{"record_type":"pith_number_record","schema_url":"https://pith.science/schemas/pith-number/v1.json","pith_number":"pith:2006:BHUYXNXPV5GMW27M6TQ27LHQJO","short_pith_number":"pith:BHUYXNXP","schema_version":"1.0","canonical_sha256":"09e98bb6efaf4ccb6becf4e1afacf04ba859a45fff25e6d23429e2abb1e93c6b","source":{"kind":"arxiv","id":"q-bio/0601010","version":1},"attestation_state":"computed","paper":{"title":"Quantification and Correction of Systematic Errors Due to Detector Time-Averaging in Single-Molecule Tracking Experiments","license":"","headline":"","cross_cats":["cond-mat.stat-mech","q-bio.SC"],"primary_cat":"q-bio.QM","authors_text":"Laurence Salome, Nicolas Destainville","submitted_at":"2006-01-09T09:21:23Z","abstract_excerpt":"Single-molecule tracking is a powerful way to look at the dynamic organization of plasma membranes. However, there are some limitations to its use. For example, it was recently observed, using numerical simulation, that time-averaging effects inherent to the exposure time of detectors are likely to bias the apparent motion of molecules confined in microdomains. Here, we solve this apparently limiting issue analytically. We explore this phenomenon by calculating its effects on the observed diffusion coefficients and domain sizes. We demonstrate that the real parameters can be easily recovered f"},"verification_status":{"content_addressed":true,"pith_receipt":true,"author_attested":false,"weak_author_claims":0,"strong_author_claims":0,"externally_anchored":false,"storage_verified":false,"citation_signatures":0,"replication_records":0,"graph_snapshot":true,"references_resolved":false,"formal_links_present":false},"canonical_record":{"source":{"id":"q-bio/0601010","kind":"arxiv","version":1},"metadata":{"license":"","primary_cat":"q-bio.QM","submitted_at":"2006-01-09T09:21:23Z","cross_cats_sorted":["cond-mat.stat-mech","q-bio.SC"],"title_canon_sha256":"161bf0c45579da0ac2f56d11e60ce2393546910d0ea79abdd69b7402df08e885","abstract_canon_sha256":"50b0abcea62eb35fe6a5e503f0eebb776be6825b6b2e660eebcb9436a220eef2"},"schema_version":"1.0"},"receipt":{"kind":"pith_receipt","key_id":"pith-v1-2026-05","algorithm":"ed25519","signed_at":"2026-07-04T17:02:51.561950Z","signature_b64":"7xK5n/PRNelQVVKUkfAjktiYrx0iRLmQOZ0TSajqkMFJW9sFiZC6oJ/cdjf3aqBJSm0DrPTZtdmz2926OmwDCw==","signed_message":"canonical_sha256_bytes","builder_version":"pith-number-builder-2026-05-17-v1","receipt_version":"0.3","canonical_sha256":"09e98bb6efaf4ccb6becf4e1afacf04ba859a45fff25e6d23429e2abb1e93c6b","last_reissued_at":"2026-07-04T17:02:51.561587Z","signature_status":"signed_v1","first_computed_at":"2026-07-04T17:02:51.561587Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"graph_snapshot":{"paper":{"title":"Quantification and Correction of Systematic Errors Due to Detector Time-Averaging in Single-Molecule Tracking Experiments","license":"","headline":"","cross_cats":["cond-mat.stat-mech","q-bio.SC"],"primary_cat":"q-bio.QM","authors_text":"Laurence Salome, Nicolas Destainville","submitted_at":"2006-01-09T09:21:23Z","abstract_excerpt":"Single-molecule tracking is a powerful way to look at the dynamic organization of plasma membranes. However, there are some limitations to its use. For example, it was recently observed, using numerical simulation, that time-averaging effects inherent to the exposure time of detectors are likely to bias the apparent motion of molecules confined in microdomains. Here, we solve this apparently limiting issue analytically. We explore this phenomenon by calculating its effects on the observed diffusion coefficients and domain sizes. We demonstrate that the real parameters can be easily recovered f"},"claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"q-bio/0601010","kind":"arxiv","version":1},"verdict":{"id":null,"model_set":{},"created_at":null,"strongest_claim":"","one_line_summary":"","pipeline_version":null,"weakest_assumption":"","pith_extraction_headline":""},"integrity":{"clean":true,"summary":{"advisory":0,"critical":0,"by_detector":{},"informational":0},"endpoint":"/pith/q-bio/0601010/integrity.json","findings":[],"available":true,"detectors_run":[],"snapshot_sha256":"c28c3603d3b5d939e8dc4c7e95fa8dfce3d595e45f758748cecf8e644a296938"},"references":{"count":0,"sample":[],"resolved_work":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","internal_anchors":0},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"author_claims":{"count":0,"strong_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"builder_version":"pith-number-builder-2026-05-17-v1"},"aliases":[{"alias_kind":"arxiv","alias_value":"q-bio/0601010","created_at":"2026-07-04T17:02:51.561651+00:00"},{"alias_kind":"arxiv_version","alias_value":"q-bio/0601010v1","created_at":"2026-07-04T17:02:51.561651+00:00"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.q-bio/0601010","created_at":"2026-07-04T17:02:51.561651+00:00"},{"alias_kind":"pith_short_12","alias_value":"BHUYXNXPV5GM","created_at":"2026-07-04T17:02:51.561651+00:00"},{"alias_kind":"pith_short_16","alias_value":"BHUYXNXPV5GMW27M","created_at":"2026-07-04T17:02:51.561651+00:00"},{"alias_kind":"pith_short_8","alias_value":"BHUYXNXP","created_at":"2026-07-04T17:02:51.561651+00:00"}],"events":[],"event_summary":{},"paper_claims":[],"inbound_citations":{"count":0,"internal_anchor_count":0,"sample":[]},"formal_canon":{"evidence_count":0,"sample":[],"anchors":[]},"links":{"html":"https://pith.science/pith/BHUYXNXPV5GMW27M6TQ27LHQJO","json":"https://pith.science/pith/BHUYXNXPV5GMW27M6TQ27LHQJO.json","graph_json":"https://pith.science/api/pith-number/BHUYXNXPV5GMW27M6TQ27LHQJO/graph.json","events_json":"https://pith.science/api/pith-number/BHUYXNXPV5GMW27M6TQ27LHQJO/events.json","paper":"https://pith.science/paper/BHUYXNXP"},"agent_actions":{"view_html":"https://pith.science/pith/BHUYXNXPV5GMW27M6TQ27LHQJO","download_json":"https://pith.science/pith/BHUYXNXPV5GMW27M6TQ27LHQJO.json","view_paper":"https://pith.science/paper/BHUYXNXP","resolve_alias":"https://pith.science/api/pith-number/resolve?arxiv=q-bio/0601010&json=true","fetch_graph":"https://pith.science/api/pith-number/BHUYXNXPV5GMW27M6TQ27LHQJO/graph.json","fetch_events":"https://pith.science/api/pith-number/BHUYXNXPV5GMW27M6TQ27LHQJO/events.json","actions":{"anchor_timestamp":"https://pith.science/pith/BHUYXNXPV5GMW27M6TQ27LHQJO/action/timestamp_anchor","attest_storage":"https://pith.science/pith/BHUYXNXPV5GMW27M6TQ27LHQJO/action/storage_attestation","attest_author":"https://pith.science/pith/BHUYXNXPV5GMW27M6TQ27LHQJO/action/author_attestation","sign_citation":"https://pith.science/pith/BHUYXNXPV5GMW27M6TQ27LHQJO/action/citation_signature","submit_replication":"https://pith.science/pith/BHUYXNXPV5GMW27M6TQ27LHQJO/action/replication_record"}},"created_at":"2026-07-04T17:02:51.561651+00:00","updated_at":"2026-07-04T17:02:51.561651+00:00"}