{"bundle_type":"pith_open_graph_bundle","bundle_version":"1.0","pith_number":"pith:2024:CIPWX2EMRQSL72J3TIO3VJQTJL","short_pith_number":"pith:CIPWX2EM","canonical_record":{"source":{"id":"2401.05817","kind":"arxiv","version":1},"metadata":{"license":"http://creativecommons.org/licenses/by/4.0/","primary_cat":"stat.ME","submitted_at":"2024-01-11T10:32:24Z","cross_cats_sorted":[],"title_canon_sha256":"48fb7e119d20d33414eee64346409666cb0e6e4d62e9b144610918f29c66a3af","abstract_canon_sha256":"0ed92eef900f0e2a1b61a331928346d3896d4eebb00b5e6c1b9a9eeb319e1499"},"schema_version":"1.0"},"canonical_sha256":"121f6be88c8c24bfe93b9a1dbaa6134acc8197125598aff789531548cfd6c2dd","source":{"kind":"arxiv","id":"2401.05817","version":1},"source_aliases":[{"alias_kind":"arxiv","alias_value":"2401.05817","created_at":"2026-07-05T07:32:35Z"},{"alias_kind":"arxiv_version","alias_value":"2401.05817v1","created_at":"2026-07-05T07:32:35Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.2401.05817","created_at":"2026-07-05T07:32:35Z"},{"alias_kind":"pith_short_12","alias_value":"CIPWX2EMRQSL","created_at":"2026-07-05T07:32:35Z"},{"alias_kind":"pith_short_16","alias_value":"CIPWX2EMRQSL72J3","created_at":"2026-07-05T07:32:35Z"},{"alias_kind":"pith_short_8","alias_value":"CIPWX2EM","created_at":"2026-07-05T07:32:35Z"}],"events":[{"event_type":"record_created","subject_pith_number":"pith:2024:CIPWX2EMRQSL72J3TIO3VJQTJL","target":"record","payload":{"canonical_record":{"source":{"id":"2401.05817","kind":"arxiv","version":1},"metadata":{"license":"http://creativecommons.org/licenses/by/4.0/","primary_cat":"stat.ME","submitted_at":"2024-01-11T10:32:24Z","cross_cats_sorted":[],"title_canon_sha256":"48fb7e119d20d33414eee64346409666cb0e6e4d62e9b144610918f29c66a3af","abstract_canon_sha256":"0ed92eef900f0e2a1b61a331928346d3896d4eebb00b5e6c1b9a9eeb319e1499"},"schema_version":"1.0"},"canonical_sha256":"121f6be88c8c24bfe93b9a1dbaa6134acc8197125598aff789531548cfd6c2dd","receipt":{"kind":"pith_receipt","key_id":"pith-v1-2026-05","algorithm":"ed25519","signed_at":"2026-07-05T07:32:35.884962Z","signature_b64":"Z3jUCN2McABKqXDc6eOMtmTcSnZHT2WoIOKpBLVKb+KEfuLpffFV91obVqAJU/O1JiKGfMWfaBV89D38IMSZCA==","signed_message":"canonical_sha256_bytes","builder_version":"pith-number-builder-2026-05-17-v1","receipt_version":"0.3","canonical_sha256":"121f6be88c8c24bfe93b9a1dbaa6134acc8197125598aff789531548cfd6c2dd","last_reissued_at":"2026-07-05T07:32:35.884488Z","signature_status":"signed_v1","first_computed_at":"2026-07-05T07:32:35.884488Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"source_kind":"arxiv","source_id":"2401.05817","source_version":1,"attestation_state":"computed"},"signer":{"signer_id":"pith.science","signer_type":"pith_registry","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"created_at":"2026-07-05T07:32:35Z","supersedes":[],"prev_event":null,"signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"j9KpMsqnph2tNR2/o0F/sUCRBtFyz0JchBy1wE4Dr5MTJizikgbkUsat2xp2A7a6Y50R2E26mJXexok6BeRIBw==","signed_message":"open_graph_event_sha256_bytes","signed_at":"2026-07-17T10:04:52.459901Z"},"content_sha256":"280746b3b5860b57947fb8b347d2eb47514133da17d06b4e0f4f3441ad9391c3","schema_version":"1.0","event_id":"sha256:280746b3b5860b57947fb8b347d2eb47514133da17d06b4e0f4f3441ad9391c3"},{"event_type":"graph_snapshot","subject_pith_number":"pith:2024:CIPWX2EMRQSL72J3TIO3VJQTJL","target":"graph","payload":{"graph_snapshot":{"paper":{"title":"Testing for similarity of multivariate mixed outcomes using generalised joint regression models with application to efficacy-toxicity responses","license":"http://creativecommons.org/licenses/by/4.0/","headline":"","cross_cats":[],"primary_cat":"stat.ME","authors_text":"Frank Bretz, Giampiero Marra, Kathrin M\\\"ollenhoff, Niklas Hagemann","submitted_at":"2024-01-11T10:32:24Z","abstract_excerpt":"A common problem in clinical trials is to test whether the effect of an explanatory variable on a response of interest is similar between two groups, e.g. patient or treatment groups. In this regard, similarity is defined as equivalence up to a pre-specified threshold that denotes an acceptable deviation between the two groups. This issue is typically tackled by assessing if the explanatory variable's effect on the response is similar. This assessment is based on, for example, confidence intervals of differences or a suitable distance between two parametric regression models. Typically, these "},"claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"2401.05817","kind":"arxiv","version":1},"verdict":{"id":null,"model_set":{},"created_at":null,"strongest_claim":"","one_line_summary":"","pipeline_version":null,"weakest_assumption":"","pith_extraction_headline":""},"integrity":{"clean":true,"summary":{"advisory":0,"critical":0,"by_detector":{},"informational":0},"endpoint":"/pith/2401.05817/integrity.json","findings":[],"available":true,"detectors_run":[],"snapshot_sha256":"c28c3603d3b5d939e8dc4c7e95fa8dfce3d595e45f758748cecf8e644a296938"},"references":{"count":0,"sample":[],"resolved_work":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","internal_anchors":0},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"author_claims":{"count":0,"strong_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"builder_version":"pith-number-builder-2026-05-17-v1"},"verdict_id":null},"signer":{"signer_id":"pith.science","signer_type":"pith_registry","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"created_at":"2026-07-05T07:32:35Z","supersedes":[],"prev_event":null,"signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"IZQnEwQL8Z0BQZAnc44vVpgCGiqnlaw1B3JHSxW5Y3Nrf81jdoCskxp0069CJ0ExG+hxpKHa4VzhYMeXm9BGCw==","signed_message":"open_graph_event_sha256_bytes","signed_at":"2026-07-17T10:04:52.460262Z"},"content_sha256":"0a1dbb0c1dccd75aa56df95450b6f2d6a358ac3e42d949b81d32d8a0452d86d9","schema_version":"1.0","event_id":"sha256:0a1dbb0c1dccd75aa56df95450b6f2d6a358ac3e42d949b81d32d8a0452d86d9"}],"timestamp_proofs":[],"mirror_hints":[{"mirror_type":"https","name":"Pith Resolver","base_url":"https://pith.science","bundle_url":"https://pith.science/pith/CIPWX2EMRQSL72J3TIO3VJQTJL/bundle.json","state_url":"https://pith.science/pith/CIPWX2EMRQSL72J3TIO3VJQTJL/state.json","well_known_bundle_url":"https://pith.science/.well-known/pith/CIPWX2EMRQSL72J3TIO3VJQTJL/bundle.json","status":"primary"}],"public_keys":[{"key_id":"pith-v1-2026-05","algorithm":"ed25519","format":"raw","public_key_b64":"stVStoiQhXFxp4s2pdzPNoqVNBMojDU/fJ2db5S3CbM=","public_key_hex":"b2d552b68890857171a78b36a5dccf368a953413288c353f7c9d9d6f94b709b3","fingerprint_sha256_b32_first128bits":"RVFV5Z2OI2J3ZUO7ERDEBCYNKS","fingerprint_sha256_hex":"8d4b5ee74e4693bcd1df2446408b0d54","rotates_at":null,"url":"https://pith.science/pith-signing-key.json","notes":"Pith uses this Ed25519 key to sign canonical record SHA-256 digests. Verify with: ed25519_verify(public_key, message=canonical_sha256_bytes, signature=base64decode(signature_b64))."}],"merge_version":"pith-open-graph-merge-v1","built_at":"2026-07-17T10:04:52Z","links":{"resolver":"https://pith.science/pith/CIPWX2EMRQSL72J3TIO3VJQTJL","bundle":"https://pith.science/pith/CIPWX2EMRQSL72J3TIO3VJQTJL/bundle.json","state":"https://pith.science/pith/CIPWX2EMRQSL72J3TIO3VJQTJL/state.json","well_known_bundle":"https://pith.science/.well-known/pith/CIPWX2EMRQSL72J3TIO3VJQTJL/bundle.json"},"state":{"state_type":"pith_open_graph_state","state_version":"1.0","pith_number":"pith:2024:CIPWX2EMRQSL72J3TIO3VJQTJL","merge_version":"pith-open-graph-merge-v1","event_count":2,"valid_event_count":2,"invalid_event_count":0,"equivocation_count":0,"current":{"canonical_record":{"metadata":{"abstract_canon_sha256":"0ed92eef900f0e2a1b61a331928346d3896d4eebb00b5e6c1b9a9eeb319e1499","cross_cats_sorted":[],"license":"http://creativecommons.org/licenses/by/4.0/","primary_cat":"stat.ME","submitted_at":"2024-01-11T10:32:24Z","title_canon_sha256":"48fb7e119d20d33414eee64346409666cb0e6e4d62e9b144610918f29c66a3af"},"schema_version":"1.0","source":{"id":"2401.05817","kind":"arxiv","version":1}},"source_aliases":[{"alias_kind":"arxiv","alias_value":"2401.05817","created_at":"2026-07-05T07:32:35Z"},{"alias_kind":"arxiv_version","alias_value":"2401.05817v1","created_at":"2026-07-05T07:32:35Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.2401.05817","created_at":"2026-07-05T07:32:35Z"},{"alias_kind":"pith_short_12","alias_value":"CIPWX2EMRQSL","created_at":"2026-07-05T07:32:35Z"},{"alias_kind":"pith_short_16","alias_value":"CIPWX2EMRQSL72J3","created_at":"2026-07-05T07:32:35Z"},{"alias_kind":"pith_short_8","alias_value":"CIPWX2EM","created_at":"2026-07-05T07:32:35Z"}],"graph_snapshots":[{"event_id":"sha256:0a1dbb0c1dccd75aa56df95450b6f2d6a358ac3e42d949b81d32d8a0452d86d9","target":"graph","created_at":"2026-07-05T07:32:35Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"graph_snapshot":{"author_claims":{"count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","strong_count":0},"builder_version":"pith-number-builder-2026-05-17-v1","claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"integrity":{"available":true,"clean":true,"detectors_run":[],"endpoint":"/pith/2401.05817/integrity.json","findings":[],"snapshot_sha256":"c28c3603d3b5d939e8dc4c7e95fa8dfce3d595e45f758748cecf8e644a296938","summary":{"advisory":0,"by_detector":{},"critical":0,"informational":0}},"paper":{"abstract_excerpt":"A common problem in clinical trials is to test whether the effect of an explanatory variable on a response of interest is similar between two groups, e.g. patient or treatment groups. In this regard, similarity is defined as equivalence up to a pre-specified threshold that denotes an acceptable deviation between the two groups. This issue is typically tackled by assessing if the explanatory variable's effect on the response is similar. This assessment is based on, for example, confidence intervals of differences or a suitable distance between two parametric regression models. Typically, these ","authors_text":"Frank Bretz, Giampiero Marra, Kathrin M\\\"ollenhoff, Niklas Hagemann","cross_cats":[],"headline":"","license":"http://creativecommons.org/licenses/by/4.0/","primary_cat":"stat.ME","submitted_at":"2024-01-11T10:32:24Z","title":"Testing for similarity of multivariate mixed outcomes using generalised joint regression models with application to efficacy-toxicity responses"},"references":{"count":0,"internal_anchors":0,"resolved_work":0,"sample":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"2401.05817","kind":"arxiv","version":1},"verdict":{"created_at":null,"id":null,"model_set":{},"one_line_summary":"","pipeline_version":null,"pith_extraction_headline":"","strongest_claim":"","weakest_assumption":""}},"verdict_id":null}}],"author_attestations":[],"timestamp_anchors":[],"storage_attestations":[],"citation_signatures":[],"replication_records":[],"corrections":[],"mirror_hints":[],"record_created":{"event_id":"sha256:280746b3b5860b57947fb8b347d2eb47514133da17d06b4e0f4f3441ad9391c3","target":"record","created_at":"2026-07-05T07:32:35Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"attestation_state":"computed","canonical_record":{"metadata":{"abstract_canon_sha256":"0ed92eef900f0e2a1b61a331928346d3896d4eebb00b5e6c1b9a9eeb319e1499","cross_cats_sorted":[],"license":"http://creativecommons.org/licenses/by/4.0/","primary_cat":"stat.ME","submitted_at":"2024-01-11T10:32:24Z","title_canon_sha256":"48fb7e119d20d33414eee64346409666cb0e6e4d62e9b144610918f29c66a3af"},"schema_version":"1.0","source":{"id":"2401.05817","kind":"arxiv","version":1}},"canonical_sha256":"121f6be88c8c24bfe93b9a1dbaa6134acc8197125598aff789531548cfd6c2dd","receipt":{"algorithm":"ed25519","builder_version":"pith-number-builder-2026-05-17-v1","canonical_sha256":"121f6be88c8c24bfe93b9a1dbaa6134acc8197125598aff789531548cfd6c2dd","first_computed_at":"2026-07-05T07:32:35.884488Z","key_id":"pith-v1-2026-05","kind":"pith_receipt","last_reissued_at":"2026-07-05T07:32:35.884488Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","receipt_version":"0.3","signature_b64":"Z3jUCN2McABKqXDc6eOMtmTcSnZHT2WoIOKpBLVKb+KEfuLpffFV91obVqAJU/O1JiKGfMWfaBV89D38IMSZCA==","signature_status":"signed_v1","signed_at":"2026-07-05T07:32:35.884962Z","signed_message":"canonical_sha256_bytes"},"source_id":"2401.05817","source_kind":"arxiv","source_version":1}}},"equivocations":[],"invalid_events":[],"applied_event_ids":["sha256:280746b3b5860b57947fb8b347d2eb47514133da17d06b4e0f4f3441ad9391c3","sha256:0a1dbb0c1dccd75aa56df95450b6f2d6a358ac3e42d949b81d32d8a0452d86d9"],"state_sha256":"641ce4a39d770957367b45bda68e14449fa1ff781cdd543f31345d1b9be0fb0c"},"bundle_signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"F9OgJv4dSZuqVCR6waqFdcQiMrlI8EypTr90sGJeWVYfGibHJD7dC+zM1Z9sE0bISzZCj/A5mRCgnSonnTLaDw==","signed_message":"bundle_sha256_bytes","signed_at":"2026-07-17T10:04:52.462422Z","bundle_sha256":"264c997320b32483d988f283a22fa62497cfe12fe76c2a91fc0b53da31d2f889"}}