{"state_type":"pith_open_graph_state","state_version":"1.0","pith_number":"pith:2024:ASNUEAQQWDY47P4EXT4C3XRXUV","merge_version":"pith-open-graph-merge-v1","event_count":2,"valid_event_count":2,"invalid_event_count":0,"equivocation_count":0,"current":{"canonical_record":{"metadata":{"abstract_canon_sha256":"70f24fcd059b157584bc74a400c95b590edf1c22985517fb995f7f669491c76b","cross_cats_sorted":[],"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"stat.ME","submitted_at":"2024-12-08T17:13:06Z","title_canon_sha256":"19012a9bad94c24273e8e11ab1e0d1d128168500c75b2eb347a71e77314a16bd"},"schema_version":"1.0","source":{"id":"2412.05998","kind":"arxiv","version":4}},"source_aliases":[{"alias_kind":"arxiv","alias_value":"2412.05998","created_at":"2026-06-02T02:04:45Z"},{"alias_kind":"arxiv_version","alias_value":"2412.05998v4","created_at":"2026-06-02T02:04:45Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.2412.05998","created_at":"2026-06-02T02:04:45Z"},{"alias_kind":"pith_short_12","alias_value":"ASNUEAQQWDY4","created_at":"2026-06-02T02:04:45Z"},{"alias_kind":"pith_short_16","alias_value":"ASNUEAQQWDY47P4E","created_at":"2026-06-02T02:04:45Z"},{"alias_kind":"pith_short_8","alias_value":"ASNUEAQQ","created_at":"2026-06-02T02:04:45Z"}],"graph_snapshots":[{"event_id":"sha256:fc86c028dcb099938cde93c6d7200817a235bc89ffec344ec64da4fd84c25330","target":"graph","created_at":"2026-06-02T02:04:45Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"graph_snapshot":{"author_claims":{"count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","strong_count":0},"builder_version":"pith-number-builder-2026-05-17-v1","claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"integrity":{"available":true,"clean":true,"detectors_run":[],"endpoint":"/pith/2412.05998/integrity.json","findings":[],"snapshot_sha256":"c28c3603d3b5d939e8dc4c7e95fa8dfce3d595e45f758748cecf8e644a296938","summary":{"advisory":0,"by_detector":{},"critical":0,"informational":0}},"paper":{"abstract_excerpt":"Motivation: The gut microbiome shapes cancer therapy response through its influence on host metabolism. While prior studies examine pairwise associations between individual genera and metabolites, there is limited methodology for identifying microbial genera that systematically regulate the overall metabolome. Scalable statistical tools are needed to uncover such system-level 'master predictors' in high-dimensional microbiome-metabolome data.\n  Results: We introduce B-MASTER, a scalable Bayesian multivariate regression framework combining L1 sparsity and L2 group shrinkage to identify essentia","authors_text":"Christine Peterson, Priyam Das, Sounak Chakraborty, Tanujit Dey","cross_cats":[],"headline":"","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"stat.ME","submitted_at":"2024-12-08T17:13:06Z","title":"B-MASTER: Scalable Bayesian Multivariate Regression for Master Predictor Discovery in Colorectal Cancer Microbiome-Metabolite Profiles"},"references":{"count":0,"internal_anchors":0,"resolved_work":0,"sample":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"2412.05998","kind":"arxiv","version":4},"verdict":{"created_at":null,"id":null,"model_set":{},"one_line_summary":"","pipeline_version":null,"pith_extraction_headline":"","strongest_claim":"","weakest_assumption":""}},"verdict_id":null}}],"author_attestations":[],"timestamp_anchors":[],"storage_attestations":[],"citation_signatures":[],"replication_records":[],"corrections":[],"mirror_hints":[],"record_created":{"event_id":"sha256:cad1742d29a0c562dd8bf73634a64831db5fac64234a34ae84be1490316d96dd","target":"record","created_at":"2026-06-02T02:04:45Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"attestation_state":"computed","canonical_record":{"metadata":{"abstract_canon_sha256":"70f24fcd059b157584bc74a400c95b590edf1c22985517fb995f7f669491c76b","cross_cats_sorted":[],"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"stat.ME","submitted_at":"2024-12-08T17:13:06Z","title_canon_sha256":"19012a9bad94c24273e8e11ab1e0d1d128168500c75b2eb347a71e77314a16bd"},"schema_version":"1.0","source":{"id":"2412.05998","kind":"arxiv","version":4}},"canonical_sha256":"049b420210b0f1cfbf84bcf82dde37a57ea3fbeb6698184e551b145e7f692647","receipt":{"algorithm":"ed25519","builder_version":"pith-number-builder-2026-05-17-v1","canonical_sha256":"049b420210b0f1cfbf84bcf82dde37a57ea3fbeb6698184e551b145e7f692647","first_computed_at":"2026-06-02T02:04:45.574622Z","key_id":"pith-v1-2026-05","kind":"pith_receipt","last_reissued_at":"2026-06-02T02:04:45.574622Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","receipt_version":"0.3","signature_b64":"R0vNT1gjOUh65l5hF4fbMOo0h5Re90VLY6EdU9bprSBj9O1RDDG5XS+1+SIH8+nLeaFUOCumwJQp5RAD31M2Ag==","signature_status":"signed_v1","signed_at":"2026-06-02T02:04:45.575013Z","signed_message":"canonical_sha256_bytes"},"source_id":"2412.05998","source_kind":"arxiv","source_version":4}}},"equivocations":[],"invalid_events":[],"applied_event_ids":["sha256:cad1742d29a0c562dd8bf73634a64831db5fac64234a34ae84be1490316d96dd","sha256:fc86c028dcb099938cde93c6d7200817a235bc89ffec344ec64da4fd84c25330"],"state_sha256":"7db0eedf29c5111af554a558a2fe946976e25e794c93007cb6b30397d6333eb2"}