{"state_type":"pith_open_graph_state","state_version":"1.0","pith_number":"pith:2017:BTFUEULJ2GV4CIMP2RBKO33UAI","merge_version":"pith-open-graph-merge-v1","event_count":2,"valid_event_count":2,"invalid_event_count":0,"equivocation_count":0,"current":{"canonical_record":{"metadata":{"abstract_canon_sha256":"adfc6f0bb369d14cce0a366ce58c5ff6f561038fbf4793e4ebbcf800b981957a","cross_cats_sorted":[],"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.GN","submitted_at":"2017-05-22T16:54:56Z","title_canon_sha256":"abdd6ee0d189dd795659d623bacdf5ddf688f65379a6f5b75bf671cc5ffe270c"},"schema_version":"1.0","source":{"id":"1705.07850","kind":"arxiv","version":2}},"source_aliases":[{"alias_kind":"arxiv","alias_value":"1705.07850","created_at":"2026-05-18T00:17:01Z"},{"alias_kind":"arxiv_version","alias_value":"1705.07850v2","created_at":"2026-05-18T00:17:01Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.1705.07850","created_at":"2026-05-18T00:17:01Z"},{"alias_kind":"pith_short_12","alias_value":"BTFUEULJ2GV4","created_at":"2026-05-18T12:31:08Z"},{"alias_kind":"pith_short_16","alias_value":"BTFUEULJ2GV4CIMP","created_at":"2026-05-18T12:31:08Z"},{"alias_kind":"pith_short_8","alias_value":"BTFUEULJ","created_at":"2026-05-18T12:31:08Z"}],"graph_snapshots":[{"event_id":"sha256:b81f98791f010838211ecd5d212230072430ebfe1c33e6d8cccb092fb0840a17","target":"graph","created_at":"2026-05-18T00:17:01Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"graph_snapshot":{"author_claims":{"count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","strong_count":0},"builder_version":"pith-number-builder-2026-05-17-v1","claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"paper":{"abstract_excerpt":"Essential genes constitute the core of genes which cannot be mutated too much nor lost along the evolutionary history of a species. Natural selection is expected to be stricter on essential genes and on conserved (highly shared) genes, than on genes that are either nonessential or peculiar to a single or a few species. In order to further assess this expectation, we study here how essentiality of a gene is connected with its degree of conservation among several unrelated bacterial species, each one characterised by its own codon usage bias. Confirming previous results on E. coli, we show the e","authors_text":"Andrea Giansanti, Giulio Cimini, Maddalena Dilucca","cross_cats":[],"headline":"","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.GN","submitted_at":"2017-05-22T16:54:56Z","title":"Essentiality, conservation, evolutionary pressure and codon bias in bacterial genes"},"references":{"count":0,"internal_anchors":0,"resolved_work":0,"sample":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"1705.07850","kind":"arxiv","version":2},"verdict":{"created_at":null,"id":null,"model_set":{},"one_line_summary":"","pipeline_version":null,"pith_extraction_headline":"","strongest_claim":"","weakest_assumption":""}},"verdict_id":null}}],"author_attestations":[],"timestamp_anchors":[],"storage_attestations":[],"citation_signatures":[],"replication_records":[],"corrections":[],"mirror_hints":[],"record_created":{"event_id":"sha256:dab553981779e90cdd294be9c6beef7f05d0375f1d763908b5222471483e292b","target":"record","created_at":"2026-05-18T00:17:01Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"attestation_state":"computed","canonical_record":{"metadata":{"abstract_canon_sha256":"adfc6f0bb369d14cce0a366ce58c5ff6f561038fbf4793e4ebbcf800b981957a","cross_cats_sorted":[],"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.GN","submitted_at":"2017-05-22T16:54:56Z","title_canon_sha256":"abdd6ee0d189dd795659d623bacdf5ddf688f65379a6f5b75bf671cc5ffe270c"},"schema_version":"1.0","source":{"id":"1705.07850","kind":"arxiv","version":2}},"canonical_sha256":"0ccb425169d1abc1218fd442a76f74020bc4c81f63c56ff1592a649dc0c9ddd5","receipt":{"algorithm":"ed25519","builder_version":"pith-number-builder-2026-05-17-v1","canonical_sha256":"0ccb425169d1abc1218fd442a76f74020bc4c81f63c56ff1592a649dc0c9ddd5","first_computed_at":"2026-05-18T00:17:01.869514Z","key_id":"pith-v1-2026-05","kind":"pith_receipt","last_reissued_at":"2026-05-18T00:17:01.869514Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","receipt_version":"0.3","signature_b64":"LeoLCNfSlkf+He3lLg4Q1Ec+IVFFoclecy/yPSQbvjZfE1K7egy93h5tO+iO4hCMmXz5sxJWFgCbLLEVHI8EAw==","signature_status":"signed_v1","signed_at":"2026-05-18T00:17:01.870049Z","signed_message":"canonical_sha256_bytes"},"source_id":"1705.07850","source_kind":"arxiv","source_version":2}}},"equivocations":[],"invalid_events":[],"applied_event_ids":["sha256:dab553981779e90cdd294be9c6beef7f05d0375f1d763908b5222471483e292b","sha256:b81f98791f010838211ecd5d212230072430ebfe1c33e6d8cccb092fb0840a17"],"state_sha256":"c336dd3b943d3fe3351ce75503761b0b82f6baa45e87049c863ee9db9d981ed8"}