{"bundle_type":"pith_open_graph_bundle","bundle_version":"1.0","pith_number":"pith:2019:ATRR4Z2AIG3ZG74LF6I7COJRIM","short_pith_number":"pith:ATRR4Z2A","canonical_record":{"source":{"id":"1903.05610","kind":"arxiv","version":3},"metadata":{"license":"http://creativecommons.org/licenses/by-nc-sa/4.0/","primary_cat":"q-bio.NC","submitted_at":"2019-03-13T17:16:52Z","cross_cats_sorted":[],"title_canon_sha256":"cf98773dfeccf1574659a28788fff781afb657223859fccec208b67837b32076","abstract_canon_sha256":"209b87b0aaccc9be38e5f2ebb6e633d410966bd4e21b9c33110829bf9a6a8a90"},"schema_version":"1.0"},"canonical_sha256":"04e31e674041b7937f8b2f91f1393143138d55d88529f57b84b6455a276fa3a6","source":{"kind":"arxiv","id":"1903.05610","version":3},"source_aliases":[{"alias_kind":"arxiv","alias_value":"1903.05610","created_at":"2026-05-17T23:48:19Z"},{"alias_kind":"arxiv_version","alias_value":"1903.05610v3","created_at":"2026-05-17T23:48:19Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.1903.05610","created_at":"2026-05-17T23:48:19Z"},{"alias_kind":"pith_short_12","alias_value":"ATRR4Z2AIG3Z","created_at":"2026-05-18T12:33:12Z"},{"alias_kind":"pith_short_16","alias_value":"ATRR4Z2AIG3ZG74L","created_at":"2026-05-18T12:33:12Z"},{"alias_kind":"pith_short_8","alias_value":"ATRR4Z2A","created_at":"2026-05-18T12:33:12Z"}],"events":[{"event_type":"record_created","subject_pith_number":"pith:2019:ATRR4Z2AIG3ZG74LF6I7COJRIM","target":"record","payload":{"canonical_record":{"source":{"id":"1903.05610","kind":"arxiv","version":3},"metadata":{"license":"http://creativecommons.org/licenses/by-nc-sa/4.0/","primary_cat":"q-bio.NC","submitted_at":"2019-03-13T17:16:52Z","cross_cats_sorted":[],"title_canon_sha256":"cf98773dfeccf1574659a28788fff781afb657223859fccec208b67837b32076","abstract_canon_sha256":"209b87b0aaccc9be38e5f2ebb6e633d410966bd4e21b9c33110829bf9a6a8a90"},"schema_version":"1.0"},"canonical_sha256":"04e31e674041b7937f8b2f91f1393143138d55d88529f57b84b6455a276fa3a6","receipt":{"kind":"pith_receipt","key_id":"pith-v1-2026-05","algorithm":"ed25519","signed_at":"2026-05-17T23:48:19.776835Z","signature_b64":"XUj4OSUGCy3EyxEYNwcbvNtG58RWZCV67ApuFv95mCovF6QN0/pc3+GDHrNqrPMSpxxRrIvcJBvaiNvtNjveCg==","signed_message":"canonical_sha256_bytes","builder_version":"pith-number-builder-2026-05-17-v1","receipt_version":"0.3","canonical_sha256":"04e31e674041b7937f8b2f91f1393143138d55d88529f57b84b6455a276fa3a6","last_reissued_at":"2026-05-17T23:48:19.776299Z","signature_status":"signed_v1","first_computed_at":"2026-05-17T23:48:19.776299Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"source_kind":"arxiv","source_id":"1903.05610","source_version":3,"attestation_state":"computed"},"signer":{"signer_id":"pith.science","signer_type":"pith_registry","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"created_at":"2026-05-17T23:48:19Z","supersedes":[],"prev_event":null,"signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"lVFfv4OnciVBohbRU4e/9Q92ihrcyG3esi3gQeIOHeXf7ZxNDhGnf9DOGY8hJR3WrqBwwaniwqwQma4r7sHbBQ==","signed_message":"open_graph_event_sha256_bytes","signed_at":"2026-06-09T10:30:26.925874Z"},"content_sha256":"a954a2bcb8923cc7c5d9cf6f3007522959b2a262f2e070be751f56ef775b0012","schema_version":"1.0","event_id":"sha256:a954a2bcb8923cc7c5d9cf6f3007522959b2a262f2e070be751f56ef775b0012"},{"event_type":"graph_snapshot","subject_pith_number":"pith:2019:ATRR4Z2AIG3ZG74LF6I7COJRIM","target":"graph","payload":{"graph_snapshot":{"paper":{"title":"How Can Memories Last for Days, Years, or a Lifetime? Proposed Mechanisms for Maintaining Synaptic Potentiation and Memory","license":"http://creativecommons.org/licenses/by-nc-sa/4.0/","headline":"","cross_cats":[],"primary_cat":"q-bio.NC","authors_text":"Douglas A. Baxter, John H. Byrne, Paul Smolen","submitted_at":"2019-03-13T17:16:52Z","abstract_excerpt":"With memory encoding reliant on persistent changes in the properties of synapses, a key question is how can memories be maintained from days to months or a lifetime given molecular turnover? It is likely that positive feedback loops are necessary to persistently maintain the strength of synapses that participate in encoding. Such feedback may occur within signal-transduction cascades and/or the regulation of translation, and it may occur within specific subcellular compartments or within neuronal networks. Not surprisingly, numerous positive feedback loops have been proposed. Some posited loop"},"claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"1903.05610","kind":"arxiv","version":3},"verdict":{"id":null,"model_set":{},"created_at":null,"strongest_claim":"","one_line_summary":"","pipeline_version":null,"weakest_assumption":"","pith_extraction_headline":""},"references":{"count":0,"sample":[],"resolved_work":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","internal_anchors":0},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"author_claims":{"count":0,"strong_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"builder_version":"pith-number-builder-2026-05-17-v1"},"verdict_id":null},"signer":{"signer_id":"pith.science","signer_type":"pith_registry","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"created_at":"2026-05-17T23:48:19Z","supersedes":[],"prev_event":null,"signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"f9pXjG0tBMs9YBiNQ4iVoFXev4BauAMIs33IukawxqpczdPtigJDZApcToktQSayDPMv4qmdhUK0QKXfUIcVAA==","signed_message":"open_graph_event_sha256_bytes","signed_at":"2026-06-09T10:30:26.926714Z"},"content_sha256":"29cdbb07e24bb69df85e0ec3a14312bc67e67a80afdc8637aec82279f56b023e","schema_version":"1.0","event_id":"sha256:29cdbb07e24bb69df85e0ec3a14312bc67e67a80afdc8637aec82279f56b023e"}],"timestamp_proofs":[],"mirror_hints":[{"mirror_type":"https","name":"Pith Resolver","base_url":"https://pith.science","bundle_url":"https://pith.science/pith/ATRR4Z2AIG3ZG74LF6I7COJRIM/bundle.json","state_url":"https://pith.science/pith/ATRR4Z2AIG3ZG74LF6I7COJRIM/state.json","well_known_bundle_url":"https://pith.science/.well-known/pith/ATRR4Z2AIG3ZG74LF6I7COJRIM/bundle.json","status":"primary"}],"public_keys":[{"key_id":"pith-v1-2026-05","algorithm":"ed25519","format":"raw","public_key_b64":"stVStoiQhXFxp4s2pdzPNoqVNBMojDU/fJ2db5S3CbM=","public_key_hex":"b2d552b68890857171a78b36a5dccf368a953413288c353f7c9d9d6f94b709b3","fingerprint_sha256_b32_first128bits":"RVFV5Z2OI2J3ZUO7ERDEBCYNKS","fingerprint_sha256_hex":"8d4b5ee74e4693bcd1df2446408b0d54","rotates_at":null,"url":"https://pith.science/pith-signing-key.json","notes":"Pith uses this Ed25519 key to sign canonical record SHA-256 digests. Verify with: ed25519_verify(public_key, message=canonical_sha256_bytes, signature=base64decode(signature_b64))."}],"merge_version":"pith-open-graph-merge-v1","built_at":"2026-06-09T10:30:26Z","links":{"resolver":"https://pith.science/pith/ATRR4Z2AIG3ZG74LF6I7COJRIM","bundle":"https://pith.science/pith/ATRR4Z2AIG3ZG74LF6I7COJRIM/bundle.json","state":"https://pith.science/pith/ATRR4Z2AIG3ZG74LF6I7COJRIM/state.json","well_known_bundle":"https://pith.science/.well-known/pith/ATRR4Z2AIG3ZG74LF6I7COJRIM/bundle.json"},"state":{"state_type":"pith_open_graph_state","state_version":"1.0","pith_number":"pith:2019:ATRR4Z2AIG3ZG74LF6I7COJRIM","merge_version":"pith-open-graph-merge-v1","event_count":2,"valid_event_count":2,"invalid_event_count":0,"equivocation_count":0,"current":{"canonical_record":{"metadata":{"abstract_canon_sha256":"209b87b0aaccc9be38e5f2ebb6e633d410966bd4e21b9c33110829bf9a6a8a90","cross_cats_sorted":[],"license":"http://creativecommons.org/licenses/by-nc-sa/4.0/","primary_cat":"q-bio.NC","submitted_at":"2019-03-13T17:16:52Z","title_canon_sha256":"cf98773dfeccf1574659a28788fff781afb657223859fccec208b67837b32076"},"schema_version":"1.0","source":{"id":"1903.05610","kind":"arxiv","version":3}},"source_aliases":[{"alias_kind":"arxiv","alias_value":"1903.05610","created_at":"2026-05-17T23:48:19Z"},{"alias_kind":"arxiv_version","alias_value":"1903.05610v3","created_at":"2026-05-17T23:48:19Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.1903.05610","created_at":"2026-05-17T23:48:19Z"},{"alias_kind":"pith_short_12","alias_value":"ATRR4Z2AIG3Z","created_at":"2026-05-18T12:33:12Z"},{"alias_kind":"pith_short_16","alias_value":"ATRR4Z2AIG3ZG74L","created_at":"2026-05-18T12:33:12Z"},{"alias_kind":"pith_short_8","alias_value":"ATRR4Z2A","created_at":"2026-05-18T12:33:12Z"}],"graph_snapshots":[{"event_id":"sha256:29cdbb07e24bb69df85e0ec3a14312bc67e67a80afdc8637aec82279f56b023e","target":"graph","created_at":"2026-05-17T23:48:19Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"graph_snapshot":{"author_claims":{"count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","strong_count":0},"builder_version":"pith-number-builder-2026-05-17-v1","claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"paper":{"abstract_excerpt":"With memory encoding reliant on persistent changes in the properties of synapses, a key question is how can memories be maintained from days to months or a lifetime given molecular turnover? It is likely that positive feedback loops are necessary to persistently maintain the strength of synapses that participate in encoding. Such feedback may occur within signal-transduction cascades and/or the regulation of translation, and it may occur within specific subcellular compartments or within neuronal networks. Not surprisingly, numerous positive feedback loops have been proposed. Some posited loop","authors_text":"Douglas A. Baxter, John H. Byrne, Paul Smolen","cross_cats":[],"headline":"","license":"http://creativecommons.org/licenses/by-nc-sa/4.0/","primary_cat":"q-bio.NC","submitted_at":"2019-03-13T17:16:52Z","title":"How Can Memories Last for Days, Years, or a Lifetime? Proposed Mechanisms for Maintaining Synaptic Potentiation and Memory"},"references":{"count":0,"internal_anchors":0,"resolved_work":0,"sample":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"1903.05610","kind":"arxiv","version":3},"verdict":{"created_at":null,"id":null,"model_set":{},"one_line_summary":"","pipeline_version":null,"pith_extraction_headline":"","strongest_claim":"","weakest_assumption":""}},"verdict_id":null}}],"author_attestations":[],"timestamp_anchors":[],"storage_attestations":[],"citation_signatures":[],"replication_records":[],"corrections":[],"mirror_hints":[],"record_created":{"event_id":"sha256:a954a2bcb8923cc7c5d9cf6f3007522959b2a262f2e070be751f56ef775b0012","target":"record","created_at":"2026-05-17T23:48:19Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"attestation_state":"computed","canonical_record":{"metadata":{"abstract_canon_sha256":"209b87b0aaccc9be38e5f2ebb6e633d410966bd4e21b9c33110829bf9a6a8a90","cross_cats_sorted":[],"license":"http://creativecommons.org/licenses/by-nc-sa/4.0/","primary_cat":"q-bio.NC","submitted_at":"2019-03-13T17:16:52Z","title_canon_sha256":"cf98773dfeccf1574659a28788fff781afb657223859fccec208b67837b32076"},"schema_version":"1.0","source":{"id":"1903.05610","kind":"arxiv","version":3}},"canonical_sha256":"04e31e674041b7937f8b2f91f1393143138d55d88529f57b84b6455a276fa3a6","receipt":{"algorithm":"ed25519","builder_version":"pith-number-builder-2026-05-17-v1","canonical_sha256":"04e31e674041b7937f8b2f91f1393143138d55d88529f57b84b6455a276fa3a6","first_computed_at":"2026-05-17T23:48:19.776299Z","key_id":"pith-v1-2026-05","kind":"pith_receipt","last_reissued_at":"2026-05-17T23:48:19.776299Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","receipt_version":"0.3","signature_b64":"XUj4OSUGCy3EyxEYNwcbvNtG58RWZCV67ApuFv95mCovF6QN0/pc3+GDHrNqrPMSpxxRrIvcJBvaiNvtNjveCg==","signature_status":"signed_v1","signed_at":"2026-05-17T23:48:19.776835Z","signed_message":"canonical_sha256_bytes"},"source_id":"1903.05610","source_kind":"arxiv","source_version":3}}},"equivocations":[],"invalid_events":[],"applied_event_ids":["sha256:a954a2bcb8923cc7c5d9cf6f3007522959b2a262f2e070be751f56ef775b0012","sha256:29cdbb07e24bb69df85e0ec3a14312bc67e67a80afdc8637aec82279f56b023e"],"state_sha256":"e62d894323d715602b04edd3160acf6ca351cebc5d0fe0715b6075a76cc1d79c"},"bundle_signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"r5BKxsz40ISHAnMiFny9UCY1hrhyB5NHt3IEhYpaE1/vJe6LTJcZ9Xa7Lt5+oGZvoVXfdmxRQBi/eNVLCs7JDA==","signed_message":"bundle_sha256_bytes","signed_at":"2026-06-09T10:30:26.930847Z","bundle_sha256":"79bb35b8e34f3dce288ac656c3b14158896edf531bf79d1685acaf6339cb0278"}}