at":"2026-05-31T21:26:47.322376Z","bundle_sha256":"8f7a53c85529f55e324975d0518f16d7f3001a2bee59d49b5ca66217f76302c9"}}