{"bundle_type":"pith_open_graph_bundle","bundle_version":"1.0","pith_number":"pith:2014:BEEKGFO6OIAUGQLXEMMEYZQPEH","short_pith_number":"pith:BEEKGFO6","canonical_record":{"source":{"id":"1407.6534","kind":"arxiv","version":1},"metadata":{"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.MN","submitted_at":"2014-07-24T11:34:28Z","cross_cats_sorted":[],"title_canon_sha256":"8044d2f63f11387c9feef6147d26f12729f3199ce593df5977a9bfa1c058320f","abstract_canon_sha256":"ee6f09531dc57cfed858e906ae3d202a3bee133ae759ec4ee070cf2876b8e265"},"schema_version":"1.0"},"canonical_sha256":"0908a315de720143417723184c660f21d0b26ee02c6dc6673145f1214e92621e","source":{"kind":"arxiv","id":"1407.6534","version":1},"source_aliases":[{"alias_kind":"arxiv","alias_value":"1407.6534","created_at":"2026-05-18T02:46:38Z"},{"alias_kind":"arxiv_version","alias_value":"1407.6534v1","created_at":"2026-05-18T02:46:38Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.1407.6534","created_at":"2026-05-18T02:46:38Z"},{"alias_kind":"pith_short_12","alias_value":"BEEKGFO6OIAU","created_at":"2026-05-18T12:28:22Z"},{"alias_kind":"pith_short_16","alias_value":"BEEKGFO6OIAUGQLX","created_at":"2026-05-18T12:28:22Z"},{"alias_kind":"pith_short_8","alias_value":"BEEKGFO6","created_at":"2026-05-18T12:28:22Z"}],"events":[{"event_type":"record_created","subject_pith_number":"pith:2014:BEEKGFO6OIAUGQLXEMMEYZQPEH","target":"record","payload":{"canonical_record":{"source":{"id":"1407.6534","kind":"arxiv","version":1},"metadata":{"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.MN","submitted_at":"2014-07-24T11:34:28Z","cross_cats_sorted":[],"title_canon_sha256":"8044d2f63f11387c9feef6147d26f12729f3199ce593df5977a9bfa1c058320f","abstract_canon_sha256":"ee6f09531dc57cfed858e906ae3d202a3bee133ae759ec4ee070cf2876b8e265"},"schema_version":"1.0"},"canonical_sha256":"0908a315de720143417723184c660f21d0b26ee02c6dc6673145f1214e92621e","receipt":{"kind":"pith_receipt","key_id":"pith-v1-2026-05","algorithm":"ed25519","signed_at":"2026-05-18T02:46:38.533660Z","signature_b64":"88f7MBC5YxC7A4y8e6pHf9f9SRYfjbS/czBp4qU84HVP7neEU76DsJ6DY9MyJqWx6IPU+MQ8xRL/RSAPXktuBA==","signed_message":"canonical_sha256_bytes","builder_version":"pith-number-builder-2026-05-17-v1","receipt_version":"0.3","canonical_sha256":"0908a315de720143417723184c660f21d0b26ee02c6dc6673145f1214e92621e","last_reissued_at":"2026-05-18T02:46:38.533127Z","signature_status":"signed_v1","first_computed_at":"2026-05-18T02:46:38.533127Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"source_kind":"arxiv","source_id":"1407.6534","source_version":1,"attestation_state":"computed"},"signer":{"signer_id":"pith.science","signer_type":"pith_registry","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"created_at":"2026-05-18T02:46:38Z","supersedes":[],"prev_event":null,"signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"AVdqa6Fh1uWIR2R4pjrleIDWLKaAVl7AmI3F1IZlB660K/Iqy66dtz88H4FseYt1cSPd/FOg3+WqeR9AdvfgAA==","signed_message":"open_graph_event_sha256_bytes","signed_at":"2026-06-01T10:00:26.164497Z"},"content_sha256":"9c6fede543f02874724c53030181d7739a9ef4af140e856512297728ac74ad9d","schema_version":"1.0","event_id":"sha256:9c6fede543f02874724c53030181d7739a9ef4af140e856512297728ac74ad9d"},{"event_type":"graph_snapshot","subject_pith_number":"pith:2014:BEEKGFO6OIAUGQLXEMMEYZQPEH","target":"graph","payload":{"graph_snapshot":{"paper":{"title":"Fast reconstruction of compact context-specific metabolic networks via integration of microarray data","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","headline":"","cross_cats":[],"primary_cat":"q-bio.MN","authors_text":"Maria Pires Pacheco, Thomas Sauter","submitted_at":"2014-07-24T11:34:28Z","abstract_excerpt":"Recently we proposed an algorithm for the fast reconstruction of compact context-specific metabolic networks (FASTCORE) that allowed dropping the reconstruction time to the time order of seconds (Vlassis et al.,2014). This extremely low computational demand opens new possibilities for improving the quality of the models. Several rounds of model reconstruction, testing of the model's predictions against real experimental data, curation steps of the input model and the set of core reactions as well as cross-validations assays are required to reconstruct high-quality models. These semi-automated "},"claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"1407.6534","kind":"arxiv","version":1},"verdict":{"id":null,"model_set":{},"created_at":null,"strongest_claim":"","one_line_summary":"","pipeline_version":null,"weakest_assumption":"","pith_extraction_headline":""},"references":{"count":0,"sample":[],"resolved_work":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","internal_anchors":0},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"author_claims":{"count":0,"strong_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"builder_version":"pith-number-builder-2026-05-17-v1"},"verdict_id":null},"signer":{"signer_id":"pith.science","signer_type":"pith_registry","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"created_at":"2026-05-18T02:46:38Z","supersedes":[],"prev_event":null,"signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"Wf9C5bP7OV9FQgXdLZIBrX1Zrxe5UUWptjZjBX1KahJck+gUSt52yjCryT5qOjVV8XeVzgtjEMBT6UH8QMySDA==","signed_message":"open_graph_event_sha256_bytes","signed_at":"2026-06-01T10:00:26.164855Z"},"content_sha256":"900ff640f069841bc4759531a1a83d9c7f2d7be2bd4eabe39c42cb171f3e2aa1","schema_version":"1.0","event_id":"sha256:900ff640f069841bc4759531a1a83d9c7f2d7be2bd4eabe39c42cb171f3e2aa1"}],"timestamp_proofs":[],"mirror_hints":[{"mirror_type":"https","name":"Pith Resolver","base_url":"https://pith.science","bundle_url":"https://pith.science/pith/BEEKGFO6OIAUGQLXEMMEYZQPEH/bundle.json","state_url":"https://pith.science/pith/BEEKGFO6OIAUGQLXEMMEYZQPEH/state.json","well_known_bundle_url":"https://pith.science/.well-known/pith/BEEKGFO6OIAUGQLXEMMEYZQPEH/bundle.json","status":"primary"}],"public_keys":[{"key_id":"pith-v1-2026-05","algorithm":"ed25519","format":"raw","public_key_b64":"stVStoiQhXFxp4s2pdzPNoqVNBMojDU/fJ2db5S3CbM=","public_key_hex":"b2d552b68890857171a78b36a5dccf368a953413288c353f7c9d9d6f94b709b3","fingerprint_sha256_b32_first128bits":"RVFV5Z2OI2J3ZUO7ERDEBCYNKS","fingerprint_sha256_hex":"8d4b5ee74e4693bcd1df2446408b0d54","rotates_at":null,"url":"https://pith.science/pith-signing-key.json","notes":"Pith uses this Ed25519 key to sign canonical record SHA-256 digests. Verify with: ed25519_verify(public_key, message=canonical_sha256_bytes, signature=base64decode(signature_b64))."}],"merge_version":"pith-open-graph-merge-v1","built_at":"2026-06-01T10:00:26Z","links":{"resolver":"https://pith.science/pith/BEEKGFO6OIAUGQLXEMMEYZQPEH","bundle":"https://pith.science/pith/BEEKGFO6OIAUGQLXEMMEYZQPEH/bundle.json","state":"https://pith.science/pith/BEEKGFO6OIAUGQLXEMMEYZQPEH/state.json","well_known_bundle":"https://pith.science/.well-known/pith/BEEKGFO6OIAUGQLXEMMEYZQPEH/bundle.json"},"state":{"state_type":"pith_open_graph_state","state_version":"1.0","pith_number":"pith:2014:BEEKGFO6OIAUGQLXEMMEYZQPEH","merge_version":"pith-open-graph-merge-v1","event_count":2,"valid_event_count":2,"invalid_event_count":0,"equivocation_count":0,"current":{"canonical_record":{"metadata":{"abstract_canon_sha256":"ee6f09531dc57cfed858e906ae3d202a3bee133ae759ec4ee070cf2876b8e265","cross_cats_sorted":[],"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.MN","submitted_at":"2014-07-24T11:34:28Z","title_canon_sha256":"8044d2f63f11387c9feef6147d26f12729f3199ce593df5977a9bfa1c058320f"},"schema_version":"1.0","source":{"id":"1407.6534","kind":"arxiv","version":1}},"source_aliases":[{"alias_kind":"arxiv","alias_value":"1407.6534","created_at":"2026-05-18T02:46:38Z"},{"alias_kind":"arxiv_version","alias_value":"1407.6534v1","created_at":"2026-05-18T02:46:38Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.1407.6534","created_at":"2026-05-18T02:46:38Z"},{"alias_kind":"pith_short_12","alias_value":"BEEKGFO6OIAU","created_at":"2026-05-18T12:28:22Z"},{"alias_kind":"pith_short_16","alias_value":"BEEKGFO6OIAUGQLX","created_at":"2026-05-18T12:28:22Z"},{"alias_kind":"pith_short_8","alias_value":"BEEKGFO6","created_at":"2026-05-18T12:28:22Z"}],"graph_snapshots":[{"event_id":"sha256:900ff640f069841bc4759531a1a83d9c7f2d7be2bd4eabe39c42cb171f3e2aa1","target":"graph","created_at":"2026-05-18T02:46:38Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"graph_snapshot":{"author_claims":{"count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","strong_count":0},"builder_version":"pith-number-builder-2026-05-17-v1","claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"paper":{"abstract_excerpt":"Recently we proposed an algorithm for the fast reconstruction of compact context-specific metabolic networks (FASTCORE) that allowed dropping the reconstruction time to the time order of seconds (Vlassis et al.,2014). This extremely low computational demand opens new possibilities for improving the quality of the models. Several rounds of model reconstruction, testing of the model's predictions against real experimental data, curation steps of the input model and the set of core reactions as well as cross-validations assays are required to reconstruct high-quality models. These semi-automated ","authors_text":"Maria Pires Pacheco, Thomas Sauter","cross_cats":[],"headline":"","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.MN","submitted_at":"2014-07-24T11:34:28Z","title":"Fast reconstruction of compact context-specific metabolic networks via integration of microarray data"},"references":{"count":0,"internal_anchors":0,"resolved_work":0,"sample":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"1407.6534","kind":"arxiv","version":1},"verdict":{"created_at":null,"id":null,"model_set":{},"one_line_summary":"","pipeline_version":null,"pith_extraction_headline":"","strongest_claim":"","weakest_assumption":""}},"verdict_id":null}}],"author_attestations":[],"timestamp_anchors":[],"storage_attestations":[],"citation_signatures":[],"replication_records":[],"corrections":[],"mirror_hints":[],"record_created":{"event_id":"sha256:9c6fede543f02874724c53030181d7739a9ef4af140e856512297728ac74ad9d","target":"record","created_at":"2026-05-18T02:46:38Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"attestation_state":"computed","canonical_record":{"metadata":{"abstract_canon_sha256":"ee6f09531dc57cfed858e906ae3d202a3bee133ae759ec4ee070cf2876b8e265","cross_cats_sorted":[],"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.MN","submitted_at":"2014-07-24T11:34:28Z","title_canon_sha256":"8044d2f63f11387c9feef6147d26f12729f3199ce593df5977a9bfa1c058320f"},"schema_version":"1.0","source":{"id":"1407.6534","kind":"arxiv","version":1}},"canonical_sha256":"0908a315de720143417723184c660f21d0b26ee02c6dc6673145f1214e92621e","receipt":{"algorithm":"ed25519","builder_version":"pith-number-builder-2026-05-17-v1","canonical_sha256":"0908a315de720143417723184c660f21d0b26ee02c6dc6673145f1214e92621e","first_computed_at":"2026-05-18T02:46:38.533127Z","key_id":"pith-v1-2026-05","kind":"pith_receipt","last_reissued_at":"2026-05-18T02:46:38.533127Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","receipt_version":"0.3","signature_b64":"88f7MBC5YxC7A4y8e6pHf9f9SRYfjbS/czBp4qU84HVP7neEU76DsJ6DY9MyJqWx6IPU+MQ8xRL/RSAPXktuBA==","signature_status":"signed_v1","signed_at":"2026-05-18T02:46:38.533660Z","signed_message":"canonical_sha256_bytes"},"source_id":"1407.6534","source_kind":"arxiv","source_version":1}}},"equivocations":[],"invalid_events":[],"applied_event_ids":["sha256:9c6fede543f02874724c53030181d7739a9ef4af140e856512297728ac74ad9d","sha256:900ff640f069841bc4759531a1a83d9c7f2d7be2bd4eabe39c42cb171f3e2aa1"],"state_sha256":"a8f5634392b4c89798bfb6bdb0216f37c654ee31028a39bf7841d07ee40ac166"},"bundle_signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"cIog7qmMyVi/Ufy6HQbCXFiOY6HgtO15uyjqO31LNxv84BNxQemwR5mIJbD2d3MqZrzS7/K8LhgA3CU8xjEVAw==","signed_message":"bundle_sha256_bytes","signed_at":"2026-06-01T10:00:26.166793Z","bundle_sha256":"6eb3e0ea04bb18a8900d07cd35e2059977dbf7908c9f63d16ce64f5acc8bc6f6"}}