{"state_type":"pith_open_graph_state","state_version":"1.0","pith_number":"pith:2022:C2V5D5GLDW56ATUIUFAM27KNX7","merge_version":"pith-open-graph-merge-v1","event_count":2,"valid_event_count":2,"invalid_event_count":0,"equivocation_count":0,"current":{"canonical_record":{"metadata":{"abstract_canon_sha256":"f4026da2edf92c3106efe135de77534dc7f9d79a3a0fc7a6f0dd9be35b77fd5f","cross_cats_sorted":["cs.LG"],"license":"http://creativecommons.org/licenses/by-nc-sa/4.0/","primary_cat":"eess.IV","submitted_at":"2022-01-19T08:26:49Z","title_canon_sha256":"08d5ea7799529d04f0ef40ac11d0a9ecaa78269d54e935e6da749d151e84a985"},"schema_version":"1.0","source":{"id":"2201.07463","kind":"arxiv","version":1}},"source_aliases":[{"alias_kind":"arxiv","alias_value":"2201.07463","created_at":"2026-07-05T03:49:46Z"},{"alias_kind":"arxiv_version","alias_value":"2201.07463v1","created_at":"2026-07-05T03:49:46Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.2201.07463","created_at":"2026-07-05T03:49:46Z"},{"alias_kind":"pith_short_12","alias_value":"C2V5D5GLDW56","created_at":"2026-07-05T03:49:46Z"},{"alias_kind":"pith_short_16","alias_value":"C2V5D5GLDW56ATUI","created_at":"2026-07-05T03:49:46Z"},{"alias_kind":"pith_short_8","alias_value":"C2V5D5GL","created_at":"2026-07-05T03:49:46Z"}],"graph_snapshots":[{"event_id":"sha256:0f4d7d05b1db58572a35cad9634dd5704547e43d49455df55d971de84b78596d","target":"graph","created_at":"2026-07-05T03:49:46Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"graph_snapshot":{"author_claims":{"count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","strong_count":0},"builder_version":"pith-number-builder-2026-05-17-v1","claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"integrity":{"available":true,"clean":true,"detectors_run":[],"endpoint":"/pith/2201.07463/integrity.json","findings":[],"snapshot_sha256":"c28c3603d3b5d939e8dc4c7e95fa8dfce3d595e45f758748cecf8e644a296938","summary":{"advisory":0,"by_detector":{},"critical":0,"informational":0}},"paper":{"abstract_excerpt":"The current multiple sclerosis (MS) diagnostic criteria lack specificity, and this may lead to misdiagnosis, which remains an issue in present-day clinical practice. In addition, conventional biomarkers only moderately correlate with MS disease progression. Recently, advanced MS lesional imaging biomarkers such as cortical lesions (CL), the central vein sign (CVS), and paramagnetic rim lesions (PRL), visible in specialized magnetic resonance imaging (MRI) sequences, have shown higher specificity in differential diagnosis. Moreover, studies have shown that CL and PRL are potential prognostic bi","authors_text":"Cristina Granziera, Daniel S Reich, Erin S Beck, Francesco La Rosa, Jean-Philippe Thiran, Martina Absinta, Maxence Wynen, Meritxell Bach Cuadra, Omar Al-Louzi, Pascal Sati, Pietro Maggi, Russell T Shinohara, Till Huelnhagen, Tobias Kober","cross_cats":["cs.LG"],"headline":"","license":"http://creativecommons.org/licenses/by-nc-sa/4.0/","primary_cat":"eess.IV","submitted_at":"2022-01-19T08:26:49Z","title":"Cortical lesions, central vein sign, and paramagnetic rim lesions in multiple sclerosis: emerging machine learning techniques and future avenues"},"references":{"count":0,"internal_anchors":0,"resolved_work":0,"sample":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"2201.07463","kind":"arxiv","version":1},"verdict":{"created_at":null,"id":null,"model_set":{},"one_line_summary":"","pipeline_version":null,"pith_extraction_headline":"","strongest_claim":"","weakest_assumption":""}},"verdict_id":null}}],"author_attestations":[],"timestamp_anchors":[],"storage_attestations":[],"citation_signatures":[],"replication_records":[],"corrections":[],"mirror_hints":[],"record_created":{"event_id":"sha256:18ff6e760692b44f3f798a4ca468c48da13c2eb4b5c219b3e1ceee7b6eadfc50","target":"record","created_at":"2026-07-05T03:49:46Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"attestation_state":"computed","canonical_record":{"metadata":{"abstract_canon_sha256":"f4026da2edf92c3106efe135de77534dc7f9d79a3a0fc7a6f0dd9be35b77fd5f","cross_cats_sorted":["cs.LG"],"license":"http://creativecommons.org/licenses/by-nc-sa/4.0/","primary_cat":"eess.IV","submitted_at":"2022-01-19T08:26:49Z","title_canon_sha256":"08d5ea7799529d04f0ef40ac11d0a9ecaa78269d54e935e6da749d151e84a985"},"schema_version":"1.0","source":{"id":"2201.07463","kind":"arxiv","version":1}},"canonical_sha256":"16abd1f4cb1dbbe04e88a140cd7d4dbfc695c0b1b5b133e6072f73dc09d20812","receipt":{"algorithm":"ed25519","builder_version":"pith-number-builder-2026-05-17-v1","canonical_sha256":"16abd1f4cb1dbbe04e88a140cd7d4dbfc695c0b1b5b133e6072f73dc09d20812","first_computed_at":"2026-07-05T03:49:46.770130Z","key_id":"pith-v1-2026-05","kind":"pith_receipt","last_reissued_at":"2026-07-05T03:49:46.770130Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","receipt_version":"0.3","signature_b64":"pvoeW7dsBrOAPq8m/R1Krx0WboZS1BVAZTUCxrVkpQGhp6n8Jtk0cusQRg2vMycnANIU7Ax985/YSBKmjt0zAg==","signature_status":"signed_v1","signed_at":"2026-07-05T03:49:46.770606Z","signed_message":"canonical_sha256_bytes"},"source_id":"2201.07463","source_kind":"arxiv","source_version":1}}},"equivocations":[],"invalid_events":[],"applied_event_ids":["sha256:18ff6e760692b44f3f798a4ca468c48da13c2eb4b5c219b3e1ceee7b6eadfc50","sha256:0f4d7d05b1db58572a35cad9634dd5704547e43d49455df55d971de84b78596d"],"state_sha256":"f6965afda3b9b9eb6a98aeea9b34bc56eba0792cb2625263e246479fe132085b"}