{"bundle_type":"pith_open_graph_bundle","bundle_version":"1.0","pith_number":"pith:2011:COQVFQXUIFKV5O2HIVHEM5N7PB","short_pith_number":"pith:COQVFQXU","canonical_record":{"source":{"id":"1111.2510","kind":"arxiv","version":1},"metadata":{"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"cond-mat.soft","submitted_at":"2011-11-10T16:21:44Z","cross_cats_sorted":[],"title_canon_sha256":"993383b0372024bdb1053fe5b4858fc958e04a7e606917c4cc71e47304e3c7b5","abstract_canon_sha256":"12c85bc5d080d83072628496b882c7bbcd9e191c0aec65b29dc7cc6188cfd814"},"schema_version":"1.0"},"canonical_sha256":"13a152c2f441555ebb47454e4675bf784795e12c920af2cd9b12421f7dd9c516","source":{"kind":"arxiv","id":"1111.2510","version":1},"source_aliases":[{"alias_kind":"arxiv","alias_value":"1111.2510","created_at":"2026-05-18T03:54:27Z"},{"alias_kind":"arxiv_version","alias_value":"1111.2510v1","created_at":"2026-05-18T03:54:27Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.1111.2510","created_at":"2026-05-18T03:54:27Z"},{"alias_kind":"pith_short_12","alias_value":"COQVFQXUIFKV","created_at":"2026-05-18T12:26:26Z"},{"alias_kind":"pith_short_16","alias_value":"COQVFQXUIFKV5O2H","created_at":"2026-05-18T12:26:26Z"},{"alias_kind":"pith_short_8","alias_value":"COQVFQXU","created_at":"2026-05-18T12:26:26Z"}],"events":[{"event_type":"record_created","subject_pith_number":"pith:2011:COQVFQXUIFKV5O2HIVHEM5N7PB","target":"record","payload":{"canonical_record":{"source":{"id":"1111.2510","kind":"arxiv","version":1},"metadata":{"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"cond-mat.soft","submitted_at":"2011-11-10T16:21:44Z","cross_cats_sorted":[],"title_canon_sha256":"993383b0372024bdb1053fe5b4858fc958e04a7e606917c4cc71e47304e3c7b5","abstract_canon_sha256":"12c85bc5d080d83072628496b882c7bbcd9e191c0aec65b29dc7cc6188cfd814"},"schema_version":"1.0"},"canonical_sha256":"13a152c2f441555ebb47454e4675bf784795e12c920af2cd9b12421f7dd9c516","receipt":{"kind":"pith_receipt","key_id":"pith-v1-2026-05","algorithm":"ed25519","signed_at":"2026-05-18T03:54:27.650753Z","signature_b64":"aiRFWGc5+MfAf8FppMw3NST/r7Wy25ZzA358PqZM5SeK4/j0PBqv0d4JOgRuTQg/JLMHaem9zn4DvHcmjcS8BQ==","signed_message":"canonical_sha256_bytes","builder_version":"pith-number-builder-2026-05-17-v1","receipt_version":"0.3","canonical_sha256":"13a152c2f441555ebb47454e4675bf784795e12c920af2cd9b12421f7dd9c516","last_reissued_at":"2026-05-18T03:54:27.650023Z","signature_status":"signed_v1","first_computed_at":"2026-05-18T03:54:27.650023Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"source_kind":"arxiv","source_id":"1111.2510","source_version":1,"attestation_state":"computed"},"signer":{"signer_id":"pith.science","signer_type":"pith_registry","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"created_at":"2026-05-18T03:54:27Z","supersedes":[],"prev_event":null,"signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"axjbyahN200ZZeojHzldozlRL20UUFWtxFfN1h/XpCuNNfPE89xpKOZugAnH2Y0+Nou5Vz/B5ESUhocybpHeAA==","signed_message":"open_graph_event_sha256_bytes","signed_at":"2026-06-23T15:01:59.890842Z"},"content_sha256":"9f564c0a601fd210b7060f32007009488397b170b0290767a84c992f260e0154","schema_version":"1.0","event_id":"sha256:9f564c0a601fd210b7060f32007009488397b170b0290767a84c992f260e0154"},{"event_type":"graph_snapshot","subject_pith_number":"pith:2011:COQVFQXUIFKV5O2HIVHEM5N7PB","target":"graph","payload":{"graph_snapshot":{"paper":{"title":"Thermoresponsive micropatterned substrates for single cell studies","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","headline":"","cross_cats":[],"primary_cat":"cond-mat.soft","authors_text":"Kalpana Mandal (LIPhy), Lionel Bureau (LIPhy), Martial Balland (LIPhy)","submitted_at":"2011-11-10T16:21:44Z","abstract_excerpt":"We describe the design of micropatterned surfaces for single cell studies, based on thermoresponsive polymer brushes. We show that brushes made of poly(N-isopropylacrylamide) grafted at high surface density display excellent protein and cell anti-adhesive properties. Such brushes are readily patterned at the micron scale via deep UV photolithography. A proper choice of the adhesive pattern shapes, combined with the temperature-dependent swelling properties of PNIPAM, allow us to use the polymer brush as a microactuator which induces cell detachment when the temperature is reduced below 32degC."},"claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"1111.2510","kind":"arxiv","version":1},"verdict":{"id":null,"model_set":{},"created_at":null,"strongest_claim":"","one_line_summary":"","pipeline_version":null,"weakest_assumption":"","pith_extraction_headline":""},"references":{"count":0,"sample":[],"resolved_work":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","internal_anchors":0},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"author_claims":{"count":0,"strong_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"builder_version":"pith-number-builder-2026-05-17-v1"},"verdict_id":null},"signer":{"signer_id":"pith.science","signer_type":"pith_registry","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"created_at":"2026-05-18T03:54:27Z","supersedes":[],"prev_event":null,"signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"lUCGFHZCDxztD5cu5XQUtEyKDlONv5wRh2EZDl4uZQFs5dkh/dZxbU9Q99U+n6501kfSxjH2SLAHf2wv/tB3Ag==","signed_message":"open_graph_event_sha256_bytes","signed_at":"2026-06-23T15:01:59.891187Z"},"content_sha256":"b03408572c4bcec2f0837a7b4a85106748c7b306b32d94678b6b53c5ba35596a","schema_version":"1.0","event_id":"sha256:b03408572c4bcec2f0837a7b4a85106748c7b306b32d94678b6b53c5ba35596a"}],"timestamp_proofs":[],"mirror_hints":[{"mirror_type":"https","name":"Pith Resolver","base_url":"https://pith.science","bundle_url":"https://pith.science/pith/COQVFQXUIFKV5O2HIVHEM5N7PB/bundle.json","state_url":"https://pith.science/pith/COQVFQXUIFKV5O2HIVHEM5N7PB/state.json","well_known_bundle_url":"https://pith.science/.well-known/pith/COQVFQXUIFKV5O2HIVHEM5N7PB/bundle.json","status":"primary"}],"public_keys":[{"key_id":"pith-v1-2026-05","algorithm":"ed25519","format":"raw","public_key_b64":"stVStoiQhXFxp4s2pdzPNoqVNBMojDU/fJ2db5S3CbM=","public_key_hex":"b2d552b68890857171a78b36a5dccf368a953413288c353f7c9d9d6f94b709b3","fingerprint_sha256_b32_first128bits":"RVFV5Z2OI2J3ZUO7ERDEBCYNKS","fingerprint_sha256_hex":"8d4b5ee74e4693bcd1df2446408b0d54","rotates_at":null,"url":"https://pith.science/pith-signing-key.json","notes":"Pith uses this Ed25519 key to sign canonical record SHA-256 digests. Verify with: ed25519_verify(public_key, message=canonical_sha256_bytes, signature=base64decode(signature_b64))."}],"merge_version":"pith-open-graph-merge-v1","built_at":"2026-06-23T15:01:59Z","links":{"resolver":"https://pith.science/pith/COQVFQXUIFKV5O2HIVHEM5N7PB","bundle":"https://pith.science/pith/COQVFQXUIFKV5O2HIVHEM5N7PB/bundle.json","state":"https://pith.science/pith/COQVFQXUIFKV5O2HIVHEM5N7PB/state.json","well_known_bundle":"https://pith.science/.well-known/pith/COQVFQXUIFKV5O2HIVHEM5N7PB/bundle.json"},"state":{"state_type":"pith_open_graph_state","state_version":"1.0","pith_number":"pith:2011:COQVFQXUIFKV5O2HIVHEM5N7PB","merge_version":"pith-open-graph-merge-v1","event_count":2,"valid_event_count":2,"invalid_event_count":0,"equivocation_count":0,"current":{"canonical_record":{"metadata":{"abstract_canon_sha256":"12c85bc5d080d83072628496b882c7bbcd9e191c0aec65b29dc7cc6188cfd814","cross_cats_sorted":[],"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"cond-mat.soft","submitted_at":"2011-11-10T16:21:44Z","title_canon_sha256":"993383b0372024bdb1053fe5b4858fc958e04a7e606917c4cc71e47304e3c7b5"},"schema_version":"1.0","source":{"id":"1111.2510","kind":"arxiv","version":1}},"source_aliases":[{"alias_kind":"arxiv","alias_value":"1111.2510","created_at":"2026-05-18T03:54:27Z"},{"alias_kind":"arxiv_version","alias_value":"1111.2510v1","created_at":"2026-05-18T03:54:27Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.1111.2510","created_at":"2026-05-18T03:54:27Z"},{"alias_kind":"pith_short_12","alias_value":"COQVFQXUIFKV","created_at":"2026-05-18T12:26:26Z"},{"alias_kind":"pith_short_16","alias_value":"COQVFQXUIFKV5O2H","created_at":"2026-05-18T12:26:26Z"},{"alias_kind":"pith_short_8","alias_value":"COQVFQXU","created_at":"2026-05-18T12:26:26Z"}],"graph_snapshots":[{"event_id":"sha256:b03408572c4bcec2f0837a7b4a85106748c7b306b32d94678b6b53c5ba35596a","target":"graph","created_at":"2026-05-18T03:54:27Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"graph_snapshot":{"author_claims":{"count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","strong_count":0},"builder_version":"pith-number-builder-2026-05-17-v1","claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"paper":{"abstract_excerpt":"We describe the design of micropatterned surfaces for single cell studies, based on thermoresponsive polymer brushes. We show that brushes made of poly(N-isopropylacrylamide) grafted at high surface density display excellent protein and cell anti-adhesive properties. Such brushes are readily patterned at the micron scale via deep UV photolithography. A proper choice of the adhesive pattern shapes, combined with the temperature-dependent swelling properties of PNIPAM, allow us to use the polymer brush as a microactuator which induces cell detachment when the temperature is reduced below 32degC.","authors_text":"Kalpana Mandal (LIPhy), Lionel Bureau (LIPhy), Martial Balland (LIPhy)","cross_cats":[],"headline":"","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"cond-mat.soft","submitted_at":"2011-11-10T16:21:44Z","title":"Thermoresponsive micropatterned substrates for single cell studies"},"references":{"count":0,"internal_anchors":0,"resolved_work":0,"sample":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"1111.2510","kind":"arxiv","version":1},"verdict":{"created_at":null,"id":null,"model_set":{},"one_line_summary":"","pipeline_version":null,"pith_extraction_headline":"","strongest_claim":"","weakest_assumption":""}},"verdict_id":null}}],"author_attestations":[],"timestamp_anchors":[],"storage_attestations":[],"citation_signatures":[],"replication_records":[],"corrections":[],"mirror_hints":[],"record_created":{"event_id":"sha256:9f564c0a601fd210b7060f32007009488397b170b0290767a84c992f260e0154","target":"record","created_at":"2026-05-18T03:54:27Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"attestation_state":"computed","canonical_record":{"metadata":{"abstract_canon_sha256":"12c85bc5d080d83072628496b882c7bbcd9e191c0aec65b29dc7cc6188cfd814","cross_cats_sorted":[],"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"cond-mat.soft","submitted_at":"2011-11-10T16:21:44Z","title_canon_sha256":"993383b0372024bdb1053fe5b4858fc958e04a7e606917c4cc71e47304e3c7b5"},"schema_version":"1.0","source":{"id":"1111.2510","kind":"arxiv","version":1}},"canonical_sha256":"13a152c2f441555ebb47454e4675bf784795e12c920af2cd9b12421f7dd9c516","receipt":{"algorithm":"ed25519","builder_version":"pith-number-builder-2026-05-17-v1","canonical_sha256":"13a152c2f441555ebb47454e4675bf784795e12c920af2cd9b12421f7dd9c516","first_computed_at":"2026-05-18T03:54:27.650023Z","key_id":"pith-v1-2026-05","kind":"pith_receipt","last_reissued_at":"2026-05-18T03:54:27.650023Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","receipt_version":"0.3","signature_b64":"aiRFWGc5+MfAf8FppMw3NST/r7Wy25ZzA358PqZM5SeK4/j0PBqv0d4JOgRuTQg/JLMHaem9zn4DvHcmjcS8BQ==","signature_status":"signed_v1","signed_at":"2026-05-18T03:54:27.650753Z","signed_message":"canonical_sha256_bytes"},"source_id":"1111.2510","source_kind":"arxiv","source_version":1}}},"equivocations":[],"invalid_events":[],"applied_event_ids":["sha256:9f564c0a601fd210b7060f32007009488397b170b0290767a84c992f260e0154","sha256:b03408572c4bcec2f0837a7b4a85106748c7b306b32d94678b6b53c5ba35596a"],"state_sha256":"853edd16025872557b5fe505bcf94d965f8ba91c01e8e49e9aff4f51d83082bd"},"bundle_signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"hTktlI9/e4515HaQJcJa/JFx8MAJy1dN9Wu/TMj63KBQfcphm28OlOG3ciLERtIv3TGx/8ZUZjxeCAA3W5VnBQ==","signed_message":"bundle_sha256_bytes","signed_at":"2026-06-23T15:01:59.893370Z","bundle_sha256":"1cb2fc78a6004ac1366b924276c516f8c1f810eef4727ee9789d5159dbab7983"}}