{"bundle_type":"pith_open_graph_bundle","bundle_version":"1.0","pith_number":"pith:2019:BM2T653QW66PAW4DX6RIOFABRW","short_pith_number":"pith:BM2T653Q","canonical_record":{"source":{"id":"1901.08635","kind":"arxiv","version":1},"metadata":{"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.MN","submitted_at":"2019-01-24T20:32:52Z","cross_cats_sorted":[],"title_canon_sha256":"1534978deca9f7ee692e063fa375bf854056f320b827cbb3e479a37d5dfb4ab1","abstract_canon_sha256":"6f42a818df74987f34fa6a43f5e27dbe334bdf7409a41608c84045aa2679807e"},"schema_version":"1.0"},"canonical_sha256":"0b353f7770b7bcf05b83bfa28714018da26e1ad69db24aa960f837e4a1082890","source":{"kind":"arxiv","id":"1901.08635","version":1},"source_aliases":[{"alias_kind":"arxiv","alias_value":"1901.08635","created_at":"2026-05-17T23:55:33Z"},{"alias_kind":"arxiv_version","alias_value":"1901.08635v1","created_at":"2026-05-17T23:55:33Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.1901.08635","created_at":"2026-05-17T23:55:33Z"},{"alias_kind":"pith_short_12","alias_value":"BM2T653QW66P","created_at":"2026-05-18T12:33:12Z"},{"alias_kind":"pith_short_16","alias_value":"BM2T653QW66PAW4D","created_at":"2026-05-18T12:33:12Z"},{"alias_kind":"pith_short_8","alias_value":"BM2T653Q","created_at":"2026-05-18T12:33:12Z"}],"events":[{"event_type":"record_created","subject_pith_number":"pith:2019:BM2T653QW66PAW4DX6RIOFABRW","target":"record","payload":{"canonical_record":{"source":{"id":"1901.08635","kind":"arxiv","version":1},"metadata":{"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.MN","submitted_at":"2019-01-24T20:32:52Z","cross_cats_sorted":[],"title_canon_sha256":"1534978deca9f7ee692e063fa375bf854056f320b827cbb3e479a37d5dfb4ab1","abstract_canon_sha256":"6f42a818df74987f34fa6a43f5e27dbe334bdf7409a41608c84045aa2679807e"},"schema_version":"1.0"},"canonical_sha256":"0b353f7770b7bcf05b83bfa28714018da26e1ad69db24aa960f837e4a1082890","receipt":{"kind":"pith_receipt","key_id":"pith-v1-2026-05","algorithm":"ed25519","signed_at":"2026-05-17T23:55:33.536744Z","signature_b64":"b/R9/Al24TgCZC3QPdKhbdxyleSgD4x4ghjhVdnVAo6vdaCQduIq2EdVkHTiGn8f2hXaS8sK+hc5xKFWbxuoDg==","signed_message":"canonical_sha256_bytes","builder_version":"pith-number-builder-2026-05-17-v1","receipt_version":"0.3","canonical_sha256":"0b353f7770b7bcf05b83bfa28714018da26e1ad69db24aa960f837e4a1082890","last_reissued_at":"2026-05-17T23:55:33.536235Z","signature_status":"signed_v1","first_computed_at":"2026-05-17T23:55:33.536235Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"source_kind":"arxiv","source_id":"1901.08635","source_version":1,"attestation_state":"computed"},"signer":{"signer_id":"pith.science","signer_type":"pith_registry","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"created_at":"2026-05-17T23:55:33Z","supersedes":[],"prev_event":null,"signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"cb+cOdWV7lPA+ic7z9/xC28YZvJiiZIWclOy2lmPuZecmG4EJW3GtPtmQa4BvgDnbCMMXsEVVF9OhVdtP1owAA==","signed_message":"open_graph_event_sha256_bytes","signed_at":"2026-05-27T19:14:36.788245Z"},"content_sha256":"98771d16f24b1fa048425b4d35d8c6a1da246a544acaa4e8f4409af14170e384","schema_version":"1.0","event_id":"sha256:98771d16f24b1fa048425b4d35d8c6a1da246a544acaa4e8f4409af14170e384"},{"event_type":"graph_snapshot","subject_pith_number":"pith:2019:BM2T653QW66PAW4DX6RIOFABRW","target":"graph","payload":{"graph_snapshot":{"paper":{"title":"Stochastic modeling of phenotypic switching and chemoresistance in cancer cell populations","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","headline":"","cross_cats":[],"primary_cat":"q-bio.MN","authors_text":"Bala Sundaram, Gwendolyn M. Cramer, Jonathan P. Celli, Niraj Kumar, Rahul V. Kulkarni, Seyed Alireza Zamani Dahaj","submitted_at":"2019-01-24T20:32:52Z","abstract_excerpt":"Phenotypic heterogeneity in cancer cells is widely observed and is often linked to drug resistance. In several cases, such heterogeneity in drug sensitivity of tumors is driven by stochastic and reversible acquisition of a drug tolerant phenotype by individual cells even in an isogenic population. Accumulating evidence further suggests that cell-fate transitions such as the epithelial to mesenchymal transition (EMT) are associated with drug resistance. In this study, we analyze stochastic models of phenotypic switching to provide a framework for analyzing cell-fate transitions such as EMT as a"},"claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"1901.08635","kind":"arxiv","version":1},"verdict":{"id":null,"model_set":{},"created_at":null,"strongest_claim":"","one_line_summary":"","pipeline_version":null,"weakest_assumption":"","pith_extraction_headline":""},"references":{"count":0,"sample":[],"resolved_work":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","internal_anchors":0},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"author_claims":{"count":0,"strong_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"builder_version":"pith-number-builder-2026-05-17-v1"},"verdict_id":null},"signer":{"signer_id":"pith.science","signer_type":"pith_registry","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"created_at":"2026-05-17T23:55:33Z","supersedes":[],"prev_event":null,"signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"+rUupfjMHaWcibytRSeui3Zs/BAbfmwAyLktTaJcOBmyn3eTD2rj8KE1IdhDswtbEJM9lPp7WTIRL1Y5QRUWAA==","signed_message":"open_graph_event_sha256_bytes","signed_at":"2026-05-27T19:14:36.788933Z"},"content_sha256":"f95f333b75e2820187de201c80b524fe4438414da6a2dc01ee2dc60ea9a282f2","schema_version":"1.0","event_id":"sha256:f95f333b75e2820187de201c80b524fe4438414da6a2dc01ee2dc60ea9a282f2"}],"timestamp_proofs":[],"mirror_hints":[{"mirror_type":"https","name":"Pith Resolver","base_url":"https://pith.science","bundle_url":"https://pith.science/pith/BM2T653QW66PAW4DX6RIOFABRW/bundle.json","state_url":"https://pith.science/pith/BM2T653QW66PAW4DX6RIOFABRW/state.json","well_known_bundle_url":"https://pith.science/.well-known/pith/BM2T653QW66PAW4DX6RIOFABRW/bundle.json","status":"primary"}],"public_keys":[{"key_id":"pith-v1-2026-05","algorithm":"ed25519","format":"raw","public_key_b64":"stVStoiQhXFxp4s2pdzPNoqVNBMojDU/fJ2db5S3CbM=","public_key_hex":"b2d552b68890857171a78b36a5dccf368a953413288c353f7c9d9d6f94b709b3","fingerprint_sha256_b32_first128bits":"RVFV5Z2OI2J3ZUO7ERDEBCYNKS","fingerprint_sha256_hex":"8d4b5ee74e4693bcd1df2446408b0d54","rotates_at":null,"url":"https://pith.science/pith-signing-key.json","notes":"Pith uses this Ed25519 key to sign canonical record SHA-256 digests. Verify with: ed25519_verify(public_key, message=canonical_sha256_bytes, signature=base64decode(signature_b64))."}],"merge_version":"pith-open-graph-merge-v1","built_at":"2026-05-27T19:14:36Z","links":{"resolver":"https://pith.science/pith/BM2T653QW66PAW4DX6RIOFABRW","bundle":"https://pith.science/pith/BM2T653QW66PAW4DX6RIOFABRW/bundle.json","state":"https://pith.science/pith/BM2T653QW66PAW4DX6RIOFABRW/state.json","well_known_bundle":"https://pith.science/.well-known/pith/BM2T653QW66PAW4DX6RIOFABRW/bundle.json"},"state":{"state_type":"pith_open_graph_state","state_version":"1.0","pith_number":"pith:2019:BM2T653QW66PAW4DX6RIOFABRW","merge_version":"pith-open-graph-merge-v1","event_count":2,"valid_event_count":2,"invalid_event_count":0,"equivocation_count":0,"current":{"canonical_record":{"metadata":{"abstract_canon_sha256":"6f42a818df74987f34fa6a43f5e27dbe334bdf7409a41608c84045aa2679807e","cross_cats_sorted":[],"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.MN","submitted_at":"2019-01-24T20:32:52Z","title_canon_sha256":"1534978deca9f7ee692e063fa375bf854056f320b827cbb3e479a37d5dfb4ab1"},"schema_version":"1.0","source":{"id":"1901.08635","kind":"arxiv","version":1}},"source_aliases":[{"alias_kind":"arxiv","alias_value":"1901.08635","created_at":"2026-05-17T23:55:33Z"},{"alias_kind":"arxiv_version","alias_value":"1901.08635v1","created_at":"2026-05-17T23:55:33Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.1901.08635","created_at":"2026-05-17T23:55:33Z"},{"alias_kind":"pith_short_12","alias_value":"BM2T653QW66P","created_at":"2026-05-18T12:33:12Z"},{"alias_kind":"pith_short_16","alias_value":"BM2T653QW66PAW4D","created_at":"2026-05-18T12:33:12Z"},{"alias_kind":"pith_short_8","alias_value":"BM2T653Q","created_at":"2026-05-18T12:33:12Z"}],"graph_snapshots":[{"event_id":"sha256:f95f333b75e2820187de201c80b524fe4438414da6a2dc01ee2dc60ea9a282f2","target":"graph","created_at":"2026-05-17T23:55:33Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"graph_snapshot":{"author_claims":{"count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","strong_count":0},"builder_version":"pith-number-builder-2026-05-17-v1","claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"paper":{"abstract_excerpt":"Phenotypic heterogeneity in cancer cells is widely observed and is often linked to drug resistance. In several cases, such heterogeneity in drug sensitivity of tumors is driven by stochastic and reversible acquisition of a drug tolerant phenotype by individual cells even in an isogenic population. Accumulating evidence further suggests that cell-fate transitions such as the epithelial to mesenchymal transition (EMT) are associated with drug resistance. In this study, we analyze stochastic models of phenotypic switching to provide a framework for analyzing cell-fate transitions such as EMT as a","authors_text":"Bala Sundaram, Gwendolyn M. Cramer, Jonathan P. Celli, Niraj Kumar, Rahul V. Kulkarni, Seyed Alireza Zamani Dahaj","cross_cats":[],"headline":"","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.MN","submitted_at":"2019-01-24T20:32:52Z","title":"Stochastic modeling of phenotypic switching and chemoresistance in cancer cell populations"},"references":{"count":0,"internal_anchors":0,"resolved_work":0,"sample":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"1901.08635","kind":"arxiv","version":1},"verdict":{"created_at":null,"id":null,"model_set":{},"one_line_summary":"","pipeline_version":null,"pith_extraction_headline":"","strongest_claim":"","weakest_assumption":""}},"verdict_id":null}}],"author_attestations":[],"timestamp_anchors":[],"storage_attestations":[],"citation_signatures":[],"replication_records":[],"corrections":[],"mirror_hints":[],"record_created":{"event_id":"sha256:98771d16f24b1fa048425b4d35d8c6a1da246a544acaa4e8f4409af14170e384","target":"record","created_at":"2026-05-17T23:55:33Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"attestation_state":"computed","canonical_record":{"metadata":{"abstract_canon_sha256":"6f42a818df74987f34fa6a43f5e27dbe334bdf7409a41608c84045aa2679807e","cross_cats_sorted":[],"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.MN","submitted_at":"2019-01-24T20:32:52Z","title_canon_sha256":"1534978deca9f7ee692e063fa375bf854056f320b827cbb3e479a37d5dfb4ab1"},"schema_version":"1.0","source":{"id":"1901.08635","kind":"arxiv","version":1}},"canonical_sha256":"0b353f7770b7bcf05b83bfa28714018da26e1ad69db24aa960f837e4a1082890","receipt":{"algorithm":"ed25519","builder_version":"pith-number-builder-2026-05-17-v1","canonical_sha256":"0b353f7770b7bcf05b83bfa28714018da26e1ad69db24aa960f837e4a1082890","first_computed_at":"2026-05-17T23:55:33.536235Z","key_id":"pith-v1-2026-05","kind":"pith_receipt","last_reissued_at":"2026-05-17T23:55:33.536235Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","receipt_version":"0.3","signature_b64":"b/R9/Al24TgCZC3QPdKhbdxyleSgD4x4ghjhVdnVAo6vdaCQduIq2EdVkHTiGn8f2hXaS8sK+hc5xKFWbxuoDg==","signature_status":"signed_v1","signed_at":"2026-05-17T23:55:33.536744Z","signed_message":"canonical_sha256_bytes"},"source_id":"1901.08635","source_kind":"arxiv","source_version":1}}},"equivocations":[],"invalid_events":[],"applied_event_ids":["sha256:98771d16f24b1fa048425b4d35d8c6a1da246a544acaa4e8f4409af14170e384","sha256:f95f333b75e2820187de201c80b524fe4438414da6a2dc01ee2dc60ea9a282f2"],"state_sha256":"469fa4afdeabd431c6b84a7276e33c9b776306e7855f6404b7d2252bc1e01d19"},"bundle_signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"2FQ+oe+c2QCMsdsCWtCHRJ9m7441e4sXd0LmQhiljSHh+MyQo3QHyRtxHZs5gKZQ0X++k9FrRPfav6pC5GvsAg==","signed_message":"bundle_sha256_bytes","signed_at":"2026-05-27T19:14:36.792356Z","bundle_sha256":"79bf4432e4722d5168caccb84751be51d08389c8d935e1597d9081e0ff43742b"}}