{"record_type":"pith_number_record","schema_url":"https://pith.science/schemas/pith-number/v1.json","pith_number":"pith:2024:CSN56STRVKNHWCRJTK6NU7YSKG","short_pith_number":"pith:CSN56STR","schema_version":"1.0","canonical_sha256":"149bdf4a71aa9a7b0a299abcda7f1251a4d7d6b9018641faf85fca36497833ed","source":{"kind":"arxiv","id":"2407.08871","version":1},"attestation_state":"computed","paper":{"title":"Quantifying the Influence of Combined Lung and Kidney Support Using a Cardiovascular Model and Sensitivity Analysis-Informed Parameter Identification","license":"http://creativecommons.org/licenses/by-nc-sa/4.0/","headline":"","cross_cats":["cs.NA","math.NA"],"primary_cat":"physics.med-ph","authors_text":"Ana Martins Costa, Bettina Wiegmann, Jan-Niklas Thiel, Jutta Arens, Michael Neidlin, Ulrich Steinseifer","submitted_at":"2024-07-11T21:11:36Z","abstract_excerpt":"Combined extracorporeal membrane oxygenation (ECMO) and continuous renal replacement therapy (CRRT) pose complex hemodynamic challenges in intensive care. In this study, a comprehensive lumped parameter model (LPM) is developed to simulate the cardiovascular system, incorporating ECMO and CRRT circuit dynamics. The model is used to analyze nine CRRT-ECMO connection schemes under varying flow conditions. Using a robust parameter identification framework based on global sensitivity analysis (GSA) and multi-start gradient-based optimization, we calibrated the model on 30 clinical data points from"},"verification_status":{"content_addressed":true,"pith_receipt":true,"author_attested":false,"weak_author_claims":0,"strong_author_claims":0,"externally_anchored":false,"storage_verified":false,"citation_signatures":0,"replication_records":0,"graph_snapshot":true,"references_resolved":false,"formal_links_present":false},"canonical_record":{"source":{"id":"2407.08871","kind":"arxiv","version":1},"metadata":{"license":"http://creativecommons.org/licenses/by-nc-sa/4.0/","primary_cat":"physics.med-ph","submitted_at":"2024-07-11T21:11:36Z","cross_cats_sorted":["cs.NA","math.NA"],"title_canon_sha256":"2e7a41f6a20f1fc8facd21fcd059220b86c58fbf43ea119201c0f3258e719112","abstract_canon_sha256":"a208837ae15fb0c2ad4b777950e6cc005222acd76e7b4b196f066016623b1936"},"schema_version":"1.0"},"receipt":{"kind":"pith_receipt","key_id":"pith-v1-2026-05","algorithm":"ed25519","signed_at":"2026-07-05T08:42:57.577146Z","signature_b64":"i/0e+Rbpn31kROlCW348pobi/dMz5yzxD7nMhWsktRFWlRcVswRQpN5BrrH3SnERv01Yy/hVP0OiMiE377iwDA==","signed_message":"canonical_sha256_bytes","builder_version":"pith-number-builder-2026-05-17-v1","receipt_version":"0.3","canonical_sha256":"149bdf4a71aa9a7b0a299abcda7f1251a4d7d6b9018641faf85fca36497833ed","last_reissued_at":"2026-07-05T08:42:57.576747Z","signature_status":"signed_v1","first_computed_at":"2026-07-05T08:42:57.576747Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"graph_snapshot":{"paper":{"title":"Quantifying the Influence of Combined Lung and Kidney Support Using a Cardiovascular Model and Sensitivity Analysis-Informed Parameter Identification","license":"http://creativecommons.org/licenses/by-nc-sa/4.0/","headline":"","cross_cats":["cs.NA","math.NA"],"primary_cat":"physics.med-ph","authors_text":"Ana Martins Costa, Bettina Wiegmann, Jan-Niklas Thiel, Jutta Arens, Michael Neidlin, Ulrich Steinseifer","submitted_at":"2024-07-11T21:11:36Z","abstract_excerpt":"Combined extracorporeal membrane oxygenation (ECMO) and continuous renal replacement therapy (CRRT) pose complex hemodynamic challenges in intensive care. In this study, a comprehensive lumped parameter model (LPM) is developed to simulate the cardiovascular system, incorporating ECMO and CRRT circuit dynamics. The model is used to analyze nine CRRT-ECMO connection schemes under varying flow conditions. Using a robust parameter identification framework based on global sensitivity analysis (GSA) and multi-start gradient-based optimization, we calibrated the model on 30 clinical data points from"},"claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"2407.08871","kind":"arxiv","version":1},"verdict":{"id":null,"model_set":{},"created_at":null,"strongest_claim":"","one_line_summary":"","pipeline_version":null,"weakest_assumption":"","pith_extraction_headline":""},"integrity":{"clean":true,"summary":{"advisory":0,"critical":0,"by_detector":{},"informational":0},"endpoint":"/pith/2407.08871/integrity.json","findings":[],"available":true,"detectors_run":[],"snapshot_sha256":"c28c3603d3b5d939e8dc4c7e95fa8dfce3d595e45f758748cecf8e644a296938"},"references":{"count":0,"sample":[],"resolved_work":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","internal_anchors":0},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"author_claims":{"count":0,"strong_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"builder_version":"pith-number-builder-2026-05-17-v1"},"aliases":[{"alias_kind":"arxiv","alias_value":"2407.08871","created_at":"2026-07-05T08:42:57.576803+00:00"},{"alias_kind":"arxiv_version","alias_value":"2407.08871v1","created_at":"2026-07-05T08:42:57.576803+00:00"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.2407.08871","created_at":"2026-07-05T08:42:57.576803+00:00"},{"alias_kind":"pith_short_12","alias_value":"CSN56STRVKNH","created_at":"2026-07-05T08:42:57.576803+00:00"},{"alias_kind":"pith_short_16","alias_value":"CSN56STRVKNHWCRJ","created_at":"2026-07-05T08:42:57.576803+00:00"},{"alias_kind":"pith_short_8","alias_value":"CSN56STR","created_at":"2026-07-05T08:42:57.576803+00:00"}],"events":[],"event_summary":{},"paper_claims":[],"inbound_citations":{"count":0,"internal_anchor_count":0,"sample":[]},"formal_canon":{"evidence_count":0,"sample":[],"anchors":[]},"links":{"html":"https://pith.science/pith/CSN56STRVKNHWCRJTK6NU7YSKG","json":"https://pith.science/pith/CSN56STRVKNHWCRJTK6NU7YSKG.json","graph_json":"https://pith.science/api/pith-number/CSN56STRVKNHWCRJTK6NU7YSKG/graph.json","events_json":"https://pith.science/api/pith-number/CSN56STRVKNHWCRJTK6NU7YSKG/events.json","paper":"https://pith.science/paper/CSN56STR"},"agent_actions":{"view_html":"https://pith.science/pith/CSN56STRVKNHWCRJTK6NU7YSKG","download_json":"https://pith.science/pith/CSN56STRVKNHWCRJTK6NU7YSKG.json","view_paper":"https://pith.science/paper/CSN56STR","resolve_alias":"https://pith.science/api/pith-number/resolve?arxiv=2407.08871&json=true","fetch_graph":"https://pith.science/api/pith-number/CSN56STRVKNHWCRJTK6NU7YSKG/graph.json","fetch_events":"https://pith.science/api/pith-number/CSN56STRVKNHWCRJTK6NU7YSKG/events.json","actions":{"anchor_timestamp":"https://pith.science/pith/CSN56STRVKNHWCRJTK6NU7YSKG/action/timestamp_anchor","attest_storage":"https://pith.science/pith/CSN56STRVKNHWCRJTK6NU7YSKG/action/storage_attestation","attest_author":"https://pith.science/pith/CSN56STRVKNHWCRJTK6NU7YSKG/action/author_attestation","sign_citation":"https://pith.science/pith/CSN56STRVKNHWCRJTK6NU7YSKG/action/citation_signature","submit_replication":"https://pith.science/pith/CSN56STRVKNHWCRJTK6NU7YSKG/action/replication_record"}},"created_at":"2026-07-05T08:42:57.576803+00:00","updated_at":"2026-07-05T08:42:57.576803+00:00"}