{"bundle_type":"pith_open_graph_bundle","bundle_version":"1.0","pith_number":"pith:2021:CL6SHF4IYRRW2H7OLH4M2RVNQK","short_pith_number":"pith:CL6SHF4I","canonical_record":{"source":{"id":"2103.00621","kind":"arxiv","version":1},"metadata":{"license":"http://creativecommons.org/licenses/by/4.0/","primary_cat":"q-bio.MN","submitted_at":"2021-02-28T21:23:54Z","cross_cats_sorted":["q-bio.QM"],"title_canon_sha256":"66807b9ca8694d2e016572d47a8d7c3809f8f5dfa6ce0dae5948e418ef34f81b","abstract_canon_sha256":"0b3ab263f8dfb8de5f134ba4718fcaef8d72c88528244a700aea918145578e21"},"schema_version":"1.0"},"canonical_sha256":"12fd239788c4636d1fee59f8cd46ad82a7123c89f846f459345c04860bb9a506","source":{"kind":"arxiv","id":"2103.00621","version":1},"source_aliases":[{"alias_kind":"arxiv","alias_value":"2103.00621","created_at":"2026-07-05T02:19:07Z"},{"alias_kind":"arxiv_version","alias_value":"2103.00621v1","created_at":"2026-07-05T02:19:07Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.2103.00621","created_at":"2026-07-05T02:19:07Z"},{"alias_kind":"pith_short_12","alias_value":"CL6SHF4IYRRW","created_at":"2026-07-05T02:19:07Z"},{"alias_kind":"pith_short_16","alias_value":"CL6SHF4IYRRW2H7O","created_at":"2026-07-05T02:19:07Z"},{"alias_kind":"pith_short_8","alias_value":"CL6SHF4I","created_at":"2026-07-05T02:19:07Z"}],"events":[{"event_type":"record_created","subject_pith_number":"pith:2021:CL6SHF4IYRRW2H7OLH4M2RVNQK","target":"record","payload":{"canonical_record":{"source":{"id":"2103.00621","kind":"arxiv","version":1},"metadata":{"license":"http://creativecommons.org/licenses/by/4.0/","primary_cat":"q-bio.MN","submitted_at":"2021-02-28T21:23:54Z","cross_cats_sorted":["q-bio.QM"],"title_canon_sha256":"66807b9ca8694d2e016572d47a8d7c3809f8f5dfa6ce0dae5948e418ef34f81b","abstract_canon_sha256":"0b3ab263f8dfb8de5f134ba4718fcaef8d72c88528244a700aea918145578e21"},"schema_version":"1.0"},"canonical_sha256":"12fd239788c4636d1fee59f8cd46ad82a7123c89f846f459345c04860bb9a506","receipt":{"kind":"pith_receipt","key_id":"pith-v1-2026-05","algorithm":"ed25519","signed_at":"2026-07-05T02:19:07.674103Z","signature_b64":"VncpOmOSKxm4GnSVL1Tfg39jh69cT5Qfxf+U2MpyhgRmMj+PL6+OMRJL2gju91eotcJdKzuA5qY6SZiZEct6BA==","signed_message":"canonical_sha256_bytes","builder_version":"pith-number-builder-2026-05-17-v1","receipt_version":"0.3","canonical_sha256":"12fd239788c4636d1fee59f8cd46ad82a7123c89f846f459345c04860bb9a506","last_reissued_at":"2026-07-05T02:19:07.673652Z","signature_status":"signed_v1","first_computed_at":"2026-07-05T02:19:07.673652Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"source_kind":"arxiv","source_id":"2103.00621","source_version":1,"attestation_state":"computed"},"signer":{"signer_id":"pith.science","signer_type":"pith_registry","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"created_at":"2026-07-05T02:19:07Z","supersedes":[],"prev_event":null,"signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"y32gvtvXu4U0Ka1qBjReCKRQ9Bnnqs8MTFeQClOJhdy4ppI+w637Melm+a/LN6cE8fMuFmpNX3nHAEDrmbsGDA==","signed_message":"open_graph_event_sha256_bytes","signed_at":"2026-08-23T15:09:03.496757Z"},"content_sha256":"76f77fead0773cda5db2f285a675a2b81c9bdc25f8217c027574b874ff73b977","schema_version":"1.0","event_id":"sha256:76f77fead0773cda5db2f285a675a2b81c9bdc25f8217c027574b874ff73b977"},{"event_type":"graph_snapshot","subject_pith_number":"pith:2021:CL6SHF4IYRRW2H7OLH4M2RVNQK","target":"graph","payload":{"graph_snapshot":{"paper":{"title":"eQuilibrator 3.0 -- a platform for the estimation of thermodynamic constants","license":"http://creativecommons.org/licenses/by/4.0/","headline":"","cross_cats":["q-bio.QM"],"primary_cat":"q-bio.MN","authors_text":"Dana Mozaffari, Elad Noor, Kevin M. Shebek, Mattia G. Gollub, Moritz E. Beber","submitted_at":"2021-02-28T21:23:54Z","abstract_excerpt":"eQuilibrator (equilibrator.weizmann.ac.il) is a calculator for biochemical equilibrium constants and Gibbs free energies, originally designed as a web-based interface. While the website now counts ${\\sim}1000$ distinct monthly users, its design could not accommodate larger compound databases and it lacked an application programming interface (API) for integration in other tools developed by the systems biology community. Here, we report a new python-based package for eQuilibrator, that comes with many new features such as a 50-fold larger compound database, the ability to add novel compound st"},"claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"2103.00621","kind":"arxiv","version":1},"verdict":{"id":null,"model_set":{},"created_at":null,"strongest_claim":"","one_line_summary":"","pipeline_version":null,"weakest_assumption":"","pith_extraction_headline":""},"integrity":{"clean":true,"summary":{"advisory":0,"critical":0,"by_detector":{},"informational":0},"endpoint":"/pith/2103.00621/integrity.json","findings":[],"available":true,"detectors_run":[],"snapshot_sha256":"c28c3603d3b5d939e8dc4c7e95fa8dfce3d595e45f758748cecf8e644a296938"},"references":{"count":0,"sample":[],"resolved_work":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","internal_anchors":0},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"author_claims":{"count":0,"strong_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"builder_version":"pith-number-builder-2026-05-17-v1"},"verdict_id":null},"signer":{"signer_id":"pith.science","signer_type":"pith_registry","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"created_at":"2026-07-05T02:19:07Z","supersedes":[],"prev_event":null,"signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"M8MzQ34Ceze7U92GgRiANuMkYEtBAjfIkbgKi8piJh0KjKY5fNk0zKAzeo3QBtanhPdE7IVmF7r0QwEWlLE7Bw==","signed_message":"open_graph_event_sha256_bytes","signed_at":"2026-08-23T15:09:03.497091Z"},"content_sha256":"5f94571f58deca1790b59a69936a9da1299c2e65b7670e6131b5e97f67c8523c","schema_version":"1.0","event_id":"sha256:5f94571f58deca1790b59a69936a9da1299c2e65b7670e6131b5e97f67c8523c"}],"timestamp_proofs":[],"mirror_hints":[{"mirror_type":"https","name":"Pith Resolver","base_url":"https://pith.science","bundle_url":"https://pith.science/pith/CL6SHF4IYRRW2H7OLH4M2RVNQK/bundle.json","state_url":"https://pith.science/pith/CL6SHF4IYRRW2H7OLH4M2RVNQK/state.json","well_known_bundle_url":"https://pith.science/.well-known/pith/CL6SHF4IYRRW2H7OLH4M2RVNQK/bundle.json","status":"primary"}],"public_keys":[{"key_id":"pith-v1-2026-05","algorithm":"ed25519","format":"raw","public_key_b64":"stVStoiQhXFxp4s2pdzPNoqVNBMojDU/fJ2db5S3CbM=","public_key_hex":"b2d552b68890857171a78b36a5dccf368a953413288c353f7c9d9d6f94b709b3","fingerprint_sha256_b32_first128bits":"RVFV5Z2OI2J3ZUO7ERDEBCYNKS","fingerprint_sha256_hex":"8d4b5ee74e4693bcd1df2446408b0d54","rotates_at":null,"url":"https://pith.science/pith-signing-key.json","notes":"Pith uses this Ed25519 key to sign canonical record SHA-256 digests. Verify with: ed25519_verify(public_key, message=canonical_sha256_bytes, signature=base64decode(signature_b64))."}],"merge_version":"pith-open-graph-merge-v1","built_at":"2026-08-23T15:09:03Z","links":{"resolver":"https://pith.science/pith/CL6SHF4IYRRW2H7OLH4M2RVNQK","bundle":"https://pith.science/pith/CL6SHF4IYRRW2H7OLH4M2RVNQK/bundle.json","state":"https://pith.science/pith/CL6SHF4IYRRW2H7OLH4M2RVNQK/state.json","well_known_bundle":"https://pith.science/.well-known/pith/CL6SHF4IYRRW2H7OLH4M2RVNQK/bundle.json"},"state":{"state_type":"pith_open_graph_state","state_version":"1.0","pith_number":"pith:2021:CL6SHF4IYRRW2H7OLH4M2RVNQK","merge_version":"pith-open-graph-merge-v1","event_count":2,"valid_event_count":2,"invalid_event_count":0,"equivocation_count":0,"current":{"canonical_record":{"metadata":{"abstract_canon_sha256":"0b3ab263f8dfb8de5f134ba4718fcaef8d72c88528244a700aea918145578e21","cross_cats_sorted":["q-bio.QM"],"license":"http://creativecommons.org/licenses/by/4.0/","primary_cat":"q-bio.MN","submitted_at":"2021-02-28T21:23:54Z","title_canon_sha256":"66807b9ca8694d2e016572d47a8d7c3809f8f5dfa6ce0dae5948e418ef34f81b"},"schema_version":"1.0","source":{"id":"2103.00621","kind":"arxiv","version":1}},"source_aliases":[{"alias_kind":"arxiv","alias_value":"2103.00621","created_at":"2026-07-05T02:19:07Z"},{"alias_kind":"arxiv_version","alias_value":"2103.00621v1","created_at":"2026-07-05T02:19:07Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.2103.00621","created_at":"2026-07-05T02:19:07Z"},{"alias_kind":"pith_short_12","alias_value":"CL6SHF4IYRRW","created_at":"2026-07-05T02:19:07Z"},{"alias_kind":"pith_short_16","alias_value":"CL6SHF4IYRRW2H7O","created_at":"2026-07-05T02:19:07Z"},{"alias_kind":"pith_short_8","alias_value":"CL6SHF4I","created_at":"2026-07-05T02:19:07Z"}],"graph_snapshots":[{"event_id":"sha256:5f94571f58deca1790b59a69936a9da1299c2e65b7670e6131b5e97f67c8523c","target":"graph","created_at":"2026-07-05T02:19:07Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"graph_snapshot":{"author_claims":{"count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","strong_count":0},"builder_version":"pith-number-builder-2026-05-17-v1","claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"integrity":{"available":true,"clean":true,"detectors_run":[],"endpoint":"/pith/2103.00621/integrity.json","findings":[],"snapshot_sha256":"c28c3603d3b5d939e8dc4c7e95fa8dfce3d595e45f758748cecf8e644a296938","summary":{"advisory":0,"by_detector":{},"critical":0,"informational":0}},"paper":{"abstract_excerpt":"eQuilibrator (equilibrator.weizmann.ac.il) is a calculator for biochemical equilibrium constants and Gibbs free energies, originally designed as a web-based interface. While the website now counts ${\\sim}1000$ distinct monthly users, its design could not accommodate larger compound databases and it lacked an application programming interface (API) for integration in other tools developed by the systems biology community. Here, we report a new python-based package for eQuilibrator, that comes with many new features such as a 50-fold larger compound database, the ability to add novel compound st","authors_text":"Dana Mozaffari, Elad Noor, Kevin M. Shebek, Mattia G. Gollub, Moritz E. Beber","cross_cats":["q-bio.QM"],"headline":"","license":"http://creativecommons.org/licenses/by/4.0/","primary_cat":"q-bio.MN","submitted_at":"2021-02-28T21:23:54Z","title":"eQuilibrator 3.0 -- a platform for the estimation of thermodynamic constants"},"references":{"count":0,"internal_anchors":0,"resolved_work":0,"sample":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"2103.00621","kind":"arxiv","version":1},"verdict":{"created_at":null,"id":null,"model_set":{},"one_line_summary":"","pipeline_version":null,"pith_extraction_headline":"","strongest_claim":"","weakest_assumption":""}},"verdict_id":null}}],"author_attestations":[],"timestamp_anchors":[],"storage_attestations":[],"citation_signatures":[],"replication_records":[],"corrections":[],"mirror_hints":[],"record_created":{"event_id":"sha256:76f77fead0773cda5db2f285a675a2b81c9bdc25f8217c027574b874ff73b977","target":"record","created_at":"2026-07-05T02:19:07Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"attestation_state":"computed","canonical_record":{"metadata":{"abstract_canon_sha256":"0b3ab263f8dfb8de5f134ba4718fcaef8d72c88528244a700aea918145578e21","cross_cats_sorted":["q-bio.QM"],"license":"http://creativecommons.org/licenses/by/4.0/","primary_cat":"q-bio.MN","submitted_at":"2021-02-28T21:23:54Z","title_canon_sha256":"66807b9ca8694d2e016572d47a8d7c3809f8f5dfa6ce0dae5948e418ef34f81b"},"schema_version":"1.0","source":{"id":"2103.00621","kind":"arxiv","version":1}},"canonical_sha256":"12fd239788c4636d1fee59f8cd46ad82a7123c89f846f459345c04860bb9a506","receipt":{"algorithm":"ed25519","builder_version":"pith-number-builder-2026-05-17-v1","canonical_sha256":"12fd239788c4636d1fee59f8cd46ad82a7123c89f846f459345c04860bb9a506","first_computed_at":"2026-07-05T02:19:07.673652Z","key_id":"pith-v1-2026-05","kind":"pith_receipt","last_reissued_at":"2026-07-05T02:19:07.673652Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","receipt_version":"0.3","signature_b64":"VncpOmOSKxm4GnSVL1Tfg39jh69cT5Qfxf+U2MpyhgRmMj+PL6+OMRJL2gju91eotcJdKzuA5qY6SZiZEct6BA==","signature_status":"signed_v1","signed_at":"2026-07-05T02:19:07.674103Z","signed_message":"canonical_sha256_bytes"},"source_id":"2103.00621","source_kind":"arxiv","source_version":1}}},"equivocations":[],"invalid_events":[],"applied_event_ids":["sha256:76f77fead0773cda5db2f285a675a2b81c9bdc25f8217c027574b874ff73b977","sha256:5f94571f58deca1790b59a69936a9da1299c2e65b7670e6131b5e97f67c8523c"],"state_sha256":"ff2f2ad269e43d9e3a7bb32b70451df89fa02112fcbaf9cbcb4c39edfc1a14ab"},"bundle_signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"fsTo5rfxPJW7wijiTyvp9NRLGl2XJv/pNYO8JiF85tVJEk7yzeIf7rZ5HqGQ+ZwcAYqmgpvyWyWyJEKdZfraBA==","signed_message":"bundle_sha256_bytes","signed_at":"2026-08-23T15:09:03.500923Z","bundle_sha256":"7b92a6ff5ba5a30c84c45e62306a3be10600007a00535a5552da2d559b8ffaff"}}