{"bundle_type":"pith_open_graph_bundle","bundle_version":"1.0","pith_number":"pith:2026:COJPBC5DEWMOAQQM2JQY3H2WRJ","short_pith_number":"pith:COJPBC5D","canonical_record":{"source":{"id":"2606.02130","kind":"arxiv","version":1},"metadata":{"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"stat.ME","submitted_at":"2026-06-01T11:57:36Z","cross_cats_sorted":[],"title_canon_sha256":"46ed976a7c3ac0daab2d9ae07e42e7ab7894fff9b56ecc8c0b6a0ac3f99ffbf1","abstract_canon_sha256":"b9a875ae56d0e66e6273167c3c92a8490d4b7f7923ad7bc4a258f3a4e2f0efde"},"schema_version":"1.0"},"canonical_sha256":"1392f08ba32598e0420cd2618d9f568a5633bbfe0ac368f899bdea62fd180043","source":{"kind":"arxiv","id":"2606.02130","version":1},"source_aliases":[{"alias_kind":"arxiv","alias_value":"2606.02130","created_at":"2026-06-02T02:05:07Z"},{"alias_kind":"arxiv_version","alias_value":"2606.02130v1","created_at":"2026-06-02T02:05:07Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.2606.02130","created_at":"2026-06-02T02:05:07Z"},{"alias_kind":"pith_short_12","alias_value":"COJPBC5DEWMO","created_at":"2026-06-02T02:05:07Z"},{"alias_kind":"pith_short_16","alias_value":"COJPBC5DEWMOAQQM","created_at":"2026-06-02T02:05:07Z"},{"alias_kind":"pith_short_8","alias_value":"COJPBC5D","created_at":"2026-06-02T02:05:07Z"}],"events":[{"event_type":"record_created","subject_pith_number":"pith:2026:COJPBC5DEWMOAQQM2JQY3H2WRJ","target":"record","payload":{"canonical_record":{"source":{"id":"2606.02130","kind":"arxiv","version":1},"metadata":{"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"stat.ME","submitted_at":"2026-06-01T11:57:36Z","cross_cats_sorted":[],"title_canon_sha256":"46ed976a7c3ac0daab2d9ae07e42e7ab7894fff9b56ecc8c0b6a0ac3f99ffbf1","abstract_canon_sha256":"b9a875ae56d0e66e6273167c3c92a8490d4b7f7923ad7bc4a258f3a4e2f0efde"},"schema_version":"1.0"},"canonical_sha256":"1392f08ba32598e0420cd2618d9f568a5633bbfe0ac368f899bdea62fd180043","receipt":{"kind":"pith_receipt","key_id":"pith-v1-2026-05","algorithm":"ed25519","signed_at":"2026-06-02T02:05:07.255237Z","signature_b64":"i04Mp8TFLPtbHXbXHfLK2/GEr7lDfS8CuyY2w/CwaA1Vl1k4YmmXbawaCfhCmRfl0qQDBcp93t2oaL++ee+/CQ==","signed_message":"canonical_sha256_bytes","builder_version":"pith-number-builder-2026-05-17-v1","receipt_version":"0.3","canonical_sha256":"1392f08ba32598e0420cd2618d9f568a5633bbfe0ac368f899bdea62fd180043","last_reissued_at":"2026-06-02T02:05:07.254828Z","signature_status":"signed_v1","first_computed_at":"2026-06-02T02:05:07.254828Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"source_kind":"arxiv","source_id":"2606.02130","source_version":1,"attestation_state":"computed"},"signer":{"signer_id":"pith.science","signer_type":"pith_registry","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"created_at":"2026-06-02T02:05:07Z","supersedes":[],"prev_event":null,"signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"l4y74ThtqNJ1mex9WQfbeukLUCHhH78zc2efaOOeot3gLn0HjnsIv5ztpHqgV5rQsl4ZBin78CSObKxAJkPlCg==","signed_message":"open_graph_event_sha256_bytes","signed_at":"2026-06-08T19:45:32.143736Z"},"content_sha256":"a927d1f81c0dae60a23aef2dd53ce32974c4ac40919d594f909be2daa83ec028","schema_version":"1.0","event_id":"sha256:a927d1f81c0dae60a23aef2dd53ce32974c4ac40919d594f909be2daa83ec028"},{"event_type":"graph_snapshot","subject_pith_number":"pith:2026:COJPBC5DEWMOAQQM2JQY3H2WRJ","target":"graph","payload":{"graph_snapshot":{"paper":{"title":"Methods for adjusting for covariate measurement error in flexible modelling of functional form: designing a blinded, controlled neutral comparison simulation study","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","headline":"","cross_cats":[],"primary_cat":"stat.ME","authors_text":"Anne C M Thi\\'ebaut (CESP), Aris Perperouglou (GSK), CESP), Frank E Harrell, Laurence S Freedman, Michal Abrahamowicz, Mohammed Sedki (IGR, Paul Gustafson (UBC), Steve Ferreira Guerra, Willi Sauerbrei","submitted_at":"2026-06-01T11:57:36Z","abstract_excerpt":"This article describes the design of a neutral comparison study in the context of empirical studies where the interest is in learning the functional relationship between a continuous errorprone exposure variable and a binary outcome. The performance of combinations of measurement error correction methods and flexible regression modeling techniques was compared using a simulation study. The project involved four independent teams, one devoted to data generation and evaluation, the other three to specific methods of measurement error correction (Simulation-Extrapolation, Regression-Calibration a"},"claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"2606.02130","kind":"arxiv","version":1},"verdict":{"id":null,"model_set":{},"created_at":null,"strongest_claim":"","one_line_summary":"","pipeline_version":null,"weakest_assumption":"","pith_extraction_headline":""},"integrity":{"clean":true,"summary":{"advisory":0,"critical":0,"by_detector":{},"informational":0},"endpoint":"/pith/2606.02130/integrity.json","findings":[],"available":true,"detectors_run":[],"snapshot_sha256":"c28c3603d3b5d939e8dc4c7e95fa8dfce3d595e45f758748cecf8e644a296938"},"references":{"count":0,"sample":[],"resolved_work":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","internal_anchors":0},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"author_claims":{"count":0,"strong_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"builder_version":"pith-number-builder-2026-05-17-v1"},"verdict_id":null},"signer":{"signer_id":"pith.science","signer_type":"pith_registry","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"created_at":"2026-06-02T02:05:07Z","supersedes":[],"prev_event":null,"signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"pe+DBtRXeoYgFuJHbpWnbccO5wR1zeGxZqGZZZzom+64c+M7Ij4UHCE+SZNxlstMvwY+8J97TXdtNZuSTnYdAg==","signed_message":"open_graph_event_sha256_bytes","signed_at":"2026-06-08T19:45:32.144533Z"},"content_sha256":"463d4d7014171ab31a45ac9987a8d7e5ea70eccb81c9b3f70ef113ae6eb1b391","schema_version":"1.0","event_id":"sha256:463d4d7014171ab31a45ac9987a8d7e5ea70eccb81c9b3f70ef113ae6eb1b391"}],"timestamp_proofs":[],"mirror_hints":[{"mirror_type":"https","name":"Pith Resolver","base_url":"https://pith.science","bundle_url":"https://pith.science/pith/COJPBC5DEWMOAQQM2JQY3H2WRJ/bundle.json","state_url":"https://pith.science/pith/COJPBC5DEWMOAQQM2JQY3H2WRJ/state.json","well_known_bundle_url":"https://pith.science/.well-known/pith/COJPBC5DEWMOAQQM2JQY3H2WRJ/bundle.json","status":"primary"}],"public_keys":[{"key_id":"pith-v1-2026-05","algorithm":"ed25519","format":"raw","public_key_b64":"stVStoiQhXFxp4s2pdzPNoqVNBMojDU/fJ2db5S3CbM=","public_key_hex":"b2d552b68890857171a78b36a5dccf368a953413288c353f7c9d9d6f94b709b3","fingerprint_sha256_b32_first128bits":"RVFV5Z2OI2J3ZUO7ERDEBCYNKS","fingerprint_sha256_hex":"8d4b5ee74e4693bcd1df2446408b0d54","rotates_at":null,"url":"https://pith.science/pith-signing-key.json","notes":"Pith uses this Ed25519 key to sign canonical record SHA-256 digests. Verify with: ed25519_verify(public_key, message=canonical_sha256_bytes, signature=base64decode(signature_b64))."}],"merge_version":"pith-open-graph-merge-v1","built_at":"2026-06-08T19:45:32Z","links":{"resolver":"https://pith.science/pith/COJPBC5DEWMOAQQM2JQY3H2WRJ","bundle":"https://pith.science/pith/COJPBC5DEWMOAQQM2JQY3H2WRJ/bundle.json","state":"https://pith.science/pith/COJPBC5DEWMOAQQM2JQY3H2WRJ/state.json","well_known_bundle":"https://pith.science/.well-known/pith/COJPBC5DEWMOAQQM2JQY3H2WRJ/bundle.json"},"state":{"state_type":"pith_open_graph_state","state_version":"1.0","pith_number":"pith:2026:COJPBC5DEWMOAQQM2JQY3H2WRJ","merge_version":"pith-open-graph-merge-v1","event_count":2,"valid_event_count":2,"invalid_event_count":0,"equivocation_count":0,"current":{"canonical_record":{"metadata":{"abstract_canon_sha256":"b9a875ae56d0e66e6273167c3c92a8490d4b7f7923ad7bc4a258f3a4e2f0efde","cross_cats_sorted":[],"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"stat.ME","submitted_at":"2026-06-01T11:57:36Z","title_canon_sha256":"46ed976a7c3ac0daab2d9ae07e42e7ab7894fff9b56ecc8c0b6a0ac3f99ffbf1"},"schema_version":"1.0","source":{"id":"2606.02130","kind":"arxiv","version":1}},"source_aliases":[{"alias_kind":"arxiv","alias_value":"2606.02130","created_at":"2026-06-02T02:05:07Z"},{"alias_kind":"arxiv_version","alias_value":"2606.02130v1","created_at":"2026-06-02T02:05:07Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.2606.02130","created_at":"2026-06-02T02:05:07Z"},{"alias_kind":"pith_short_12","alias_value":"COJPBC5DEWMO","created_at":"2026-06-02T02:05:07Z"},{"alias_kind":"pith_short_16","alias_value":"COJPBC5DEWMOAQQM","created_at":"2026-06-02T02:05:07Z"},{"alias_kind":"pith_short_8","alias_value":"COJPBC5D","created_at":"2026-06-02T02:05:07Z"}],"graph_snapshots":[{"event_id":"sha256:463d4d7014171ab31a45ac9987a8d7e5ea70eccb81c9b3f70ef113ae6eb1b391","target":"graph","created_at":"2026-06-02T02:05:07Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"graph_snapshot":{"author_claims":{"count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","strong_count":0},"builder_version":"pith-number-builder-2026-05-17-v1","claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"integrity":{"available":true,"clean":true,"detectors_run":[],"endpoint":"/pith/2606.02130/integrity.json","findings":[],"snapshot_sha256":"c28c3603d3b5d939e8dc4c7e95fa8dfce3d595e45f758748cecf8e644a296938","summary":{"advisory":0,"by_detector":{},"critical":0,"informational":0}},"paper":{"abstract_excerpt":"This article describes the design of a neutral comparison study in the context of empirical studies where the interest is in learning the functional relationship between a continuous errorprone exposure variable and a binary outcome. The performance of combinations of measurement error correction methods and flexible regression modeling techniques was compared using a simulation study. The project involved four independent teams, one devoted to data generation and evaluation, the other three to specific methods of measurement error correction (Simulation-Extrapolation, Regression-Calibration a","authors_text":"Anne C M Thi\\'ebaut (CESP), Aris Perperouglou (GSK), CESP), Frank E Harrell, Laurence S Freedman, Michal Abrahamowicz, Mohammed Sedki (IGR, Paul Gustafson (UBC), Steve Ferreira Guerra, Willi Sauerbrei","cross_cats":[],"headline":"","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"stat.ME","submitted_at":"2026-06-01T11:57:36Z","title":"Methods for adjusting for covariate measurement error in flexible modelling of functional form: designing a blinded, controlled neutral comparison simulation study"},"references":{"count":0,"internal_anchors":0,"resolved_work":0,"sample":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"2606.02130","kind":"arxiv","version":1},"verdict":{"created_at":null,"id":null,"model_set":{},"one_line_summary":"","pipeline_version":null,"pith_extraction_headline":"","strongest_claim":"","weakest_assumption":""}},"verdict_id":null}}],"author_attestations":[],"timestamp_anchors":[],"storage_attestations":[],"citation_signatures":[],"replication_records":[],"corrections":[],"mirror_hints":[],"record_created":{"event_id":"sha256:a927d1f81c0dae60a23aef2dd53ce32974c4ac40919d594f909be2daa83ec028","target":"record","created_at":"2026-06-02T02:05:07Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"attestation_state":"computed","canonical_record":{"metadata":{"abstract_canon_sha256":"b9a875ae56d0e66e6273167c3c92a8490d4b7f7923ad7bc4a258f3a4e2f0efde","cross_cats_sorted":[],"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"stat.ME","submitted_at":"2026-06-01T11:57:36Z","title_canon_sha256":"46ed976a7c3ac0daab2d9ae07e42e7ab7894fff9b56ecc8c0b6a0ac3f99ffbf1"},"schema_version":"1.0","source":{"id":"2606.02130","kind":"arxiv","version":1}},"canonical_sha256":"1392f08ba32598e0420cd2618d9f568a5633bbfe0ac368f899bdea62fd180043","receipt":{"algorithm":"ed25519","builder_version":"pith-number-builder-2026-05-17-v1","canonical_sha256":"1392f08ba32598e0420cd2618d9f568a5633bbfe0ac368f899bdea62fd180043","first_computed_at":"2026-06-02T02:05:07.254828Z","key_id":"pith-v1-2026-05","kind":"pith_receipt","last_reissued_at":"2026-06-02T02:05:07.254828Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","receipt_version":"0.3","signature_b64":"i04Mp8TFLPtbHXbXHfLK2/GEr7lDfS8CuyY2w/CwaA1Vl1k4YmmXbawaCfhCmRfl0qQDBcp93t2oaL++ee+/CQ==","signature_status":"signed_v1","signed_at":"2026-06-02T02:05:07.255237Z","signed_message":"canonical_sha256_bytes"},"source_id":"2606.02130","source_kind":"arxiv","source_version":1}}},"equivocations":[],"invalid_events":[],"applied_event_ids":["sha256:a927d1f81c0dae60a23aef2dd53ce32974c4ac40919d594f909be2daa83ec028","sha256:463d4d7014171ab31a45ac9987a8d7e5ea70eccb81c9b3f70ef113ae6eb1b391"],"state_sha256":"845ea68c798b2bcf6d00e26024489e10695ff32ce5425b5b2ca0920491f48e43"},"bundle_signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"wd6oPXihQzaJ/6ExIYLVPYWx+IhDy77NbBTeIAqEeS4w0HgtWdcAL2v3opPy8YJdvZ/tt95lIghV9qKYxutwAA==","signed_message":"bundle_sha256_bytes","signed_at":"2026-06-08T19:45:32.148590Z","bundle_sha256":"566706dac1222e1c4e96fdb027e2fd315e8c32236331effd6752171ee4177b38"}}