{"bundle_type":"pith_open_graph_bundle","bundle_version":"1.0","pith_number":"pith:2019:CO35C7PBEPWYCEBWOSKIUBBXMF","short_pith_number":"pith:CO35C7PB","canonical_record":{"source":{"id":"1905.10441","kind":"arxiv","version":2},"metadata":{"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.TO","submitted_at":"2019-05-10T20:46:27Z","cross_cats_sorted":[],"title_canon_sha256":"570e73c2413660f62ab54b6078677672bbdfdb72535e4cc2d2237255c88e5448","abstract_canon_sha256":"c5ee8b7a4138b25bda12fa630607c73b84934362e875b5c0c01b7e2a04b54195"},"schema_version":"1.0"},"canonical_sha256":"13b7d17de123ed81103674948a04376147ebea3ca2902ef42f37390b418b599e","source":{"kind":"arxiv","id":"1905.10441","version":2},"source_aliases":[{"alias_kind":"arxiv","alias_value":"1905.10441","created_at":"2026-05-17T23:41:30Z"},{"alias_kind":"arxiv_version","alias_value":"1905.10441v2","created_at":"2026-05-17T23:41:30Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.1905.10441","created_at":"2026-05-17T23:41:30Z"},{"alias_kind":"pith_short_12","alias_value":"CO35C7PBEPWY","created_at":"2026-05-18T12:33:15Z"},{"alias_kind":"pith_short_16","alias_value":"CO35C7PBEPWYCEBW","created_at":"2026-05-18T12:33:15Z"},{"alias_kind":"pith_short_8","alias_value":"CO35C7PB","created_at":"2026-05-18T12:33:15Z"}],"events":[{"event_type":"record_created","subject_pith_number":"pith:2019:CO35C7PBEPWYCEBWOSKIUBBXMF","target":"record","payload":{"canonical_record":{"source":{"id":"1905.10441","kind":"arxiv","version":2},"metadata":{"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.TO","submitted_at":"2019-05-10T20:46:27Z","cross_cats_sorted":[],"title_canon_sha256":"570e73c2413660f62ab54b6078677672bbdfdb72535e4cc2d2237255c88e5448","abstract_canon_sha256":"c5ee8b7a4138b25bda12fa630607c73b84934362e875b5c0c01b7e2a04b54195"},"schema_version":"1.0"},"canonical_sha256":"13b7d17de123ed81103674948a04376147ebea3ca2902ef42f37390b418b599e","receipt":{"kind":"pith_receipt","key_id":"pith-v1-2026-05","algorithm":"ed25519","signed_at":"2026-05-17T23:41:30.298964Z","signature_b64":"APDS6ZIoUpixgqIo1z22It2NsiGrfHQKXEXcfkNsbfq/KuBnlOwmBDWqGgqNcIJOLCOdKWtbiSMk4vLnW3QIBg==","signed_message":"canonical_sha256_bytes","builder_version":"pith-number-builder-2026-05-17-v1","receipt_version":"0.3","canonical_sha256":"13b7d17de123ed81103674948a04376147ebea3ca2902ef42f37390b418b599e","last_reissued_at":"2026-05-17T23:41:30.298247Z","signature_status":"signed_v1","first_computed_at":"2026-05-17T23:41:30.298247Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"source_kind":"arxiv","source_id":"1905.10441","source_version":2,"attestation_state":"computed"},"signer":{"signer_id":"pith.science","signer_type":"pith_registry","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"created_at":"2026-05-17T23:41:30Z","supersedes":[],"prev_event":null,"signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"831YwjUQjIjzxI6VCwnVIJq566ZmliN97kXSe2nqkej9DG6bFw4IF3Lo5YXBDgPHZz9sQpjq1eiWagM28sgADA==","signed_message":"open_graph_event_sha256_bytes","signed_at":"2026-06-09T17:06:28.770018Z"},"content_sha256":"4e2164e93c5db784234da96b20cc01902c7c73bdbcaa5fdc081a2c199e73450b","schema_version":"1.0","event_id":"sha256:4e2164e93c5db784234da96b20cc01902c7c73bdbcaa5fdc081a2c199e73450b"},{"event_type":"graph_snapshot","subject_pith_number":"pith:2019:CO35C7PBEPWYCEBWOSKIUBBXMF","target":"graph","payload":{"graph_snapshot":{"paper":{"title":"Towards a Multiphysics Model for Tumor Response to Combined-Hyperthermia-Radiotherapy Treatment","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","headline":"","cross_cats":[],"primary_cat":"q-bio.TO","authors_text":"Barry D. Ganapol, Japan K. Patel, Richard Vasques","submitted_at":"2019-05-10T20:46:27Z","abstract_excerpt":"We develop a multiphysics-based model to predict the response of localized tumors to combined-hyperthermia-radiotherapy (CHR) treatment. This procedure combines hyperthermia (tumor heating) with standard radiotherapy to improve efficacy of the overall treatment. In addition to directly killing tumor cells, tumor heating amends several parameters within the tumor microenvironment. This leads to radiosensitization, which improves the performance of radiotherapy while reducing the side-effects of excess radiation in the surrounding normal tissue. Existing tools to model this kind of treatment con"},"claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"1905.10441","kind":"arxiv","version":2},"verdict":{"id":null,"model_set":{},"created_at":null,"strongest_claim":"","one_line_summary":"","pipeline_version":null,"weakest_assumption":"","pith_extraction_headline":""},"references":{"count":0,"sample":[],"resolved_work":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","internal_anchors":0},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"author_claims":{"count":0,"strong_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"builder_version":"pith-number-builder-2026-05-17-v1"},"verdict_id":null},"signer":{"signer_id":"pith.science","signer_type":"pith_registry","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"created_at":"2026-05-17T23:41:30Z","supersedes":[],"prev_event":null,"signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"Tkio7xtoJ7j6q/ih+oosyTlgavwSAv2OKqASo9bXs5EsZaTEO1LxS7BeU5QyIU4G6mM3uH//eFlp/ouHHNeLDg==","signed_message":"open_graph_event_sha256_bytes","signed_at":"2026-06-09T17:06:28.770787Z"},"content_sha256":"5df02b951f4cb793105bfd7881fd71b4bef39cb1cc83625631907ceab0f2d6bf","schema_version":"1.0","event_id":"sha256:5df02b951f4cb793105bfd7881fd71b4bef39cb1cc83625631907ceab0f2d6bf"}],"timestamp_proofs":[],"mirror_hints":[{"mirror_type":"https","name":"Pith Resolver","base_url":"https://pith.science","bundle_url":"https://pith.science/pith/CO35C7PBEPWYCEBWOSKIUBBXMF/bundle.json","state_url":"https://pith.science/pith/CO35C7PBEPWYCEBWOSKIUBBXMF/state.json","well_known_bundle_url":"https://pith.science/.well-known/pith/CO35C7PBEPWYCEBWOSKIUBBXMF/bundle.json","status":"primary"}],"public_keys":[{"key_id":"pith-v1-2026-05","algorithm":"ed25519","format":"raw","public_key_b64":"stVStoiQhXFxp4s2pdzPNoqVNBMojDU/fJ2db5S3CbM=","public_key_hex":"b2d552b68890857171a78b36a5dccf368a953413288c353f7c9d9d6f94b709b3","fingerprint_sha256_b32_first128bits":"RVFV5Z2OI2J3ZUO7ERDEBCYNKS","fingerprint_sha256_hex":"8d4b5ee74e4693bcd1df2446408b0d54","rotates_at":null,"url":"https://pith.science/pith-signing-key.json","notes":"Pith uses this Ed25519 key to sign canonical record SHA-256 digests. Verify with: ed25519_verify(public_key, message=canonical_sha256_bytes, signature=base64decode(signature_b64))."}],"merge_version":"pith-open-graph-merge-v1","built_at":"2026-06-09T17:06:28Z","links":{"resolver":"https://pith.science/pith/CO35C7PBEPWYCEBWOSKIUBBXMF","bundle":"https://pith.science/pith/CO35C7PBEPWYCEBWOSKIUBBXMF/bundle.json","state":"https://pith.science/pith/CO35C7PBEPWYCEBWOSKIUBBXMF/state.json","well_known_bundle":"https://pith.science/.well-known/pith/CO35C7PBEPWYCEBWOSKIUBBXMF/bundle.json"},"state":{"state_type":"pith_open_graph_state","state_version":"1.0","pith_number":"pith:2019:CO35C7PBEPWYCEBWOSKIUBBXMF","merge_version":"pith-open-graph-merge-v1","event_count":2,"valid_event_count":2,"invalid_event_count":0,"equivocation_count":0,"current":{"canonical_record":{"metadata":{"abstract_canon_sha256":"c5ee8b7a4138b25bda12fa630607c73b84934362e875b5c0c01b7e2a04b54195","cross_cats_sorted":[],"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.TO","submitted_at":"2019-05-10T20:46:27Z","title_canon_sha256":"570e73c2413660f62ab54b6078677672bbdfdb72535e4cc2d2237255c88e5448"},"schema_version":"1.0","source":{"id":"1905.10441","kind":"arxiv","version":2}},"source_aliases":[{"alias_kind":"arxiv","alias_value":"1905.10441","created_at":"2026-05-17T23:41:30Z"},{"alias_kind":"arxiv_version","alias_value":"1905.10441v2","created_at":"2026-05-17T23:41:30Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.1905.10441","created_at":"2026-05-17T23:41:30Z"},{"alias_kind":"pith_short_12","alias_value":"CO35C7PBEPWY","created_at":"2026-05-18T12:33:15Z"},{"alias_kind":"pith_short_16","alias_value":"CO35C7PBEPWYCEBW","created_at":"2026-05-18T12:33:15Z"},{"alias_kind":"pith_short_8","alias_value":"CO35C7PB","created_at":"2026-05-18T12:33:15Z"}],"graph_snapshots":[{"event_id":"sha256:5df02b951f4cb793105bfd7881fd71b4bef39cb1cc83625631907ceab0f2d6bf","target":"graph","created_at":"2026-05-17T23:41:30Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"graph_snapshot":{"author_claims":{"count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","strong_count":0},"builder_version":"pith-number-builder-2026-05-17-v1","claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"paper":{"abstract_excerpt":"We develop a multiphysics-based model to predict the response of localized tumors to combined-hyperthermia-radiotherapy (CHR) treatment. This procedure combines hyperthermia (tumor heating) with standard radiotherapy to improve efficacy of the overall treatment. In addition to directly killing tumor cells, tumor heating amends several parameters within the tumor microenvironment. This leads to radiosensitization, which improves the performance of radiotherapy while reducing the side-effects of excess radiation in the surrounding normal tissue. Existing tools to model this kind of treatment con","authors_text":"Barry D. Ganapol, Japan K. Patel, Richard Vasques","cross_cats":[],"headline":"","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.TO","submitted_at":"2019-05-10T20:46:27Z","title":"Towards a Multiphysics Model for Tumor Response to Combined-Hyperthermia-Radiotherapy Treatment"},"references":{"count":0,"internal_anchors":0,"resolved_work":0,"sample":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"1905.10441","kind":"arxiv","version":2},"verdict":{"created_at":null,"id":null,"model_set":{},"one_line_summary":"","pipeline_version":null,"pith_extraction_headline":"","strongest_claim":"","weakest_assumption":""}},"verdict_id":null}}],"author_attestations":[],"timestamp_anchors":[],"storage_attestations":[],"citation_signatures":[],"replication_records":[],"corrections":[],"mirror_hints":[],"record_created":{"event_id":"sha256:4e2164e93c5db784234da96b20cc01902c7c73bdbcaa5fdc081a2c199e73450b","target":"record","created_at":"2026-05-17T23:41:30Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"attestation_state":"computed","canonical_record":{"metadata":{"abstract_canon_sha256":"c5ee8b7a4138b25bda12fa630607c73b84934362e875b5c0c01b7e2a04b54195","cross_cats_sorted":[],"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.TO","submitted_at":"2019-05-10T20:46:27Z","title_canon_sha256":"570e73c2413660f62ab54b6078677672bbdfdb72535e4cc2d2237255c88e5448"},"schema_version":"1.0","source":{"id":"1905.10441","kind":"arxiv","version":2}},"canonical_sha256":"13b7d17de123ed81103674948a04376147ebea3ca2902ef42f37390b418b599e","receipt":{"algorithm":"ed25519","builder_version":"pith-number-builder-2026-05-17-v1","canonical_sha256":"13b7d17de123ed81103674948a04376147ebea3ca2902ef42f37390b418b599e","first_computed_at":"2026-05-17T23:41:30.298247Z","key_id":"pith-v1-2026-05","kind":"pith_receipt","last_reissued_at":"2026-05-17T23:41:30.298247Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","receipt_version":"0.3","signature_b64":"APDS6ZIoUpixgqIo1z22It2NsiGrfHQKXEXcfkNsbfq/KuBnlOwmBDWqGgqNcIJOLCOdKWtbiSMk4vLnW3QIBg==","signature_status":"signed_v1","signed_at":"2026-05-17T23:41:30.298964Z","signed_message":"canonical_sha256_bytes"},"source_id":"1905.10441","source_kind":"arxiv","source_version":2}}},"equivocations":[],"invalid_events":[],"applied_event_ids":["sha256:4e2164e93c5db784234da96b20cc01902c7c73bdbcaa5fdc081a2c199e73450b","sha256:5df02b951f4cb793105bfd7881fd71b4bef39cb1cc83625631907ceab0f2d6bf"],"state_sha256":"6da03fc86360ae86087bb3201f350143dd47649eabbb562482c1b585c50e7bf4"},"bundle_signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"cHc8+opBCOx0BUqzcDJ0skpwAbAqKvDaisZgp06nERk0xFDwRPyMYagXfirdkLxK0TUlmrddVw3sE3Oo4FKFBA==","signed_message":"bundle_sha256_bytes","signed_at":"2026-06-09T17:06:28.775014Z","bundle_sha256":"a34de61dd00ec343acab80be7e51549592563906ea97da733bc694b564c0c893"}}