{"record_type":"pith_number_record","schema_url":"https://pith.science/schemas/pith-number/v1.json","pith_number":"pith:2016:B64FRWB4452KMGA6SMMSANXNRS","short_pith_number":"pith:B64FRWB4","schema_version":"1.0","canonical_sha256":"0fb858d83ce774a6181e93192036ed8cb72031377cbfa83ea0ddc1206b8f2467","source":{"kind":"arxiv","id":"1609.01570","version":1},"attestation_state":"computed","paper":{"title":"Personalized Mathematical Model Predicting Endotoxin-Induced Inflammatory Responses in Young Men","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","headline":"","cross_cats":["q-bio.TO"],"primary_cat":"q-bio.QM","authors_text":"Dennis O. Frank-Ito, Hien T. Tran, Jesper Mehlsen, Johnny T. Ottesen, Kirsten M{\\o}ller, Mette S. Olufsen, Renee Brady, Susanne Brix, Susanne Janum","submitted_at":"2016-09-06T14:24:35Z","abstract_excerpt":"The initial reaction of the body to pathogenic microbial infection or severe tissue trauma is an acute inflammatory response. The magnitude of such a response is of critical importance, since an uncontrolled response can cause further tissue damage, sepsis, and ultimately death, while an insufficient response can result in inadequate clearance of pathogens. A normal inflammatory response helps to annihilate threats posed by microbial pathogenic ligands, such as endotoxins, and thus, restore the body to a healthy state. Using a personalized mathematical model, comprehension and a detailed descr"},"verification_status":{"content_addressed":true,"pith_receipt":true,"author_attested":false,"weak_author_claims":0,"strong_author_claims":0,"externally_anchored":false,"storage_verified":false,"citation_signatures":0,"replication_records":0,"graph_snapshot":true,"references_resolved":false,"formal_links_present":false},"canonical_record":{"source":{"id":"1609.01570","kind":"arxiv","version":1},"metadata":{"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.QM","submitted_at":"2016-09-06T14:24:35Z","cross_cats_sorted":["q-bio.TO"],"title_canon_sha256":"4383b7e1a96a77e69a059ae61b351f6c47c8a4c933769d39775b4f312360729f","abstract_canon_sha256":"698e0d8a7e6dbe527d033ba4bf18cd0d6d2a7c2cfa59b20c3d39c0603514a769"},"schema_version":"1.0"},"receipt":{"kind":"pith_receipt","key_id":"pith-v1-2026-05","algorithm":"ed25519","signed_at":"2026-05-18T01:05:39.267294Z","signature_b64":"yB/FJlaU8/TPii9x6oggV/uz27uqY0xXlnMXPhwYJbb8OwjzV7zZH+aSQAosqohSyqDCTfjkRYwDhVjnlg/XBQ==","signed_message":"canonical_sha256_bytes","builder_version":"pith-number-builder-2026-05-17-v1","receipt_version":"0.3","canonical_sha256":"0fb858d83ce774a6181e93192036ed8cb72031377cbfa83ea0ddc1206b8f2467","last_reissued_at":"2026-05-18T01:05:39.266808Z","signature_status":"signed_v1","first_computed_at":"2026-05-18T01:05:39.266808Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"graph_snapshot":{"paper":{"title":"Personalized Mathematical Model Predicting Endotoxin-Induced Inflammatory Responses in Young Men","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","headline":"","cross_cats":["q-bio.TO"],"primary_cat":"q-bio.QM","authors_text":"Dennis O. Frank-Ito, Hien T. Tran, Jesper Mehlsen, Johnny T. Ottesen, Kirsten M{\\o}ller, Mette S. Olufsen, Renee Brady, Susanne Brix, Susanne Janum","submitted_at":"2016-09-06T14:24:35Z","abstract_excerpt":"The initial reaction of the body to pathogenic microbial infection or severe tissue trauma is an acute inflammatory response. The magnitude of such a response is of critical importance, since an uncontrolled response can cause further tissue damage, sepsis, and ultimately death, while an insufficient response can result in inadequate clearance of pathogens. A normal inflammatory response helps to annihilate threats posed by microbial pathogenic ligands, such as endotoxins, and thus, restore the body to a healthy state. Using a personalized mathematical model, comprehension and a detailed descr"},"claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"1609.01570","kind":"arxiv","version":1},"verdict":{"id":null,"model_set":{},"created_at":null,"strongest_claim":"","one_line_summary":"","pipeline_version":null,"weakest_assumption":"","pith_extraction_headline":""},"references":{"count":0,"sample":[],"resolved_work":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","internal_anchors":0},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"author_claims":{"count":0,"strong_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"builder_version":"pith-number-builder-2026-05-17-v1"},"aliases":[{"alias_kind":"arxiv","alias_value":"1609.01570","created_at":"2026-05-18T01:05:39.266893+00:00"},{"alias_kind":"arxiv_version","alias_value":"1609.01570v1","created_at":"2026-05-18T01:05:39.266893+00:00"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.1609.01570","created_at":"2026-05-18T01:05:39.266893+00:00"},{"alias_kind":"pith_short_12","alias_value":"B64FRWB4452K","created_at":"2026-05-18T12:30:07.202191+00:00"},{"alias_kind":"pith_short_16","alias_value":"B64FRWB4452KMGA6","created_at":"2026-05-18T12:30:07.202191+00:00"},{"alias_kind":"pith_short_8","alias_value":"B64FRWB4","created_at":"2026-05-18T12:30:07.202191+00:00"}],"events":[],"event_summary":{},"paper_claims":[],"inbound_citations":{"count":0,"internal_anchor_count":0,"sample":[]},"formal_canon":{"evidence_count":0,"sample":[],"anchors":[]},"links":{"html":"https://pith.science/pith/B64FRWB4452KMGA6SMMSANXNRS","json":"https://pith.science/pith/B64FRWB4452KMGA6SMMSANXNRS.json","graph_json":"https://pith.science/api/pith-number/B64FRWB4452KMGA6SMMSANXNRS/graph.json","events_json":"https://pith.science/api/pith-number/B64FRWB4452KMGA6SMMSANXNRS/events.json","paper":"https://pith.science/paper/B64FRWB4"},"agent_actions":{"view_html":"https://pith.science/pith/B64FRWB4452KMGA6SMMSANXNRS","download_json":"https://pith.science/pith/B64FRWB4452KMGA6SMMSANXNRS.json","view_paper":"https://pith.science/paper/B64FRWB4","resolve_alias":"https://pith.science/api/pith-number/resolve?arxiv=1609.01570&json=true","fetch_graph":"https://pith.science/api/pith-number/B64FRWB4452KMGA6SMMSANXNRS/graph.json","fetch_events":"https://pith.science/api/pith-number/B64FRWB4452KMGA6SMMSANXNRS/events.json","actions":{"anchor_timestamp":"https://pith.science/pith/B64FRWB4452KMGA6SMMSANXNRS/action/timestamp_anchor","attest_storage":"https://pith.science/pith/B64FRWB4452KMGA6SMMSANXNRS/action/storage_attestation","attest_author":"https://pith.science/pith/B64FRWB4452KMGA6SMMSANXNRS/action/author_attestation","sign_citation":"https://pith.science/pith/B64FRWB4452KMGA6SMMSANXNRS/action/citation_signature","submit_replication":"https://pith.science/pith/B64FRWB4452KMGA6SMMSANXNRS/action/replication_record"}},"created_at":"2026-05-18T01:05:39.266893+00:00","updated_at":"2026-05-18T01:05:39.266893+00:00"}