{"record_type":"pith_number_record","schema_url":"https://pith.science/schemas/pith-number/v1.json","pith_number":"pith:2014:CAKMRJLDLMTVS4H4CIGYI6DTCL","short_pith_number":"pith:CAKMRJLD","schema_version":"1.0","canonical_sha256":"1014c8a5635b275970fc120d84787312e77e1629cc7fa05bbd711931ba8f2bc3","source":{"kind":"arxiv","id":"1411.5695","version":1},"attestation_state":"computed","paper":{"title":"High-throughput screening for modulators of cellular contractile force","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","headline":"","cross_cats":["q-bio.QM","q-bio.TO"],"primary_cat":"physics.bio-ph","authors_text":"Aleksandar Marinkovic, Anton Simeonov, Bohao Chen, Chan Young Park, Daniel J. Tschumperlin, David J. Maloney, Dhananjay Tambe, Enhua H. Zhou, James P. Butler, Jeffrey J. Fredberg, Julian Solway, Maria Dowell, Mark Johnson, Matthew Frykenberg, Ramaswamy Krishnan, Stephanie Burger, Tera Lavoie, W. Daniel Stamer","submitted_at":"2014-11-20T21:01:55Z","abstract_excerpt":"When cellular contractile forces are central to pathophysiology, these forces comprise a logical target of therapy. Nevertheless, existing high-throughput screens are limited to upstream signaling intermediates with poorly defined relationship to such a physiological endpoint. Using cellular force as the target, here we screened libraries to identify novel drug candidates in the case of human airway smooth muscle cells in the context of asthma, and also in the case of Schlemm's canal endothelial cells in the context of glaucoma. This approach identified several drug candidates for both asthma "},"verification_status":{"content_addressed":true,"pith_receipt":true,"author_attested":false,"weak_author_claims":0,"strong_author_claims":0,"externally_anchored":false,"storage_verified":false,"citation_signatures":0,"replication_records":0,"graph_snapshot":true,"references_resolved":false,"formal_links_present":false},"canonical_record":{"source":{"id":"1411.5695","kind":"arxiv","version":1},"metadata":{"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"physics.bio-ph","submitted_at":"2014-11-20T21:01:55Z","cross_cats_sorted":["q-bio.QM","q-bio.TO"],"title_canon_sha256":"dc3eb447f2dbbf303eec27ecd26b46f331a51c0a2e95061255afbe50d2fe4b2f","abstract_canon_sha256":"9440543a4c1f875ecfd0ae193667cc78e0db5dd2ae4517de0bbee95e0d0f11be"},"schema_version":"1.0"},"receipt":{"kind":"pith_receipt","key_id":"pith-v1-2026-05","algorithm":"ed25519","signed_at":"2026-05-18T02:33:07.258010Z","signature_b64":"C9k/amFpD9mgOA0UcTVr5He0tsfBBDVseaX8cA1woxP0fDJwqsfmB2SQYOBnGsYk6mS04KdvAerN0ajyutYqAg==","signed_message":"canonical_sha256_bytes","builder_version":"pith-number-builder-2026-05-17-v1","receipt_version":"0.3","canonical_sha256":"1014c8a5635b275970fc120d84787312e77e1629cc7fa05bbd711931ba8f2bc3","last_reissued_at":"2026-05-18T02:33:07.257618Z","signature_status":"signed_v1","first_computed_at":"2026-05-18T02:33:07.257618Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"graph_snapshot":{"paper":{"title":"High-throughput screening for modulators of cellular contractile force","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","headline":"","cross_cats":["q-bio.QM","q-bio.TO"],"primary_cat":"physics.bio-ph","authors_text":"Aleksandar Marinkovic, Anton Simeonov, Bohao Chen, Chan Young Park, Daniel J. Tschumperlin, David J. Maloney, Dhananjay Tambe, Enhua H. Zhou, James P. Butler, Jeffrey J. Fredberg, Julian Solway, Maria Dowell, Mark Johnson, Matthew Frykenberg, Ramaswamy Krishnan, Stephanie Burger, Tera Lavoie, W. Daniel Stamer","submitted_at":"2014-11-20T21:01:55Z","abstract_excerpt":"When cellular contractile forces are central to pathophysiology, these forces comprise a logical target of therapy. Nevertheless, existing high-throughput screens are limited to upstream signaling intermediates with poorly defined relationship to such a physiological endpoint. Using cellular force as the target, here we screened libraries to identify novel drug candidates in the case of human airway smooth muscle cells in the context of asthma, and also in the case of Schlemm's canal endothelial cells in the context of glaucoma. This approach identified several drug candidates for both asthma "},"claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"1411.5695","kind":"arxiv","version":1},"verdict":{"id":null,"model_set":{},"created_at":null,"strongest_claim":"","one_line_summary":"","pipeline_version":null,"weakest_assumption":"","pith_extraction_headline":""},"references":{"count":0,"sample":[],"resolved_work":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","internal_anchors":0},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"author_claims":{"count":0,"strong_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"builder_version":"pith-number-builder-2026-05-17-v1"},"aliases":[{"alias_kind":"arxiv","alias_value":"1411.5695","created_at":"2026-05-18T02:33:07.257678+00:00"},{"alias_kind":"arxiv_version","alias_value":"1411.5695v1","created_at":"2026-05-18T02:33:07.257678+00:00"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.1411.5695","created_at":"2026-05-18T02:33:07.257678+00:00"},{"alias_kind":"pith_short_12","alias_value":"CAKMRJLDLMTV","created_at":"2026-05-18T12:28:22.404517+00:00"},{"alias_kind":"pith_short_16","alias_value":"CAKMRJLDLMTVS4H4","created_at":"2026-05-18T12:28:22.404517+00:00"},{"alias_kind":"pith_short_8","alias_value":"CAKMRJLD","created_at":"2026-05-18T12:28:22.404517+00:00"}],"events":[],"event_summary":{},"paper_claims":[],"inbound_citations":{"count":0,"internal_anchor_count":0,"sample":[]},"formal_canon":{"evidence_count":0,"sample":[],"anchors":[]},"links":{"html":"https://pith.science/pith/CAKMRJLDLMTVS4H4CIGYI6DTCL","json":"https://pith.science/pith/CAKMRJLDLMTVS4H4CIGYI6DTCL.json","graph_json":"https://pith.science/api/pith-number/CAKMRJLDLMTVS4H4CIGYI6DTCL/graph.json","events_json":"https://pith.science/api/pith-number/CAKMRJLDLMTVS4H4CIGYI6DTCL/events.json","paper":"https://pith.science/paper/CAKMRJLD"},"agent_actions":{"view_html":"https://pith.science/pith/CAKMRJLDLMTVS4H4CIGYI6DTCL","download_json":"https://pith.science/pith/CAKMRJLDLMTVS4H4CIGYI6DTCL.json","view_paper":"https://pith.science/paper/CAKMRJLD","resolve_alias":"https://pith.science/api/pith-number/resolve?arxiv=1411.5695&json=true","fetch_graph":"https://pith.science/api/pith-number/CAKMRJLDLMTVS4H4CIGYI6DTCL/graph.json","fetch_events":"https://pith.science/api/pith-number/CAKMRJLDLMTVS4H4CIGYI6DTCL/events.json","actions":{"anchor_timestamp":"https://pith.science/pith/CAKMRJLDLMTVS4H4CIGYI6DTCL/action/timestamp_anchor","attest_storage":"https://pith.science/pith/CAKMRJLDLMTVS4H4CIGYI6DTCL/action/storage_attestation","attest_author":"https://pith.science/pith/CAKMRJLDLMTVS4H4CIGYI6DTCL/action/author_attestation","sign_citation":"https://pith.science/pith/CAKMRJLDLMTVS4H4CIGYI6DTCL/action/citation_signature","submit_replication":"https://pith.science/pith/CAKMRJLDLMTVS4H4CIGYI6DTCL/action/replication_record"}},"created_at":"2026-05-18T02:33:07.257678+00:00","updated_at":"2026-05-18T02:33:07.257678+00:00"}