{"bundle_type":"pith_open_graph_bundle","bundle_version":"1.0","pith_number":"pith:2016:ASULEUC2B5EASDYW65XSKYOJGJ","short_pith_number":"pith:ASULEUC2","canonical_record":{"source":{"id":"1605.01639","kind":"arxiv","version":6},"metadata":{"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.MN","submitted_at":"2016-05-05T16:09:08Z","cross_cats_sorted":["cs.SI","physics.soc-ph"],"title_canon_sha256":"facadd05d0a78c025868b92ee73524d9a9bdd2da7aaaa115428029f75012c9bc","abstract_canon_sha256":"b461ff577f8001c8b8be48a4ee2c737a14dffb606e9f1f84eb16abce044b6554"},"schema_version":"1.0"},"canonical_sha256":"04a8b2505a0f48090f16f76f2561c9326d66e13a4bf63827420f4996ec0ce122","source":{"kind":"arxiv","id":"1605.01639","version":6},"source_aliases":[{"alias_kind":"arxiv","alias_value":"1605.01639","created_at":"2026-05-18T00:19:59Z"},{"alias_kind":"arxiv_version","alias_value":"1605.01639v6","created_at":"2026-05-18T00:19:59Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.1605.01639","created_at":"2026-05-18T00:19:59Z"},{"alias_kind":"pith_short_12","alias_value":"ASULEUC2B5EA","created_at":"2026-05-18T12:30:07Z"},{"alias_kind":"pith_short_16","alias_value":"ASULEUC2B5EASDYW","created_at":"2026-05-18T12:30:07Z"},{"alias_kind":"pith_short_8","alias_value":"ASULEUC2","created_at":"2026-05-18T12:30:07Z"}],"events":[{"event_type":"record_created","subject_pith_number":"pith:2016:ASULEUC2B5EASDYW65XSKYOJGJ","target":"record","payload":{"canonical_record":{"source":{"id":"1605.01639","kind":"arxiv","version":6},"metadata":{"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.MN","submitted_at":"2016-05-05T16:09:08Z","cross_cats_sorted":["cs.SI","physics.soc-ph"],"title_canon_sha256":"facadd05d0a78c025868b92ee73524d9a9bdd2da7aaaa115428029f75012c9bc","abstract_canon_sha256":"b461ff577f8001c8b8be48a4ee2c737a14dffb606e9f1f84eb16abce044b6554"},"schema_version":"1.0"},"canonical_sha256":"04a8b2505a0f48090f16f76f2561c9326d66e13a4bf63827420f4996ec0ce122","receipt":{"kind":"pith_receipt","key_id":"pith-v1-2026-05","algorithm":"ed25519","signed_at":"2026-05-18T00:19:59.492990Z","signature_b64":"YRRdZcOTkRDLIGyZCHSZKdE7KRfjd/3QZRXb81q/fsXfePr8RxlqQ+gI73jgliPZq5GrfrLw+TsCNOYbpuNHBQ==","signed_message":"canonical_sha256_bytes","builder_version":"pith-number-builder-2026-05-17-v1","receipt_version":"0.3","canonical_sha256":"04a8b2505a0f48090f16f76f2561c9326d66e13a4bf63827420f4996ec0ce122","last_reissued_at":"2026-05-18T00:19:59.492370Z","signature_status":"signed_v1","first_computed_at":"2026-05-18T00:19:59.492370Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"source_kind":"arxiv","source_id":"1605.01639","source_version":6,"attestation_state":"computed"},"signer":{"signer_id":"pith.science","signer_type":"pith_registry","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"created_at":"2026-05-18T00:19:59Z","supersedes":[],"prev_event":null,"signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"DTFqDGRbFC1pM3oRm37HWTqW1NEmM0TGmKYtUwzymznE57LDEdAMiQ8IQR8w6eaKNe4MzEaGmINcsN4NI2XgDQ==","signed_message":"open_graph_event_sha256_bytes","signed_at":"2026-05-26T12:00:04.634497Z"},"content_sha256":"bed1b74c77728dbcedfde938cc8ae0d5023136724141c2d3fce4de5211a9df37","schema_version":"1.0","event_id":"sha256:bed1b74c77728dbcedfde938cc8ae0d5023136724141c2d3fce4de5211a9df37"},{"event_type":"graph_snapshot","subject_pith_number":"pith:2016:ASULEUC2B5EASDYW65XSKYOJGJ","target":"graph","payload":{"graph_snapshot":{"paper":{"title":"Flux-dependent graphs for metabolic networks","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","headline":"","cross_cats":["cs.SI","physics.soc-ph"],"primary_cat":"q-bio.MN","authors_text":"Diego Oyarz\\'un, Gabriel Bosque, Jes\\'us Pic\\'o, Mariano Beguerisse-D\\'iaz, Mauricio Barahona","submitted_at":"2016-05-05T16:09:08Z","abstract_excerpt":"Cells adapt their metabolic fluxes in response to changes in the environment. We present a framework for the systematic construction of flux-based graphs derived from organism-wide metabolic networks. Our graphs encode the directionality of metabolic fluxes via edges that represent the flow of metabolites from source to target reactions. The methodology can be applied in the absence of a specific biological context by modelling fluxes probabilistically, or can be tailored to different environmental conditions by incorporating flux distributions computed through constraint-based approaches such"},"claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"1605.01639","kind":"arxiv","version":6},"verdict":{"id":null,"model_set":{},"created_at":null,"strongest_claim":"","one_line_summary":"","pipeline_version":null,"weakest_assumption":"","pith_extraction_headline":""},"references":{"count":0,"sample":[],"resolved_work":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","internal_anchors":0},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"author_claims":{"count":0,"strong_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"builder_version":"pith-number-builder-2026-05-17-v1"},"verdict_id":null},"signer":{"signer_id":"pith.science","signer_type":"pith_registry","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"created_at":"2026-05-18T00:19:59Z","supersedes":[],"prev_event":null,"signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"+SonryvAU4nnEs+FvLkTzgXufSkws2wFIkl3T6sKEsGiv9GcHnxmn7zdVl3hN1LdeSlJSnvz3/m8gF8+SPn6BA==","signed_message":"open_graph_event_sha256_bytes","signed_at":"2026-05-26T12:00:04.635202Z"},"content_sha256":"44e0e3ee8c18ad3336bb3adde6a0fdf0442ad8f56f62c0d219fffd6cacdf3ee3","schema_version":"1.0","event_id":"sha256:44e0e3ee8c18ad3336bb3adde6a0fdf0442ad8f56f62c0d219fffd6cacdf3ee3"}],"timestamp_proofs":[],"mirror_hints":[{"mirror_type":"https","name":"Pith Resolver","base_url":"https://pith.science","bundle_url":"https://pith.science/pith/ASULEUC2B5EASDYW65XSKYOJGJ/bundle.json","state_url":"https://pith.science/pith/ASULEUC2B5EASDYW65XSKYOJGJ/state.json","well_known_bundle_url":"https://pith.science/.well-known/pith/ASULEUC2B5EASDYW65XSKYOJGJ/bundle.json","status":"primary"}],"public_keys":[{"key_id":"pith-v1-2026-05","algorithm":"ed25519","format":"raw","public_key_b64":"stVStoiQhXFxp4s2pdzPNoqVNBMojDU/fJ2db5S3CbM=","public_key_hex":"b2d552b68890857171a78b36a5dccf368a953413288c353f7c9d9d6f94b709b3","fingerprint_sha256_b32_first128bits":"RVFV5Z2OI2J3ZUO7ERDEBCYNKS","fingerprint_sha256_hex":"8d4b5ee74e4693bcd1df2446408b0d54","rotates_at":null,"url":"https://pith.science/pith-signing-key.json","notes":"Pith uses this Ed25519 key to sign canonical record SHA-256 digests. Verify with: ed25519_verify(public_key, message=canonical_sha256_bytes, signature=base64decode(signature_b64))."}],"merge_version":"pith-open-graph-merge-v1","built_at":"2026-05-26T12:00:04Z","links":{"resolver":"https://pith.science/pith/ASULEUC2B5EASDYW65XSKYOJGJ","bundle":"https://pith.science/pith/ASULEUC2B5EASDYW65XSKYOJGJ/bundle.json","state":"https://pith.science/pith/ASULEUC2B5EASDYW65XSKYOJGJ/state.json","well_known_bundle":"https://pith.science/.well-known/pith/ASULEUC2B5EASDYW65XSKYOJGJ/bundle.json"},"state":{"state_type":"pith_open_graph_state","state_version":"1.0","pith_number":"pith:2016:ASULEUC2B5EASDYW65XSKYOJGJ","merge_version":"pith-open-graph-merge-v1","event_count":2,"valid_event_count":2,"invalid_event_count":0,"equivocation_count":0,"current":{"canonical_record":{"metadata":{"abstract_canon_sha256":"b461ff577f8001c8b8be48a4ee2c737a14dffb606e9f1f84eb16abce044b6554","cross_cats_sorted":["cs.SI","physics.soc-ph"],"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.MN","submitted_at":"2016-05-05T16:09:08Z","title_canon_sha256":"facadd05d0a78c025868b92ee73524d9a9bdd2da7aaaa115428029f75012c9bc"},"schema_version":"1.0","source":{"id":"1605.01639","kind":"arxiv","version":6}},"source_aliases":[{"alias_kind":"arxiv","alias_value":"1605.01639","created_at":"2026-05-18T00:19:59Z"},{"alias_kind":"arxiv_version","alias_value":"1605.01639v6","created_at":"2026-05-18T00:19:59Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.1605.01639","created_at":"2026-05-18T00:19:59Z"},{"alias_kind":"pith_short_12","alias_value":"ASULEUC2B5EA","created_at":"2026-05-18T12:30:07Z"},{"alias_kind":"pith_short_16","alias_value":"ASULEUC2B5EASDYW","created_at":"2026-05-18T12:30:07Z"},{"alias_kind":"pith_short_8","alias_value":"ASULEUC2","created_at":"2026-05-18T12:30:07Z"}],"graph_snapshots":[{"event_id":"sha256:44e0e3ee8c18ad3336bb3adde6a0fdf0442ad8f56f62c0d219fffd6cacdf3ee3","target":"graph","created_at":"2026-05-18T00:19:59Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"graph_snapshot":{"author_claims":{"count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","strong_count":0},"builder_version":"pith-number-builder-2026-05-17-v1","claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"paper":{"abstract_excerpt":"Cells adapt their metabolic fluxes in response to changes in the environment. We present a framework for the systematic construction of flux-based graphs derived from organism-wide metabolic networks. Our graphs encode the directionality of metabolic fluxes via edges that represent the flow of metabolites from source to target reactions. The methodology can be applied in the absence of a specific biological context by modelling fluxes probabilistically, or can be tailored to different environmental conditions by incorporating flux distributions computed through constraint-based approaches such","authors_text":"Diego Oyarz\\'un, Gabriel Bosque, Jes\\'us Pic\\'o, Mariano Beguerisse-D\\'iaz, Mauricio Barahona","cross_cats":["cs.SI","physics.soc-ph"],"headline":"","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.MN","submitted_at":"2016-05-05T16:09:08Z","title":"Flux-dependent graphs for metabolic networks"},"references":{"count":0,"internal_anchors":0,"resolved_work":0,"sample":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"1605.01639","kind":"arxiv","version":6},"verdict":{"created_at":null,"id":null,"model_set":{},"one_line_summary":"","pipeline_version":null,"pith_extraction_headline":"","strongest_claim":"","weakest_assumption":""}},"verdict_id":null}}],"author_attestations":[],"timestamp_anchors":[],"storage_attestations":[],"citation_signatures":[],"replication_records":[],"corrections":[],"mirror_hints":[],"record_created":{"event_id":"sha256:bed1b74c77728dbcedfde938cc8ae0d5023136724141c2d3fce4de5211a9df37","target":"record","created_at":"2026-05-18T00:19:59Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"attestation_state":"computed","canonical_record":{"metadata":{"abstract_canon_sha256":"b461ff577f8001c8b8be48a4ee2c737a14dffb606e9f1f84eb16abce044b6554","cross_cats_sorted":["cs.SI","physics.soc-ph"],"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.MN","submitted_at":"2016-05-05T16:09:08Z","title_canon_sha256":"facadd05d0a78c025868b92ee73524d9a9bdd2da7aaaa115428029f75012c9bc"},"schema_version":"1.0","source":{"id":"1605.01639","kind":"arxiv","version":6}},"canonical_sha256":"04a8b2505a0f48090f16f76f2561c9326d66e13a4bf63827420f4996ec0ce122","receipt":{"algorithm":"ed25519","builder_version":"pith-number-builder-2026-05-17-v1","canonical_sha256":"04a8b2505a0f48090f16f76f2561c9326d66e13a4bf63827420f4996ec0ce122","first_computed_at":"2026-05-18T00:19:59.492370Z","key_id":"pith-v1-2026-05","kind":"pith_receipt","last_reissued_at":"2026-05-18T00:19:59.492370Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","receipt_version":"0.3","signature_b64":"YRRdZcOTkRDLIGyZCHSZKdE7KRfjd/3QZRXb81q/fsXfePr8RxlqQ+gI73jgliPZq5GrfrLw+TsCNOYbpuNHBQ==","signature_status":"signed_v1","signed_at":"2026-05-18T00:19:59.492990Z","signed_message":"canonical_sha256_bytes"},"source_id":"1605.01639","source_kind":"arxiv","source_version":6}}},"equivocations":[],"invalid_events":[],"applied_event_ids":["sha256:bed1b74c77728dbcedfde938cc8ae0d5023136724141c2d3fce4de5211a9df37","sha256:44e0e3ee8c18ad3336bb3adde6a0fdf0442ad8f56f62c0d219fffd6cacdf3ee3"],"state_sha256":"5e052e49b7683cf482e0526353dc799a23f06c1ce30f96f1264a011b3aa76b21"},"bundle_signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"+BFIKI/0cZcaRa6iGEV8taxL+uvfWU9U1Jwncb6zM9hlkcBZN69wxNDm8dZJt/NUpx9OEM1IfW6/eFv98TNAAg==","signed_message":"bundle_sha256_bytes","signed_at":"2026-05-26T12:00:04.638973Z","bundle_sha256":"35d760b5d6e3db5673ca7088bc3e9fb1180d05a04e8dfc802cc3528a7a4ac966"}}