{"bundle_type":"pith_open_graph_bundle","bundle_version":"1.0","pith_number":"pith:2026:CEJAH7ZXXYYYHWVJYND6GOASZG","short_pith_number":"pith:CEJAH7ZX","canonical_record":{"source":{"id":"2601.01830","kind":"arxiv","version":3},"metadata":{"license":"http://creativecommons.org/licenses/by-nc-nd/4.0/","primary_cat":"stat.ME","submitted_at":"2026-01-05T06:50:07Z","cross_cats_sorted":["stat.AP"],"title_canon_sha256":"78e1818d793bb6e68de171adfd81b91a01b393fa745f3e92389d516d15ecf8a5","abstract_canon_sha256":"339c1185b84a6703e6ee9a5d5558bef04c1bbc70028aaed611c35f706a431399"},"schema_version":"1.0"},"canonical_sha256":"111203ff37be3183daa9c347e33812c998cfc2fa04e499097d3613df1897a8dc","source":{"kind":"arxiv","id":"2601.01830","version":3},"source_aliases":[{"alias_kind":"arxiv","alias_value":"2601.01830","created_at":"2026-06-09T01:04:40Z"},{"alias_kind":"arxiv_version","alias_value":"2601.01830v3","created_at":"2026-06-09T01:04:40Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.2601.01830","created_at":"2026-06-09T01:04:40Z"},{"alias_kind":"pith_short_12","alias_value":"CEJAH7ZXXYYY","created_at":"2026-06-09T01:04:40Z"},{"alias_kind":"pith_short_16","alias_value":"CEJAH7ZXXYYYHWVJ","created_at":"2026-06-09T01:04:40Z"},{"alias_kind":"pith_short_8","alias_value":"CEJAH7ZX","created_at":"2026-06-09T01:04:40Z"}],"events":[{"event_type":"record_created","subject_pith_number":"pith:2026:CEJAH7ZXXYYYHWVJYND6GOASZG","target":"record","payload":{"canonical_record":{"source":{"id":"2601.01830","kind":"arxiv","version":3},"metadata":{"license":"http://creativecommons.org/licenses/by-nc-nd/4.0/","primary_cat":"stat.ME","submitted_at":"2026-01-05T06:50:07Z","cross_cats_sorted":["stat.AP"],"title_canon_sha256":"78e1818d793bb6e68de171adfd81b91a01b393fa745f3e92389d516d15ecf8a5","abstract_canon_sha256":"339c1185b84a6703e6ee9a5d5558bef04c1bbc70028aaed611c35f706a431399"},"schema_version":"1.0"},"canonical_sha256":"111203ff37be3183daa9c347e33812c998cfc2fa04e499097d3613df1897a8dc","receipt":{"kind":"pith_receipt","key_id":"pith-v1-2026-05","algorithm":"ed25519","signed_at":"2026-06-09T01:04:40.712662Z","signature_b64":"Fz17M118jK3u2jCjv3s5f6suVunGU6By3r7BzegNgOJvcvPrWLC4XAzf41F/iHKAHd9GVAw6LYHRtZtGjOAvDQ==","signed_message":"canonical_sha256_bytes","builder_version":"pith-number-builder-2026-05-17-v1","receipt_version":"0.3","canonical_sha256":"111203ff37be3183daa9c347e33812c998cfc2fa04e499097d3613df1897a8dc","last_reissued_at":"2026-06-09T01:04:40.712215Z","signature_status":"signed_v1","first_computed_at":"2026-06-09T01:04:40.712215Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"source_kind":"arxiv","source_id":"2601.01830","source_version":3,"attestation_state":"computed"},"signer":{"signer_id":"pith.science","signer_type":"pith_registry","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"created_at":"2026-06-09T01:04:40Z","supersedes":[],"prev_event":null,"signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"JZ5Z6/3VY/mcfty4Flk28HHYB75FDMPmmAmsdMkOxWluJgiwV8Gx/P7ufe4UTGXhsxnq+ikv7hBkPKrmJMhuBQ==","signed_message":"open_graph_event_sha256_bytes","signed_at":"2026-06-11T07:42:50.497050Z"},"content_sha256":"db64d0eb168505d643560dc0d1af72c00ef356593d6adde9a6cd272cd947f9e4","schema_version":"1.0","event_id":"sha256:db64d0eb168505d643560dc0d1af72c00ef356593d6adde9a6cd272cd947f9e4"},{"event_type":"graph_snapshot","subject_pith_number":"pith:2026:CEJAH7ZXXYYYHWVJYND6GOASZG","target":"graph","payload":{"graph_snapshot":{"paper":{"title":"Confounder-robust causal discovery and inference in Perturb-seq using proxy and instrumental variables","license":"http://creativecommons.org/licenses/by-nc-nd/4.0/","headline":"","cross_cats":["stat.AP"],"primary_cat":"stat.ME","authors_text":"Hongzhe Li, Kwangmoon Park","submitted_at":"2026-01-05T06:50:07Z","abstract_excerpt":"Emerging single-cell technologies that combine CRISPR-based genetic perturbations with single-cell RNA sequencing, such as Perturb-seq, offer unprecedented opportunities to uncover cause-and-effect relationships among genes. Nonetheless, Perturb-seq experiments are subject to unobserved factors that, if not properly handled, can severely bias the inferred causal relationships between genes. These latent factors may arise not only from intrinsic molecular features of the regulatory elements, but also from unmeasured genes omitted due to cost-constrained experimental designs. Although methods fo"},"claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"2601.01830","kind":"arxiv","version":3},"verdict":{"id":null,"model_set":{},"created_at":null,"strongest_claim":"","one_line_summary":"","pipeline_version":null,"weakest_assumption":"","pith_extraction_headline":""},"integrity":{"clean":true,"summary":{"advisory":0,"critical":0,"by_detector":{},"informational":0},"endpoint":"/pith/2601.01830/integrity.json","findings":[],"available":true,"detectors_run":[],"snapshot_sha256":"c28c3603d3b5d939e8dc4c7e95fa8dfce3d595e45f758748cecf8e644a296938"},"references":{"count":0,"sample":[],"resolved_work":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","internal_anchors":0},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"author_claims":{"count":0,"strong_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"builder_version":"pith-number-builder-2026-05-17-v1"},"verdict_id":null},"signer":{"signer_id":"pith.science","signer_type":"pith_registry","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"created_at":"2026-06-09T01:04:40Z","supersedes":[],"prev_event":null,"signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"2v/fx8CUL/EHILJy60sRqqvdMXemTtAziuNXSGqXgeZMJv4tmh8OZiUdiF7Rdtfsb8W8ea2USGg1Xei/9ZolBw==","signed_message":"open_graph_event_sha256_bytes","signed_at":"2026-06-11T07:42:50.497787Z"},"content_sha256":"1276b9c52f7f39fef05bff328fda64e1455709c59aeb8d4da3a20272972116e8","schema_version":"1.0","event_id":"sha256:1276b9c52f7f39fef05bff328fda64e1455709c59aeb8d4da3a20272972116e8"}],"timestamp_proofs":[],"mirror_hints":[{"mirror_type":"https","name":"Pith Resolver","base_url":"https://pith.science","bundle_url":"https://pith.science/pith/CEJAH7ZXXYYYHWVJYND6GOASZG/bundle.json","state_url":"https://pith.science/pith/CEJAH7ZXXYYYHWVJYND6GOASZG/state.json","well_known_bundle_url":"https://pith.science/.well-known/pith/CEJAH7ZXXYYYHWVJYND6GOASZG/bundle.json","status":"primary"}],"public_keys":[{"key_id":"pith-v1-2026-05","algorithm":"ed25519","format":"raw","public_key_b64":"stVStoiQhXFxp4s2pdzPNoqVNBMojDU/fJ2db5S3CbM=","public_key_hex":"b2d552b68890857171a78b36a5dccf368a953413288c353f7c9d9d6f94b709b3","fingerprint_sha256_b32_first128bits":"RVFV5Z2OI2J3ZUO7ERDEBCYNKS","fingerprint_sha256_hex":"8d4b5ee74e4693bcd1df2446408b0d54","rotates_at":null,"url":"https://pith.science/pith-signing-key.json","notes":"Pith uses this Ed25519 key to sign canonical record SHA-256 digests. Verify with: ed25519_verify(public_key, message=canonical_sha256_bytes, signature=base64decode(signature_b64))."}],"merge_version":"pith-open-graph-merge-v1","built_at":"2026-06-11T07:42:50Z","links":{"resolver":"https://pith.science/pith/CEJAH7ZXXYYYHWVJYND6GOASZG","bundle":"https://pith.science/pith/CEJAH7ZXXYYYHWVJYND6GOASZG/bundle.json","state":"https://pith.science/pith/CEJAH7ZXXYYYHWVJYND6GOASZG/state.json","well_known_bundle":"https://pith.science/.well-known/pith/CEJAH7ZXXYYYHWVJYND6GOASZG/bundle.json"},"state":{"state_type":"pith_open_graph_state","state_version":"1.0","pith_number":"pith:2026:CEJAH7ZXXYYYHWVJYND6GOASZG","merge_version":"pith-open-graph-merge-v1","event_count":2,"valid_event_count":2,"invalid_event_count":0,"equivocation_count":0,"current":{"canonical_record":{"metadata":{"abstract_canon_sha256":"339c1185b84a6703e6ee9a5d5558bef04c1bbc70028aaed611c35f706a431399","cross_cats_sorted":["stat.AP"],"license":"http://creativecommons.org/licenses/by-nc-nd/4.0/","primary_cat":"stat.ME","submitted_at":"2026-01-05T06:50:07Z","title_canon_sha256":"78e1818d793bb6e68de171adfd81b91a01b393fa745f3e92389d516d15ecf8a5"},"schema_version":"1.0","source":{"id":"2601.01830","kind":"arxiv","version":3}},"source_aliases":[{"alias_kind":"arxiv","alias_value":"2601.01830","created_at":"2026-06-09T01:04:40Z"},{"alias_kind":"arxiv_version","alias_value":"2601.01830v3","created_at":"2026-06-09T01:04:40Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.2601.01830","created_at":"2026-06-09T01:04:40Z"},{"alias_kind":"pith_short_12","alias_value":"CEJAH7ZXXYYY","created_at":"2026-06-09T01:04:40Z"},{"alias_kind":"pith_short_16","alias_value":"CEJAH7ZXXYYYHWVJ","created_at":"2026-06-09T01:04:40Z"},{"alias_kind":"pith_short_8","alias_value":"CEJAH7ZX","created_at":"2026-06-09T01:04:40Z"}],"graph_snapshots":[{"event_id":"sha256:1276b9c52f7f39fef05bff328fda64e1455709c59aeb8d4da3a20272972116e8","target":"graph","created_at":"2026-06-09T01:04:40Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"graph_snapshot":{"author_claims":{"count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","strong_count":0},"builder_version":"pith-number-builder-2026-05-17-v1","claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"integrity":{"available":true,"clean":true,"detectors_run":[],"endpoint":"/pith/2601.01830/integrity.json","findings":[],"snapshot_sha256":"c28c3603d3b5d939e8dc4c7e95fa8dfce3d595e45f758748cecf8e644a296938","summary":{"advisory":0,"by_detector":{},"critical":0,"informational":0}},"paper":{"abstract_excerpt":"Emerging single-cell technologies that combine CRISPR-based genetic perturbations with single-cell RNA sequencing, such as Perturb-seq, offer unprecedented opportunities to uncover cause-and-effect relationships among genes. Nonetheless, Perturb-seq experiments are subject to unobserved factors that, if not properly handled, can severely bias the inferred causal relationships between genes. These latent factors may arise not only from intrinsic molecular features of the regulatory elements, but also from unmeasured genes omitted due to cost-constrained experimental designs. Although methods fo","authors_text":"Hongzhe Li, Kwangmoon Park","cross_cats":["stat.AP"],"headline":"","license":"http://creativecommons.org/licenses/by-nc-nd/4.0/","primary_cat":"stat.ME","submitted_at":"2026-01-05T06:50:07Z","title":"Confounder-robust causal discovery and inference in Perturb-seq using proxy and instrumental variables"},"references":{"count":0,"internal_anchors":0,"resolved_work":0,"sample":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"2601.01830","kind":"arxiv","version":3},"verdict":{"created_at":null,"id":null,"model_set":{},"one_line_summary":"","pipeline_version":null,"pith_extraction_headline":"","strongest_claim":"","weakest_assumption":""}},"verdict_id":null}}],"author_attestations":[],"timestamp_anchors":[],"storage_attestations":[],"citation_signatures":[],"replication_records":[],"corrections":[],"mirror_hints":[],"record_created":{"event_id":"sha256:db64d0eb168505d643560dc0d1af72c00ef356593d6adde9a6cd272cd947f9e4","target":"record","created_at":"2026-06-09T01:04:40Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"attestation_state":"computed","canonical_record":{"metadata":{"abstract_canon_sha256":"339c1185b84a6703e6ee9a5d5558bef04c1bbc70028aaed611c35f706a431399","cross_cats_sorted":["stat.AP"],"license":"http://creativecommons.org/licenses/by-nc-nd/4.0/","primary_cat":"stat.ME","submitted_at":"2026-01-05T06:50:07Z","title_canon_sha256":"78e1818d793bb6e68de171adfd81b91a01b393fa745f3e92389d516d15ecf8a5"},"schema_version":"1.0","source":{"id":"2601.01830","kind":"arxiv","version":3}},"canonical_sha256":"111203ff37be3183daa9c347e33812c998cfc2fa04e499097d3613df1897a8dc","receipt":{"algorithm":"ed25519","builder_version":"pith-number-builder-2026-05-17-v1","canonical_sha256":"111203ff37be3183daa9c347e33812c998cfc2fa04e499097d3613df1897a8dc","first_computed_at":"2026-06-09T01:04:40.712215Z","key_id":"pith-v1-2026-05","kind":"pith_receipt","last_reissued_at":"2026-06-09T01:04:40.712215Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","receipt_version":"0.3","signature_b64":"Fz17M118jK3u2jCjv3s5f6suVunGU6By3r7BzegNgOJvcvPrWLC4XAzf41F/iHKAHd9GVAw6LYHRtZtGjOAvDQ==","signature_status":"signed_v1","signed_at":"2026-06-09T01:04:40.712662Z","signed_message":"canonical_sha256_bytes"},"source_id":"2601.01830","source_kind":"arxiv","source_version":3}}},"equivocations":[],"invalid_events":[],"applied_event_ids":["sha256:db64d0eb168505d643560dc0d1af72c00ef356593d6adde9a6cd272cd947f9e4","sha256:1276b9c52f7f39fef05bff328fda64e1455709c59aeb8d4da3a20272972116e8"],"state_sha256":"d63f1829f656864705af0d5e62cb13088052b5b5215d52a700abf5a562c3f852"},"bundle_signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"M9TPd4aTkeN4QgjOlOQ+pxsxgMOvu7i8Jr4IvGMoF+nvUBNEMLzN2pU0sRmFZ16cnsA2Sw0W/1qTdotCdYRHBg==","signed_message":"bundle_sha256_bytes","signed_at":"2026-06-11T07:42:50.502627Z","bundle_sha256":"68e5d3c457f31b53ee06cfa9105d65c628b2e534193f5e73661fbc35741e9ace"}}