{"bundle_type":"pith_open_graph_bundle","bundle_version":"1.0","pith_number":"pith:2011:BD34GG6HEUNDTBOGRCDCRFHDXD","short_pith_number":"pith:BD34GG6H","canonical_record":{"source":{"id":"1105.2530","kind":"arxiv","version":1},"metadata":{"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.MN","submitted_at":"2011-05-12T17:04:52Z","cross_cats_sorted":["cond-mat.stat-mech","physics.bio-ph"],"title_canon_sha256":"dacf9428cb3787f1f9252f2a2c963c331f6b21d59229cffef2b3c1b7ad18a4c3","abstract_canon_sha256":"c17048c950e784beeebe616d540c49577fb6669db6d749826c6eb9c370a56826"},"schema_version":"1.0"},"canonical_sha256":"08f7c31bc7251a3985c688862894e3b8ded5e88dd24f95b1ef033fc61a05f013","source":{"kind":"arxiv","id":"1105.2530","version":1},"source_aliases":[{"alias_kind":"arxiv","alias_value":"1105.2530","created_at":"2026-05-18T04:22:10Z"},{"alias_kind":"arxiv_version","alias_value":"1105.2530v1","created_at":"2026-05-18T04:22:10Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.1105.2530","created_at":"2026-05-18T04:22:10Z"},{"alias_kind":"pith_short_12","alias_value":"BD34GG6HEUND","created_at":"2026-05-18T12:26:24Z"},{"alias_kind":"pith_short_16","alias_value":"BD34GG6HEUNDTBOG","created_at":"2026-05-18T12:26:24Z"},{"alias_kind":"pith_short_8","alias_value":"BD34GG6H","created_at":"2026-05-18T12:26:24Z"}],"events":[{"event_type":"record_created","subject_pith_number":"pith:2011:BD34GG6HEUNDTBOGRCDCRFHDXD","target":"record","payload":{"canonical_record":{"source":{"id":"1105.2530","kind":"arxiv","version":1},"metadata":{"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.MN","submitted_at":"2011-05-12T17:04:52Z","cross_cats_sorted":["cond-mat.stat-mech","physics.bio-ph"],"title_canon_sha256":"dacf9428cb3787f1f9252f2a2c963c331f6b21d59229cffef2b3c1b7ad18a4c3","abstract_canon_sha256":"c17048c950e784beeebe616d540c49577fb6669db6d749826c6eb9c370a56826"},"schema_version":"1.0"},"canonical_sha256":"08f7c31bc7251a3985c688862894e3b8ded5e88dd24f95b1ef033fc61a05f013","receipt":{"kind":"pith_receipt","key_id":"pith-v1-2026-05","algorithm":"ed25519","signed_at":"2026-05-18T04:22:10.478882Z","signature_b64":"lUbyOKqclwOfa/dFK9tIuyk868VeWl8eNkEQCVwfpbxNEkmpTMQntWNhgUH5BMsJ9zUYOHH/7Fc/ZyrWNZZfAQ==","signed_message":"canonical_sha256_bytes","builder_version":"pith-number-builder-2026-05-17-v1","receipt_version":"0.3","canonical_sha256":"08f7c31bc7251a3985c688862894e3b8ded5e88dd24f95b1ef033fc61a05f013","last_reissued_at":"2026-05-18T04:22:10.478394Z","signature_status":"signed_v1","first_computed_at":"2026-05-18T04:22:10.478394Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"source_kind":"arxiv","source_id":"1105.2530","source_version":1,"attestation_state":"computed"},"signer":{"signer_id":"pith.science","signer_type":"pith_registry","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"created_at":"2026-05-18T04:22:10Z","supersedes":[],"prev_event":null,"signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"RikbqsLD/KwZf8L4YG111Sc05h1f+TTS8eOp4IYHPFOO6/bw3P1yyGk0FhND+4nW1gachvQWJtHfvfaWkbROBA==","signed_message":"open_graph_event_sha256_bytes","signed_at":"2026-06-02T05:00:01.880160Z"},"content_sha256":"6037284d89873f8c0c96e8c382365c360310814bc8c1440a18fb60c3a8f80a92","schema_version":"1.0","event_id":"sha256:6037284d89873f8c0c96e8c382365c360310814bc8c1440a18fb60c3a8f80a92"},{"event_type":"graph_snapshot","subject_pith_number":"pith:2011:BD34GG6HEUNDTBOGRCDCRFHDXD","target":"graph","payload":{"graph_snapshot":{"paper":{"title":"Nonlinear regulation of commitment to apoptosis by simultaneous inhibition of Bcl-2 and XIAP in leukemia and lymphoma cells","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","headline":"","cross_cats":["cond-mat.stat-mech","physics.bio-ph"],"primary_cat":"q-bio.MN","authors_text":"Arjun Nair, Joanna Skommer, Somkanya C Das, Subhadip Raychaudhuri, Thomas Brittain","submitted_at":"2011-05-12T17:04:52Z","abstract_excerpt":"Apoptosis is a complex pathway regulated by the concerted action of multiple pro- and anti-apoptotic molecules. The intrinsic (mitochondrial) pathway of apoptosis is governed up-stream of mitochondria, by the family of Bcl-2 proteins, and down-stream of mitochondria, by low-probability events, such as apoptosome formation, and by feedback circuits involving caspases and inhibitor of apoptosis proteins (IAPs), such as XIAP. All these regulatory mechanisms ensure that cells only commit to death once a threshold of damage has been reached and the anti-apoptotic reserve of the cell is overcome. As"},"claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"1105.2530","kind":"arxiv","version":1},"verdict":{"id":null,"model_set":{},"created_at":null,"strongest_claim":"","one_line_summary":"","pipeline_version":null,"weakest_assumption":"","pith_extraction_headline":""},"references":{"count":0,"sample":[],"resolved_work":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","internal_anchors":0},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"author_claims":{"count":0,"strong_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"builder_version":"pith-number-builder-2026-05-17-v1"},"verdict_id":null},"signer":{"signer_id":"pith.science","signer_type":"pith_registry","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"created_at":"2026-05-18T04:22:10Z","supersedes":[],"prev_event":null,"signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"CLqQlbXwXFpWwMWyWGGhBgXhwaT+xfVdI2Dfv973Is2S1+zAUW4ULWr6Q9ro6MnFNVReLzOttpBM7PWVFZRBDw==","signed_message":"open_graph_event_sha256_bytes","signed_at":"2026-06-02T05:00:01.880714Z"},"content_sha256":"05a346247d04c27b801e8f1dcbbe0f027f6db09645d34ca8dbdc733df9bd8735","schema_version":"1.0","event_id":"sha256:05a346247d04c27b801e8f1dcbbe0f027f6db09645d34ca8dbdc733df9bd8735"}],"timestamp_proofs":[],"mirror_hints":[{"mirror_type":"https","name":"Pith Resolver","base_url":"https://pith.science","bundle_url":"https://pith.science/pith/BD34GG6HEUNDTBOGRCDCRFHDXD/bundle.json","state_url":"https://pith.science/pith/BD34GG6HEUNDTBOGRCDCRFHDXD/state.json","well_known_bundle_url":"https://pith.science/.well-known/pith/BD34GG6HEUNDTBOGRCDCRFHDXD/bundle.json","status":"primary"}],"public_keys":[{"key_id":"pith-v1-2026-05","algorithm":"ed25519","format":"raw","public_key_b64":"stVStoiQhXFxp4s2pdzPNoqVNBMojDU/fJ2db5S3CbM=","public_key_hex":"b2d552b68890857171a78b36a5dccf368a953413288c353f7c9d9d6f94b709b3","fingerprint_sha256_b32_first128bits":"RVFV5Z2OI2J3ZUO7ERDEBCYNKS","fingerprint_sha256_hex":"8d4b5ee74e4693bcd1df2446408b0d54","rotates_at":null,"url":"https://pith.science/pith-signing-key.json","notes":"Pith uses this Ed25519 key to sign canonical record SHA-256 digests. Verify with: ed25519_verify(public_key, message=canonical_sha256_bytes, signature=base64decode(signature_b64))."}],"merge_version":"pith-open-graph-merge-v1","built_at":"2026-06-02T05:00:01Z","links":{"resolver":"https://pith.science/pith/BD34GG6HEUNDTBOGRCDCRFHDXD","bundle":"https://pith.science/pith/BD34GG6HEUNDTBOGRCDCRFHDXD/bundle.json","state":"https://pith.science/pith/BD34GG6HEUNDTBOGRCDCRFHDXD/state.json","well_known_bundle":"https://pith.science/.well-known/pith/BD34GG6HEUNDTBOGRCDCRFHDXD/bundle.json"},"state":{"state_type":"pith_open_graph_state","state_version":"1.0","pith_number":"pith:2011:BD34GG6HEUNDTBOGRCDCRFHDXD","merge_version":"pith-open-graph-merge-v1","event_count":2,"valid_event_count":2,"invalid_event_count":0,"equivocation_count":0,"current":{"canonical_record":{"metadata":{"abstract_canon_sha256":"c17048c950e784beeebe616d540c49577fb6669db6d749826c6eb9c370a56826","cross_cats_sorted":["cond-mat.stat-mech","physics.bio-ph"],"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.MN","submitted_at":"2011-05-12T17:04:52Z","title_canon_sha256":"dacf9428cb3787f1f9252f2a2c963c331f6b21d59229cffef2b3c1b7ad18a4c3"},"schema_version":"1.0","source":{"id":"1105.2530","kind":"arxiv","version":1}},"source_aliases":[{"alias_kind":"arxiv","alias_value":"1105.2530","created_at":"2026-05-18T04:22:10Z"},{"alias_kind":"arxiv_version","alias_value":"1105.2530v1","created_at":"2026-05-18T04:22:10Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.1105.2530","created_at":"2026-05-18T04:22:10Z"},{"alias_kind":"pith_short_12","alias_value":"BD34GG6HEUND","created_at":"2026-05-18T12:26:24Z"},{"alias_kind":"pith_short_16","alias_value":"BD34GG6HEUNDTBOG","created_at":"2026-05-18T12:26:24Z"},{"alias_kind":"pith_short_8","alias_value":"BD34GG6H","created_at":"2026-05-18T12:26:24Z"}],"graph_snapshots":[{"event_id":"sha256:05a346247d04c27b801e8f1dcbbe0f027f6db09645d34ca8dbdc733df9bd8735","target":"graph","created_at":"2026-05-18T04:22:10Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"graph_snapshot":{"author_claims":{"count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","strong_count":0},"builder_version":"pith-number-builder-2026-05-17-v1","claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"paper":{"abstract_excerpt":"Apoptosis is a complex pathway regulated by the concerted action of multiple pro- and anti-apoptotic molecules. The intrinsic (mitochondrial) pathway of apoptosis is governed up-stream of mitochondria, by the family of Bcl-2 proteins, and down-stream of mitochondria, by low-probability events, such as apoptosome formation, and by feedback circuits involving caspases and inhibitor of apoptosis proteins (IAPs), such as XIAP. All these regulatory mechanisms ensure that cells only commit to death once a threshold of damage has been reached and the anti-apoptotic reserve of the cell is overcome. As","authors_text":"Arjun Nair, Joanna Skommer, Somkanya C Das, Subhadip Raychaudhuri, Thomas Brittain","cross_cats":["cond-mat.stat-mech","physics.bio-ph"],"headline":"","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.MN","submitted_at":"2011-05-12T17:04:52Z","title":"Nonlinear regulation of commitment to apoptosis by simultaneous inhibition of Bcl-2 and XIAP in leukemia and lymphoma cells"},"references":{"count":0,"internal_anchors":0,"resolved_work":0,"sample":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"1105.2530","kind":"arxiv","version":1},"verdict":{"created_at":null,"id":null,"model_set":{},"one_line_summary":"","pipeline_version":null,"pith_extraction_headline":"","strongest_claim":"","weakest_assumption":""}},"verdict_id":null}}],"author_attestations":[],"timestamp_anchors":[],"storage_attestations":[],"citation_signatures":[],"replication_records":[],"corrections":[],"mirror_hints":[],"record_created":{"event_id":"sha256:6037284d89873f8c0c96e8c382365c360310814bc8c1440a18fb60c3a8f80a92","target":"record","created_at":"2026-05-18T04:22:10Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"attestation_state":"computed","canonical_record":{"metadata":{"abstract_canon_sha256":"c17048c950e784beeebe616d540c49577fb6669db6d749826c6eb9c370a56826","cross_cats_sorted":["cond-mat.stat-mech","physics.bio-ph"],"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.MN","submitted_at":"2011-05-12T17:04:52Z","title_canon_sha256":"dacf9428cb3787f1f9252f2a2c963c331f6b21d59229cffef2b3c1b7ad18a4c3"},"schema_version":"1.0","source":{"id":"1105.2530","kind":"arxiv","version":1}},"canonical_sha256":"08f7c31bc7251a3985c688862894e3b8ded5e88dd24f95b1ef033fc61a05f013","receipt":{"algorithm":"ed25519","builder_version":"pith-number-builder-2026-05-17-v1","canonical_sha256":"08f7c31bc7251a3985c688862894e3b8ded5e88dd24f95b1ef033fc61a05f013","first_computed_at":"2026-05-18T04:22:10.478394Z","key_id":"pith-v1-2026-05","kind":"pith_receipt","last_reissued_at":"2026-05-18T04:22:10.478394Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","receipt_version":"0.3","signature_b64":"lUbyOKqclwOfa/dFK9tIuyk868VeWl8eNkEQCVwfpbxNEkmpTMQntWNhgUH5BMsJ9zUYOHH/7Fc/ZyrWNZZfAQ==","signature_status":"signed_v1","signed_at":"2026-05-18T04:22:10.478882Z","signed_message":"canonical_sha256_bytes"},"source_id":"1105.2530","source_kind":"arxiv","source_version":1}}},"equivocations":[],"invalid_events":[],"applied_event_ids":["sha256:6037284d89873f8c0c96e8c382365c360310814bc8c1440a18fb60c3a8f80a92","sha256:05a346247d04c27b801e8f1dcbbe0f027f6db09645d34ca8dbdc733df9bd8735"],"state_sha256":"36cd091479defed618e9c59b08dd07c68f676b81db4d6ae8b3b769d7e1422841"},"bundle_signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"sBIf28y2YWU+csGLezDSZeGX/6k+fvFMt0OxwnCWsosafPRhVMhru95X5ja5E942ugem1T8iGcxXo7V3B03SBg==","signed_message":"bundle_sha256_bytes","signed_at":"2026-06-02T05:00:01.883321Z","bundle_sha256":"ce16fc1bbc1f8a777390f9604150ba41515086056dd48e81ca080807723b5780"}}