{"bundle_type":"pith_open_graph_bundle","bundle_version":"1.0","pith_number":"pith:2014:CDCU4DRYJO2DCJM4775LYNKP5T","short_pith_number":"pith:CDCU4DRY","canonical_record":{"source":{"id":"1408.5216","kind":"arxiv","version":1},"metadata":{"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.QM","submitted_at":"2014-08-22T06:45:43Z","cross_cats_sorted":[],"title_canon_sha256":"f02eb8a14b57379624b68a5b9b02bbc4cfcc58319f8ff3aba3bdbf429f999679","abstract_canon_sha256":"524bbfd8f1b5e5f5b811756be3f12a06fb6cab6c406e24e86aa42aac004d6b91"},"schema_version":"1.0"},"canonical_sha256":"10c54e0e384bb431259cfffabc354fece8b8acc9677937bffaf91dd7dd0f5e76","source":{"kind":"arxiv","id":"1408.5216","version":1},"source_aliases":[{"alias_kind":"arxiv","alias_value":"1408.5216","created_at":"2026-05-18T02:44:39Z"},{"alias_kind":"arxiv_version","alias_value":"1408.5216v1","created_at":"2026-05-18T02:44:39Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.1408.5216","created_at":"2026-05-18T02:44:39Z"},{"alias_kind":"pith_short_12","alias_value":"CDCU4DRYJO2D","created_at":"2026-05-18T12:28:22Z"},{"alias_kind":"pith_short_16","alias_value":"CDCU4DRYJO2DCJM4","created_at":"2026-05-18T12:28:22Z"},{"alias_kind":"pith_short_8","alias_value":"CDCU4DRY","created_at":"2026-05-18T12:28:22Z"}],"events":[{"event_type":"record_created","subject_pith_number":"pith:2014:CDCU4DRYJO2DCJM4775LYNKP5T","target":"record","payload":{"canonical_record":{"source":{"id":"1408.5216","kind":"arxiv","version":1},"metadata":{"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.QM","submitted_at":"2014-08-22T06:45:43Z","cross_cats_sorted":[],"title_canon_sha256":"f02eb8a14b57379624b68a5b9b02bbc4cfcc58319f8ff3aba3bdbf429f999679","abstract_canon_sha256":"524bbfd8f1b5e5f5b811756be3f12a06fb6cab6c406e24e86aa42aac004d6b91"},"schema_version":"1.0"},"canonical_sha256":"10c54e0e384bb431259cfffabc354fece8b8acc9677937bffaf91dd7dd0f5e76","receipt":{"kind":"pith_receipt","key_id":"pith-v1-2026-05","algorithm":"ed25519","signed_at":"2026-05-18T02:44:39.091680Z","signature_b64":"lD+mIvuHvEzdMPAjcq+X8BbwEUYjDF5cI7Rb95djv9XZuaaLDn1FUo//EFICtfgEDrnUuyTehZeFDsRU3s9kBw==","signed_message":"canonical_sha256_bytes","builder_version":"pith-number-builder-2026-05-17-v1","receipt_version":"0.3","canonical_sha256":"10c54e0e384bb431259cfffabc354fece8b8acc9677937bffaf91dd7dd0f5e76","last_reissued_at":"2026-05-18T02:44:39.091138Z","signature_status":"signed_v1","first_computed_at":"2026-05-18T02:44:39.091138Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"source_kind":"arxiv","source_id":"1408.5216","source_version":1,"attestation_state":"computed"},"signer":{"signer_id":"pith.science","signer_type":"pith_registry","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"created_at":"2026-05-18T02:44:39Z","supersedes":[],"prev_event":null,"signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"a1MdIu0VNSMDr2vNuwantYxbRaCWrGXpOxxNtgfn+4J0wUjTreJMd3P0AH2mQsyr6WtnYOaFTYrs1UF3SNsJDA==","signed_message":"open_graph_event_sha256_bytes","signed_at":"2026-06-12T00:24:51.063832Z"},"content_sha256":"0ee8772a30225fd81fd3d63749dce3c95528a5f519dfad33cc62755dd099c144","schema_version":"1.0","event_id":"sha256:0ee8772a30225fd81fd3d63749dce3c95528a5f519dfad33cc62755dd099c144"},{"event_type":"graph_snapshot","subject_pith_number":"pith:2014:CDCU4DRYJO2DCJM4775LYNKP5T","target":"graph","payload":{"graph_snapshot":{"paper":{"title":"Numerical modeling of inhomogeneous DNA replication kinetics","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","headline":"","cross_cats":[],"primary_cat":"q-bio.QM","authors_text":"Antoine Dub\\'e, John Bechhoefer, Michel G. Gauthier","submitted_at":"2014-08-22T06:45:43Z","abstract_excerpt":"We present a calculation technique for modeling inhomogeneous DNA replication kinetics, where replication factors such as initiation rates or fork speeds can change with both position and time. We can use our model to simulate data sets obtained by molecular combing, a widely used experimental technique for probing replication. We can also infer information about the replication program by fitting our model to experimental data sets and also test the efficacy of planned experiments by fitting our model to simulated data sets. We consider asynchronous data sets and illustrate how a lack of sync"},"claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"1408.5216","kind":"arxiv","version":1},"verdict":{"id":null,"model_set":{},"created_at":null,"strongest_claim":"","one_line_summary":"","pipeline_version":null,"weakest_assumption":"","pith_extraction_headline":""},"references":{"count":0,"sample":[],"resolved_work":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","internal_anchors":0},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"author_claims":{"count":0,"strong_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"builder_version":"pith-number-builder-2026-05-17-v1"},"verdict_id":null},"signer":{"signer_id":"pith.science","signer_type":"pith_registry","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"created_at":"2026-05-18T02:44:39Z","supersedes":[],"prev_event":null,"signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"wEcczNZsoS5da6QqKoEIMG4NuRzhCbNJ5q+vqerv+tAAY7mSMG9d1a9I4xvzr/8qeySh6k7cJ05Wf76NKykXCQ==","signed_message":"open_graph_event_sha256_bytes","signed_at":"2026-06-12T00:24:51.064172Z"},"content_sha256":"90e5198f19396d63c5a23e99ef74911fed6a297eafd1124124231e4f55164bd0","schema_version":"1.0","event_id":"sha256:90e5198f19396d63c5a23e99ef74911fed6a297eafd1124124231e4f55164bd0"}],"timestamp_proofs":[],"mirror_hints":[{"mirror_type":"https","name":"Pith Resolver","base_url":"https://pith.science","bundle_url":"https://pith.science/pith/CDCU4DRYJO2DCJM4775LYNKP5T/bundle.json","state_url":"https://pith.science/pith/CDCU4DRYJO2DCJM4775LYNKP5T/state.json","well_known_bundle_url":"https://pith.science/.well-known/pith/CDCU4DRYJO2DCJM4775LYNKP5T/bundle.json","status":"primary"}],"public_keys":[{"key_id":"pith-v1-2026-05","algorithm":"ed25519","format":"raw","public_key_b64":"stVStoiQhXFxp4s2pdzPNoqVNBMojDU/fJ2db5S3CbM=","public_key_hex":"b2d552b68890857171a78b36a5dccf368a953413288c353f7c9d9d6f94b709b3","fingerprint_sha256_b32_first128bits":"RVFV5Z2OI2J3ZUO7ERDEBCYNKS","fingerprint_sha256_hex":"8d4b5ee74e4693bcd1df2446408b0d54","rotates_at":null,"url":"https://pith.science/pith-signing-key.json","notes":"Pith uses this Ed25519 key to sign canonical record SHA-256 digests. Verify with: ed25519_verify(public_key, message=canonical_sha256_bytes, signature=base64decode(signature_b64))."}],"merge_version":"pith-open-graph-merge-v1","built_at":"2026-06-12T00:24:51Z","links":{"resolver":"https://pith.science/pith/CDCU4DRYJO2DCJM4775LYNKP5T","bundle":"https://pith.science/pith/CDCU4DRYJO2DCJM4775LYNKP5T/bundle.json","state":"https://pith.science/pith/CDCU4DRYJO2DCJM4775LYNKP5T/state.json","well_known_bundle":"https://pith.science/.well-known/pith/CDCU4DRYJO2DCJM4775LYNKP5T/bundle.json"},"state":{"state_type":"pith_open_graph_state","state_version":"1.0","pith_number":"pith:2014:CDCU4DRYJO2DCJM4775LYNKP5T","merge_version":"pith-open-graph-merge-v1","event_count":2,"valid_event_count":2,"invalid_event_count":0,"equivocation_count":0,"current":{"canonical_record":{"metadata":{"abstract_canon_sha256":"524bbfd8f1b5e5f5b811756be3f12a06fb6cab6c406e24e86aa42aac004d6b91","cross_cats_sorted":[],"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.QM","submitted_at":"2014-08-22T06:45:43Z","title_canon_sha256":"f02eb8a14b57379624b68a5b9b02bbc4cfcc58319f8ff3aba3bdbf429f999679"},"schema_version":"1.0","source":{"id":"1408.5216","kind":"arxiv","version":1}},"source_aliases":[{"alias_kind":"arxiv","alias_value":"1408.5216","created_at":"2026-05-18T02:44:39Z"},{"alias_kind":"arxiv_version","alias_value":"1408.5216v1","created_at":"2026-05-18T02:44:39Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.1408.5216","created_at":"2026-05-18T02:44:39Z"},{"alias_kind":"pith_short_12","alias_value":"CDCU4DRYJO2D","created_at":"2026-05-18T12:28:22Z"},{"alias_kind":"pith_short_16","alias_value":"CDCU4DRYJO2DCJM4","created_at":"2026-05-18T12:28:22Z"},{"alias_kind":"pith_short_8","alias_value":"CDCU4DRY","created_at":"2026-05-18T12:28:22Z"}],"graph_snapshots":[{"event_id":"sha256:90e5198f19396d63c5a23e99ef74911fed6a297eafd1124124231e4f55164bd0","target":"graph","created_at":"2026-05-18T02:44:39Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"graph_snapshot":{"author_claims":{"count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","strong_count":0},"builder_version":"pith-number-builder-2026-05-17-v1","claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"paper":{"abstract_excerpt":"We present a calculation technique for modeling inhomogeneous DNA replication kinetics, where replication factors such as initiation rates or fork speeds can change with both position and time. We can use our model to simulate data sets obtained by molecular combing, a widely used experimental technique for probing replication. We can also infer information about the replication program by fitting our model to experimental data sets and also test the efficacy of planned experiments by fitting our model to simulated data sets. We consider asynchronous data sets and illustrate how a lack of sync","authors_text":"Antoine Dub\\'e, John Bechhoefer, Michel G. Gauthier","cross_cats":[],"headline":"","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.QM","submitted_at":"2014-08-22T06:45:43Z","title":"Numerical modeling of inhomogeneous DNA replication kinetics"},"references":{"count":0,"internal_anchors":0,"resolved_work":0,"sample":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"1408.5216","kind":"arxiv","version":1},"verdict":{"created_at":null,"id":null,"model_set":{},"one_line_summary":"","pipeline_version":null,"pith_extraction_headline":"","strongest_claim":"","weakest_assumption":""}},"verdict_id":null}}],"author_attestations":[],"timestamp_anchors":[],"storage_attestations":[],"citation_signatures":[],"replication_records":[],"corrections":[],"mirror_hints":[],"record_created":{"event_id":"sha256:0ee8772a30225fd81fd3d63749dce3c95528a5f519dfad33cc62755dd099c144","target":"record","created_at":"2026-05-18T02:44:39Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"attestation_state":"computed","canonical_record":{"metadata":{"abstract_canon_sha256":"524bbfd8f1b5e5f5b811756be3f12a06fb6cab6c406e24e86aa42aac004d6b91","cross_cats_sorted":[],"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.QM","submitted_at":"2014-08-22T06:45:43Z","title_canon_sha256":"f02eb8a14b57379624b68a5b9b02bbc4cfcc58319f8ff3aba3bdbf429f999679"},"schema_version":"1.0","source":{"id":"1408.5216","kind":"arxiv","version":1}},"canonical_sha256":"10c54e0e384bb431259cfffabc354fece8b8acc9677937bffaf91dd7dd0f5e76","receipt":{"algorithm":"ed25519","builder_version":"pith-number-builder-2026-05-17-v1","canonical_sha256":"10c54e0e384bb431259cfffabc354fece8b8acc9677937bffaf91dd7dd0f5e76","first_computed_at":"2026-05-18T02:44:39.091138Z","key_id":"pith-v1-2026-05","kind":"pith_receipt","last_reissued_at":"2026-05-18T02:44:39.091138Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","receipt_version":"0.3","signature_b64":"lD+mIvuHvEzdMPAjcq+X8BbwEUYjDF5cI7Rb95djv9XZuaaLDn1FUo//EFICtfgEDrnUuyTehZeFDsRU3s9kBw==","signature_status":"signed_v1","signed_at":"2026-05-18T02:44:39.091680Z","signed_message":"canonical_sha256_bytes"},"source_id":"1408.5216","source_kind":"arxiv","source_version":1}}},"equivocations":[],"invalid_events":[],"applied_event_ids":["sha256:0ee8772a30225fd81fd3d63749dce3c95528a5f519dfad33cc62755dd099c144","sha256:90e5198f19396d63c5a23e99ef74911fed6a297eafd1124124231e4f55164bd0"],"state_sha256":"4634f01c10370c5acb3777c3462b37355df31e5ad4a3a73471b9a43e626e5151"},"bundle_signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"9Wsr5yZ9QDOHFc6H9mypTUOHPbkI+dqCP2KTTFfrTH3/xAzj8gQhhZ3Y++r9YTJvVISXMl45z63pY0Mmc0zSAA==","signed_message":"bundle_sha256_bytes","signed_at":"2026-06-12T00:24:51.065980Z","bundle_sha256":"72e56da6a865f542f7aba3e545892eaad0043765f5b65b31e6f1d03263e4c0dc"}}