{"bundle_type":"pith_open_graph_bundle","bundle_version":"1.0","pith_number":"pith:2023:CQHRIWG5JOGDNBKFP4P64QM7WS","short_pith_number":"pith:CQHRIWG5","canonical_record":{"source":{"id":"2310.13806","kind":"arxiv","version":1},"metadata":{"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.BM","submitted_at":"2023-10-20T20:36:13Z","cross_cats_sorted":["cs.AI","cs.LG","q-bio.QM"],"title_canon_sha256":"19122f0b07e5b8e7782bed60042eaf1521cc9c102eebf05752ac6e2a8cbd1da5","abstract_canon_sha256":"234b96e8eb8a66c3bdcfcbe3e04a65e7ebca9f165902a024b6e7359d22969e4f"},"schema_version":"1.0"},"canonical_sha256":"140f1458dd4b8c3685457f1fee419fb483175efb09fd15124d37f687e244076d","source":{"kind":"arxiv","id":"2310.13806","version":1},"source_aliases":[{"alias_kind":"arxiv","alias_value":"2310.13806","created_at":"2026-07-05T07:03:35Z"},{"alias_kind":"arxiv_version","alias_value":"2310.13806v1","created_at":"2026-07-05T07:03:35Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.2310.13806","created_at":"2026-07-05T07:03:35Z"},{"alias_kind":"pith_short_12","alias_value":"CQHRIWG5JOGD","created_at":"2026-07-05T07:03:35Z"},{"alias_kind":"pith_short_16","alias_value":"CQHRIWG5JOGDNBKF","created_at":"2026-07-05T07:03:35Z"},{"alias_kind":"pith_short_8","alias_value":"CQHRIWG5","created_at":"2026-07-05T07:03:35Z"}],"events":[{"event_type":"record_created","subject_pith_number":"pith:2023:CQHRIWG5JOGDNBKFP4P64QM7WS","target":"record","payload":{"canonical_record":{"source":{"id":"2310.13806","kind":"arxiv","version":1},"metadata":{"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.BM","submitted_at":"2023-10-20T20:36:13Z","cross_cats_sorted":["cs.AI","cs.LG","q-bio.QM"],"title_canon_sha256":"19122f0b07e5b8e7782bed60042eaf1521cc9c102eebf05752ac6e2a8cbd1da5","abstract_canon_sha256":"234b96e8eb8a66c3bdcfcbe3e04a65e7ebca9f165902a024b6e7359d22969e4f"},"schema_version":"1.0"},"canonical_sha256":"140f1458dd4b8c3685457f1fee419fb483175efb09fd15124d37f687e244076d","receipt":{"kind":"pith_receipt","key_id":"pith-v1-2026-05","algorithm":"ed25519","signed_at":"2026-07-05T07:03:35.054477Z","signature_b64":"EMJC0SFTn0J+F/VE+fadfbAN9lNs6FygL24IF0RbnGoe54IYIlty30sSogYm9N/GqykThRsqpIsaeAcBsSmRBw==","signed_message":"canonical_sha256_bytes","builder_version":"pith-number-builder-2026-05-17-v1","receipt_version":"0.3","canonical_sha256":"140f1458dd4b8c3685457f1fee419fb483175efb09fd15124d37f687e244076d","last_reissued_at":"2026-07-05T07:03:35.054068Z","signature_status":"signed_v1","first_computed_at":"2026-07-05T07:03:35.054068Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"source_kind":"arxiv","source_id":"2310.13806","source_version":1,"attestation_state":"computed"},"signer":{"signer_id":"pith.science","signer_type":"pith_registry","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"created_at":"2026-07-05T07:03:35Z","supersedes":[],"prev_event":null,"signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"2Oi1U3UpB2gXTmjaehy4Jz02UItZsLFYojFiC7N+LCk9yyptgZMXTCQA+phPRz6qPmYq+aoSKxkwbS2xIAu0Bg==","signed_message":"open_graph_event_sha256_bytes","signed_at":"2026-07-06T16:25:51.178783Z"},"content_sha256":"a00a11e20a9ebd3fe5ed33bd710bdc93d0421292d4c68d6fa924c165071a185f","schema_version":"1.0","event_id":"sha256:a00a11e20a9ebd3fe5ed33bd710bdc93d0421292d4c68d6fa924c165071a185f"},{"event_type":"graph_snapshot","subject_pith_number":"pith:2023:CQHRIWG5JOGDNBKFP4P64QM7WS","target":"graph","payload":{"graph_snapshot":{"paper":{"title":"RoseNet: Predicting Energy Metrics of Double InDel Mutants Using Deep Learning","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","headline":"","cross_cats":["cs.AI","cs.LG","q-bio.QM"],"primary_cat":"q-bio.BM","authors_text":"Brian Hutchinson, Filip Jagodzinski, Katie Christensen, Sarah Coffland","submitted_at":"2023-10-20T20:36:13Z","abstract_excerpt":"An amino acid insertion or deletion, or InDel, can have profound and varying functional impacts on a protein's structure. InDel mutations in the transmembrane conductor regulator protein for example give rise to cystic fibrosis. Unfortunately performing InDel mutations on physical proteins and studying their effects is a time prohibitive process. Consequently, modeling InDels computationally can supplement and inform wet lab experiments. In this work, we make use of our data sets of exhaustive double InDel mutations for three proteins which we computationally generated using a robotics inspire"},"claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"2310.13806","kind":"arxiv","version":1},"verdict":{"id":null,"model_set":{},"created_at":null,"strongest_claim":"","one_line_summary":"","pipeline_version":null,"weakest_assumption":"","pith_extraction_headline":""},"integrity":{"clean":true,"summary":{"advisory":0,"critical":0,"by_detector":{},"informational":0},"endpoint":"/pith/2310.13806/integrity.json","findings":[],"available":true,"detectors_run":[],"snapshot_sha256":"c28c3603d3b5d939e8dc4c7e95fa8dfce3d595e45f758748cecf8e644a296938"},"references":{"count":0,"sample":[],"resolved_work":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","internal_anchors":0},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"author_claims":{"count":0,"strong_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"builder_version":"pith-number-builder-2026-05-17-v1"},"verdict_id":null},"signer":{"signer_id":"pith.science","signer_type":"pith_registry","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"created_at":"2026-07-05T07:03:35Z","supersedes":[],"prev_event":null,"signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"ugbiqGl9iQixvlRDmqXYVWlR/k/EFSzn0+PUYgo3DwhYQkzm/4ndPMiW5o+dHyJopqbMMLH/732pgHf1JUWSDA==","signed_message":"open_graph_event_sha256_bytes","signed_at":"2026-07-06T16:25:51.179161Z"},"content_sha256":"ea8ce80bea0c4add62add6d523875f29a0edede3db72fa77265ce9e8dfc0b5ac","schema_version":"1.0","event_id":"sha256:ea8ce80bea0c4add62add6d523875f29a0edede3db72fa77265ce9e8dfc0b5ac"}],"timestamp_proofs":[],"mirror_hints":[{"mirror_type":"https","name":"Pith Resolver","base_url":"https://pith.science","bundle_url":"https://pith.science/pith/CQHRIWG5JOGDNBKFP4P64QM7WS/bundle.json","state_url":"https://pith.science/pith/CQHRIWG5JOGDNBKFP4P64QM7WS/state.json","well_known_bundle_url":"https://pith.science/.well-known/pith/CQHRIWG5JOGDNBKFP4P64QM7WS/bundle.json","status":"primary"}],"public_keys":[{"key_id":"pith-v1-2026-05","algorithm":"ed25519","format":"raw","public_key_b64":"stVStoiQhXFxp4s2pdzPNoqVNBMojDU/fJ2db5S3CbM=","public_key_hex":"b2d552b68890857171a78b36a5dccf368a953413288c353f7c9d9d6f94b709b3","fingerprint_sha256_b32_first128bits":"RVFV5Z2OI2J3ZUO7ERDEBCYNKS","fingerprint_sha256_hex":"8d4b5ee74e4693bcd1df2446408b0d54","rotates_at":null,"url":"https://pith.science/pith-signing-key.json","notes":"Pith uses this Ed25519 key to sign canonical record SHA-256 digests. Verify with: ed25519_verify(public_key, message=canonical_sha256_bytes, signature=base64decode(signature_b64))."}],"merge_version":"pith-open-graph-merge-v1","built_at":"2026-07-06T16:25:51Z","links":{"resolver":"https://pith.science/pith/CQHRIWG5JOGDNBKFP4P64QM7WS","bundle":"https://pith.science/pith/CQHRIWG5JOGDNBKFP4P64QM7WS/bundle.json","state":"https://pith.science/pith/CQHRIWG5JOGDNBKFP4P64QM7WS/state.json","well_known_bundle":"https://pith.science/.well-known/pith/CQHRIWG5JOGDNBKFP4P64QM7WS/bundle.json"},"state":{"state_type":"pith_open_graph_state","state_version":"1.0","pith_number":"pith:2023:CQHRIWG5JOGDNBKFP4P64QM7WS","merge_version":"pith-open-graph-merge-v1","event_count":2,"valid_event_count":2,"invalid_event_count":0,"equivocation_count":0,"current":{"canonical_record":{"metadata":{"abstract_canon_sha256":"234b96e8eb8a66c3bdcfcbe3e04a65e7ebca9f165902a024b6e7359d22969e4f","cross_cats_sorted":["cs.AI","cs.LG","q-bio.QM"],"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.BM","submitted_at":"2023-10-20T20:36:13Z","title_canon_sha256":"19122f0b07e5b8e7782bed60042eaf1521cc9c102eebf05752ac6e2a8cbd1da5"},"schema_version":"1.0","source":{"id":"2310.13806","kind":"arxiv","version":1}},"source_aliases":[{"alias_kind":"arxiv","alias_value":"2310.13806","created_at":"2026-07-05T07:03:35Z"},{"alias_kind":"arxiv_version","alias_value":"2310.13806v1","created_at":"2026-07-05T07:03:35Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.2310.13806","created_at":"2026-07-05T07:03:35Z"},{"alias_kind":"pith_short_12","alias_value":"CQHRIWG5JOGD","created_at":"2026-07-05T07:03:35Z"},{"alias_kind":"pith_short_16","alias_value":"CQHRIWG5JOGDNBKF","created_at":"2026-07-05T07:03:35Z"},{"alias_kind":"pith_short_8","alias_value":"CQHRIWG5","created_at":"2026-07-05T07:03:35Z"}],"graph_snapshots":[{"event_id":"sha256:ea8ce80bea0c4add62add6d523875f29a0edede3db72fa77265ce9e8dfc0b5ac","target":"graph","created_at":"2026-07-05T07:03:35Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"graph_snapshot":{"author_claims":{"count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","strong_count":0},"builder_version":"pith-number-builder-2026-05-17-v1","claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"integrity":{"available":true,"clean":true,"detectors_run":[],"endpoint":"/pith/2310.13806/integrity.json","findings":[],"snapshot_sha256":"c28c3603d3b5d939e8dc4c7e95fa8dfce3d595e45f758748cecf8e644a296938","summary":{"advisory":0,"by_detector":{},"critical":0,"informational":0}},"paper":{"abstract_excerpt":"An amino acid insertion or deletion, or InDel, can have profound and varying functional impacts on a protein's structure. InDel mutations in the transmembrane conductor regulator protein for example give rise to cystic fibrosis. Unfortunately performing InDel mutations on physical proteins and studying their effects is a time prohibitive process. Consequently, modeling InDels computationally can supplement and inform wet lab experiments. In this work, we make use of our data sets of exhaustive double InDel mutations for three proteins which we computationally generated using a robotics inspire","authors_text":"Brian Hutchinson, Filip Jagodzinski, Katie Christensen, Sarah Coffland","cross_cats":["cs.AI","cs.LG","q-bio.QM"],"headline":"","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.BM","submitted_at":"2023-10-20T20:36:13Z","title":"RoseNet: Predicting Energy Metrics of Double InDel Mutants Using Deep Learning"},"references":{"count":0,"internal_anchors":0,"resolved_work":0,"sample":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"2310.13806","kind":"arxiv","version":1},"verdict":{"created_at":null,"id":null,"model_set":{},"one_line_summary":"","pipeline_version":null,"pith_extraction_headline":"","strongest_claim":"","weakest_assumption":""}},"verdict_id":null}}],"author_attestations":[],"timestamp_anchors":[],"storage_attestations":[],"citation_signatures":[],"replication_records":[],"corrections":[],"mirror_hints":[],"record_created":{"event_id":"sha256:a00a11e20a9ebd3fe5ed33bd710bdc93d0421292d4c68d6fa924c165071a185f","target":"record","created_at":"2026-07-05T07:03:35Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"attestation_state":"computed","canonical_record":{"metadata":{"abstract_canon_sha256":"234b96e8eb8a66c3bdcfcbe3e04a65e7ebca9f165902a024b6e7359d22969e4f","cross_cats_sorted":["cs.AI","cs.LG","q-bio.QM"],"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.BM","submitted_at":"2023-10-20T20:36:13Z","title_canon_sha256":"19122f0b07e5b8e7782bed60042eaf1521cc9c102eebf05752ac6e2a8cbd1da5"},"schema_version":"1.0","source":{"id":"2310.13806","kind":"arxiv","version":1}},"canonical_sha256":"140f1458dd4b8c3685457f1fee419fb483175efb09fd15124d37f687e244076d","receipt":{"algorithm":"ed25519","builder_version":"pith-number-builder-2026-05-17-v1","canonical_sha256":"140f1458dd4b8c3685457f1fee419fb483175efb09fd15124d37f687e244076d","first_computed_at":"2026-07-05T07:03:35.054068Z","key_id":"pith-v1-2026-05","kind":"pith_receipt","last_reissued_at":"2026-07-05T07:03:35.054068Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","receipt_version":"0.3","signature_b64":"EMJC0SFTn0J+F/VE+fadfbAN9lNs6FygL24IF0RbnGoe54IYIlty30sSogYm9N/GqykThRsqpIsaeAcBsSmRBw==","signature_status":"signed_v1","signed_at":"2026-07-05T07:03:35.054477Z","signed_message":"canonical_sha256_bytes"},"source_id":"2310.13806","source_kind":"arxiv","source_version":1}}},"equivocations":[],"invalid_events":[],"applied_event_ids":["sha256:a00a11e20a9ebd3fe5ed33bd710bdc93d0421292d4c68d6fa924c165071a185f","sha256:ea8ce80bea0c4add62add6d523875f29a0edede3db72fa77265ce9e8dfc0b5ac"],"state_sha256":"301b7d804a68f93e2e39f1a7376ff52e0ec60421f7c43fc80d70e0fe7db8709b"},"bundle_signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"DkJH5BEinrnX4F88al6nsgv/zZ6Y6jfZk9HUotozhMkeWA64rYIasf6tCexoVsec6we+yar2UmX1HPwsZ1tiBg==","signed_message":"bundle_sha256_bytes","signed_at":"2026-07-06T16:25:51.181457Z","bundle_sha256":"7fa5e6905761e9d935c09b12da4348b9fcbd0ce4ad78e08519d635cac40534cc"}}