{"record_type":"pith_number_record","schema_url":"https://pith.science/schemas/pith-number/v1.json","pith_number":"pith:2013:BQBYQLWU2J5YTBJRL2M6RDAFXP","short_pith_number":"pith:BQBYQLWU","schema_version":"1.0","canonical_sha256":"0c03882ed4d27b8985315e99e88c05bbf0c869f68725673301644e9fb9008234","source":{"kind":"arxiv","id":"1302.2724","version":1},"attestation_state":"computed","paper":{"title":"Extrinsic noise driven phenotype switching in a self-regulating gene","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","headline":"","cross_cats":["cond-mat.stat-mech","q-bio.QM"],"primary_cat":"q-bio.MN","authors_text":"Elijah Roberts, Michael Assaf, Nigel Goldenfeld, Zaida Luthey-Schulten","submitted_at":"2013-02-12T07:41:10Z","abstract_excerpt":"Due to inherent noise in intracellular networks cellular decisions can be random, so genetically identical cells can display different phenotypic behavior even in identical environments. Most previous work in understanding the decision-making process has focused on the role of intrinsic noise in these systems. Yet, especially in the high copy-number regime, extrinsic noise has been shown to be much more significant. Here, using a prototypical example of a bistable self-regulating gene model, we develop a theoretical framework describing the combined effect of intrinsic and extrinsic noise on t"},"verification_status":{"content_addressed":true,"pith_receipt":true,"author_attested":false,"weak_author_claims":0,"strong_author_claims":0,"externally_anchored":false,"storage_verified":false,"citation_signatures":0,"replication_records":0,"graph_snapshot":true,"references_resolved":false,"formal_links_present":false},"canonical_record":{"source":{"id":"1302.2724","kind":"arxiv","version":1},"metadata":{"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.MN","submitted_at":"2013-02-12T07:41:10Z","cross_cats_sorted":["cond-mat.stat-mech","q-bio.QM"],"title_canon_sha256":"f111af808ef0ebf266257a3dbeb090b15bedcda8a5593ecc82f86f6044484d04","abstract_canon_sha256":"221d39ca8aba5b69abe6e5bf39787598cf7ca6538eed1976aea5e845920fa405"},"schema_version":"1.0"},"receipt":{"kind":"pith_receipt","key_id":"pith-v1-2026-05","algorithm":"ed25519","signed_at":"2026-05-18T01:51:42.298391Z","signature_b64":"qkJ1HNA+yyoRCWkzxMs40XdNi0Fg3p2bkZsMwfWsgj6KrXDJyAliZlW6YTMPUffAXsoZqpNkmqoCDitBeERRBA==","signed_message":"canonical_sha256_bytes","builder_version":"pith-number-builder-2026-05-17-v1","receipt_version":"0.3","canonical_sha256":"0c03882ed4d27b8985315e99e88c05bbf0c869f68725673301644e9fb9008234","last_reissued_at":"2026-05-18T01:51:42.297874Z","signature_status":"signed_v1","first_computed_at":"2026-05-18T01:51:42.297874Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"graph_snapshot":{"paper":{"title":"Extrinsic noise driven phenotype switching in a self-regulating gene","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","headline":"","cross_cats":["cond-mat.stat-mech","q-bio.QM"],"primary_cat":"q-bio.MN","authors_text":"Elijah Roberts, Michael Assaf, Nigel Goldenfeld, Zaida Luthey-Schulten","submitted_at":"2013-02-12T07:41:10Z","abstract_excerpt":"Due to inherent noise in intracellular networks cellular decisions can be random, so genetically identical cells can display different phenotypic behavior even in identical environments. Most previous work in understanding the decision-making process has focused on the role of intrinsic noise in these systems. Yet, especially in the high copy-number regime, extrinsic noise has been shown to be much more significant. Here, using a prototypical example of a bistable self-regulating gene model, we develop a theoretical framework describing the combined effect of intrinsic and extrinsic noise on t"},"claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"1302.2724","kind":"arxiv","version":1},"verdict":{"id":null,"model_set":{},"created_at":null,"strongest_claim":"","one_line_summary":"","pipeline_version":null,"weakest_assumption":"","pith_extraction_headline":""},"references":{"count":0,"sample":[],"resolved_work":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","internal_anchors":0},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"author_claims":{"count":0,"strong_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"builder_version":"pith-number-builder-2026-05-17-v1"},"aliases":[{"alias_kind":"arxiv","alias_value":"1302.2724","created_at":"2026-05-18T01:51:42.297969+00:00"},{"alias_kind":"arxiv_version","alias_value":"1302.2724v1","created_at":"2026-05-18T01:51:42.297969+00:00"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.1302.2724","created_at":"2026-05-18T01:51:42.297969+00:00"},{"alias_kind":"pith_short_12","alias_value":"BQBYQLWU2J5Y","created_at":"2026-05-18T12:27:40.988391+00:00"},{"alias_kind":"pith_short_16","alias_value":"BQBYQLWU2J5YTBJR","created_at":"2026-05-18T12:27:40.988391+00:00"},{"alias_kind":"pith_short_8","alias_value":"BQBYQLWU","created_at":"2026-05-18T12:27:40.988391+00:00"}],"events":[],"event_summary":{},"paper_claims":[],"inbound_citations":{"count":0,"internal_anchor_count":0,"sample":[]},"formal_canon":{"evidence_count":0,"sample":[],"anchors":[]},"links":{"html":"https://pith.science/pith/BQBYQLWU2J5YTBJRL2M6RDAFXP","json":"https://pith.science/pith/BQBYQLWU2J5YTBJRL2M6RDAFXP.json","graph_json":"https://pith.science/api/pith-number/BQBYQLWU2J5YTBJRL2M6RDAFXP/graph.json","events_json":"https://pith.science/api/pith-number/BQBYQLWU2J5YTBJRL2M6RDAFXP/events.json","paper":"https://pith.science/paper/BQBYQLWU"},"agent_actions":{"view_html":"https://pith.science/pith/BQBYQLWU2J5YTBJRL2M6RDAFXP","download_json":"https://pith.science/pith/BQBYQLWU2J5YTBJRL2M6RDAFXP.json","view_paper":"https://pith.science/paper/BQBYQLWU","resolve_alias":"https://pith.science/api/pith-number/resolve?arxiv=1302.2724&json=true","fetch_graph":"https://pith.science/api/pith-number/BQBYQLWU2J5YTBJRL2M6RDAFXP/graph.json","fetch_events":"https://pith.science/api/pith-number/BQBYQLWU2J5YTBJRL2M6RDAFXP/events.json","actions":{"anchor_timestamp":"https://pith.science/pith/BQBYQLWU2J5YTBJRL2M6RDAFXP/action/timestamp_anchor","attest_storage":"https://pith.science/pith/BQBYQLWU2J5YTBJRL2M6RDAFXP/action/storage_attestation","attest_author":"https://pith.science/pith/BQBYQLWU2J5YTBJRL2M6RDAFXP/action/author_attestation","sign_citation":"https://pith.science/pith/BQBYQLWU2J5YTBJRL2M6RDAFXP/action/citation_signature","submit_replication":"https://pith.science/pith/BQBYQLWU2J5YTBJRL2M6RDAFXP/action/replication_record"}},"created_at":"2026-05-18T01:51:42.297969+00:00","updated_at":"2026-05-18T01:51:42.297969+00:00"}