{"bundle_type":"pith_open_graph_bundle","bundle_version":"1.0","pith_number":"pith:2019:BC2G6IE6IYFRDKZU4Q3PTPHGTA","short_pith_number":"pith:BC2G6IE6","canonical_record":{"source":{"id":"1904.07780","kind":"arxiv","version":1},"metadata":{"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.CB","submitted_at":"2019-04-16T16:04:50Z","cross_cats_sorted":["q-bio.MN"],"title_canon_sha256":"8076054acaeb809fa1e58733e9c11fd75a1574c93aa15f4c27cf6ed0c1afd5df","abstract_canon_sha256":"fa123a5957cdb02411c17084651bf36f356fcb882bd4a209992cdfad5665aa6b"},"schema_version":"1.0"},"canonical_sha256":"08b46f209e460b11ab34e436f9bce69819a0b635edf498a8abc0d5cec33f2133","source":{"kind":"arxiv","id":"1904.07780","version":1},"source_aliases":[{"alias_kind":"arxiv","alias_value":"1904.07780","created_at":"2026-05-17T23:48:24Z"},{"alias_kind":"arxiv_version","alias_value":"1904.07780v1","created_at":"2026-05-17T23:48:24Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.1904.07780","created_at":"2026-05-17T23:48:24Z"},{"alias_kind":"pith_short_12","alias_value":"BC2G6IE6IYFR","created_at":"2026-05-18T12:33:12Z"},{"alias_kind":"pith_short_16","alias_value":"BC2G6IE6IYFRDKZU","created_at":"2026-05-18T12:33:12Z"},{"alias_kind":"pith_short_8","alias_value":"BC2G6IE6","created_at":"2026-05-18T12:33:12Z"}],"events":[{"event_type":"record_created","subject_pith_number":"pith:2019:BC2G6IE6IYFRDKZU4Q3PTPHGTA","target":"record","payload":{"canonical_record":{"source":{"id":"1904.07780","kind":"arxiv","version":1},"metadata":{"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.CB","submitted_at":"2019-04-16T16:04:50Z","cross_cats_sorted":["q-bio.MN"],"title_canon_sha256":"8076054acaeb809fa1e58733e9c11fd75a1574c93aa15f4c27cf6ed0c1afd5df","abstract_canon_sha256":"fa123a5957cdb02411c17084651bf36f356fcb882bd4a209992cdfad5665aa6b"},"schema_version":"1.0"},"canonical_sha256":"08b46f209e460b11ab34e436f9bce69819a0b635edf498a8abc0d5cec33f2133","receipt":{"kind":"pith_receipt","key_id":"pith-v1-2026-05","algorithm":"ed25519","signed_at":"2026-05-17T23:48:24.257248Z","signature_b64":"n5KrnctRCzoqq65x6ffDLJalkotK2Zqk4J4yytv05jDmNSfsiwm0Xj5l2BFkX5dJmGoksEJsARHecQGVufvwBg==","signed_message":"canonical_sha256_bytes","builder_version":"pith-number-builder-2026-05-17-v1","receipt_version":"0.3","canonical_sha256":"08b46f209e460b11ab34e436f9bce69819a0b635edf498a8abc0d5cec33f2133","last_reissued_at":"2026-05-17T23:48:24.256635Z","signature_status":"signed_v1","first_computed_at":"2026-05-17T23:48:24.256635Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"source_kind":"arxiv","source_id":"1904.07780","source_version":1,"attestation_state":"computed"},"signer":{"signer_id":"pith.science","signer_type":"pith_registry","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"created_at":"2026-05-17T23:48:24Z","supersedes":[],"prev_event":null,"signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"H90yP6CkMLZzROUZqIheu5AxrTeYbHxjFAw1sRSg9pJAK6MRZ9NDBq/za5E0iQm5Zv1Nlksn4BjC7aYLSSz0CQ==","signed_message":"open_graph_event_sha256_bytes","signed_at":"2026-05-22T11:14:45.178166Z"},"content_sha256":"b191afccb4687f09c2824b4d05238101a62ab9e4aa51ad3ccf895d56efb86b46","schema_version":"1.0","event_id":"sha256:b191afccb4687f09c2824b4d05238101a62ab9e4aa51ad3ccf895d56efb86b46"},{"event_type":"graph_snapshot","subject_pith_number":"pith:2019:BC2G6IE6IYFRDKZU4Q3PTPHGTA","target":"graph","payload":{"graph_snapshot":{"paper":{"title":"Quantifying cancer epithelial-mesenchymal plasticity and its association with stemness and immune response","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","headline":"","cross_cats":["q-bio.MN"],"primary_cat":"q-bio.CB","authors_text":"Dongya Jia, Federico Bocci, Herbert Levine, Jose N. Onuchic, Mohit Kumar Jolly, Shubham Tripathi, Xuefei Li, Youyuan Deng","submitted_at":"2019-04-16T16:04:50Z","abstract_excerpt":"Cancer cells can acquire a spectrum of stable hybrid epithelial/mesenchymal (E/M) states during epithelial-mesenchymal transition (EMT). Cells in these hybrid E/M phenotypes often combine epithelial and mesenchymal features and tend to migrate collectively commonly as small clusters. Such collectively migrating cancer cells play a pivotal role in seeding metastases and their presence in cancer patients indicates an adverse prognostic factor. Moreover, cancer cells in hybrid E/M phenotypes tend to be more associated with stemness which endows them with tumor-initiation ability and therapy resis"},"claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"1904.07780","kind":"arxiv","version":1},"verdict":{"id":null,"model_set":{},"created_at":null,"strongest_claim":"","one_line_summary":"","pipeline_version":null,"weakest_assumption":"","pith_extraction_headline":""},"references":{"count":0,"sample":[],"resolved_work":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","internal_anchors":0},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"author_claims":{"count":0,"strong_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"builder_version":"pith-number-builder-2026-05-17-v1"},"verdict_id":null},"signer":{"signer_id":"pith.science","signer_type":"pith_registry","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"created_at":"2026-05-17T23:48:24Z","supersedes":[],"prev_event":null,"signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"fF9vhXMh4JKYMO9Cz8UNFi9Y414PoYqzO+z7sxvGR5FNikTQsQLc3sInJcKNXZCemyt/+ZiC7w9bjRihXWwqDg==","signed_message":"open_graph_event_sha256_bytes","signed_at":"2026-05-22T11:14:45.178845Z"},"content_sha256":"5d51bf3da510b056c5647e579d202a906ba707d5b88db1e5ac98b1b9c95e872e","schema_version":"1.0","event_id":"sha256:5d51bf3da510b056c5647e579d202a906ba707d5b88db1e5ac98b1b9c95e872e"}],"timestamp_proofs":[],"mirror_hints":[{"mirror_type":"https","name":"Pith Resolver","base_url":"https://pith.science","bundle_url":"https://pith.science/pith/BC2G6IE6IYFRDKZU4Q3PTPHGTA/bundle.json","state_url":"https://pith.science/pith/BC2G6IE6IYFRDKZU4Q3PTPHGTA/state.json","well_known_bundle_url":"https://pith.science/.well-known/pith/BC2G6IE6IYFRDKZU4Q3PTPHGTA/bundle.json","status":"primary"}],"public_keys":[{"key_id":"pith-v1-2026-05","algorithm":"ed25519","format":"raw","public_key_b64":"stVStoiQhXFxp4s2pdzPNoqVNBMojDU/fJ2db5S3CbM=","public_key_hex":"b2d552b68890857171a78b36a5dccf368a953413288c353f7c9d9d6f94b709b3","fingerprint_sha256_b32_first128bits":"RVFV5Z2OI2J3ZUO7ERDEBCYNKS","fingerprint_sha256_hex":"8d4b5ee74e4693bcd1df2446408b0d54","rotates_at":null,"url":"https://pith.science/pith-signing-key.json","notes":"Pith uses this Ed25519 key to sign canonical record SHA-256 digests. Verify with: ed25519_verify(public_key, message=canonical_sha256_bytes, signature=base64decode(signature_b64))."}],"merge_version":"pith-open-graph-merge-v1","built_at":"2026-05-22T11:14:45Z","links":{"resolver":"https://pith.science/pith/BC2G6IE6IYFRDKZU4Q3PTPHGTA","bundle":"https://pith.science/pith/BC2G6IE6IYFRDKZU4Q3PTPHGTA/bundle.json","state":"https://pith.science/pith/BC2G6IE6IYFRDKZU4Q3PTPHGTA/state.json","well_known_bundle":"https://pith.science/.well-known/pith/BC2G6IE6IYFRDKZU4Q3PTPHGTA/bundle.json"},"state":{"state_type":"pith_open_graph_state","state_version":"1.0","pith_number":"pith:2019:BC2G6IE6IYFRDKZU4Q3PTPHGTA","merge_version":"pith-open-graph-merge-v1","event_count":2,"valid_event_count":2,"invalid_event_count":0,"equivocation_count":0,"current":{"canonical_record":{"metadata":{"abstract_canon_sha256":"fa123a5957cdb02411c17084651bf36f356fcb882bd4a209992cdfad5665aa6b","cross_cats_sorted":["q-bio.MN"],"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.CB","submitted_at":"2019-04-16T16:04:50Z","title_canon_sha256":"8076054acaeb809fa1e58733e9c11fd75a1574c93aa15f4c27cf6ed0c1afd5df"},"schema_version":"1.0","source":{"id":"1904.07780","kind":"arxiv","version":1}},"source_aliases":[{"alias_kind":"arxiv","alias_value":"1904.07780","created_at":"2026-05-17T23:48:24Z"},{"alias_kind":"arxiv_version","alias_value":"1904.07780v1","created_at":"2026-05-17T23:48:24Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.1904.07780","created_at":"2026-05-17T23:48:24Z"},{"alias_kind":"pith_short_12","alias_value":"BC2G6IE6IYFR","created_at":"2026-05-18T12:33:12Z"},{"alias_kind":"pith_short_16","alias_value":"BC2G6IE6IYFRDKZU","created_at":"2026-05-18T12:33:12Z"},{"alias_kind":"pith_short_8","alias_value":"BC2G6IE6","created_at":"2026-05-18T12:33:12Z"}],"graph_snapshots":[{"event_id":"sha256:5d51bf3da510b056c5647e579d202a906ba707d5b88db1e5ac98b1b9c95e872e","target":"graph","created_at":"2026-05-17T23:48:24Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"graph_snapshot":{"author_claims":{"count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","strong_count":0},"builder_version":"pith-number-builder-2026-05-17-v1","claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"paper":{"abstract_excerpt":"Cancer cells can acquire a spectrum of stable hybrid epithelial/mesenchymal (E/M) states during epithelial-mesenchymal transition (EMT). Cells in these hybrid E/M phenotypes often combine epithelial and mesenchymal features and tend to migrate collectively commonly as small clusters. Such collectively migrating cancer cells play a pivotal role in seeding metastases and their presence in cancer patients indicates an adverse prognostic factor. Moreover, cancer cells in hybrid E/M phenotypes tend to be more associated with stemness which endows them with tumor-initiation ability and therapy resis","authors_text":"Dongya Jia, Federico Bocci, Herbert Levine, Jose N. Onuchic, Mohit Kumar Jolly, Shubham Tripathi, Xuefei Li, Youyuan Deng","cross_cats":["q-bio.MN"],"headline":"","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.CB","submitted_at":"2019-04-16T16:04:50Z","title":"Quantifying cancer epithelial-mesenchymal plasticity and its association with stemness and immune response"},"references":{"count":0,"internal_anchors":0,"resolved_work":0,"sample":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"1904.07780","kind":"arxiv","version":1},"verdict":{"created_at":null,"id":null,"model_set":{},"one_line_summary":"","pipeline_version":null,"pith_extraction_headline":"","strongest_claim":"","weakest_assumption":""}},"verdict_id":null}}],"author_attestations":[],"timestamp_anchors":[],"storage_attestations":[],"citation_signatures":[],"replication_records":[],"corrections":[],"mirror_hints":[],"record_created":{"event_id":"sha256:b191afccb4687f09c2824b4d05238101a62ab9e4aa51ad3ccf895d56efb86b46","target":"record","created_at":"2026-05-17T23:48:24Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"attestation_state":"computed","canonical_record":{"metadata":{"abstract_canon_sha256":"fa123a5957cdb02411c17084651bf36f356fcb882bd4a209992cdfad5665aa6b","cross_cats_sorted":["q-bio.MN"],"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.CB","submitted_at":"2019-04-16T16:04:50Z","title_canon_sha256":"8076054acaeb809fa1e58733e9c11fd75a1574c93aa15f4c27cf6ed0c1afd5df"},"schema_version":"1.0","source":{"id":"1904.07780","kind":"arxiv","version":1}},"canonical_sha256":"08b46f209e460b11ab34e436f9bce69819a0b635edf498a8abc0d5cec33f2133","receipt":{"algorithm":"ed25519","builder_version":"pith-number-builder-2026-05-17-v1","canonical_sha256":"08b46f209e460b11ab34e436f9bce69819a0b635edf498a8abc0d5cec33f2133","first_computed_at":"2026-05-17T23:48:24.256635Z","key_id":"pith-v1-2026-05","kind":"pith_receipt","last_reissued_at":"2026-05-17T23:48:24.256635Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","receipt_version":"0.3","signature_b64":"n5KrnctRCzoqq65x6ffDLJalkotK2Zqk4J4yytv05jDmNSfsiwm0Xj5l2BFkX5dJmGoksEJsARHecQGVufvwBg==","signature_status":"signed_v1","signed_at":"2026-05-17T23:48:24.257248Z","signed_message":"canonical_sha256_bytes"},"source_id":"1904.07780","source_kind":"arxiv","source_version":1}}},"equivocations":[],"invalid_events":[],"applied_event_ids":["sha256:b191afccb4687f09c2824b4d05238101a62ab9e4aa51ad3ccf895d56efb86b46","sha256:5d51bf3da510b056c5647e579d202a906ba707d5b88db1e5ac98b1b9c95e872e"],"state_sha256":"8e92f03cc3689a96b896cb8cd836c966b4456d794bbee671d453893cd98153d1"},"bundle_signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"xXDfj4jn3d3fKq1efiPJv1yjAgslNTpW4iojRBFU9D7AnYxz/YTwx/XPXPbskhR265A1bNMY/2Yy3DYru5EdBA==","signed_message":"bundle_sha256_bytes","signed_at":"2026-05-22T11:14:45.183568Z","bundle_sha256":"94154f18837841620cfb31fc2d38e4325905d56182715f5756a2ba77815d5f5a"}}