{"bundle_type":"pith_open_graph_bundle","bundle_version":"1.0","pith_number":"pith:2013:CBOGPBSK2S3YC7VM5EQGMBNE4J","short_pith_number":"pith:CBOGPBSK","canonical_record":{"source":{"id":"1304.6966","kind":"arxiv","version":2},"metadata":{"license":"http://creativecommons.org/licenses/publicdomain/","primary_cat":"q-bio.GN","submitted_at":"2013-04-25T17:34:52Z","cross_cats_sorted":["stat.AP"],"title_canon_sha256":"03e9d68e53bd35890465f081ba553ba5f1c2cd976c72ed7581ef364bfc81842c","abstract_canon_sha256":"8e0b328feb34b5b60b1064258cd9eff8fd33d3bf406ca0c2354ec354bd104699"},"schema_version":"1.0"},"canonical_sha256":"105c67864ad4b7817eace9206605a4e2642295858980d55f600e7f9d02138a12","source":{"kind":"arxiv","id":"1304.6966","version":2},"source_aliases":[{"alias_kind":"arxiv","alias_value":"1304.6966","created_at":"2026-05-18T02:57:14Z"},{"alias_kind":"arxiv_version","alias_value":"1304.6966v2","created_at":"2026-05-18T02:57:14Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.1304.6966","created_at":"2026-05-18T02:57:14Z"},{"alias_kind":"pith_short_12","alias_value":"CBOGPBSK2S3Y","created_at":"2026-05-18T12:27:40Z"},{"alias_kind":"pith_short_16","alias_value":"CBOGPBSK2S3YC7VM","created_at":"2026-05-18T12:27:40Z"},{"alias_kind":"pith_short_8","alias_value":"CBOGPBSK","created_at":"2026-05-18T12:27:40Z"}],"events":[{"event_type":"record_created","subject_pith_number":"pith:2013:CBOGPBSK2S3YC7VM5EQGMBNE4J","target":"record","payload":{"canonical_record":{"source":{"id":"1304.6966","kind":"arxiv","version":2},"metadata":{"license":"http://creativecommons.org/licenses/publicdomain/","primary_cat":"q-bio.GN","submitted_at":"2013-04-25T17:34:52Z","cross_cats_sorted":["stat.AP"],"title_canon_sha256":"03e9d68e53bd35890465f081ba553ba5f1c2cd976c72ed7581ef364bfc81842c","abstract_canon_sha256":"8e0b328feb34b5b60b1064258cd9eff8fd33d3bf406ca0c2354ec354bd104699"},"schema_version":"1.0"},"canonical_sha256":"105c67864ad4b7817eace9206605a4e2642295858980d55f600e7f9d02138a12","receipt":{"kind":"pith_receipt","key_id":"pith-v1-2026-05","algorithm":"ed25519","signed_at":"2026-05-18T02:57:14.844145Z","signature_b64":"FYoiPJ4f/Zs9bez/KDymms1z27fjyaKYYy8WGo1gxAcfTtGN/FM9AVf2CGsGKbHZgM+l9cZfv4ZYb+lH0mXpDA==","signed_message":"canonical_sha256_bytes","builder_version":"pith-number-builder-2026-05-17-v1","receipt_version":"0.3","canonical_sha256":"105c67864ad4b7817eace9206605a4e2642295858980d55f600e7f9d02138a12","last_reissued_at":"2026-05-18T02:57:14.843508Z","signature_status":"signed_v1","first_computed_at":"2026-05-18T02:57:14.843508Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"source_kind":"arxiv","source_id":"1304.6966","source_version":2,"attestation_state":"computed"},"signer":{"signer_id":"pith.science","signer_type":"pith_registry","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"created_at":"2026-05-18T02:57:14Z","supersedes":[],"prev_event":null,"signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"mIRblVBelZ97GzEqqlAuj/3awWX2pGRejVG8K2aa2FbjAefOv8D4pN/PD07GDGC1Uf4pSOoVR5eCMcAI0cdZDg==","signed_message":"open_graph_event_sha256_bytes","signed_at":"2026-06-09T06:10:49.255992Z"},"content_sha256":"fe5f1d50795bce1eef65e4a37dfae3057cebd96d0a1bc2f7ea84d3317dc2c3ce","schema_version":"1.0","event_id":"sha256:fe5f1d50795bce1eef65e4a37dfae3057cebd96d0a1bc2f7ea84d3317dc2c3ce"},{"event_type":"graph_snapshot","subject_pith_number":"pith:2013:CBOGPBSK2S3YC7VM5EQGMBNE4J","target":"graph","payload":{"graph_snapshot":{"paper":{"title":"On the Reproducibility of TCGA Ovarian Cancer MicroRNA Profiles","license":"http://creativecommons.org/licenses/publicdomain/","headline":"","cross_cats":["stat.AP"],"primary_cat":"q-bio.GN","authors_text":"Claire M. Mach, Genevera Allen, Matthew L. Anderson, Ying-Wooi Wan, Zhandong Liu","submitted_at":"2013-04-25T17:34:52Z","abstract_excerpt":"Dysregulated microRNA (miRNA) expression is a well-established feature of human cancer. However, the role of specific miRNAs in determining cancer outcomes remains unclear. Using Level 3 expression data from the Cancer Genome Atlas (TCGA), we identified 61 miRNAs that are associated with overall survival in 469 ovarian cancers profiled by microarray (p<0.01). We also identified 12 miRNAs that are associated with survival when miRNAs were profiled in the same specimens using Next Generation Sequencing (miRNA-Seq) (p<0.01). Surprisingly, only 1 miRNA transcript is associated with ovarian cancer "},"claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"1304.6966","kind":"arxiv","version":2},"verdict":{"id":null,"model_set":{},"created_at":null,"strongest_claim":"","one_line_summary":"","pipeline_version":null,"weakest_assumption":"","pith_extraction_headline":""},"references":{"count":0,"sample":[],"resolved_work":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","internal_anchors":0},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"author_claims":{"count":0,"strong_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"builder_version":"pith-number-builder-2026-05-17-v1"},"verdict_id":null},"signer":{"signer_id":"pith.science","signer_type":"pith_registry","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"created_at":"2026-05-18T02:57:14Z","supersedes":[],"prev_event":null,"signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"crdTVuxU+xkdGF13W33el/FzsWw7VdC7LvanFjcPKJfQ1FXg0THO4o0HumjBcYaoAzyPmZR1kCIEGp6uGqkbBA==","signed_message":"open_graph_event_sha256_bytes","signed_at":"2026-06-09T06:10:49.256759Z"},"content_sha256":"8fc301bb82622cf2302ed807f0daf4e786788080d9a391d3738d5812716e37eb","schema_version":"1.0","event_id":"sha256:8fc301bb82622cf2302ed807f0daf4e786788080d9a391d3738d5812716e37eb"}],"timestamp_proofs":[],"mirror_hints":[{"mirror_type":"https","name":"Pith Resolver","base_url":"https://pith.science","bundle_url":"https://pith.science/pith/CBOGPBSK2S3YC7VM5EQGMBNE4J/bundle.json","state_url":"https://pith.science/pith/CBOGPBSK2S3YC7VM5EQGMBNE4J/state.json","well_known_bundle_url":"https://pith.science/.well-known/pith/CBOGPBSK2S3YC7VM5EQGMBNE4J/bundle.json","status":"primary"}],"public_keys":[{"key_id":"pith-v1-2026-05","algorithm":"ed25519","format":"raw","public_key_b64":"stVStoiQhXFxp4s2pdzPNoqVNBMojDU/fJ2db5S3CbM=","public_key_hex":"b2d552b68890857171a78b36a5dccf368a953413288c353f7c9d9d6f94b709b3","fingerprint_sha256_b32_first128bits":"RVFV5Z2OI2J3ZUO7ERDEBCYNKS","fingerprint_sha256_hex":"8d4b5ee74e4693bcd1df2446408b0d54","rotates_at":null,"url":"https://pith.science/pith-signing-key.json","notes":"Pith uses this Ed25519 key to sign canonical record SHA-256 digests. Verify with: ed25519_verify(public_key, message=canonical_sha256_bytes, signature=base64decode(signature_b64))."}],"merge_version":"pith-open-graph-merge-v1","built_at":"2026-06-09T06:10:49Z","links":{"resolver":"https://pith.science/pith/CBOGPBSK2S3YC7VM5EQGMBNE4J","bundle":"https://pith.science/pith/CBOGPBSK2S3YC7VM5EQGMBNE4J/bundle.json","state":"https://pith.science/pith/CBOGPBSK2S3YC7VM5EQGMBNE4J/state.json","well_known_bundle":"https://pith.science/.well-known/pith/CBOGPBSK2S3YC7VM5EQGMBNE4J/bundle.json"},"state":{"state_type":"pith_open_graph_state","state_version":"1.0","pith_number":"pith:2013:CBOGPBSK2S3YC7VM5EQGMBNE4J","merge_version":"pith-open-graph-merge-v1","event_count":2,"valid_event_count":2,"invalid_event_count":0,"equivocation_count":0,"current":{"canonical_record":{"metadata":{"abstract_canon_sha256":"8e0b328feb34b5b60b1064258cd9eff8fd33d3bf406ca0c2354ec354bd104699","cross_cats_sorted":["stat.AP"],"license":"http://creativecommons.org/licenses/publicdomain/","primary_cat":"q-bio.GN","submitted_at":"2013-04-25T17:34:52Z","title_canon_sha256":"03e9d68e53bd35890465f081ba553ba5f1c2cd976c72ed7581ef364bfc81842c"},"schema_version":"1.0","source":{"id":"1304.6966","kind":"arxiv","version":2}},"source_aliases":[{"alias_kind":"arxiv","alias_value":"1304.6966","created_at":"2026-05-18T02:57:14Z"},{"alias_kind":"arxiv_version","alias_value":"1304.6966v2","created_at":"2026-05-18T02:57:14Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.1304.6966","created_at":"2026-05-18T02:57:14Z"},{"alias_kind":"pith_short_12","alias_value":"CBOGPBSK2S3Y","created_at":"2026-05-18T12:27:40Z"},{"alias_kind":"pith_short_16","alias_value":"CBOGPBSK2S3YC7VM","created_at":"2026-05-18T12:27:40Z"},{"alias_kind":"pith_short_8","alias_value":"CBOGPBSK","created_at":"2026-05-18T12:27:40Z"}],"graph_snapshots":[{"event_id":"sha256:8fc301bb82622cf2302ed807f0daf4e786788080d9a391d3738d5812716e37eb","target":"graph","created_at":"2026-05-18T02:57:14Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"graph_snapshot":{"author_claims":{"count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","strong_count":0},"builder_version":"pith-number-builder-2026-05-17-v1","claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"paper":{"abstract_excerpt":"Dysregulated microRNA (miRNA) expression is a well-established feature of human cancer. However, the role of specific miRNAs in determining cancer outcomes remains unclear. Using Level 3 expression data from the Cancer Genome Atlas (TCGA), we identified 61 miRNAs that are associated with overall survival in 469 ovarian cancers profiled by microarray (p<0.01). We also identified 12 miRNAs that are associated with survival when miRNAs were profiled in the same specimens using Next Generation Sequencing (miRNA-Seq) (p<0.01). Surprisingly, only 1 miRNA transcript is associated with ovarian cancer ","authors_text":"Claire M. Mach, Genevera Allen, Matthew L. Anderson, Ying-Wooi Wan, Zhandong Liu","cross_cats":["stat.AP"],"headline":"","license":"http://creativecommons.org/licenses/publicdomain/","primary_cat":"q-bio.GN","submitted_at":"2013-04-25T17:34:52Z","title":"On the Reproducibility of TCGA Ovarian Cancer MicroRNA Profiles"},"references":{"count":0,"internal_anchors":0,"resolved_work":0,"sample":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"1304.6966","kind":"arxiv","version":2},"verdict":{"created_at":null,"id":null,"model_set":{},"one_line_summary":"","pipeline_version":null,"pith_extraction_headline":"","strongest_claim":"","weakest_assumption":""}},"verdict_id":null}}],"author_attestations":[],"timestamp_anchors":[],"storage_attestations":[],"citation_signatures":[],"replication_records":[],"corrections":[],"mirror_hints":[],"record_created":{"event_id":"sha256:fe5f1d50795bce1eef65e4a37dfae3057cebd96d0a1bc2f7ea84d3317dc2c3ce","target":"record","created_at":"2026-05-18T02:57:14Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"attestation_state":"computed","canonical_record":{"metadata":{"abstract_canon_sha256":"8e0b328feb34b5b60b1064258cd9eff8fd33d3bf406ca0c2354ec354bd104699","cross_cats_sorted":["stat.AP"],"license":"http://creativecommons.org/licenses/publicdomain/","primary_cat":"q-bio.GN","submitted_at":"2013-04-25T17:34:52Z","title_canon_sha256":"03e9d68e53bd35890465f081ba553ba5f1c2cd976c72ed7581ef364bfc81842c"},"schema_version":"1.0","source":{"id":"1304.6966","kind":"arxiv","version":2}},"canonical_sha256":"105c67864ad4b7817eace9206605a4e2642295858980d55f600e7f9d02138a12","receipt":{"algorithm":"ed25519","builder_version":"pith-number-builder-2026-05-17-v1","canonical_sha256":"105c67864ad4b7817eace9206605a4e2642295858980d55f600e7f9d02138a12","first_computed_at":"2026-05-18T02:57:14.843508Z","key_id":"pith-v1-2026-05","kind":"pith_receipt","last_reissued_at":"2026-05-18T02:57:14.843508Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","receipt_version":"0.3","signature_b64":"FYoiPJ4f/Zs9bez/KDymms1z27fjyaKYYy8WGo1gxAcfTtGN/FM9AVf2CGsGKbHZgM+l9cZfv4ZYb+lH0mXpDA==","signature_status":"signed_v1","signed_at":"2026-05-18T02:57:14.844145Z","signed_message":"canonical_sha256_bytes"},"source_id":"1304.6966","source_kind":"arxiv","source_version":2}}},"equivocations":[],"invalid_events":[],"applied_event_ids":["sha256:fe5f1d50795bce1eef65e4a37dfae3057cebd96d0a1bc2f7ea84d3317dc2c3ce","sha256:8fc301bb82622cf2302ed807f0daf4e786788080d9a391d3738d5812716e37eb"],"state_sha256":"88e146b5a3c48bd1c5cf8959a4ddffcf0daa955fffa3c626eca42b76ee53ea6d"},"bundle_signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"/QwBGUVsy6l9roAycDXdaONKJggHN9uWPUcyRndELtq0K8lghXEJFcqxo4f1xoshs+3UzB9L65mMO1j3liFWAA==","signed_message":"bundle_sha256_bytes","signed_at":"2026-06-09T06:10:49.260589Z","bundle_sha256":"ca45d9fc5f3c397b3e07cb938eb9bf4638a6d76fb8d8731ad91cbafe6e7da407"}}