{"bundle_type":"pith_open_graph_bundle","bundle_version":"1.0","pith_number":"pith:2015:BZUSR2XQHZ7KAOSSZDVKTOIVZ3","short_pith_number":"pith:BZUSR2XQ","canonical_record":{"source":{"id":"1503.06448","kind":"arxiv","version":1},"metadata":{"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"stat.ME","submitted_at":"2015-03-22T17:53:11Z","cross_cats_sorted":[],"title_canon_sha256":"5a52ba0a539ec297ca567104d2128a77562fa0967c6a14f0530f551afe6be171","abstract_canon_sha256":"20a17919ecbeaae1b0293ebfd0571e775dcec6a096f8249f744eebe5329880c7"},"schema_version":"1.0"},"canonical_sha256":"0e6928eaf03e7ea03a52c8eaa9b915cee0e5fd78bd8d7b0ba7accce1a3aceeee","source":{"kind":"arxiv","id":"1503.06448","version":1},"source_aliases":[{"alias_kind":"arxiv","alias_value":"1503.06448","created_at":"2026-05-18T02:20:38Z"},{"alias_kind":"arxiv_version","alias_value":"1503.06448v1","created_at":"2026-05-18T02:20:38Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.1503.06448","created_at":"2026-05-18T02:20:38Z"},{"alias_kind":"pith_short_12","alias_value":"BZUSR2XQHZ7K","created_at":"2026-05-18T12:29:14Z"},{"alias_kind":"pith_short_16","alias_value":"BZUSR2XQHZ7KAOSS","created_at":"2026-05-18T12:29:14Z"},{"alias_kind":"pith_short_8","alias_value":"BZUSR2XQ","created_at":"2026-05-18T12:29:14Z"}],"events":[{"event_type":"record_created","subject_pith_number":"pith:2015:BZUSR2XQHZ7KAOSSZDVKTOIVZ3","target":"record","payload":{"canonical_record":{"source":{"id":"1503.06448","kind":"arxiv","version":1},"metadata":{"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"stat.ME","submitted_at":"2015-03-22T17:53:11Z","cross_cats_sorted":[],"title_canon_sha256":"5a52ba0a539ec297ca567104d2128a77562fa0967c6a14f0530f551afe6be171","abstract_canon_sha256":"20a17919ecbeaae1b0293ebfd0571e775dcec6a096f8249f744eebe5329880c7"},"schema_version":"1.0"},"canonical_sha256":"0e6928eaf03e7ea03a52c8eaa9b915cee0e5fd78bd8d7b0ba7accce1a3aceeee","receipt":{"kind":"pith_receipt","key_id":"pith-v1-2026-05","algorithm":"ed25519","signed_at":"2026-05-18T02:20:38.369805Z","signature_b64":"WHdnTq+GIL42eMk9vVFyS3AbKlWAxYwKuPWZA2wxKewy8YUs4OcqzycacGP8YHZsCqB9tHug8RaD5t8pNpz4Aw==","signed_message":"canonical_sha256_bytes","builder_version":"pith-number-builder-2026-05-17-v1","receipt_version":"0.3","canonical_sha256":"0e6928eaf03e7ea03a52c8eaa9b915cee0e5fd78bd8d7b0ba7accce1a3aceeee","last_reissued_at":"2026-05-18T02:20:38.368768Z","signature_status":"signed_v1","first_computed_at":"2026-05-18T02:20:38.368768Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"source_kind":"arxiv","source_id":"1503.06448","source_version":1,"attestation_state":"computed"},"signer":{"signer_id":"pith.science","signer_type":"pith_registry","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"created_at":"2026-05-18T02:20:38Z","supersedes":[],"prev_event":null,"signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"1EKpnKQ58VDb9xixx3CjBW9itoAvFqZW/C5Caoy5vvQAFGEDCukjOounCLZ+4qi6/gidmWpR2Zh+JS5TZeBwBw==","signed_message":"open_graph_event_sha256_bytes","signed_at":"2026-05-31T22:23:09.061955Z"},"content_sha256":"7961fc867c36cbb3ca1afe309a49f0a250fefd9e4cb22a14bf97f81aed6bd5e5","schema_version":"1.0","event_id":"sha256:7961fc867c36cbb3ca1afe309a49f0a250fefd9e4cb22a14bf97f81aed6bd5e5"},{"event_type":"graph_snapshot","subject_pith_number":"pith:2015:BZUSR2XQHZ7KAOSSZDVKTOIVZ3","target":"graph","payload":{"graph_snapshot":{"paper":{"title":"Personalized Screening Intervals for Biomarkers using Joint Models for Longitudinal and Survival Data","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","headline":"","cross_cats":[],"primary_cat":"stat.ME","authors_text":"Dimitris Rizopoulos, Ewout W. Steyerberg, Jeremy M.G. Taylor, Johanna J.M. Takkenberg, Joost van Rosmalen","submitted_at":"2015-03-22T17:53:11Z","abstract_excerpt":"Screening and surveillance are routinely used in medicine for early detection of disease and close monitoring of progression. Biomarkers are one of the primarily tools used for these tasks, but their successful translation to clinical practice is closely linked to their ability to accurately predict clinical endpoints during follow-up. Motivated by a study of patients who received a human tissue valve in the aortic position, in this work we are interested in optimizing and personalizing screening intervals for longitudinal biomarker measurements. Our aim in this paper is twofold: First, to app"},"claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"1503.06448","kind":"arxiv","version":1},"verdict":{"id":null,"model_set":{},"created_at":null,"strongest_claim":"","one_line_summary":"","pipeline_version":null,"weakest_assumption":"","pith_extraction_headline":""},"references":{"count":0,"sample":[],"resolved_work":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","internal_anchors":0},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"author_claims":{"count":0,"strong_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"builder_version":"pith-number-builder-2026-05-17-v1"},"verdict_id":null},"signer":{"signer_id":"pith.science","signer_type":"pith_registry","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"created_at":"2026-05-18T02:20:38Z","supersedes":[],"prev_event":null,"signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"/irZ/ibwTIuRTA2pJkyAjuYJEql0tv+A7gXUMNUJcO9YM/RM5FNCMz3hsRLX1Vi0WV4LqBq53xE/eeupohn2AA==","signed_message":"open_graph_event_sha256_bytes","signed_at":"2026-05-31T22:23:09.062556Z"},"content_sha256":"16818eb3047c8fa43024b6a80371034ba530383a3133197d24d86bdf46833da7","schema_version":"1.0","event_id":"sha256:16818eb3047c8fa43024b6a80371034ba530383a3133197d24d86bdf46833da7"}],"timestamp_proofs":[],"mirror_hints":[{"mirror_type":"https","name":"Pith Resolver","base_url":"https://pith.science","bundle_url":"https://pith.science/pith/BZUSR2XQHZ7KAOSSZDVKTOIVZ3/bundle.json","state_url":"https://pith.science/pith/BZUSR2XQHZ7KAOSSZDVKTOIVZ3/state.json","well_known_bundle_url":"https://pith.science/.well-known/pith/BZUSR2XQHZ7KAOSSZDVKTOIVZ3/bundle.json","status":"primary"}],"public_keys":[{"key_id":"pith-v1-2026-05","algorithm":"ed25519","format":"raw","public_key_b64":"stVStoiQhXFxp4s2pdzPNoqVNBMojDU/fJ2db5S3CbM=","public_key_hex":"b2d552b68890857171a78b36a5dccf368a953413288c353f7c9d9d6f94b709b3","fingerprint_sha256_b32_first128bits":"RVFV5Z2OI2J3ZUO7ERDEBCYNKS","fingerprint_sha256_hex":"8d4b5ee74e4693bcd1df2446408b0d54","rotates_at":null,"url":"https://pith.science/pith-signing-key.json","notes":"Pith uses this Ed25519 key to sign canonical record SHA-256 digests. Verify with: ed25519_verify(public_key, message=canonical_sha256_bytes, signature=base64decode(signature_b64))."}],"merge_version":"pith-open-graph-merge-v1","built_at":"2026-05-31T22:23:09Z","links":{"resolver":"https://pith.science/pith/BZUSR2XQHZ7KAOSSZDVKTOIVZ3","bundle":"https://pith.science/pith/BZUSR2XQHZ7KAOSSZDVKTOIVZ3/bundle.json","state":"https://pith.science/pith/BZUSR2XQHZ7KAOSSZDVKTOIVZ3/state.json","well_known_bundle":"https://pith.science/.well-known/pith/BZUSR2XQHZ7KAOSSZDVKTOIVZ3/bundle.json"},"state":{"state_type":"pith_open_graph_state","state_version":"1.0","pith_number":"pith:2015:BZUSR2XQHZ7KAOSSZDVKTOIVZ3","merge_version":"pith-open-graph-merge-v1","event_count":2,"valid_event_count":2,"invalid_event_count":0,"equivocation_count":0,"current":{"canonical_record":{"metadata":{"abstract_canon_sha256":"20a17919ecbeaae1b0293ebfd0571e775dcec6a096f8249f744eebe5329880c7","cross_cats_sorted":[],"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"stat.ME","submitted_at":"2015-03-22T17:53:11Z","title_canon_sha256":"5a52ba0a539ec297ca567104d2128a77562fa0967c6a14f0530f551afe6be171"},"schema_version":"1.0","source":{"id":"1503.06448","kind":"arxiv","version":1}},"source_aliases":[{"alias_kind":"arxiv","alias_value":"1503.06448","created_at":"2026-05-18T02:20:38Z"},{"alias_kind":"arxiv_version","alias_value":"1503.06448v1","created_at":"2026-05-18T02:20:38Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.1503.06448","created_at":"2026-05-18T02:20:38Z"},{"alias_kind":"pith_short_12","alias_value":"BZUSR2XQHZ7K","created_at":"2026-05-18T12:29:14Z"},{"alias_kind":"pith_short_16","alias_value":"BZUSR2XQHZ7KAOSS","created_at":"2026-05-18T12:29:14Z"},{"alias_kind":"pith_short_8","alias_value":"BZUSR2XQ","created_at":"2026-05-18T12:29:14Z"}],"graph_snapshots":[{"event_id":"sha256:16818eb3047c8fa43024b6a80371034ba530383a3133197d24d86bdf46833da7","target":"graph","created_at":"2026-05-18T02:20:38Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"graph_snapshot":{"author_claims":{"count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","strong_count":0},"builder_version":"pith-number-builder-2026-05-17-v1","claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"paper":{"abstract_excerpt":"Screening and surveillance are routinely used in medicine for early detection of disease and close monitoring of progression. Biomarkers are one of the primarily tools used for these tasks, but their successful translation to clinical practice is closely linked to their ability to accurately predict clinical endpoints during follow-up. Motivated by a study of patients who received a human tissue valve in the aortic position, in this work we are interested in optimizing and personalizing screening intervals for longitudinal biomarker measurements. Our aim in this paper is twofold: First, to app","authors_text":"Dimitris Rizopoulos, Ewout W. Steyerberg, Jeremy M.G. Taylor, Johanna J.M. Takkenberg, Joost van Rosmalen","cross_cats":[],"headline":"","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"stat.ME","submitted_at":"2015-03-22T17:53:11Z","title":"Personalized Screening Intervals for Biomarkers using Joint Models for Longitudinal and Survival Data"},"references":{"count":0,"internal_anchors":0,"resolved_work":0,"sample":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"1503.06448","kind":"arxiv","version":1},"verdict":{"created_at":null,"id":null,"model_set":{},"one_line_summary":"","pipeline_version":null,"pith_extraction_headline":"","strongest_claim":"","weakest_assumption":""}},"verdict_id":null}}],"author_attestations":[],"timestamp_anchors":[],"storage_attestations":[],"citation_signatures":[],"replication_records":[],"corrections":[],"mirror_hints":[],"record_created":{"event_id":"sha256:7961fc867c36cbb3ca1afe309a49f0a250fefd9e4cb22a14bf97f81aed6bd5e5","target":"record","created_at":"2026-05-18T02:20:38Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"attestation_state":"computed","canonical_record":{"metadata":{"abstract_canon_sha256":"20a17919ecbeaae1b0293ebfd0571e775dcec6a096f8249f744eebe5329880c7","cross_cats_sorted":[],"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"stat.ME","submitted_at":"2015-03-22T17:53:11Z","title_canon_sha256":"5a52ba0a539ec297ca567104d2128a77562fa0967c6a14f0530f551afe6be171"},"schema_version":"1.0","source":{"id":"1503.06448","kind":"arxiv","version":1}},"canonical_sha256":"0e6928eaf03e7ea03a52c8eaa9b915cee0e5fd78bd8d7b0ba7accce1a3aceeee","receipt":{"algorithm":"ed25519","builder_version":"pith-number-builder-2026-05-17-v1","canonical_sha256":"0e6928eaf03e7ea03a52c8eaa9b915cee0e5fd78bd8d7b0ba7accce1a3aceeee","first_computed_at":"2026-05-18T02:20:38.368768Z","key_id":"pith-v1-2026-05","kind":"pith_receipt","last_reissued_at":"2026-05-18T02:20:38.368768Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","receipt_version":"0.3","signature_b64":"WHdnTq+GIL42eMk9vVFyS3AbKlWAxYwKuPWZA2wxKewy8YUs4OcqzycacGP8YHZsCqB9tHug8RaD5t8pNpz4Aw==","signature_status":"signed_v1","signed_at":"2026-05-18T02:20:38.369805Z","signed_message":"canonical_sha256_bytes"},"source_id":"1503.06448","source_kind":"arxiv","source_version":1}}},"equivocations":[],"invalid_events":[],"applied_event_ids":["sha256:7961fc867c36cbb3ca1afe309a49f0a250fefd9e4cb22a14bf97f81aed6bd5e5","sha256:16818eb3047c8fa43024b6a80371034ba530383a3133197d24d86bdf46833da7"],"state_sha256":"da5b445bb4bd252135cfb7759166abc728300f8bccf7007e3f390aba37a0a735"},"bundle_signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"JhDc0Hi9ZAtzhvVHFuyzyyR0Dfr3bYhDkUSD1EUFSo1fVuapAaFRiK0ftrpoc7INKth/Mc3UDjV4QJLhtHJHDw==","signed_message":"bundle_sha256_bytes","signed_at":"2026-05-31T22:23:09.065808Z","bundle_sha256":"751845782b31253e366ec303bce8673b56b308081556d9a546787034233e455c"}}