{"record_type":"pith_number_record","schema_url":"https://pith.science/schemas/pith-number/v1.json","pith_number":"pith:2016:BLNC4VI4MKR5M33YCI5CSLXCPL","short_pith_number":"pith:BLNC4VI4","schema_version":"1.0","canonical_sha256":"0ada2e551c62a3d66f78123a292ee27aca6ac5c9924d29bf26fc3bdf38d3e2b2","source":{"kind":"arxiv","id":"1612.01571","version":1},"attestation_state":"computed","paper":{"title":"Time-delayed model of RNA interference","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","headline":"","cross_cats":["nlin.CD","q-bio.MN"],"primary_cat":"q-bio.QM","authors_text":"G. Neofytou, K.B. Blyuss, Y.N. Kyrychko","submitted_at":"2016-12-05T21:55:52Z","abstract_excerpt":"RNA interference (RNAi) is a fundamental cellular process that inhibits gene expression through cleavage and destruction of target mRNA. It is responsible for a number of important intracellular functions, from being the first line of immune defence against pathogens to regulating development and morphogenesis. In this paper we consider a mathematical model of RNAi with particular emphasis on time delays associated with two aspects of primed amplification: binding of siRNA to aberrant RNA, and binding of siRNA to mRNA, both of which result in the expanded production of dsRNA responsible for RN"},"verification_status":{"content_addressed":true,"pith_receipt":true,"author_attested":false,"weak_author_claims":0,"strong_author_claims":0,"externally_anchored":false,"storage_verified":false,"citation_signatures":0,"replication_records":0,"graph_snapshot":true,"references_resolved":false,"formal_links_present":false},"canonical_record":{"source":{"id":"1612.01571","kind":"arxiv","version":1},"metadata":{"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.QM","submitted_at":"2016-12-05T21:55:52Z","cross_cats_sorted":["nlin.CD","q-bio.MN"],"title_canon_sha256":"570b224c2ac5910eaa3312d4e75a8f3115bb8e743e78f06a0c44aeb89db7de2c","abstract_canon_sha256":"6d56643c769e662e7077c7d3703bea2a716de98c5d48896060ac9373cb8c33da"},"schema_version":"1.0"},"receipt":{"kind":"pith_receipt","key_id":"pith-v1-2026-05","algorithm":"ed25519","signed_at":"2026-05-18T00:40:32.905842Z","signature_b64":"z6+P08GoCa+ywk3fh/pTl7hN7MZtwbPt8W3UJHLgWQAyl24LL1kE6Ot7yz88Qp3Q1JYu1D+NhS8WjTugFbGMCA==","signed_message":"canonical_sha256_bytes","builder_version":"pith-number-builder-2026-05-17-v1","receipt_version":"0.3","canonical_sha256":"0ada2e551c62a3d66f78123a292ee27aca6ac5c9924d29bf26fc3bdf38d3e2b2","last_reissued_at":"2026-05-18T00:40:32.905227Z","signature_status":"signed_v1","first_computed_at":"2026-05-18T00:40:32.905227Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"graph_snapshot":{"paper":{"title":"Time-delayed model of RNA interference","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","headline":"","cross_cats":["nlin.CD","q-bio.MN"],"primary_cat":"q-bio.QM","authors_text":"G. Neofytou, K.B. Blyuss, Y.N. Kyrychko","submitted_at":"2016-12-05T21:55:52Z","abstract_excerpt":"RNA interference (RNAi) is a fundamental cellular process that inhibits gene expression through cleavage and destruction of target mRNA. It is responsible for a number of important intracellular functions, from being the first line of immune defence against pathogens to regulating development and morphogenesis. In this paper we consider a mathematical model of RNAi with particular emphasis on time delays associated with two aspects of primed amplification: binding of siRNA to aberrant RNA, and binding of siRNA to mRNA, both of which result in the expanded production of dsRNA responsible for RN"},"claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"1612.01571","kind":"arxiv","version":1},"verdict":{"id":null,"model_set":{},"created_at":null,"strongest_claim":"","one_line_summary":"","pipeline_version":null,"weakest_assumption":"","pith_extraction_headline":""},"references":{"count":0,"sample":[],"resolved_work":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","internal_anchors":0},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"author_claims":{"count":0,"strong_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"builder_version":"pith-number-builder-2026-05-17-v1"},"aliases":[{"alias_kind":"arxiv","alias_value":"1612.01571","created_at":"2026-05-18T00:40:32.905323+00:00"},{"alias_kind":"arxiv_version","alias_value":"1612.01571v1","created_at":"2026-05-18T00:40:32.905323+00:00"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.1612.01571","created_at":"2026-05-18T00:40:32.905323+00:00"},{"alias_kind":"pith_short_12","alias_value":"BLNC4VI4MKR5","created_at":"2026-05-18T12:30:07.202191+00:00"},{"alias_kind":"pith_short_16","alias_value":"BLNC4VI4MKR5M33Y","created_at":"2026-05-18T12:30:07.202191+00:00"},{"alias_kind":"pith_short_8","alias_value":"BLNC4VI4","created_at":"2026-05-18T12:30:07.202191+00:00"}],"events":[],"event_summary":{},"paper_claims":[],"inbound_citations":{"count":0,"internal_anchor_count":0,"sample":[]},"formal_canon":{"evidence_count":0,"sample":[],"anchors":[]},"links":{"html":"https://pith.science/pith/BLNC4VI4MKR5M33YCI5CSLXCPL","json":"https://pith.science/pith/BLNC4VI4MKR5M33YCI5CSLXCPL.json","graph_json":"https://pith.science/api/pith-number/BLNC4VI4MKR5M33YCI5CSLXCPL/graph.json","events_json":"https://pith.science/api/pith-number/BLNC4VI4MKR5M33YCI5CSLXCPL/events.json","paper":"https://pith.science/paper/BLNC4VI4"},"agent_actions":{"view_html":"https://pith.science/pith/BLNC4VI4MKR5M33YCI5CSLXCPL","download_json":"https://pith.science/pith/BLNC4VI4MKR5M33YCI5CSLXCPL.json","view_paper":"https://pith.science/paper/BLNC4VI4","resolve_alias":"https://pith.science/api/pith-number/resolve?arxiv=1612.01571&json=true","fetch_graph":"https://pith.science/api/pith-number/BLNC4VI4MKR5M33YCI5CSLXCPL/graph.json","fetch_events":"https://pith.science/api/pith-number/BLNC4VI4MKR5M33YCI5CSLXCPL/events.json","actions":{"anchor_timestamp":"https://pith.science/pith/BLNC4VI4MKR5M33YCI5CSLXCPL/action/timestamp_anchor","attest_storage":"https://pith.science/pith/BLNC4VI4MKR5M33YCI5CSLXCPL/action/storage_attestation","attest_author":"https://pith.science/pith/BLNC4VI4MKR5M33YCI5CSLXCPL/action/author_attestation","sign_citation":"https://pith.science/pith/BLNC4VI4MKR5M33YCI5CSLXCPL/action/citation_signature","submit_replication":"https://pith.science/pith/BLNC4VI4MKR5M33YCI5CSLXCPL/action/replication_record"}},"created_at":"2026-05-18T00:40:32.905323+00:00","updated_at":"2026-05-18T00:40:32.905323+00:00"}