{"record_type":"pith_number_record","schema_url":"https://pith.science/schemas/pith-number/v1.json","pith_number":"pith:2025:CHOURLSFXMXVGBRSV3NOQSADUD","short_pith_number":"pith:CHOURLSF","schema_version":"1.0","canonical_sha256":"11dd48ae45bb2f530632aedae84803a0f0ce68790ae03870d2077420a0ecad24","source":{"kind":"arxiv","id":"2503.00002","version":1},"attestation_state":"computed","paper":{"title":"Failure of Optimal Design Theory? A Case Study in Toxicology Using Sequential Robust Optimal Design Framework","license":"http://creativecommons.org/licenses/by/4.0/","headline":"","cross_cats":["stat.AP","stat.CO"],"primary_cat":"stat.ME","authors_text":"Elvis Han Cui, Jessica Munson, Michael Collins, Weng Kee Wong","submitted_at":"2025-02-11T02:37:11Z","abstract_excerpt":"This paper presents a quasi-sequential optimal design framework for toxicology experiments, specifically applied to sea urchin embryos. The authors propose a novel approach combining robust optimal design with adaptive, stage-based testing to improve efficiency in toxicological studies, particularly where traditional uniform designs fall short. The methodology uses statistical models to refine dose levels across experimental phases, aiming for increased precision while reducing costs and complexity. Key components include selecting an initial design, iterative dose optimization based on prelim"},"verification_status":{"content_addressed":true,"pith_receipt":true,"author_attested":false,"weak_author_claims":0,"strong_author_claims":0,"externally_anchored":false,"storage_verified":false,"citation_signatures":0,"replication_records":0,"graph_snapshot":true,"references_resolved":false,"formal_links_present":false},"canonical_record":{"source":{"id":"2503.00002","kind":"arxiv","version":1},"metadata":{"license":"http://creativecommons.org/licenses/by/4.0/","primary_cat":"stat.ME","submitted_at":"2025-02-11T02:37:11Z","cross_cats_sorted":["stat.AP","stat.CO"],"title_canon_sha256":"3aa745466af2cf2e5b7ce00d840f789ae772b030cd5ca4293f20eb3863a18f33","abstract_canon_sha256":"595a0fb40d88bc55008d25f4f6ee0cdfd2c582a5643c684808adce6b167339d9"},"schema_version":"1.0"},"receipt":{"kind":"pith_receipt","key_id":"pith-v1-2026-05","algorithm":"ed25519","signed_at":"2026-07-05T10:22:15.891431Z","signature_b64":"sC9tYyhjZsYBT6XZ+nRNw0YaeoSim3SUSAVa/g6du90mju2k7JEbZkX9GZTyEem5OSbjQB7aUYgOF7Impvt6DQ==","signed_message":"canonical_sha256_bytes","builder_version":"pith-number-builder-2026-05-17-v1","receipt_version":"0.3","canonical_sha256":"11dd48ae45bb2f530632aedae84803a0f0ce68790ae03870d2077420a0ecad24","last_reissued_at":"2026-07-05T10:22:15.890871Z","signature_status":"signed_v1","first_computed_at":"2026-07-05T10:22:15.890871Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"graph_snapshot":{"paper":{"title":"Failure of Optimal Design Theory? A Case Study in Toxicology Using Sequential Robust Optimal Design Framework","license":"http://creativecommons.org/licenses/by/4.0/","headline":"","cross_cats":["stat.AP","stat.CO"],"primary_cat":"stat.ME","authors_text":"Elvis Han Cui, Jessica Munson, Michael Collins, Weng Kee Wong","submitted_at":"2025-02-11T02:37:11Z","abstract_excerpt":"This paper presents a quasi-sequential optimal design framework for toxicology experiments, specifically applied to sea urchin embryos. The authors propose a novel approach combining robust optimal design with adaptive, stage-based testing to improve efficiency in toxicological studies, particularly where traditional uniform designs fall short. The methodology uses statistical models to refine dose levels across experimental phases, aiming for increased precision while reducing costs and complexity. Key components include selecting an initial design, iterative dose optimization based on prelim"},"claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"2503.00002","kind":"arxiv","version":1},"verdict":{"id":null,"model_set":{},"created_at":null,"strongest_claim":"","one_line_summary":"","pipeline_version":null,"weakest_assumption":"","pith_extraction_headline":""},"integrity":{"clean":true,"summary":{"advisory":0,"critical":0,"by_detector":{},"informational":0},"endpoint":"/pith/2503.00002/integrity.json","findings":[],"available":true,"detectors_run":[],"snapshot_sha256":"c28c3603d3b5d939e8dc4c7e95fa8dfce3d595e45f758748cecf8e644a296938"},"references":{"count":0,"sample":[],"resolved_work":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","internal_anchors":0},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"author_claims":{"count":0,"strong_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"builder_version":"pith-number-builder-2026-05-17-v1"},"aliases":[{"alias_kind":"arxiv","alias_value":"2503.00002","created_at":"2026-07-05T10:22:15.890936+00:00"},{"alias_kind":"arxiv_version","alias_value":"2503.00002v1","created_at":"2026-07-05T10:22:15.890936+00:00"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.2503.00002","created_at":"2026-07-05T10:22:15.890936+00:00"},{"alias_kind":"pith_short_12","alias_value":"CHOURLSFXMXV","created_at":"2026-07-05T10:22:15.890936+00:00"},{"alias_kind":"pith_short_16","alias_value":"CHOURLSFXMXVGBRS","created_at":"2026-07-05T10:22:15.890936+00:00"},{"alias_kind":"pith_short_8","alias_value":"CHOURLSF","created_at":"2026-07-05T10:22:15.890936+00:00"}],"events":[],"event_summary":{},"paper_claims":[],"inbound_citations":{"count":0,"internal_anchor_count":0,"sample":[]},"formal_canon":{"evidence_count":0,"sample":[],"anchors":[]},"links":{"html":"https://pith.science/pith/CHOURLSFXMXVGBRSV3NOQSADUD","json":"https://pith.science/pith/CHOURLSFXMXVGBRSV3NOQSADUD.json","graph_json":"https://pith.science/api/pith-number/CHOURLSFXMXVGBRSV3NOQSADUD/graph.json","events_json":"https://pith.science/api/pith-number/CHOURLSFXMXVGBRSV3NOQSADUD/events.json","paper":"https://pith.science/paper/CHOURLSF"},"agent_actions":{"view_html":"https://pith.science/pith/CHOURLSFXMXVGBRSV3NOQSADUD","download_json":"https://pith.science/pith/CHOURLSFXMXVGBRSV3NOQSADUD.json","view_paper":"https://pith.science/paper/CHOURLSF","resolve_alias":"https://pith.science/api/pith-number/resolve?arxiv=2503.00002&json=true","fetch_graph":"https://pith.science/api/pith-number/CHOURLSFXMXVGBRSV3NOQSADUD/graph.json","fetch_events":"https://pith.science/api/pith-number/CHOURLSFXMXVGBRSV3NOQSADUD/events.json","actions":{"anchor_timestamp":"https://pith.science/pith/CHOURLSFXMXVGBRSV3NOQSADUD/action/timestamp_anchor","attest_storage":"https://pith.science/pith/CHOURLSFXMXVGBRSV3NOQSADUD/action/storage_attestation","attest_author":"https://pith.science/pith/CHOURLSFXMXVGBRSV3NOQSADUD/action/author_attestation","sign_citation":"https://pith.science/pith/CHOURLSFXMXVGBRSV3NOQSADUD/action/citation_signature","submit_replication":"https://pith.science/pith/CHOURLSFXMXVGBRSV3NOQSADUD/action/replication_record"}},"created_at":"2026-07-05T10:22:15.890936+00:00","updated_at":"2026-07-05T10:22:15.890936+00:00"}