{"state_type":"pith_open_graph_state","state_version":"1.0","pith_number":"pith:2018:ASQDE4T5HF3GGOADYPF2FHJMJM","merge_version":"pith-open-graph-merge-v1","event_count":2,"valid_event_count":2,"invalid_event_count":0,"equivocation_count":0,"current":{"canonical_record":{"metadata":{"abstract_canon_sha256":"12c586194386de778a8060055b19ac237fd610aaa0c64633184afe0e2da11c2c","cross_cats_sorted":[],"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"math.OC","submitted_at":"2018-04-04T14:13:32Z","title_canon_sha256":"391b6aaefd3dec7c5d2fdba536007c22bad0394858eaf302494cf90f7e01ac3d"},"schema_version":"1.0","source":{"id":"1804.01426","kind":"arxiv","version":1}},"source_aliases":[{"alias_kind":"arxiv","alias_value":"1804.01426","created_at":"2026-05-18T00:19:15Z"},{"alias_kind":"arxiv_version","alias_value":"1804.01426v1","created_at":"2026-05-18T00:19:15Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.1804.01426","created_at":"2026-05-18T00:19:15Z"},{"alias_kind":"pith_short_12","alias_value":"ASQDE4T5HF3G","created_at":"2026-05-18T12:32:13Z"},{"alias_kind":"pith_short_16","alias_value":"ASQDE4T5HF3GGOAD","created_at":"2026-05-18T12:32:13Z"},{"alias_kind":"pith_short_8","alias_value":"ASQDE4T5","created_at":"2026-05-18T12:32:13Z"}],"graph_snapshots":[{"event_id":"sha256:b359b587269e731d613ea2794be203fe595bcbe5b81ec5f402416ac9bb42f34e","target":"graph","created_at":"2026-05-18T00:19:15Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"graph_snapshot":{"author_claims":{"count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","strong_count":0},"builder_version":"pith-number-builder-2026-05-17-v1","claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"paper":{"abstract_excerpt":"Microorganisms have developed complex regulatory features controlling their reaction and internal adaptation to changing environments. When modeling these organisms we usually do not have full understanding of the regulation and rely on substituting it with an optimization problem using a biologically reasonable objective function. The resulting constraint-based methods like the Flux Balance Analysis (FBA) and Resource Balance Analysis (RBA) have proven to be powerful tools to predict growth rates, by-products, and pathway usage for fixed environments. In this work, we focus on the dynamic enz","authors_text":"Alexandra-M. Reimers, Henning Lindhorst, Steffen Waldherr","cross_cats":[],"headline":"","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"math.OC","submitted_at":"2018-04-04T14:13:32Z","title":"Dynamic modeling of enzyme controlled metabolic networks using a receding time horizon"},"references":{"count":0,"internal_anchors":0,"resolved_work":0,"sample":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"1804.01426","kind":"arxiv","version":1},"verdict":{"created_at":null,"id":null,"model_set":{},"one_line_summary":"","pipeline_version":null,"pith_extraction_headline":"","strongest_claim":"","weakest_assumption":""}},"verdict_id":null}}],"author_attestations":[],"timestamp_anchors":[],"storage_attestations":[],"citation_signatures":[],"replication_records":[],"corrections":[],"mirror_hints":[],"record_created":{"event_id":"sha256:a686a89a171b213798283ec5744a6242ba73139870be882be6bca64aa66adf1d","target":"record","created_at":"2026-05-18T00:19:15Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"attestation_state":"computed","canonical_record":{"metadata":{"abstract_canon_sha256":"12c586194386de778a8060055b19ac237fd610aaa0c64633184afe0e2da11c2c","cross_cats_sorted":[],"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"math.OC","submitted_at":"2018-04-04T14:13:32Z","title_canon_sha256":"391b6aaefd3dec7c5d2fdba536007c22bad0394858eaf302494cf90f7e01ac3d"},"schema_version":"1.0","source":{"id":"1804.01426","kind":"arxiv","version":1}},"canonical_sha256":"04a032727d3976633803c3cba29d2c4b03e6f2ec284b26dff3dbac3f6d8d4ffa","receipt":{"algorithm":"ed25519","builder_version":"pith-number-builder-2026-05-17-v1","canonical_sha256":"04a032727d3976633803c3cba29d2c4b03e6f2ec284b26dff3dbac3f6d8d4ffa","first_computed_at":"2026-05-18T00:19:15.068885Z","key_id":"pith-v1-2026-05","kind":"pith_receipt","last_reissued_at":"2026-05-18T00:19:15.068885Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","receipt_version":"0.3","signature_b64":"UuHnr34muSTwluf2aW3/1Xo9YhIsORm+ZlcXfqrZmHU5E4dLQiU/llsl3M3EY7h5P3WDZC78VWrGuXEPssAYBQ==","signature_status":"signed_v1","signed_at":"2026-05-18T00:19:15.069454Z","signed_message":"canonical_sha256_bytes"},"source_id":"1804.01426","source_kind":"arxiv","source_version":1}}},"equivocations":[],"invalid_events":[],"applied_event_ids":["sha256:a686a89a171b213798283ec5744a6242ba73139870be882be6bca64aa66adf1d","sha256:b359b587269e731d613ea2794be203fe595bcbe5b81ec5f402416ac9bb42f34e"],"state_sha256":"28525da3b58968738f6529a43842b15b3531b030c7a63d054e25b925df550dc1"}