{"bundle_type":"pith_open_graph_bundle","bundle_version":"1.0","pith_number":"pith:2013:CB6EBBWZEAXCKHY6HILFEU7O2K","short_pith_number":"pith:CB6EBBWZ","canonical_record":{"source":{"id":"1309.2032","kind":"arxiv","version":1},"metadata":{"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.MN","submitted_at":"2013-09-09T02:19:28Z","cross_cats_sorted":["physics.bio-ph"],"title_canon_sha256":"00696235273d94075ec24be47dcb1535444181f8f73efc404531a9b7fa26ed73","abstract_canon_sha256":"c744e46587b1c9e577e318efaec1cb40f2ab5e59f8d2a5882c0d3180e3470fb7"},"schema_version":"1.0"},"canonical_sha256":"107c4086d9202e251f1e3a165253eed2b4502e1cee2e7da00bf6ca80af6eb015","source":{"kind":"arxiv","id":"1309.2032","version":1},"source_aliases":[{"alias_kind":"arxiv","alias_value":"1309.2032","created_at":"2026-05-18T03:13:47Z"},{"alias_kind":"arxiv_version","alias_value":"1309.2032v1","created_at":"2026-05-18T03:13:47Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.1309.2032","created_at":"2026-05-18T03:13:47Z"},{"alias_kind":"pith_short_12","alias_value":"CB6EBBWZEAXC","created_at":"2026-05-18T12:27:40Z"},{"alias_kind":"pith_short_16","alias_value":"CB6EBBWZEAXCKHY6","created_at":"2026-05-18T12:27:40Z"},{"alias_kind":"pith_short_8","alias_value":"CB6EBBWZ","created_at":"2026-05-18T12:27:40Z"}],"events":[{"event_type":"record_created","subject_pith_number":"pith:2013:CB6EBBWZEAXCKHY6HILFEU7O2K","target":"record","payload":{"canonical_record":{"source":{"id":"1309.2032","kind":"arxiv","version":1},"metadata":{"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.MN","submitted_at":"2013-09-09T02:19:28Z","cross_cats_sorted":["physics.bio-ph"],"title_canon_sha256":"00696235273d94075ec24be47dcb1535444181f8f73efc404531a9b7fa26ed73","abstract_canon_sha256":"c744e46587b1c9e577e318efaec1cb40f2ab5e59f8d2a5882c0d3180e3470fb7"},"schema_version":"1.0"},"canonical_sha256":"107c4086d9202e251f1e3a165253eed2b4502e1cee2e7da00bf6ca80af6eb015","receipt":{"kind":"pith_receipt","key_id":"pith-v1-2026-05","algorithm":"ed25519","signed_at":"2026-05-18T03:13:47.430378Z","signature_b64":"m6R1KFR+U/NZbgZXo22g+7sCImnW4mRuWohtSdcbKrUCmCKtfcaEJTwalrVkbXPr8RZfEDixI4wkFDZk2smFBg==","signed_message":"canonical_sha256_bytes","builder_version":"pith-number-builder-2026-05-17-v1","receipt_version":"0.3","canonical_sha256":"107c4086d9202e251f1e3a165253eed2b4502e1cee2e7da00bf6ca80af6eb015","last_reissued_at":"2026-05-18T03:13:47.429855Z","signature_status":"signed_v1","first_computed_at":"2026-05-18T03:13:47.429855Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"source_kind":"arxiv","source_id":"1309.2032","source_version":1,"attestation_state":"computed"},"signer":{"signer_id":"pith.science","signer_type":"pith_registry","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"created_at":"2026-05-18T03:13:47Z","supersedes":[],"prev_event":null,"signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"cBhC6JWFYWUWcJ1LzJn/DUWEwJC30pcm2AX8VZw3ktiYsVKKweDswQd+WSw347iJdYUUB3w5X9KothG8/ArXDg==","signed_message":"open_graph_event_sha256_bytes","signed_at":"2026-06-01T22:59:03.768890Z"},"content_sha256":"b48b0f1a933cd6aeb96e25898f33cf838b5d1b475cffa3d4c4fd0530ec7db6d0","schema_version":"1.0","event_id":"sha256:b48b0f1a933cd6aeb96e25898f33cf838b5d1b475cffa3d4c4fd0530ec7db6d0"},{"event_type":"graph_snapshot","subject_pith_number":"pith:2013:CB6EBBWZEAXCKHY6HILFEU7O2K","target":"graph","payload":{"graph_snapshot":{"paper":{"title":"Monte Carlo study elucidates the type 1/type 2 choice in apoptotic death signaling in normal and cancer cells","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","headline":"","cross_cats":["physics.bio-ph"],"primary_cat":"q-bio.MN","authors_text":"Somkanya C Das, Subhadip Raychaudhuri","submitted_at":"2013-09-09T02:19:28Z","abstract_excerpt":"Apoptotic cell death is coordinated through two distinct (type 1 and type 2) intracellular signaling pathways. How the type 1/type 2 choice is made remains a fundamental problem in the biology of apoptosis and has implications for apoptosis related diseases and therapy. We study the problem of type 1/type 2 choice in silico utilizing a kinetic Monte Carlo model of cell death signaling. Our results show that the type 1/type 2 choice is linked to deterministic versus stochastic cell death activation, elucidating a unique regulatory control of the apoptotic pathways. Consistent with previous find"},"claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"1309.2032","kind":"arxiv","version":1},"verdict":{"id":null,"model_set":{},"created_at":null,"strongest_claim":"","one_line_summary":"","pipeline_version":null,"weakest_assumption":"","pith_extraction_headline":""},"references":{"count":0,"sample":[],"resolved_work":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","internal_anchors":0},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"author_claims":{"count":0,"strong_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"builder_version":"pith-number-builder-2026-05-17-v1"},"verdict_id":null},"signer":{"signer_id":"pith.science","signer_type":"pith_registry","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"created_at":"2026-05-18T03:13:47Z","supersedes":[],"prev_event":null,"signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"3Tx5aglzePh+U9RsI005hgyej6508iuuptCD4u5dTeWPC5VIRqkI9B1pKuKClBkTXPd9kbCn9a19NGL0Ao8uCQ==","signed_message":"open_graph_event_sha256_bytes","signed_at":"2026-06-01T22:59:03.769241Z"},"content_sha256":"f84523f47a9991a21b76eb2b955c93ec73ba05794c3ae1777ad989a87e356e89","schema_version":"1.0","event_id":"sha256:f84523f47a9991a21b76eb2b955c93ec73ba05794c3ae1777ad989a87e356e89"}],"timestamp_proofs":[],"mirror_hints":[{"mirror_type":"https","name":"Pith Resolver","base_url":"https://pith.science","bundle_url":"https://pith.science/pith/CB6EBBWZEAXCKHY6HILFEU7O2K/bundle.json","state_url":"https://pith.science/pith/CB6EBBWZEAXCKHY6HILFEU7O2K/state.json","well_known_bundle_url":"https://pith.science/.well-known/pith/CB6EBBWZEAXCKHY6HILFEU7O2K/bundle.json","status":"primary"}],"public_keys":[{"key_id":"pith-v1-2026-05","algorithm":"ed25519","format":"raw","public_key_b64":"stVStoiQhXFxp4s2pdzPNoqVNBMojDU/fJ2db5S3CbM=","public_key_hex":"b2d552b68890857171a78b36a5dccf368a953413288c353f7c9d9d6f94b709b3","fingerprint_sha256_b32_first128bits":"RVFV5Z2OI2J3ZUO7ERDEBCYNKS","fingerprint_sha256_hex":"8d4b5ee74e4693bcd1df2446408b0d54","rotates_at":null,"url":"https://pith.science/pith-signing-key.json","notes":"Pith uses this Ed25519 key to sign canonical record SHA-256 digests. Verify with: ed25519_verify(public_key, message=canonical_sha256_bytes, signature=base64decode(signature_b64))."}],"merge_version":"pith-open-graph-merge-v1","built_at":"2026-06-01T22:59:03Z","links":{"resolver":"https://pith.science/pith/CB6EBBWZEAXCKHY6HILFEU7O2K","bundle":"https://pith.science/pith/CB6EBBWZEAXCKHY6HILFEU7O2K/bundle.json","state":"https://pith.science/pith/CB6EBBWZEAXCKHY6HILFEU7O2K/state.json","well_known_bundle":"https://pith.science/.well-known/pith/CB6EBBWZEAXCKHY6HILFEU7O2K/bundle.json"},"state":{"state_type":"pith_open_graph_state","state_version":"1.0","pith_number":"pith:2013:CB6EBBWZEAXCKHY6HILFEU7O2K","merge_version":"pith-open-graph-merge-v1","event_count":2,"valid_event_count":2,"invalid_event_count":0,"equivocation_count":0,"current":{"canonical_record":{"metadata":{"abstract_canon_sha256":"c744e46587b1c9e577e318efaec1cb40f2ab5e59f8d2a5882c0d3180e3470fb7","cross_cats_sorted":["physics.bio-ph"],"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.MN","submitted_at":"2013-09-09T02:19:28Z","title_canon_sha256":"00696235273d94075ec24be47dcb1535444181f8f73efc404531a9b7fa26ed73"},"schema_version":"1.0","source":{"id":"1309.2032","kind":"arxiv","version":1}},"source_aliases":[{"alias_kind":"arxiv","alias_value":"1309.2032","created_at":"2026-05-18T03:13:47Z"},{"alias_kind":"arxiv_version","alias_value":"1309.2032v1","created_at":"2026-05-18T03:13:47Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.1309.2032","created_at":"2026-05-18T03:13:47Z"},{"alias_kind":"pith_short_12","alias_value":"CB6EBBWZEAXC","created_at":"2026-05-18T12:27:40Z"},{"alias_kind":"pith_short_16","alias_value":"CB6EBBWZEAXCKHY6","created_at":"2026-05-18T12:27:40Z"},{"alias_kind":"pith_short_8","alias_value":"CB6EBBWZ","created_at":"2026-05-18T12:27:40Z"}],"graph_snapshots":[{"event_id":"sha256:f84523f47a9991a21b76eb2b955c93ec73ba05794c3ae1777ad989a87e356e89","target":"graph","created_at":"2026-05-18T03:13:47Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"graph_snapshot":{"author_claims":{"count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","strong_count":0},"builder_version":"pith-number-builder-2026-05-17-v1","claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"paper":{"abstract_excerpt":"Apoptotic cell death is coordinated through two distinct (type 1 and type 2) intracellular signaling pathways. How the type 1/type 2 choice is made remains a fundamental problem in the biology of apoptosis and has implications for apoptosis related diseases and therapy. We study the problem of type 1/type 2 choice in silico utilizing a kinetic Monte Carlo model of cell death signaling. Our results show that the type 1/type 2 choice is linked to deterministic versus stochastic cell death activation, elucidating a unique regulatory control of the apoptotic pathways. Consistent with previous find","authors_text":"Somkanya C Das, Subhadip Raychaudhuri","cross_cats":["physics.bio-ph"],"headline":"","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.MN","submitted_at":"2013-09-09T02:19:28Z","title":"Monte Carlo study elucidates the type 1/type 2 choice in apoptotic death signaling in normal and cancer cells"},"references":{"count":0,"internal_anchors":0,"resolved_work":0,"sample":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"1309.2032","kind":"arxiv","version":1},"verdict":{"created_at":null,"id":null,"model_set":{},"one_line_summary":"","pipeline_version":null,"pith_extraction_headline":"","strongest_claim":"","weakest_assumption":""}},"verdict_id":null}}],"author_attestations":[],"timestamp_anchors":[],"storage_attestations":[],"citation_signatures":[],"replication_records":[],"corrections":[],"mirror_hints":[],"record_created":{"event_id":"sha256:b48b0f1a933cd6aeb96e25898f33cf838b5d1b475cffa3d4c4fd0530ec7db6d0","target":"record","created_at":"2026-05-18T03:13:47Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"attestation_state":"computed","canonical_record":{"metadata":{"abstract_canon_sha256":"c744e46587b1c9e577e318efaec1cb40f2ab5e59f8d2a5882c0d3180e3470fb7","cross_cats_sorted":["physics.bio-ph"],"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.MN","submitted_at":"2013-09-09T02:19:28Z","title_canon_sha256":"00696235273d94075ec24be47dcb1535444181f8f73efc404531a9b7fa26ed73"},"schema_version":"1.0","source":{"id":"1309.2032","kind":"arxiv","version":1}},"canonical_sha256":"107c4086d9202e251f1e3a165253eed2b4502e1cee2e7da00bf6ca80af6eb015","receipt":{"algorithm":"ed25519","builder_version":"pith-number-builder-2026-05-17-v1","canonical_sha256":"107c4086d9202e251f1e3a165253eed2b4502e1cee2e7da00bf6ca80af6eb015","first_computed_at":"2026-05-18T03:13:47.429855Z","key_id":"pith-v1-2026-05","kind":"pith_receipt","last_reissued_at":"2026-05-18T03:13:47.429855Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","receipt_version":"0.3","signature_b64":"m6R1KFR+U/NZbgZXo22g+7sCImnW4mRuWohtSdcbKrUCmCKtfcaEJTwalrVkbXPr8RZfEDixI4wkFDZk2smFBg==","signature_status":"signed_v1","signed_at":"2026-05-18T03:13:47.430378Z","signed_message":"canonical_sha256_bytes"},"source_id":"1309.2032","source_kind":"arxiv","source_version":1}}},"equivocations":[],"invalid_events":[],"applied_event_ids":["sha256:b48b0f1a933cd6aeb96e25898f33cf838b5d1b475cffa3d4c4fd0530ec7db6d0","sha256:f84523f47a9991a21b76eb2b955c93ec73ba05794c3ae1777ad989a87e356e89"],"state_sha256":"3d007e28dddb7d648a8fba967659363f5bc57f0f6add88895f004826e7295e2c"},"bundle_signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"3tpg51/lyZAhE7+bDWsF2ZpZRc+9FnFcZU9lo8fDmZYpHoAlyrgJ111eSfBdsRzVoZXyMPs0FChVD5EXhzN6Bw==","signed_message":"bundle_sha256_bytes","signed_at":"2026-06-01T22:59:03.771333Z","bundle_sha256":"1c0f4bc5996f0aebb1c73520617138323bab3ee0a5493d51525820606c0bd590"}}