{"state_type":"pith_open_graph_state","state_version":"1.0","pith_number":"pith:2025:CPWQPWES4TZ3SGAK5FYJ4N6CAP","merge_version":"pith-open-graph-merge-v1","event_count":2,"valid_event_count":2,"invalid_event_count":0,"equivocation_count":0,"current":{"canonical_record":{"metadata":{"abstract_canon_sha256":"20ed8c152948e60ecb624399b01536a6f228330785c3e1b8ae29e5924136e312","cross_cats_sorted":[],"license":"http://creativecommons.org/licenses/by-nc-nd/4.0/","primary_cat":"physics.med-ph","submitted_at":"2025-06-26T11:23:04Z","title_canon_sha256":"7533700cd4905da3298830826056fc7054ce7d8243fab06315f9c58aaaea4351"},"schema_version":"1.0","source":{"id":"2506.21153","kind":"arxiv","version":1}},"source_aliases":[{"alias_kind":"arxiv","alias_value":"2506.21153","created_at":"2026-07-05T11:27:40Z"},{"alias_kind":"arxiv_version","alias_value":"2506.21153v1","created_at":"2026-07-05T11:27:40Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.2506.21153","created_at":"2026-07-05T11:27:40Z"},{"alias_kind":"pith_short_12","alias_value":"CPWQPWES4TZ3","created_at":"2026-07-05T11:27:40Z"},{"alias_kind":"pith_short_16","alias_value":"CPWQPWES4TZ3SGAK","created_at":"2026-07-05T11:27:40Z"},{"alias_kind":"pith_short_8","alias_value":"CPWQPWES","created_at":"2026-07-05T11:27:40Z"}],"graph_snapshots":[{"event_id":"sha256:125a013556707f0e2d30b8c7bd52181fa55336aa22abc67dc01dd1ed60395a88","target":"graph","created_at":"2026-07-05T11:27:40Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"graph_snapshot":{"author_claims":{"count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","strong_count":0},"builder_version":"pith-number-builder-2026-05-17-v1","claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"integrity":{"available":true,"clean":true,"detectors_run":[],"endpoint":"/pith/2506.21153/integrity.json","findings":[],"snapshot_sha256":"c28c3603d3b5d939e8dc4c7e95fa8dfce3d595e45f758748cecf8e644a296938","summary":{"advisory":0,"by_detector":{},"critical":0,"informational":0}},"paper":{"abstract_excerpt":"The distribution of produced isotopes during proton therapy can be imaged with Positron Emission Tomography (PET) to verify dose delivery. However, biological washout, driven by tissue-dependent processes such as perfusion and cellular metabolism, reduces PET signal-to-noise ratio (SNR) and limits quantitative analysis. In this work, we propose an uncertainty-aware deep learning framework to improve the estimation of washout parameters in post-proton therapy PET, not only enabling accurate correction for washout effects, but also mapping intratumoral heterogeneity as a surrogate marker of tumo","authors_text":"David Izquierdo-Garc\\'ia, Joaqu\\'in L. Herraiz, Jos\\'e Manuel Ud\\'ias, Luis Mario Fraile, Mailyn P\\'erez-Liva, Pablo Cabrales, V\\'ictor V. Onecha","cross_cats":[],"headline":"","license":"http://creativecommons.org/licenses/by-nc-nd/4.0/","primary_cat":"physics.med-ph","submitted_at":"2025-06-26T11:23:04Z","title":"Mapping intratumoral heterogeneity through PET-derived washout and deep learning after proton therapy"},"references":{"count":0,"internal_anchors":0,"resolved_work":0,"sample":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"2506.21153","kind":"arxiv","version":1},"verdict":{"created_at":null,"id":null,"model_set":{},"one_line_summary":"","pipeline_version":null,"pith_extraction_headline":"","strongest_claim":"","weakest_assumption":""}},"verdict_id":null}}],"author_attestations":[],"timestamp_anchors":[],"storage_attestations":[],"citation_signatures":[],"replication_records":[],"corrections":[],"mirror_hints":[],"record_created":{"event_id":"sha256:21392c7cf0d65def16e665c85d1238f44d643b2e27a05051ce3160d7ace4a3ab","target":"record","created_at":"2026-07-05T11:27:40Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"attestation_state":"computed","canonical_record":{"metadata":{"abstract_canon_sha256":"20ed8c152948e60ecb624399b01536a6f228330785c3e1b8ae29e5924136e312","cross_cats_sorted":[],"license":"http://creativecommons.org/licenses/by-nc-nd/4.0/","primary_cat":"physics.med-ph","submitted_at":"2025-06-26T11:23:04Z","title_canon_sha256":"7533700cd4905da3298830826056fc7054ce7d8243fab06315f9c58aaaea4351"},"schema_version":"1.0","source":{"id":"2506.21153","kind":"arxiv","version":1}},"canonical_sha256":"13ed07d892e4f3b9180ae9709e37c203cb1be91a968f34368062b451081c6608","receipt":{"algorithm":"ed25519","builder_version":"pith-number-builder-2026-05-17-v1","canonical_sha256":"13ed07d892e4f3b9180ae9709e37c203cb1be91a968f34368062b451081c6608","first_computed_at":"2026-07-05T11:27:40.673931Z","key_id":"pith-v1-2026-05","kind":"pith_receipt","last_reissued_at":"2026-07-05T11:27:40.673931Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","receipt_version":"0.3","signature_b64":"f068foMA3LGU+FWnhx/ZxLW5+tD4JA6G5EcNny8FMeV/Iwm9aVOubExFZ1SM+unbkdMTIXV9mq1cmxbAZ5s+Bg==","signature_status":"signed_v1","signed_at":"2026-07-05T11:27:40.674523Z","signed_message":"canonical_sha256_bytes"},"source_id":"2506.21153","source_kind":"arxiv","source_version":1}}},"equivocations":[],"invalid_events":[],"applied_event_ids":["sha256:21392c7cf0d65def16e665c85d1238f44d643b2e27a05051ce3160d7ace4a3ab","sha256:125a013556707f0e2d30b8c7bd52181fa55336aa22abc67dc01dd1ed60395a88"],"state_sha256":"f32b96b95c43ed625e597ed87529a8d062ca452405b865ae97e6936b863ad7fe"}