{"bundle_type":"pith_open_graph_bundle","bundle_version":"1.0","pith_number":"pith:2013:AYOAQL2DKXZANL3JQIUQFKI4AS","short_pith_number":"pith:AYOAQL2D","canonical_record":{"source":{"id":"1307.2588","kind":"arxiv","version":1},"metadata":{"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"physics.bio-ph","submitted_at":"2013-07-09T20:17:34Z","cross_cats_sorted":["physics.chem-ph","q-bio.BM"],"title_canon_sha256":"d348cac6a33c927a10b1e099dcef004b7927dea2fc3fc3d9b585ae8b23e64f43","abstract_canon_sha256":"5a53b3640b16cadd470df9099a88f6761ce45c1202ef2561ff584155e5ff97e0"},"schema_version":"1.0"},"canonical_sha256":"061c082f4355f206af69822902a91c04ac7d980d73d7e1fa061a3131b0df0ae0","source":{"kind":"arxiv","id":"1307.2588","version":1},"source_aliases":[{"alias_kind":"arxiv","alias_value":"1307.2588","created_at":"2026-05-18T03:18:50Z"},{"alias_kind":"arxiv_version","alias_value":"1307.2588v1","created_at":"2026-05-18T03:18:50Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.1307.2588","created_at":"2026-05-18T03:18:50Z"},{"alias_kind":"pith_short_12","alias_value":"AYOAQL2DKXZA","created_at":"2026-05-18T12:27:38Z"},{"alias_kind":"pith_short_16","alias_value":"AYOAQL2DKXZANL3J","created_at":"2026-05-18T12:27:38Z"},{"alias_kind":"pith_short_8","alias_value":"AYOAQL2D","created_at":"2026-05-18T12:27:38Z"}],"events":[{"event_type":"record_created","subject_pith_number":"pith:2013:AYOAQL2DKXZANL3JQIUQFKI4AS","target":"record","payload":{"canonical_record":{"source":{"id":"1307.2588","kind":"arxiv","version":1},"metadata":{"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"physics.bio-ph","submitted_at":"2013-07-09T20:17:34Z","cross_cats_sorted":["physics.chem-ph","q-bio.BM"],"title_canon_sha256":"d348cac6a33c927a10b1e099dcef004b7927dea2fc3fc3d9b585ae8b23e64f43","abstract_canon_sha256":"5a53b3640b16cadd470df9099a88f6761ce45c1202ef2561ff584155e5ff97e0"},"schema_version":"1.0"},"canonical_sha256":"061c082f4355f206af69822902a91c04ac7d980d73d7e1fa061a3131b0df0ae0","receipt":{"kind":"pith_receipt","key_id":"pith-v1-2026-05","algorithm":"ed25519","signed_at":"2026-05-18T03:18:50.995266Z","signature_b64":"gUXj/7TLjqFxk1WTkMcU+TyzelicFshEygyW6yPs5Nh/lZ6AdZPbM19zkrM4bxw8UU6lDM6lCayNc0S3SOnFCg==","signed_message":"canonical_sha256_bytes","builder_version":"pith-number-builder-2026-05-17-v1","receipt_version":"0.3","canonical_sha256":"061c082f4355f206af69822902a91c04ac7d980d73d7e1fa061a3131b0df0ae0","last_reissued_at":"2026-05-18T03:18:50.994769Z","signature_status":"signed_v1","first_computed_at":"2026-05-18T03:18:50.994769Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"source_kind":"arxiv","source_id":"1307.2588","source_version":1,"attestation_state":"computed"},"signer":{"signer_id":"pith.science","signer_type":"pith_registry","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"created_at":"2026-05-18T03:18:50Z","supersedes":[],"prev_event":null,"signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"pLyQWCXD7JUJqxNCCIqwchKSZSP5aQ/0ycSSP9s7yai2HbEFsjeqR7GAMIePA6LBJXxGKpnuKgqRnf8Hi5tBCA==","signed_message":"open_graph_event_sha256_bytes","signed_at":"2026-06-07T11:01:32.988475Z"},"content_sha256":"33bfe332a15a4d0febd2369e6e6b17d44487b0b7f0176343773180405befdd2d","schema_version":"1.0","event_id":"sha256:33bfe332a15a4d0febd2369e6e6b17d44487b0b7f0176343773180405befdd2d"},{"event_type":"graph_snapshot","subject_pith_number":"pith:2013:AYOAQL2DKXZANL3JQIUQFKI4AS","target":"graph","payload":{"graph_snapshot":{"paper":{"title":"Protein Energy Landscapes Determined by 5-Dimensional Crystallography","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","headline":"","cross_cats":["physics.chem-ph","q-bio.BM"],"primary_cat":"physics.bio-ph","authors_text":"Hyotcherl Ihee, Jason Tenboer, Marius Schmidt, Namrta Purwar, Robert Henning, Shailesh Tripathi, Vukica Srajer","submitted_at":"2013-07-09T20:17:34Z","abstract_excerpt":"Free energy landscapes decisively determine the progress of enzymatically catalyzed reactions[1]. Time-resolved macromolecular crystallography unifies transient-state kinetics with structure determination [2-4] because both can be determined from the same set of X-ray data. We demonstrate here how barriers of activation can be determined solely from five-dimensional crystallography [5]. Directly linking molecular structures with barriers of activation between them allows for gaining insight into the structural nature of the barrier. We analyze comprehensive time series of crystal-lographic dat"},"claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"1307.2588","kind":"arxiv","version":1},"verdict":{"id":null,"model_set":{},"created_at":null,"strongest_claim":"","one_line_summary":"","pipeline_version":null,"weakest_assumption":"","pith_extraction_headline":""},"references":{"count":0,"sample":[],"resolved_work":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","internal_anchors":0},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"author_claims":{"count":0,"strong_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"builder_version":"pith-number-builder-2026-05-17-v1"},"verdict_id":null},"signer":{"signer_id":"pith.science","signer_type":"pith_registry","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"created_at":"2026-05-18T03:18:50Z","supersedes":[],"prev_event":null,"signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"OAGzpXRPeAlA3F81M0BqHIBzDrjut1voS/yLbaNh+xx0wcQwGV9JLbneG86m1OnGOlVyrHwPwZIBb2esusMZAQ==","signed_message":"open_graph_event_sha256_bytes","signed_at":"2026-06-07T11:01:32.989358Z"},"content_sha256":"ebf9317061511293945b99a8111014e05a08cc547264a3ff3e294b7a018c0ef1","schema_version":"1.0","event_id":"sha256:ebf9317061511293945b99a8111014e05a08cc547264a3ff3e294b7a018c0ef1"}],"timestamp_proofs":[],"mirror_hints":[{"mirror_type":"https","name":"Pith Resolver","base_url":"https://pith.science","bundle_url":"https://pith.science/pith/AYOAQL2DKXZANL3JQIUQFKI4AS/bundle.json","state_url":"https://pith.science/pith/AYOAQL2DKXZANL3JQIUQFKI4AS/state.json","well_known_bundle_url":"https://pith.science/.well-known/pith/AYOAQL2DKXZANL3JQIUQFKI4AS/bundle.json","status":"primary"}],"public_keys":[{"key_id":"pith-v1-2026-05","algorithm":"ed25519","format":"raw","public_key_b64":"stVStoiQhXFxp4s2pdzPNoqVNBMojDU/fJ2db5S3CbM=","public_key_hex":"b2d552b68890857171a78b36a5dccf368a953413288c353f7c9d9d6f94b709b3","fingerprint_sha256_b32_first128bits":"RVFV5Z2OI2J3ZUO7ERDEBCYNKS","fingerprint_sha256_hex":"8d4b5ee74e4693bcd1df2446408b0d54","rotates_at":null,"url":"https://pith.science/pith-signing-key.json","notes":"Pith uses this Ed25519 key to sign canonical record SHA-256 digests. Verify with: ed25519_verify(public_key, message=canonical_sha256_bytes, signature=base64decode(signature_b64))."}],"merge_version":"pith-open-graph-merge-v1","built_at":"2026-06-07T11:01:32Z","links":{"resolver":"https://pith.science/pith/AYOAQL2DKXZANL3JQIUQFKI4AS","bundle":"https://pith.science/pith/AYOAQL2DKXZANL3JQIUQFKI4AS/bundle.json","state":"https://pith.science/pith/AYOAQL2DKXZANL3JQIUQFKI4AS/state.json","well_known_bundle":"https://pith.science/.well-known/pith/AYOAQL2DKXZANL3JQIUQFKI4AS/bundle.json"},"state":{"state_type":"pith_open_graph_state","state_version":"1.0","pith_number":"pith:2013:AYOAQL2DKXZANL3JQIUQFKI4AS","merge_version":"pith-open-graph-merge-v1","event_count":2,"valid_event_count":2,"invalid_event_count":0,"equivocation_count":0,"current":{"canonical_record":{"metadata":{"abstract_canon_sha256":"5a53b3640b16cadd470df9099a88f6761ce45c1202ef2561ff584155e5ff97e0","cross_cats_sorted":["physics.chem-ph","q-bio.BM"],"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"physics.bio-ph","submitted_at":"2013-07-09T20:17:34Z","title_canon_sha256":"d348cac6a33c927a10b1e099dcef004b7927dea2fc3fc3d9b585ae8b23e64f43"},"schema_version":"1.0","source":{"id":"1307.2588","kind":"arxiv","version":1}},"source_aliases":[{"alias_kind":"arxiv","alias_value":"1307.2588","created_at":"2026-05-18T03:18:50Z"},{"alias_kind":"arxiv_version","alias_value":"1307.2588v1","created_at":"2026-05-18T03:18:50Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.1307.2588","created_at":"2026-05-18T03:18:50Z"},{"alias_kind":"pith_short_12","alias_value":"AYOAQL2DKXZA","created_at":"2026-05-18T12:27:38Z"},{"alias_kind":"pith_short_16","alias_value":"AYOAQL2DKXZANL3J","created_at":"2026-05-18T12:27:38Z"},{"alias_kind":"pith_short_8","alias_value":"AYOAQL2D","created_at":"2026-05-18T12:27:38Z"}],"graph_snapshots":[{"event_id":"sha256:ebf9317061511293945b99a8111014e05a08cc547264a3ff3e294b7a018c0ef1","target":"graph","created_at":"2026-05-18T03:18:50Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"graph_snapshot":{"author_claims":{"count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","strong_count":0},"builder_version":"pith-number-builder-2026-05-17-v1","claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"paper":{"abstract_excerpt":"Free energy landscapes decisively determine the progress of enzymatically catalyzed reactions[1]. Time-resolved macromolecular crystallography unifies transient-state kinetics with structure determination [2-4] because both can be determined from the same set of X-ray data. We demonstrate here how barriers of activation can be determined solely from five-dimensional crystallography [5]. Directly linking molecular structures with barriers of activation between them allows for gaining insight into the structural nature of the barrier. We analyze comprehensive time series of crystal-lographic dat","authors_text":"Hyotcherl Ihee, Jason Tenboer, Marius Schmidt, Namrta Purwar, Robert Henning, Shailesh Tripathi, Vukica Srajer","cross_cats":["physics.chem-ph","q-bio.BM"],"headline":"","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"physics.bio-ph","submitted_at":"2013-07-09T20:17:34Z","title":"Protein Energy Landscapes Determined by 5-Dimensional Crystallography"},"references":{"count":0,"internal_anchors":0,"resolved_work":0,"sample":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"1307.2588","kind":"arxiv","version":1},"verdict":{"created_at":null,"id":null,"model_set":{},"one_line_summary":"","pipeline_version":null,"pith_extraction_headline":"","strongest_claim":"","weakest_assumption":""}},"verdict_id":null}}],"author_attestations":[],"timestamp_anchors":[],"storage_attestations":[],"citation_signatures":[],"replication_records":[],"corrections":[],"mirror_hints":[],"record_created":{"event_id":"sha256:33bfe332a15a4d0febd2369e6e6b17d44487b0b7f0176343773180405befdd2d","target":"record","created_at":"2026-05-18T03:18:50Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"attestation_state":"computed","canonical_record":{"metadata":{"abstract_canon_sha256":"5a53b3640b16cadd470df9099a88f6761ce45c1202ef2561ff584155e5ff97e0","cross_cats_sorted":["physics.chem-ph","q-bio.BM"],"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"physics.bio-ph","submitted_at":"2013-07-09T20:17:34Z","title_canon_sha256":"d348cac6a33c927a10b1e099dcef004b7927dea2fc3fc3d9b585ae8b23e64f43"},"schema_version":"1.0","source":{"id":"1307.2588","kind":"arxiv","version":1}},"canonical_sha256":"061c082f4355f206af69822902a91c04ac7d980d73d7e1fa061a3131b0df0ae0","receipt":{"algorithm":"ed25519","builder_version":"pith-number-builder-2026-05-17-v1","canonical_sha256":"061c082f4355f206af69822902a91c04ac7d980d73d7e1fa061a3131b0df0ae0","first_computed_at":"2026-05-18T03:18:50.994769Z","key_id":"pith-v1-2026-05","kind":"pith_receipt","last_reissued_at":"2026-05-18T03:18:50.994769Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","receipt_version":"0.3","signature_b64":"gUXj/7TLjqFxk1WTkMcU+TyzelicFshEygyW6yPs5Nh/lZ6AdZPbM19zkrM4bxw8UU6lDM6lCayNc0S3SOnFCg==","signature_status":"signed_v1","signed_at":"2026-05-18T03:18:50.995266Z","signed_message":"canonical_sha256_bytes"},"source_id":"1307.2588","source_kind":"arxiv","source_version":1}}},"equivocations":[],"invalid_events":[],"applied_event_ids":["sha256:33bfe332a15a4d0febd2369e6e6b17d44487b0b7f0176343773180405befdd2d","sha256:ebf9317061511293945b99a8111014e05a08cc547264a3ff3e294b7a018c0ef1"],"state_sha256":"51c3cee341ae9be54bed4435397dfdde2c8c74f2e1f5e47859054fa417e3154a"},"bundle_signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"T6XiR2BwI3czzWvTLe2gwi5XcVD0QUbloOzZTzAjxlFanOcKJ/fZYW2ajyXIbmurkAN5mrX4e/EEHwGcMX4yAg==","signed_message":"bundle_sha256_bytes","signed_at":"2026-06-07T11:01:32.993656Z","bundle_sha256":"573aa87211a6691e726c70f3630bbd7753b6e6dd17f576018692700ed03e7cd8"}}