{"bundle_type":"pith_open_graph_bundle","bundle_version":"1.0","pith_number":"pith:2017:CFUK4NV7EXNP4VFTF7RQ3HUUCI","short_pith_number":"pith:CFUK4NV7","canonical_record":{"source":{"id":"1712.00962","kind":"arxiv","version":1},"metadata":{"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.CB","submitted_at":"2017-12-04T09:10:24Z","cross_cats_sorted":[],"title_canon_sha256":"434b7b342c54d4922b47d945e2002d38974093f895deacb28eda1e1dcb4687c8","abstract_canon_sha256":"e7247b8ff9dfbe0ceae14f8f16adcf675cf70f99b9230b9439859c82bef3655f"},"schema_version":"1.0"},"canonical_sha256":"1168ae36bf25dafe54b32fe30d9e94122437119d12183367b52d7d3a9890f63d","source":{"kind":"arxiv","id":"1712.00962","version":1},"source_aliases":[{"alias_kind":"arxiv","alias_value":"1712.00962","created_at":"2026-05-18T00:28:59Z"},{"alias_kind":"arxiv_version","alias_value":"1712.00962v1","created_at":"2026-05-18T00:28:59Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.1712.00962","created_at":"2026-05-18T00:28:59Z"},{"alias_kind":"pith_short_12","alias_value":"CFUK4NV7EXNP","created_at":"2026-05-18T12:31:10Z"},{"alias_kind":"pith_short_16","alias_value":"CFUK4NV7EXNP4VFT","created_at":"2026-05-18T12:31:10Z"},{"alias_kind":"pith_short_8","alias_value":"CFUK4NV7","created_at":"2026-05-18T12:31:10Z"}],"events":[{"event_type":"record_created","subject_pith_number":"pith:2017:CFUK4NV7EXNP4VFTF7RQ3HUUCI","target":"record","payload":{"canonical_record":{"source":{"id":"1712.00962","kind":"arxiv","version":1},"metadata":{"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.CB","submitted_at":"2017-12-04T09:10:24Z","cross_cats_sorted":[],"title_canon_sha256":"434b7b342c54d4922b47d945e2002d38974093f895deacb28eda1e1dcb4687c8","abstract_canon_sha256":"e7247b8ff9dfbe0ceae14f8f16adcf675cf70f99b9230b9439859c82bef3655f"},"schema_version":"1.0"},"canonical_sha256":"1168ae36bf25dafe54b32fe30d9e94122437119d12183367b52d7d3a9890f63d","receipt":{"kind":"pith_receipt","key_id":"pith-v1-2026-05","algorithm":"ed25519","signed_at":"2026-05-18T00:28:59.890150Z","signature_b64":"GN0eM/wr1F2agtkPk6FL9wlgctNtd8ntiFlBRLOZ5FQl5KvEDI+himtNl5THP3cpTAA3lA5ucaumDR9a4wRjDg==","signed_message":"canonical_sha256_bytes","builder_version":"pith-number-builder-2026-05-17-v1","receipt_version":"0.3","canonical_sha256":"1168ae36bf25dafe54b32fe30d9e94122437119d12183367b52d7d3a9890f63d","last_reissued_at":"2026-05-18T00:28:59.889704Z","signature_status":"signed_v1","first_computed_at":"2026-05-18T00:28:59.889704Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"source_kind":"arxiv","source_id":"1712.00962","source_version":1,"attestation_state":"computed"},"signer":{"signer_id":"pith.science","signer_type":"pith_registry","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"created_at":"2026-05-18T00:28:59Z","supersedes":[],"prev_event":null,"signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"S6+kHPOUA/TWzVjxn/WzFktSmB6t6hH0PB7bbNtGZRq16oNtokKPE9Jf4zqzQIsh1nNZQ9T6hbYelVvfzwyaDw==","signed_message":"open_graph_event_sha256_bytes","signed_at":"2026-05-27T08:11:22.210630Z"},"content_sha256":"6451b8d8e223ba17a8ca506307e535da5c00f10b9ff6f6d0b2771310d17b4eb3","schema_version":"1.0","event_id":"sha256:6451b8d8e223ba17a8ca506307e535da5c00f10b9ff6f6d0b2771310d17b4eb3"},{"event_type":"graph_snapshot","subject_pith_number":"pith:2017:CFUK4NV7EXNP4VFTF7RQ3HUUCI","target":"graph","payload":{"graph_snapshot":{"paper":{"title":"A Bayesian statistical analysis of stochastic phenotypic plasticity model of cancer cells","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","headline":"","cross_cats":[],"primary_cat":"q-bio.CB","authors_text":"Da Zhou, Jie Hu, Kaiyi Chen, Shanjun Mao, Xiaofang Cao","submitted_at":"2017-12-04T09:10:24Z","abstract_excerpt":"The phenotypic plasticity of cancer cells has received special attention in recent years. Even though related models have been widely studied in terms of mathematical properties, a thorough statistical analysis on parameter estimation and model selection is still very lacking. In this study, we present a Bayesian approach on the relative frequencies of cancer stem cells (CSCs). Both Gibbs sampling and Metropolis-Hastings (MH) algorithm are used to perform point and interval estimations of cell-state transition rates between CSCs and non-CSCs. Extensive simulations demonstrate the validity of o"},"claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"1712.00962","kind":"arxiv","version":1},"verdict":{"id":null,"model_set":{},"created_at":null,"strongest_claim":"","one_line_summary":"","pipeline_version":null,"weakest_assumption":"","pith_extraction_headline":""},"references":{"count":0,"sample":[],"resolved_work":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","internal_anchors":0},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"author_claims":{"count":0,"strong_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"builder_version":"pith-number-builder-2026-05-17-v1"},"verdict_id":null},"signer":{"signer_id":"pith.science","signer_type":"pith_registry","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"created_at":"2026-05-18T00:28:59Z","supersedes":[],"prev_event":null,"signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"X3Kb2OFgWkAjl2YpZt4KoKJiye/vLH8F1OqDorIgjcGpXQflN6zvzLngUcEHvAw+fn+smrqbNLsmcVEMqXAWAQ==","signed_message":"open_graph_event_sha256_bytes","signed_at":"2026-05-27T08:11:22.211232Z"},"content_sha256":"eee518d5756c417d98e6fa6689d88f6deb4e6be7d250954530fa9bef7ed55ea8","schema_version":"1.0","event_id":"sha256:eee518d5756c417d98e6fa6689d88f6deb4e6be7d250954530fa9bef7ed55ea8"}],"timestamp_proofs":[],"mirror_hints":[{"mirror_type":"https","name":"Pith Resolver","base_url":"https://pith.science","bundle_url":"https://pith.science/pith/CFUK4NV7EXNP4VFTF7RQ3HUUCI/bundle.json","state_url":"https://pith.science/pith/CFUK4NV7EXNP4VFTF7RQ3HUUCI/state.json","well_known_bundle_url":"https://pith.science/.well-known/pith/CFUK4NV7EXNP4VFTF7RQ3HUUCI/bundle.json","status":"primary"}],"public_keys":[{"key_id":"pith-v1-2026-05","algorithm":"ed25519","format":"raw","public_key_b64":"stVStoiQhXFxp4s2pdzPNoqVNBMojDU/fJ2db5S3CbM=","public_key_hex":"b2d552b68890857171a78b36a5dccf368a953413288c353f7c9d9d6f94b709b3","fingerprint_sha256_b32_first128bits":"RVFV5Z2OI2J3ZUO7ERDEBCYNKS","fingerprint_sha256_hex":"8d4b5ee74e4693bcd1df2446408b0d54","rotates_at":null,"url":"https://pith.science/pith-signing-key.json","notes":"Pith uses this Ed25519 key to sign canonical record SHA-256 digests. Verify with: ed25519_verify(public_key, message=canonical_sha256_bytes, signature=base64decode(signature_b64))."}],"merge_version":"pith-open-graph-merge-v1","built_at":"2026-05-27T08:11:22Z","links":{"resolver":"https://pith.science/pith/CFUK4NV7EXNP4VFTF7RQ3HUUCI","bundle":"https://pith.science/pith/CFUK4NV7EXNP4VFTF7RQ3HUUCI/bundle.json","state":"https://pith.science/pith/CFUK4NV7EXNP4VFTF7RQ3HUUCI/state.json","well_known_bundle":"https://pith.science/.well-known/pith/CFUK4NV7EXNP4VFTF7RQ3HUUCI/bundle.json"},"state":{"state_type":"pith_open_graph_state","state_version":"1.0","pith_number":"pith:2017:CFUK4NV7EXNP4VFTF7RQ3HUUCI","merge_version":"pith-open-graph-merge-v1","event_count":2,"valid_event_count":2,"invalid_event_count":0,"equivocation_count":0,"current":{"canonical_record":{"metadata":{"abstract_canon_sha256":"e7247b8ff9dfbe0ceae14f8f16adcf675cf70f99b9230b9439859c82bef3655f","cross_cats_sorted":[],"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.CB","submitted_at":"2017-12-04T09:10:24Z","title_canon_sha256":"434b7b342c54d4922b47d945e2002d38974093f895deacb28eda1e1dcb4687c8"},"schema_version":"1.0","source":{"id":"1712.00962","kind":"arxiv","version":1}},"source_aliases":[{"alias_kind":"arxiv","alias_value":"1712.00962","created_at":"2026-05-18T00:28:59Z"},{"alias_kind":"arxiv_version","alias_value":"1712.00962v1","created_at":"2026-05-18T00:28:59Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.1712.00962","created_at":"2026-05-18T00:28:59Z"},{"alias_kind":"pith_short_12","alias_value":"CFUK4NV7EXNP","created_at":"2026-05-18T12:31:10Z"},{"alias_kind":"pith_short_16","alias_value":"CFUK4NV7EXNP4VFT","created_at":"2026-05-18T12:31:10Z"},{"alias_kind":"pith_short_8","alias_value":"CFUK4NV7","created_at":"2026-05-18T12:31:10Z"}],"graph_snapshots":[{"event_id":"sha256:eee518d5756c417d98e6fa6689d88f6deb4e6be7d250954530fa9bef7ed55ea8","target":"graph","created_at":"2026-05-18T00:28:59Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"graph_snapshot":{"author_claims":{"count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","strong_count":0},"builder_version":"pith-number-builder-2026-05-17-v1","claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"paper":{"abstract_excerpt":"The phenotypic plasticity of cancer cells has received special attention in recent years. Even though related models have been widely studied in terms of mathematical properties, a thorough statistical analysis on parameter estimation and model selection is still very lacking. In this study, we present a Bayesian approach on the relative frequencies of cancer stem cells (CSCs). Both Gibbs sampling and Metropolis-Hastings (MH) algorithm are used to perform point and interval estimations of cell-state transition rates between CSCs and non-CSCs. Extensive simulations demonstrate the validity of o","authors_text":"Da Zhou, Jie Hu, Kaiyi Chen, Shanjun Mao, Xiaofang Cao","cross_cats":[],"headline":"","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.CB","submitted_at":"2017-12-04T09:10:24Z","title":"A Bayesian statistical analysis of stochastic phenotypic plasticity model of cancer cells"},"references":{"count":0,"internal_anchors":0,"resolved_work":0,"sample":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"1712.00962","kind":"arxiv","version":1},"verdict":{"created_at":null,"id":null,"model_set":{},"one_line_summary":"","pipeline_version":null,"pith_extraction_headline":"","strongest_claim":"","weakest_assumption":""}},"verdict_id":null}}],"author_attestations":[],"timestamp_anchors":[],"storage_attestations":[],"citation_signatures":[],"replication_records":[],"corrections":[],"mirror_hints":[],"record_created":{"event_id":"sha256:6451b8d8e223ba17a8ca506307e535da5c00f10b9ff6f6d0b2771310d17b4eb3","target":"record","created_at":"2026-05-18T00:28:59Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"attestation_state":"computed","canonical_record":{"metadata":{"abstract_canon_sha256":"e7247b8ff9dfbe0ceae14f8f16adcf675cf70f99b9230b9439859c82bef3655f","cross_cats_sorted":[],"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.CB","submitted_at":"2017-12-04T09:10:24Z","title_canon_sha256":"434b7b342c54d4922b47d945e2002d38974093f895deacb28eda1e1dcb4687c8"},"schema_version":"1.0","source":{"id":"1712.00962","kind":"arxiv","version":1}},"canonical_sha256":"1168ae36bf25dafe54b32fe30d9e94122437119d12183367b52d7d3a9890f63d","receipt":{"algorithm":"ed25519","builder_version":"pith-number-builder-2026-05-17-v1","canonical_sha256":"1168ae36bf25dafe54b32fe30d9e94122437119d12183367b52d7d3a9890f63d","first_computed_at":"2026-05-18T00:28:59.889704Z","key_id":"pith-v1-2026-05","kind":"pith_receipt","last_reissued_at":"2026-05-18T00:28:59.889704Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","receipt_version":"0.3","signature_b64":"GN0eM/wr1F2agtkPk6FL9wlgctNtd8ntiFlBRLOZ5FQl5KvEDI+himtNl5THP3cpTAA3lA5ucaumDR9a4wRjDg==","signature_status":"signed_v1","signed_at":"2026-05-18T00:28:59.890150Z","signed_message":"canonical_sha256_bytes"},"source_id":"1712.00962","source_kind":"arxiv","source_version":1}}},"equivocations":[],"invalid_events":[],"applied_event_ids":["sha256:6451b8d8e223ba17a8ca506307e535da5c00f10b9ff6f6d0b2771310d17b4eb3","sha256:eee518d5756c417d98e6fa6689d88f6deb4e6be7d250954530fa9bef7ed55ea8"],"state_sha256":"afc1e0252cf5999c0ceead40e49f9dad9ef26f7260d74d525c86f3b24f871595"},"bundle_signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"0yoWyGNphud1qYNmjIT/UjrC1N+8bmuek2qCEMMNQoRtD9rZWhNctsNUmc1IQInC74Ep3O/VcHZ7HPi03AM1Bg==","signed_message":"bundle_sha256_bytes","signed_at":"2026-05-27T08:11:22.214164Z","bundle_sha256":"a3519da78492656c6b6c05644d21ab5187d4db3b3bbbe20d0282eacf25a6b629"}}