{"bundle_type":"pith_open_graph_bundle","bundle_version":"1.0","pith_number":"pith:2026:BGYX5YEADALARCZJKNENB2S4N3","short_pith_number":"pith:BGYX5YEA","canonical_record":{"source":{"id":"2604.12930","kind":"arxiv","version":2},"metadata":{"license":"http://creativecommons.org/licenses/by/4.0/","primary_cat":"cond-mat.soft","submitted_at":"2026-04-14T16:20:03Z","cross_cats_sorted":["nlin.AO","physics.bio-ph","q-bio.SC"],"title_canon_sha256":"96671be5ea85711e8fcec3d6334c200814368e3a743a1bb9aa32d18e9795a273","abstract_canon_sha256":"6dca262d7d144fd279ace329c60ef5c13b1afde1e405d1cefb092428de1a499c"},"schema_version":"1.0"},"canonical_sha256":"09b17ee0801816088b295348d0ea5c6eca206fe4fb59ad325f5d815228aa5730","source":{"kind":"arxiv","id":"2604.12930","version":2},"source_aliases":[{"alias_kind":"arxiv","alias_value":"2604.12930","created_at":"2026-05-22T02:04:40Z"},{"alias_kind":"arxiv_version","alias_value":"2604.12930v2","created_at":"2026-05-22T02:04:40Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.2604.12930","created_at":"2026-05-22T02:04:40Z"},{"alias_kind":"pith_short_12","alias_value":"BGYX5YEADALA","created_at":"2026-05-22T02:04:40Z"},{"alias_kind":"pith_short_16","alias_value":"BGYX5YEADALARCZJ","created_at":"2026-05-22T02:04:40Z"},{"alias_kind":"pith_short_8","alias_value":"BGYX5YEA","created_at":"2026-05-22T02:04:40Z"}],"events":[{"event_type":"record_created","subject_pith_number":"pith:2026:BGYX5YEADALARCZJKNENB2S4N3","target":"record","payload":{"canonical_record":{"source":{"id":"2604.12930","kind":"arxiv","version":2},"metadata":{"license":"http://creativecommons.org/licenses/by/4.0/","primary_cat":"cond-mat.soft","submitted_at":"2026-04-14T16:20:03Z","cross_cats_sorted":["nlin.AO","physics.bio-ph","q-bio.SC"],"title_canon_sha256":"96671be5ea85711e8fcec3d6334c200814368e3a743a1bb9aa32d18e9795a273","abstract_canon_sha256":"6dca262d7d144fd279ace329c60ef5c13b1afde1e405d1cefb092428de1a499c"},"schema_version":"1.0"},"canonical_sha256":"09b17ee0801816088b295348d0ea5c6eca206fe4fb59ad325f5d815228aa5730","receipt":{"kind":"pith_receipt","key_id":"pith-v1-2026-05","algorithm":"ed25519","signed_at":"2026-05-22T02:04:40.945165Z","signature_b64":"z4HwyE+/5R1Yaz6RjQcxovRF3Qyfw5gzbL2UC1lT8BO8qPFwNbYGcHXlYOQjqHwxL9qQH9qW+jlG+KEHLdltDw==","signed_message":"canonical_sha256_bytes","builder_version":"pith-number-builder-2026-05-17-v1","receipt_version":"0.3","canonical_sha256":"09b17ee0801816088b295348d0ea5c6eca206fe4fb59ad325f5d815228aa5730","last_reissued_at":"2026-05-22T02:04:40.944160Z","signature_status":"signed_v1","first_computed_at":"2026-05-22T02:04:40.944160Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"source_kind":"arxiv","source_id":"2604.12930","source_version":2,"attestation_state":"computed"},"signer":{"signer_id":"pith.science","signer_type":"pith_registry","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"created_at":"2026-05-22T02:04:40Z","supersedes":[],"prev_event":null,"signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"FYq850uWUm5zryBSLqlaUHvpxxxmhMYdc7PzOwlfGDvLZ7v2Jt9BTpq1sYsOCG3Aq39qKqUoOd/jstO7hcz7BA==","signed_message":"open_graph_event_sha256_bytes","signed_at":"2026-06-02T02:08:35.497606Z"},"content_sha256":"6056741fff940c7292b4cef91c3cfb3090424e6c3501b5044a04e8a3dfd46783","schema_version":"1.0","event_id":"sha256:6056741fff940c7292b4cef91c3cfb3090424e6c3501b5044a04e8a3dfd46783"},{"event_type":"graph_snapshot","subject_pith_number":"pith:2026:BGYX5YEADALARCZJKNENB2S4N3","target":"graph","payload":{"graph_snapshot":{"paper":{"title":"Building and maintaining a System of Intracellular Compartments","license":"http://creativecommons.org/licenses/by/4.0/","headline":"Vesicular transport and cisternal progression are two dynamical phases of one nonequilibrium fusion-fission process.","cross_cats":["nlin.AO","physics.bio-ph","q-bio.SC"],"primary_cat":"cond-mat.soft","authors_text":"Amit Kumar, Madan Rao","submitted_at":"2026-04-14T16:20:03Z","abstract_excerpt":"Organelle patterning and its heritability remain central mysteries in cell biology, highlighting the fundamental tension between genetic inheritance and self-assembly. Here, we explore the nonequilibrium assembly and emdedded size control of the Golgi cisternae and endosomes, amid a continuous flux of membrane traffic, within a stochastic framework of mechanochemical fusion-fission cycles that violate detailed balance. Using a dynamical systems approach, we identify distinct, robust regimes, ranging from fixed points to limit cycles with definite phase relations between cisternae. We identify "},"claims":{"count":4,"items":[{"kind":"strongest_claim","text":"Our analysis reveals that the two competing models of Golgi organization-vesicular transport and cisternal progression - are, in fact, two phases of the same underlying nonequilibrium process.","source":"verdict.strongest_claim","status":"machine_extracted","claim_id":"C1","attestation":"unclaimed"},{"kind":"weakest_assumption","text":"That the complex intracellular membrane dynamics can be adequately captured by a stochastic mechanochemical fusion-fission model violating detailed balance, with the resulting dynamical regimes directly mapping to biological phenotypes without additional molecular details.","source":"verdict.weakest_assumption","status":"machine_extracted","claim_id":"C2","attestation":"unclaimed"},{"kind":"one_line_summary","text":"A nonequilibrium dynamical systems model shows vesicular transport and cisternal progression as two phases of the same fusion-fission process governing organelle patterning and maintenance.","source":"verdict.one_line_summary","status":"machine_extracted","claim_id":"C3","attestation":"unclaimed"},{"kind":"headline","text":"Vesicular transport and cisternal progression are two dynamical phases of one nonequilibrium fusion-fission process.","source":"verdict.pith_extraction.headline","status":"machine_extracted","claim_id":"C4","attestation":"unclaimed"}],"snapshot_sha256":"a52a83768829858802e0df305283e5396b53979787485765b5e0338986dc14be"},"source":{"id":"2604.12930","kind":"arxiv","version":2},"verdict":{"id":"0bc44018-6139-4230-9a9a-19ea0c403461","model_set":{"reader":"grok-4.3"},"created_at":"2026-05-10T13:49:15.011795Z","strongest_claim":"Our analysis reveals that the two competing models of Golgi organization-vesicular transport and cisternal progression - are, in fact, two phases of the same underlying nonequilibrium process.","one_line_summary":"A nonequilibrium dynamical systems model shows vesicular transport and cisternal progression as two phases of the same fusion-fission process governing organelle patterning and maintenance.","pipeline_version":"pith-pipeline@v0.9.0","weakest_assumption":"That the complex intracellular membrane dynamics can be adequately captured by a stochastic mechanochemical fusion-fission model violating detailed balance, with the resulting dynamical regimes directly mapping to biological phenotypes without additional molecular details.","pith_extraction_headline":"Vesicular transport and cisternal progression are two dynamical phases of one nonequilibrium fusion-fission process."},"integrity":{"clean":true,"summary":{"advisory":0,"critical":0,"by_detector":{},"informational":0},"endpoint":"/pith/2604.12930/integrity.json","findings":[],"available":true,"detectors_run":[],"snapshot_sha256":"c28c3603d3b5d939e8dc4c7e95fa8dfce3d595e45f758748cecf8e644a296938"},"references":{"count":0,"sample":[],"resolved_work":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","internal_anchors":0},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"author_claims":{"count":0,"strong_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"builder_version":"pith-number-builder-2026-05-17-v1"},"verdict_id":"0bc44018-6139-4230-9a9a-19ea0c403461"},"signer":{"signer_id":"pith.science","signer_type":"pith_registry","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"created_at":"2026-05-22T02:04:40Z","supersedes":[],"prev_event":null,"signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"N795Ec623eA1qNejihAvjwOD16RFdYT+c9+KaqRlk17URGIMRM/2H8SwKewoZKiXGHOIFSjjnhaKI1DTi57kBw==","signed_message":"open_graph_event_sha256_bytes","signed_at":"2026-06-02T02:08:35.498417Z"},"content_sha256":"3501abef5d5a15f6883aaa430949674910b345fe6dfb9727862f5c755c8caa7e","schema_version":"1.0","event_id":"sha256:3501abef5d5a15f6883aaa430949674910b345fe6dfb9727862f5c755c8caa7e"}],"timestamp_proofs":[],"mirror_hints":[{"mirror_type":"https","name":"Pith Resolver","base_url":"https://pith.science","bundle_url":"https://pith.science/pith/BGYX5YEADALARCZJKNENB2S4N3/bundle.json","state_url":"https://pith.science/pith/BGYX5YEADALARCZJKNENB2S4N3/state.json","well_known_bundle_url":"https://pith.science/.well-known/pith/BGYX5YEADALARCZJKNENB2S4N3/bundle.json","status":"primary"}],"public_keys":[{"key_id":"pith-v1-2026-05","algorithm":"ed25519","format":"raw","public_key_b64":"stVStoiQhXFxp4s2pdzPNoqVNBMojDU/fJ2db5S3CbM=","public_key_hex":"b2d552b68890857171a78b36a5dccf368a953413288c353f7c9d9d6f94b709b3","fingerprint_sha256_b32_first128bits":"RVFV5Z2OI2J3ZUO7ERDEBCYNKS","fingerprint_sha256_hex":"8d4b5ee74e4693bcd1df2446408b0d54","rotates_at":null,"url":"https://pith.science/pith-signing-key.json","notes":"Pith uses this Ed25519 key to sign canonical record SHA-256 digests. Verify with: ed25519_verify(public_key, message=canonical_sha256_bytes, signature=base64decode(signature_b64))."}],"merge_version":"pith-open-graph-merge-v1","built_at":"2026-06-02T02:08:35Z","links":{"resolver":"https://pith.science/pith/BGYX5YEADALARCZJKNENB2S4N3","bundle":"https://pith.science/pith/BGYX5YEADALARCZJKNENB2S4N3/bundle.json","state":"https://pith.science/pith/BGYX5YEADALARCZJKNENB2S4N3/state.json","well_known_bundle":"https://pith.science/.well-known/pith/BGYX5YEADALARCZJKNENB2S4N3/bundle.json"},"state":{"state_type":"pith_open_graph_state","state_version":"1.0","pith_number":"pith:2026:BGYX5YEADALARCZJKNENB2S4N3","merge_version":"pith-open-graph-merge-v1","event_count":2,"valid_event_count":2,"invalid_event_count":0,"equivocation_count":0,"current":{"canonical_record":{"metadata":{"abstract_canon_sha256":"6dca262d7d144fd279ace329c60ef5c13b1afde1e405d1cefb092428de1a499c","cross_cats_sorted":["nlin.AO","physics.bio-ph","q-bio.SC"],"license":"http://creativecommons.org/licenses/by/4.0/","primary_cat":"cond-mat.soft","submitted_at":"2026-04-14T16:20:03Z","title_canon_sha256":"96671be5ea85711e8fcec3d6334c200814368e3a743a1bb9aa32d18e9795a273"},"schema_version":"1.0","source":{"id":"2604.12930","kind":"arxiv","version":2}},"source_aliases":[{"alias_kind":"arxiv","alias_value":"2604.12930","created_at":"2026-05-22T02:04:40Z"},{"alias_kind":"arxiv_version","alias_value":"2604.12930v2","created_at":"2026-05-22T02:04:40Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.2604.12930","created_at":"2026-05-22T02:04:40Z"},{"alias_kind":"pith_short_12","alias_value":"BGYX5YEADALA","created_at":"2026-05-22T02:04:40Z"},{"alias_kind":"pith_short_16","alias_value":"BGYX5YEADALARCZJ","created_at":"2026-05-22T02:04:40Z"},{"alias_kind":"pith_short_8","alias_value":"BGYX5YEA","created_at":"2026-05-22T02:04:40Z"}],"graph_snapshots":[{"event_id":"sha256:3501abef5d5a15f6883aaa430949674910b345fe6dfb9727862f5c755c8caa7e","target":"graph","created_at":"2026-05-22T02:04:40Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"graph_snapshot":{"author_claims":{"count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","strong_count":0},"builder_version":"pith-number-builder-2026-05-17-v1","claims":{"count":4,"items":[{"attestation":"unclaimed","claim_id":"C1","kind":"strongest_claim","source":"verdict.strongest_claim","status":"machine_extracted","text":"Our analysis reveals that the two competing models of Golgi organization-vesicular transport and cisternal progression - are, in fact, two phases of the same underlying nonequilibrium process."},{"attestation":"unclaimed","claim_id":"C2","kind":"weakest_assumption","source":"verdict.weakest_assumption","status":"machine_extracted","text":"That the complex intracellular membrane dynamics can be adequately captured by a stochastic mechanochemical fusion-fission model violating detailed balance, with the resulting dynamical regimes directly mapping to biological phenotypes without additional molecular details."},{"attestation":"unclaimed","claim_id":"C3","kind":"one_line_summary","source":"verdict.one_line_summary","status":"machine_extracted","text":"A nonequilibrium dynamical systems model shows vesicular transport and cisternal progression as two phases of the same fusion-fission process governing organelle patterning and maintenance."},{"attestation":"unclaimed","claim_id":"C4","kind":"headline","source":"verdict.pith_extraction.headline","status":"machine_extracted","text":"Vesicular transport and cisternal progression are two dynamical phases of one nonequilibrium fusion-fission process."}],"snapshot_sha256":"a52a83768829858802e0df305283e5396b53979787485765b5e0338986dc14be"},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"integrity":{"available":true,"clean":true,"detectors_run":[],"endpoint":"/pith/2604.12930/integrity.json","findings":[],"snapshot_sha256":"c28c3603d3b5d939e8dc4c7e95fa8dfce3d595e45f758748cecf8e644a296938","summary":{"advisory":0,"by_detector":{},"critical":0,"informational":0}},"paper":{"abstract_excerpt":"Organelle patterning and its heritability remain central mysteries in cell biology, highlighting the fundamental tension between genetic inheritance and self-assembly. Here, we explore the nonequilibrium assembly and emdedded size control of the Golgi cisternae and endosomes, amid a continuous flux of membrane traffic, within a stochastic framework of mechanochemical fusion-fission cycles that violate detailed balance. Using a dynamical systems approach, we identify distinct, robust regimes, ranging from fixed points to limit cycles with definite phase relations between cisternae. We identify ","authors_text":"Amit Kumar, Madan Rao","cross_cats":["nlin.AO","physics.bio-ph","q-bio.SC"],"headline":"Vesicular transport and cisternal progression are two dynamical phases of one nonequilibrium fusion-fission process.","license":"http://creativecommons.org/licenses/by/4.0/","primary_cat":"cond-mat.soft","submitted_at":"2026-04-14T16:20:03Z","title":"Building and maintaining a System of Intracellular Compartments"},"references":{"count":0,"internal_anchors":0,"resolved_work":0,"sample":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"2604.12930","kind":"arxiv","version":2},"verdict":{"created_at":"2026-05-10T13:49:15.011795Z","id":"0bc44018-6139-4230-9a9a-19ea0c403461","model_set":{"reader":"grok-4.3"},"one_line_summary":"A nonequilibrium dynamical systems model shows vesicular transport and cisternal progression as two phases of the same fusion-fission process governing organelle patterning and maintenance.","pipeline_version":"pith-pipeline@v0.9.0","pith_extraction_headline":"Vesicular transport and cisternal progression are two dynamical phases of one nonequilibrium fusion-fission process.","strongest_claim":"Our analysis reveals that the two competing models of Golgi organization-vesicular transport and cisternal progression - are, in fact, two phases of the same underlying nonequilibrium process.","weakest_assumption":"That the complex intracellular membrane dynamics can be adequately captured by a stochastic mechanochemical fusion-fission model violating detailed balance, with the resulting dynamical regimes directly mapping to biological phenotypes without additional molecular details."}},"verdict_id":"0bc44018-6139-4230-9a9a-19ea0c403461"}}],"author_attestations":[],"timestamp_anchors":[],"storage_attestations":[],"citation_signatures":[],"replication_records":[],"corrections":[],"mirror_hints":[],"record_created":{"event_id":"sha256:6056741fff940c7292b4cef91c3cfb3090424e6c3501b5044a04e8a3dfd46783","target":"record","created_at":"2026-05-22T02:04:40Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"attestation_state":"computed","canonical_record":{"metadata":{"abstract_canon_sha256":"6dca262d7d144fd279ace329c60ef5c13b1afde1e405d1cefb092428de1a499c","cross_cats_sorted":["nlin.AO","physics.bio-ph","q-bio.SC"],"license":"http://creativecommons.org/licenses/by/4.0/","primary_cat":"cond-mat.soft","submitted_at":"2026-04-14T16:20:03Z","title_canon_sha256":"96671be5ea85711e8fcec3d6334c200814368e3a743a1bb9aa32d18e9795a273"},"schema_version":"1.0","source":{"id":"2604.12930","kind":"arxiv","version":2}},"canonical_sha256":"09b17ee0801816088b295348d0ea5c6eca206fe4fb59ad325f5d815228aa5730","receipt":{"algorithm":"ed25519","builder_version":"pith-number-builder-2026-05-17-v1","canonical_sha256":"09b17ee0801816088b295348d0ea5c6eca206fe4fb59ad325f5d815228aa5730","first_computed_at":"2026-05-22T02:04:40.944160Z","key_id":"pith-v1-2026-05","kind":"pith_receipt","last_reissued_at":"2026-05-22T02:04:40.944160Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","receipt_version":"0.3","signature_b64":"z4HwyE+/5R1Yaz6RjQcxovRF3Qyfw5gzbL2UC1lT8BO8qPFwNbYGcHXlYOQjqHwxL9qQH9qW+jlG+KEHLdltDw==","signature_status":"signed_v1","signed_at":"2026-05-22T02:04:40.945165Z","signed_message":"canonical_sha256_bytes"},"source_id":"2604.12930","source_kind":"arxiv","source_version":2}}},"equivocations":[],"invalid_events":[],"applied_event_ids":["sha256:6056741fff940c7292b4cef91c3cfb3090424e6c3501b5044a04e8a3dfd46783","sha256:3501abef5d5a15f6883aaa430949674910b345fe6dfb9727862f5c755c8caa7e"],"state_sha256":"c016d5bb0acdf6d8827738daaa8bbc01dfc068b4beafa3208f3b39764ebea755"},"bundle_signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"SdhI+MWo1wI3DjLwjX9ZSrUDh0lmrsp9L3H4iA+uFgXXz0C3QX5fa0FQHA95ufu21TEXGWGd1UZxCnQdjoYdCg==","signed_message":"bundle_sha256_bytes","signed_at":"2026-06-02T02:08:35.501530Z","bundle_sha256":"29404d1a7668cfcfed409ecb3a4116d065f0a63839b13166919c6d2e3299627e"}}