{"state_type":"pith_open_graph_state","state_version":"1.0","pith_number":"pith:2020:CDSGKXIHWKL2WNW4LORRWEXSDH","merge_version":"pith-open-graph-merge-v1","event_count":2,"valid_event_count":2,"invalid_event_count":0,"equivocation_count":0,"current":{"canonical_record":{"metadata":{"abstract_canon_sha256":"7a3b62872d77e9c30ce2003739411368634d787cc2833508e03fce61367e1388","cross_cats_sorted":[],"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.BM","submitted_at":"2020-04-24T17:47:15Z","title_canon_sha256":"223cdebade1ba1d6a599b4ca69ce1e865a5871de4f58d639aa50581576e5f760"},"schema_version":"1.0","source":{"id":"2004.11882","kind":"arxiv","version":1}},"source_aliases":[{"alias_kind":"arxiv","alias_value":"2004.11882","created_at":"2026-07-05T00:57:58Z"},{"alias_kind":"arxiv_version","alias_value":"2004.11882v1","created_at":"2026-07-05T00:57:58Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.2004.11882","created_at":"2026-07-05T00:57:58Z"},{"alias_kind":"pith_short_12","alias_value":"CDSGKXIHWKL2","created_at":"2026-07-05T00:57:58Z"},{"alias_kind":"pith_short_16","alias_value":"CDSGKXIHWKL2WNW4","created_at":"2026-07-05T00:57:58Z"},{"alias_kind":"pith_short_8","alias_value":"CDSGKXIH","created_at":"2026-07-05T00:57:58Z"}],"graph_snapshots":[{"event_id":"sha256:0727e904a552ae3a0372605f5a81a9a26342d53d7bea99f2d59a6709a33d67ee","target":"graph","created_at":"2026-07-05T00:57:58Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"graph_snapshot":{"author_claims":{"count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","strong_count":0},"builder_version":"pith-number-builder-2026-05-17-v1","claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"integrity":{"available":true,"clean":true,"detectors_run":[],"endpoint":"/pith/2004.11882/integrity.json","findings":[],"snapshot_sha256":"c28c3603d3b5d939e8dc4c7e95fa8dfce3d595e45f758748cecf8e644a296938","summary":{"advisory":0,"by_detector":{},"critical":0,"informational":0}},"paper":{"abstract_excerpt":"The hydrogen peroxide is present in the living cell at small concentrations that increase under the action of the heavy ion beams in the process of anticancer therapy. The interactions of hydrogen peroxide with DNA, proteins and other biological molecules are poorly understood. In the present work the competitive binding of the hydrogen peroxide and water molecules with the DNA double helix backbone has been studied using the molecular dynamics method. The simulations have been carried out for the DNA double helix in a water solution with hydrogen peroxide molecules and Na$^{+}$ counterions. T","authors_text":"(2) University of P. J. \\v{S}af\\'arik in Ko\\v{s}ice, Institute of Physics at Faculty of Science \\'UFV PF UPJ\\v{S}), J. Uli\\v{c}n\\'y (2), S.M. Perepelytsya (1), S.N. Volkov (1) ((1) Bogolyubov Institute for Theoretical Physics of the National Academy of Sciences of Ukraine","cross_cats":[],"headline":"","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.BM","submitted_at":"2020-04-24T17:47:15Z","title":"Molecular dynamics study of the competitive binding of hydrogen peroxide and water molecules with the DNA phosphate groups"},"references":{"count":0,"internal_anchors":0,"resolved_work":0,"sample":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"2004.11882","kind":"arxiv","version":1},"verdict":{"created_at":null,"id":null,"model_set":{},"one_line_summary":"","pipeline_version":null,"pith_extraction_headline":"","strongest_claim":"","weakest_assumption":""}},"verdict_id":null}}],"author_attestations":[],"timestamp_anchors":[],"storage_attestations":[],"citation_signatures":[],"replication_records":[],"corrections":[],"mirror_hints":[],"record_created":{"event_id":"sha256:861e97872f9673a382e2607be222f2ee7e9b2f3443e5b4a8640de5ae15ba9a4d","target":"record","created_at":"2026-07-05T00:57:58Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"attestation_state":"computed","canonical_record":{"metadata":{"abstract_canon_sha256":"7a3b62872d77e9c30ce2003739411368634d787cc2833508e03fce61367e1388","cross_cats_sorted":[],"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.BM","submitted_at":"2020-04-24T17:47:15Z","title_canon_sha256":"223cdebade1ba1d6a599b4ca69ce1e865a5871de4f58d639aa50581576e5f760"},"schema_version":"1.0","source":{"id":"2004.11882","kind":"arxiv","version":1}},"canonical_sha256":"10e4655d07b297ab36dc5ba31b12f219d5ca60890bc1a594546b68e9a395fe67","receipt":{"algorithm":"ed25519","builder_version":"pith-number-builder-2026-05-17-v1","canonical_sha256":"10e4655d07b297ab36dc5ba31b12f219d5ca60890bc1a594546b68e9a395fe67","first_computed_at":"2026-07-05T00:57:58.746796Z","key_id":"pith-v1-2026-05","kind":"pith_receipt","last_reissued_at":"2026-07-05T00:57:58.746796Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","receipt_version":"0.3","signature_b64":"C6EJHsNwmik6A9MSvEHcAS5uWrhlH/43uFofNZW4uNC0pQGXJsHAiJEeh6zG3fuuMd8PGc4ccQ/tFDSHXmtMCQ==","signature_status":"signed_v1","signed_at":"2026-07-05T00:57:58.747279Z","signed_message":"canonical_sha256_bytes"},"source_id":"2004.11882","source_kind":"arxiv","source_version":1}}},"equivocations":[],"invalid_events":[],"applied_event_ids":["sha256:861e97872f9673a382e2607be222f2ee7e9b2f3443e5b4a8640de5ae15ba9a4d","sha256:0727e904a552ae3a0372605f5a81a9a26342d53d7bea99f2d59a6709a33d67ee"],"state_sha256":"77d15123039e5a5d91db3726f0d9e2e6deb6211e2b9a6d873168ebf8c1f695da"}