{"bundle_type":"pith_open_graph_bundle","bundle_version":"1.0","pith_number":"pith:2018:C4W6FUYTNJPE7LRSAXOP2FRD5Y","short_pith_number":"pith:C4W6FUYT","canonical_record":{"source":{"id":"1806.10161","kind":"arxiv","version":1},"metadata":{"license":"http://creativecommons.org/licenses/by/4.0/","primary_cat":"q-bio.MN","submitted_at":"2018-06-26T18:28:30Z","cross_cats_sorted":["q-bio.NC"],"title_canon_sha256":"be4076eeac88472ca5f96819d1e7bec7922f479300b152abc8ca4ed7ea8e17b4","abstract_canon_sha256":"53260bfbe61d698d01a14307ff0b39f263ff29dcd625029312c29e5972ed7ebd"},"schema_version":"1.0"},"canonical_sha256":"172de2d3136a5e4fae3205dcfd1623ee15d9498952ac7e97b004f6fa7bb9be28","source":{"kind":"arxiv","id":"1806.10161","version":1},"source_aliases":[{"alias_kind":"arxiv","alias_value":"1806.10161","created_at":"2026-05-18T00:12:13Z"},{"alias_kind":"arxiv_version","alias_value":"1806.10161v1","created_at":"2026-05-18T00:12:13Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.1806.10161","created_at":"2026-05-18T00:12:13Z"},{"alias_kind":"pith_short_12","alias_value":"C4W6FUYTNJPE","created_at":"2026-05-18T12:32:16Z"},{"alias_kind":"pith_short_16","alias_value":"C4W6FUYTNJPE7LRS","created_at":"2026-05-18T12:32:16Z"},{"alias_kind":"pith_short_8","alias_value":"C4W6FUYT","created_at":"2026-05-18T12:32:16Z"}],"events":[{"event_type":"record_created","subject_pith_number":"pith:2018:C4W6FUYTNJPE7LRSAXOP2FRD5Y","target":"record","payload":{"canonical_record":{"source":{"id":"1806.10161","kind":"arxiv","version":1},"metadata":{"license":"http://creativecommons.org/licenses/by/4.0/","primary_cat":"q-bio.MN","submitted_at":"2018-06-26T18:28:30Z","cross_cats_sorted":["q-bio.NC"],"title_canon_sha256":"be4076eeac88472ca5f96819d1e7bec7922f479300b152abc8ca4ed7ea8e17b4","abstract_canon_sha256":"53260bfbe61d698d01a14307ff0b39f263ff29dcd625029312c29e5972ed7ebd"},"schema_version":"1.0"},"canonical_sha256":"172de2d3136a5e4fae3205dcfd1623ee15d9498952ac7e97b004f6fa7bb9be28","receipt":{"kind":"pith_receipt","key_id":"pith-v1-2026-05","algorithm":"ed25519","signed_at":"2026-05-18T00:12:13.303756Z","signature_b64":"olzjdP5ZZLJDhmxEI1RZBVaOEzjaIrAhEbNFn8QzF8kGOV2VBO0zAW8nPTabxGKBYU3yYrVAWpdhaYyY6Zf+Cg==","signed_message":"canonical_sha256_bytes","builder_version":"pith-number-builder-2026-05-17-v1","receipt_version":"0.3","canonical_sha256":"172de2d3136a5e4fae3205dcfd1623ee15d9498952ac7e97b004f6fa7bb9be28","last_reissued_at":"2026-05-18T00:12:13.303138Z","signature_status":"signed_v1","first_computed_at":"2026-05-18T00:12:13.303138Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"source_kind":"arxiv","source_id":"1806.10161","source_version":1,"attestation_state":"computed"},"signer":{"signer_id":"pith.science","signer_type":"pith_registry","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"created_at":"2026-05-18T00:12:13Z","supersedes":[],"prev_event":null,"signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"8SpZDQxiShoUxwY34gCGBO/6Z2cNhtrUMEg+7SAszaBWdPnqqsyrMjzdeweUEb2BqK61zOP1Yq6CDxB6zvCUAA==","signed_message":"open_graph_event_sha256_bytes","signed_at":"2026-05-31T12:54:52.421206Z"},"content_sha256":"77f1183a9b81382cb83a2348d7324f2014a3445b30839b63aeecc88bb378b12e","schema_version":"1.0","event_id":"sha256:77f1183a9b81382cb83a2348d7324f2014a3445b30839b63aeecc88bb378b12e"},{"event_type":"graph_snapshot","subject_pith_number":"pith:2018:C4W6FUYTNJPE7LRSAXOP2FRD5Y","target":"graph","payload":{"graph_snapshot":{"paper":{"title":"Embodying probabilistic inference in biochemical circuits","license":"http://creativecommons.org/licenses/by/4.0/","headline":"","cross_cats":["q-bio.NC"],"primary_cat":"q-bio.MN","authors_text":"Michael Springer, Walter Fontana, Yarden Katz","submitted_at":"2018-06-26T18:28:30Z","abstract_excerpt":"Probabilistic inference provides a language for describing how organisms may learn from and adapt to their environment. The computations needed to implement probabilistic inference often require specific representations, akin to having the suitable data structures for implementing certain algorithms in computer programming. Yet it is unclear how such representations can be instantiated in the stochastic, parallel-running biochemical machinery found in cells (such as single-celled organisms). Here, we show how representations for supporting inference in Markov models can be embodied in cellular"},"claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"1806.10161","kind":"arxiv","version":1},"verdict":{"id":null,"model_set":{},"created_at":null,"strongest_claim":"","one_line_summary":"","pipeline_version":null,"weakest_assumption":"","pith_extraction_headline":""},"references":{"count":0,"sample":[],"resolved_work":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","internal_anchors":0},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"author_claims":{"count":0,"strong_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"builder_version":"pith-number-builder-2026-05-17-v1"},"verdict_id":null},"signer":{"signer_id":"pith.science","signer_type":"pith_registry","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"created_at":"2026-05-18T00:12:13Z","supersedes":[],"prev_event":null,"signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"gepUaNZOQJfVnouHtMy5Ly+9EBkgKtiUPwlScu1D8u7whu5qYgDNa+TUT+Xa4dtaQ/6FXJsRjgPmOw8Xcij7DQ==","signed_message":"open_graph_event_sha256_bytes","signed_at":"2026-05-31T12:54:52.421603Z"},"content_sha256":"30dd68a008664a7ec4c9ce3bbcf6124ebebe0395ea63658fbd231432676e5bb4","schema_version":"1.0","event_id":"sha256:30dd68a008664a7ec4c9ce3bbcf6124ebebe0395ea63658fbd231432676e5bb4"}],"timestamp_proofs":[],"mirror_hints":[{"mirror_type":"https","name":"Pith Resolver","base_url":"https://pith.science","bundle_url":"https://pith.science/pith/C4W6FUYTNJPE7LRSAXOP2FRD5Y/bundle.json","state_url":"https://pith.science/pith/C4W6FUYTNJPE7LRSAXOP2FRD5Y/state.json","well_known_bundle_url":"https://pith.science/.well-known/pith/C4W6FUYTNJPE7LRSAXOP2FRD5Y/bundle.json","status":"primary"}],"public_keys":[{"key_id":"pith-v1-2026-05","algorithm":"ed25519","format":"raw","public_key_b64":"stVStoiQhXFxp4s2pdzPNoqVNBMojDU/fJ2db5S3CbM=","public_key_hex":"b2d552b68890857171a78b36a5dccf368a953413288c353f7c9d9d6f94b709b3","fingerprint_sha256_b32_first128bits":"RVFV5Z2OI2J3ZUO7ERDEBCYNKS","fingerprint_sha256_hex":"8d4b5ee74e4693bcd1df2446408b0d54","rotates_at":null,"url":"https://pith.science/pith-signing-key.json","notes":"Pith uses this Ed25519 key to sign canonical record SHA-256 digests. Verify with: ed25519_verify(public_key, message=canonical_sha256_bytes, signature=base64decode(signature_b64))."}],"merge_version":"pith-open-graph-merge-v1","built_at":"2026-05-31T12:54:52Z","links":{"resolver":"https://pith.science/pith/C4W6FUYTNJPE7LRSAXOP2FRD5Y","bundle":"https://pith.science/pith/C4W6FUYTNJPE7LRSAXOP2FRD5Y/bundle.json","state":"https://pith.science/pith/C4W6FUYTNJPE7LRSAXOP2FRD5Y/state.json","well_known_bundle":"https://pith.science/.well-known/pith/C4W6FUYTNJPE7LRSAXOP2FRD5Y/bundle.json"},"state":{"state_type":"pith_open_graph_state","state_version":"1.0","pith_number":"pith:2018:C4W6FUYTNJPE7LRSAXOP2FRD5Y","merge_version":"pith-open-graph-merge-v1","event_count":2,"valid_event_count":2,"invalid_event_count":0,"equivocation_count":0,"current":{"canonical_record":{"metadata":{"abstract_canon_sha256":"53260bfbe61d698d01a14307ff0b39f263ff29dcd625029312c29e5972ed7ebd","cross_cats_sorted":["q-bio.NC"],"license":"http://creativecommons.org/licenses/by/4.0/","primary_cat":"q-bio.MN","submitted_at":"2018-06-26T18:28:30Z","title_canon_sha256":"be4076eeac88472ca5f96819d1e7bec7922f479300b152abc8ca4ed7ea8e17b4"},"schema_version":"1.0","source":{"id":"1806.10161","kind":"arxiv","version":1}},"source_aliases":[{"alias_kind":"arxiv","alias_value":"1806.10161","created_at":"2026-05-18T00:12:13Z"},{"alias_kind":"arxiv_version","alias_value":"1806.10161v1","created_at":"2026-05-18T00:12:13Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.1806.10161","created_at":"2026-05-18T00:12:13Z"},{"alias_kind":"pith_short_12","alias_value":"C4W6FUYTNJPE","created_at":"2026-05-18T12:32:16Z"},{"alias_kind":"pith_short_16","alias_value":"C4W6FUYTNJPE7LRS","created_at":"2026-05-18T12:32:16Z"},{"alias_kind":"pith_short_8","alias_value":"C4W6FUYT","created_at":"2026-05-18T12:32:16Z"}],"graph_snapshots":[{"event_id":"sha256:30dd68a008664a7ec4c9ce3bbcf6124ebebe0395ea63658fbd231432676e5bb4","target":"graph","created_at":"2026-05-18T00:12:13Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"graph_snapshot":{"author_claims":{"count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","strong_count":0},"builder_version":"pith-number-builder-2026-05-17-v1","claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"paper":{"abstract_excerpt":"Probabilistic inference provides a language for describing how organisms may learn from and adapt to their environment. The computations needed to implement probabilistic inference often require specific representations, akin to having the suitable data structures for implementing certain algorithms in computer programming. Yet it is unclear how such representations can be instantiated in the stochastic, parallel-running biochemical machinery found in cells (such as single-celled organisms). Here, we show how representations for supporting inference in Markov models can be embodied in cellular","authors_text":"Michael Springer, Walter Fontana, Yarden Katz","cross_cats":["q-bio.NC"],"headline":"","license":"http://creativecommons.org/licenses/by/4.0/","primary_cat":"q-bio.MN","submitted_at":"2018-06-26T18:28:30Z","title":"Embodying probabilistic inference in biochemical circuits"},"references":{"count":0,"internal_anchors":0,"resolved_work":0,"sample":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"1806.10161","kind":"arxiv","version":1},"verdict":{"created_at":null,"id":null,"model_set":{},"one_line_summary":"","pipeline_version":null,"pith_extraction_headline":"","strongest_claim":"","weakest_assumption":""}},"verdict_id":null}}],"author_attestations":[],"timestamp_anchors":[],"storage_attestations":[],"citation_signatures":[],"replication_records":[],"corrections":[],"mirror_hints":[],"record_created":{"event_id":"sha256:77f1183a9b81382cb83a2348d7324f2014a3445b30839b63aeecc88bb378b12e","target":"record","created_at":"2026-05-18T00:12:13Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"attestation_state":"computed","canonical_record":{"metadata":{"abstract_canon_sha256":"53260bfbe61d698d01a14307ff0b39f263ff29dcd625029312c29e5972ed7ebd","cross_cats_sorted":["q-bio.NC"],"license":"http://creativecommons.org/licenses/by/4.0/","primary_cat":"q-bio.MN","submitted_at":"2018-06-26T18:28:30Z","title_canon_sha256":"be4076eeac88472ca5f96819d1e7bec7922f479300b152abc8ca4ed7ea8e17b4"},"schema_version":"1.0","source":{"id":"1806.10161","kind":"arxiv","version":1}},"canonical_sha256":"172de2d3136a5e4fae3205dcfd1623ee15d9498952ac7e97b004f6fa7bb9be28","receipt":{"algorithm":"ed25519","builder_version":"pith-number-builder-2026-05-17-v1","canonical_sha256":"172de2d3136a5e4fae3205dcfd1623ee15d9498952ac7e97b004f6fa7bb9be28","first_computed_at":"2026-05-18T00:12:13.303138Z","key_id":"pith-v1-2026-05","kind":"pith_receipt","last_reissued_at":"2026-05-18T00:12:13.303138Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","receipt_version":"0.3","signature_b64":"olzjdP5ZZLJDhmxEI1RZBVaOEzjaIrAhEbNFn8QzF8kGOV2VBO0zAW8nPTabxGKBYU3yYrVAWpdhaYyY6Zf+Cg==","signature_status":"signed_v1","signed_at":"2026-05-18T00:12:13.303756Z","signed_message":"canonical_sha256_bytes"},"source_id":"1806.10161","source_kind":"arxiv","source_version":1}}},"equivocations":[],"invalid_events":[],"applied_event_ids":["sha256:77f1183a9b81382cb83a2348d7324f2014a3445b30839b63aeecc88bb378b12e","sha256:30dd68a008664a7ec4c9ce3bbcf6124ebebe0395ea63658fbd231432676e5bb4"],"state_sha256":"55ee65b9fd4e4bf2c8a327c4a5fd55680addf1e40c23548e375c9933107505f4"},"bundle_signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"EJFmV3pGiFbBECwpDWFg8cqxzFlGa6Sc7NPaQng9gTVILYn6Ea0p38bZLkQN1MiJwJDc/g2GIkIBC/sQgW7rBw==","signed_message":"bundle_sha256_bytes","signed_at":"2026-05-31T12:54:52.423955Z","bundle_sha256":"b9e0c7af96980cad451aa060d10fd30cb54eb020c4a8490264ec163c93a5b9de"}}